DK0438796T3 - Fremgangsmåde til enantioselektiv syntese af alkylerede oxindoler, som anvendes som mellemprodukter ved fremstilling af phy - Google Patents

Fremgangsmåde til enantioselektiv syntese af alkylerede oxindoler, som anvendes som mellemprodukter ved fremstilling af phy

Info

Publication number: DK0438796T3
Authority: DK; Denmark
Prior art keywords: phy; intermediates; preparation; enantiomers; dihydro
Prior art date: 1990-01-22

Application number

DK90125644T

Other languages

Danish (da)

English (en)

Inventor

Thomas Bing Kin Dr Lee

George S K Wong

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-22

Filing date

1990-12-28

Publication date

1999-05-25

1990-12-28 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1999-05-25 Application granted granted Critical

1999-05-25 Publication of DK0438796T3 publication Critical patent/DK0438796T3/da

Links

230000015572 biosynthetic process Effects 0.000 title abstract 3
238000003786 synthesis reaction Methods 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
150000005623 oxindoles Chemical class 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
150000003141 primary amines Chemical class 0.000 abstract 2
230000000707 stereoselective effect Effects 0.000 abstract 2
XEEBADQXIMNBQG-UHFFFAOYSA-N 3-(2-aminoethyl)-5-methoxy-1,3-dimethyl-2-indolone Chemical compound COC1=CC=C2N(C)C(=O)C(C)(CCN)C2=C1 XEEBADQXIMNBQG-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 abstract 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
150000007960 acetonitrile Chemical class 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000010531 catalytic reduction reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 abstract 1
229960001697 physostigmine Drugs 0.000 abstract 1
239000002244 precipitate Substances 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
235000002906 tartaric acid Nutrition 0.000 abstract 1
239000011975 tartaric acid Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)
Catalysts (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Inorganic Compounds Of Heavy Metals (AREA)

DK90125644T 1990-01-22 1990-12-28 Fremgangsmåde til enantioselektiv syntese af alkylerede oxindoler, som anvendes som mellemprodukter ved fremstilling af phy DK0438796T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US46988290A	1990-01-22	1990-01-22

Publications (1)

Publication Number	Publication Date
DK0438796T3 true DK0438796T3 (da)	1999-05-25

Family

ID=23865415

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90125644T DK0438796T3 (da)	1990-01-22	1990-12-28	Fremgangsmåde til enantioselektiv syntese af alkylerede oxindoler, som anvendes som mellemprodukter ved fremstilling af phy

Country Status (22)

Country	Link
EP (1)	EP0438796B1 (cs)
JP (1)	JPH0757747B2 (cs)
KR (1)	KR0175933B1 (cs)
AT (1)	ATE170173T1 (cs)
AU (1)	AU631957B2 (cs)
CA (1)	CA2034668A1 (cs)
CZ (1)	CZ278815B6 (cs)
DE (1)	DE69032595T2 (cs)
DK (1)	DK0438796T3 (cs)
ES (1)	ES2120407T3 (cs)
HR (1)	HRP930321B1 (cs)
HU (2)	HUT56539A (cs)
IE (1)	IE910194A1 (cs)
IL (1)	IL97002A (cs)
LT (1)	LT3982B (cs)
NZ (1)	NZ236837A (cs)
PH (1)	PH30059A (cs)
PT (1)	PT96534B (cs)
RU (1)	RU2072354C1 (cs)
SG (1)	SG52631A1 (cs)
YU (1)	YU9891A (cs)
ZA (1)	ZA91410B (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2075102T3 (es) *	1989-09-19	1995-10-01	Hoechst Roussel Pharma	Procedimiento para la resolucion quimica de (+/-)-1,3-dimetiloxiindoliletilaminas 5-alcoxi sustituidas.
US4914102A (en) *	1989-09-28	1990-04-03	Hoechst Roussel Pharmaceuticals, Inc.	N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5840915A (en) *	1990-01-22	1998-11-24	Hoechst Marion Roussel, Inc.	Process for the enatioselective synthesis of intermediates used
US5521320A (en) *	1990-01-22	1996-05-28	Hoechst-Roussel Pharmaceuticals Incorporated	Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine
GB0011120D0 (en) *	2000-05-09	2000-06-28	Avecia Ltd	Process
US6596870B2 (en)	2000-07-13	2003-07-22	Brandeis University	Asymmetric synthetic methods based on phase transfer catalysis
WO2002070478A1 (en)	2001-03-06	2002-09-12	Astrazeneca Ab	Indolone derivatives having vascular-damaging activity
WO2013069731A1 (ja) *	2011-11-08	2013-05-16	日産化学工業株式会社	光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物
AU2013232191B2 (en) *	2012-03-14	2017-03-30	Merck Sharp & Dohme Llc	Bis-quarternary cinchona alkaloid salts as asymmetric phase transfer catalysts

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4578509A (en)	1983-04-01	1986-03-25	Merck & Co., Inc.	Process for preparing a manipulated enantiomer mixture by asymmetric chiral phase transfer catalysis
US4791107A (en)	1986-07-16	1988-12-13	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
ES2075102T3 (es) *	1989-09-19	1995-10-01	Hoechst Roussel Pharma	Procedimiento para la resolucion quimica de (+/-)-1,3-dimetiloxiindoliletilaminas 5-alcoxi sustituidas.
US4914102A (en) *	1989-09-28	1990-04-03	Hoechst Roussel Pharmaceuticals, Inc.	N-aminocarbamates related to physostigmine, pharmacentical compositions and use
DE69515062T2 (de)	1994-11-28	2000-09-14	Minnesota Mining And Mfg. Co., St. Paul	Gegenstände mit dauerhaften farb- und/oder fluoreszenzeigenschaften

1990
- 1990-12-28 DK DK90125644T patent/DK0438796T3/da active
- 1990-12-28 DE DE69032595T patent/DE69032595T2/de not_active Expired - Fee Related
- 1990-12-28 EP EP90125644A patent/EP0438796B1/en not_active Expired - Lifetime
- 1990-12-28 SG SG1996007048A patent/SG52631A1/en unknown
- 1990-12-28 AT AT90125644T patent/ATE170173T1/de not_active IP Right Cessation
- 1990-12-28 ES ES90125644T patent/ES2120407T3/es not_active Expired - Lifetime
1991
- 1991-01-18 NZ NZ236837A patent/NZ236837A/xx unknown
- 1991-01-21 JP JP3078153A patent/JPH0757747B2/ja not_active Expired - Lifetime
- 1991-01-21 PT PT96534A patent/PT96534B/pt not_active IP Right Cessation
- 1991-01-21 HU HU91210A patent/HUT56539A/hu unknown
- 1991-01-21 PH PH41878A patent/PH30059A/en unknown
- 1991-01-21 IE IE019491A patent/IE910194A1/en not_active IP Right Cessation
- 1991-01-21 ZA ZA91410A patent/ZA91410B/xx unknown
- 1991-01-21 AU AU69496/91A patent/AU631957B2/en not_active Ceased
- 1991-01-21 RU SU914894301A patent/RU2072354C1/ru active
- 1991-01-21 HU HU9801313A patent/HU9801313D0/hu unknown
- 1991-01-21 KR KR1019910000934A patent/KR0175933B1/ko not_active Expired - Fee Related
- 1991-01-21 YU YU9891A patent/YU9891A/sh unknown
- 1991-01-21 CZ CS91123A patent/CZ278815B6/cs not_active IP Right Cessation
- 1991-01-21 CA CA002034668A patent/CA2034668A1/en not_active Abandoned
- 1991-01-22 IL IL9700291A patent/IL97002A/en not_active IP Right Cessation
1993
- 1993-03-11 HR HRP-98/91A patent/HRP930321B1/xx not_active IP Right Cessation
- 1993-12-20 LT LTIP1629A patent/LT3982B/lt not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE910194A1 (en)	1991-07-31
ZA91410B (en)	1991-10-30
KR910014349A (ko)	1991-08-31
PT96534B (pt)	1998-07-31
HRP930321A2 (en)	1996-08-31
EP0438796A3 (en)	1992-03-18
YU9891A (sh)	1994-06-24
JPH0757747B2 (ja)	1995-06-21
CS9100123A2 (en)	1991-09-15
HK1011993A1 (en)	1999-07-23
HU910210D0 (en)	1991-08-28
DE69032595D1 (de)	1998-10-01
HUT56539A (en)	1991-09-30
LTIP1629A (en)	1995-07-25
CA2034668A1 (en)	1991-07-23
PH30059A (en)	1996-11-08
RU2072354C1 (ru)	1997-01-27
DE69032595T2 (de)	1999-03-25
ATE170173T1 (de)	1998-09-15
HU9801313D0 (en)	1998-08-28
IL97002A0 (en)	1992-03-29
LT3982B (en)	1996-06-25
NZ236837A (en)	1993-03-26
AU6949691A (en)	1991-07-25
SG52631A1 (en)	1998-09-28
CZ278815B6 (en)	1994-07-13
PT96534A (pt)	1991-10-15
IL97002A (en)	1994-10-21
KR0175933B1 (ko)	1999-03-20
AU631957B2 (en)	1992-12-10
EP0438796B1 (en)	1998-08-26
HRP930321B1 (en)	1999-02-28
EP0438796A2 (en)	1991-07-31
ES2120407T3 (es)	1998-11-01
JPH04342566A (ja)	1992-11-30

Publication	Publication Date	Title
ES2067693T3 (es)	1995-04-01	Azabicicloheptanona quiral y un procedimiento para su preparacion.
DE3875073D1 (cs)	1992-11-05
BR9702180A (pt)	1999-12-28	Diazepino indóis, intermediários amino-diazepino-indóis, processo para a preparação dos compostos, utilização dos mesmos, e, medicamento.
AU6949691A (en)	1991-07-25	Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine
DK0402752T3 (da)	1996-01-15	N-Heteroaryl-purin-6-aminer, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
HUT36127A (en)	1985-08-28	Process for preparing new pyrrolo-benzoxazepines
CA1265819C (en)	1990-02-13	METHOD FOR THE PREPARATION OF ( )R-2-METHYL-HEXANE-1,2-DIOL
NO20005259D0 (no)	2000-10-19	FremgangsmÕte for fremstilling av enantiomerrent N-metyl-N- [(1S)-1-fenyl-2-((3S)-3-hydroksypyrrolidin-1-yl)etyl]-2,2- difenylacetamid
IL108829A0 (en)	1994-06-24	Enzymatic resolution of alkyl 2-piperidinecarboxylates and use of the compounds obtained as synthesis intermediates
ES557208A0 (es)	1987-12-01	Un procedimiento para preparar derivados de dihidropirrol (112-b)-isoquinoleina
DK0492350T3 (da)	1998-01-26	Fremgangsmåde til fremstilling af (S)-vinyl- og (S)-allenyl-GABA
ES8608488A1 (es)	1986-06-16	Un metodo para preparar nuevas 1-aminoalquil-amino-4-arilo- xipiperidinas sustituidas
ATE70052T1 (de)	1991-12-15	Verfahren zur herstellung von indolinen.
MY105302A (en)	1994-09-30	Process for dehydrating corticosteroid intermediates.
Tungler et al.	1995	An Investigation of the Mode of Hydrogen Addition in Stereoselective Heterogeneous Catalytic Hydrogenations
ES8605767A1 (es)	1986-04-01	Procedimiento de preparacion de un derivado del acido feni- lacetico