DK0579733T3 - Thiazolidindionderivater, fremstilling og anvendelse deraf - Google Patents

Thiazolidindionderivater, fremstilling og anvendelse deraf

Info

Publication number: DK0579733T3
Authority: DK; Denmark
Prior art keywords: preparation; thiazolidinedione derivatives; general formula; thiazolidinedione derivative; thiazolidinedione
Prior art date: 1991-04-11

Application number

DK92910028T

Other languages

Danish (da)

English (en)

Inventor

Takashi Sohda

Hitoshi Ikeda

John C Greenfield

Jerry R Colca

Edgar N Petzold

Original Assignee

Upjohn Co

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-11

Filing date

1992-04-06

Publication date

2001-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13672917&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0579733(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-04-06 Application filed by Upjohn Co, Takeda Chemical Industries Ltd filed Critical Upjohn Co

2001-10-15 Application granted granted Critical

2001-10-15 Publication of DK0579733T3 publication Critical patent/DK0579733T3/da

Links

150000001467 thiazolidinediones Chemical class 0.000 title abstract 3
UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000000055 hyoplipidemic effect Effects 0.000 abstract 1
230000002218 hypoglycaemic effect Effects 0.000 abstract 1
125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Lubricants (AREA)
Graft Or Block Polymers (AREA)
Photoreceptors In Electrophotography (AREA)

DK92910028T 1991-04-11 1992-04-06 Thiazolidindionderivater, fremstilling og anvendelse deraf DK0579733T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP7883691		1991-04-11
PCT/US1992/002566 WO1992018501A1 (fr)	1991-04-11	1992-04-06	Derives de thiazolidinedione, production et utilisation desdits derives

Publications (1)

Publication Number	Publication Date
DK0579733T3 true DK0579733T3 (da)	2001-10-15

Family

ID=13672917

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92910028T DK0579733T3 (da)	1991-04-11	1992-04-06	Thiazolidindionderivater, fremstilling og anvendelse deraf

Country Status (19)

Country	Link
EP (1)	EP0579733B1 (fr)
JP (1)	JP3176694B2 (fr)
KR (1)	KR100249988B1 (fr)
AT (1)	ATE202352T1 (fr)
AU (1)	AU1743292A (fr)
CA (1)	CA2106967C (fr)
CZ (1)	CZ196693A3 (fr)
DE (1)	DE69231886T2 (fr)
DK (1)	DK0579733T3 (fr)
ES (1)	ES2161692T3 (fr)
FI (1)	FI934426L (fr)
GR (1)	GR3036623T3 (fr)
HU (1)	HUT68370A (fr)
MX (1)	MX9201637A (fr)
NO (1)	NO933615L (fr)
PT (1)	PT100366A (fr)
SK (1)	SK109993A3 (fr)
TW (1)	TW209864B (fr)
WO (1)	WO1992018501A1 (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993022445A1 (fr) *	1992-05-05	1993-11-11	The Upjohn Company	Procede de production de metabolites de pioglitazone
TW268952B (fr) *	1993-02-26	1996-01-21	Takeda Pharm Industry Co Ltd
CZ289317B6 (cs) *	1994-04-11	2002-01-16	Sankyo Company Limited	Heterocyklická sloučenina, farmaceutický prostředek ji obsahující a její pouľití
TWI238064B (en) *	1995-06-20	2005-08-21	Takeda Chemical Industries Ltd	A pharmaceutical composition for prophylaxis and treatment of diabetes
US5952509A (en) *	1996-06-27	1999-09-14	Takeda Chemical Industries, Ltd.	Production of benzaldehyde compounds
BR9810142A (pt)	1997-06-18	2000-08-08	Smithkline Beecham Plc	Tratamento de diabete com tiazolidinadiona e sulfonil-uréia
CZ20011629A3 (cs) *	1998-11-12	2001-12-12	Smithkline Beecham Plc	Farmaceutický prostředek pro upravené uvolňování senzitizéru inzulínu a jiných antidiabetických přípravků
AR023699A1 (es)	1998-11-12	2002-09-04	Smithkline Beecham Corp	Una composicion farmaceutica que comprende un estabilizador de insulina y un procedimiento para preparar una composicion farmaceutica
GB0014969D0 (en)	2000-06-19	2000-08-09	Smithkline Beecham Plc	Novel method of treatment
DE20119200U1 (de)	2001-11-27	2003-04-10	Joh. Winklhofer & Söhne GmbH und Co KG, 81369 München	Kettenspanner mit mechanischer Verriegelung
US8216609B2 (en)	2002-08-05	2012-07-10	Torrent Pharmaceuticals Limited	Modified release composition of highly soluble drugs
US8268352B2 (en)	2002-08-05	2012-09-18	Torrent Pharmaceuticals Limited	Modified release composition for highly soluble drugs
KR100646128B1 (ko)	2005-04-21	2006-11-14	전라옥	ＰＰＡＲγ에 선택적으로 작용하는 테트라하이드로퀴놀린계열 티아졸리딘디온 유도체 및 그 합성방법
JP2009530293A (ja) *	2006-03-16	2009-08-27	メタボリックソリューションズディベロップメントカンパニー	チアゾリジンジオン類似体およびグルココルチコイドアゴニストの併用療法
AU2013200104B2 (en) *	2006-03-16	2014-05-15	Metabolic Solutions Development Company, Llc	Thiazolidinedione analogues for the treatment of metabolic inflammation mediated disease
PL2001468T3 (pl) *	2006-03-16	2013-03-29	Metabolic Solutions Dev Co Llc	Analogi tiazolidynodionu
NZ571870A (en) *	2006-03-16	2011-07-29	Metabolic Solutions Dev Co	Thiazolidinedione analogues for the treatment of hypertension and for lowering lipids
US7435741B2 (en)	2006-05-09	2008-10-14	Teva Pharmaceutical Industries, Ltd.	2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
WO2008038359A1 (fr)	2006-09-28	2008-04-03	Daido Kogyo Co., Ltd.	Tensionneur de chaîne
US8304441B2 (en)	2007-09-14	2012-11-06	Metabolic Solutions Development Company, Llc	Thiazolidinedione analogues for the treatment of metabolic diseases
KR101537830B1 (ko)	2007-09-14	2015-07-17	메타볼릭 솔루션스 디벨롭먼트 컴퍼니, 엘엘씨	고혈압 치료용 티아졸리딘디온 유사체
US8722710B2 (en)	2007-09-26	2014-05-13	Deuterx, Llc	Deuterium-enriched pioglitazone
KR20120107493A (ko) *	2009-12-15	2012-10-02	메타볼릭 솔루션스 디벨롭먼트 컴퍼니, 엘엘씨	대사성 질환의 치료를 위한 ｐｐａｒ 절약형 티아졸리딘디온염
US20130211095A1 (en) *	2010-04-19	2013-08-15	Metabolic Solutions Development Company, Llc	Novel synthesis for thiazolidinedione compounds
MX2012012092A (es) *	2010-04-19	2012-12-17	Metabolic Solutions Dev Co Llc	Sintesis novedosa para compuestos de tiazolidinadiona.
PL2603498T3 (pl)	2010-08-10	2017-06-30	Octeta Therapeutics, Llc	Nowa synteza związków tiazolidynodionu
US8895748B2 (en) *	2010-08-10	2014-11-25	Metabolic Solutions Development Company, Llc	Synthesis for thiazolidinedione compounds
US20120094959A1 (en)	2010-10-19	2012-04-19	Bonnie Blazer-Yost	Treatment of cystic diseases
WO2014152843A1 (fr) *	2013-03-14	2014-09-25	Deuterx, Llc	2,4-thiazolidinediones enrichies en deutérium et méthodes de traitement
EP3094328B1 (fr)	2014-01-15	2020-08-19	Poxel SA	Méthodes de traitement de troubles neurologiques, métaboliques et autres à l'aide de pioglitazone énantiopure enrichie en deutérium
EA202091120A3 (ru) *	2014-04-02	2020-12-30	Минорикс Терапьютикс С.Л.	Производные 2,4-тиазолинидона в лечении расстройств центральной нервной системы
WO2016071727A1 (fr)	2014-11-04	2016-05-12	INSERM (Institut National de la Santé et de la Recherche Médicale)	Méthodes pour la prévention et le traitement de la glomérulonéphrite rapidement progressive
JP7040798B2 (ja) *	2016-12-01	2022-03-23	ミノリックスセラピューティクスエセ．エレ．	非アルコール性脂肪性肝疾患を処置するための５－［［４－［２－［５－（１－ヒドロキシエチル）ピリジン－２－イル］エトキシ］フェニル］メチル］－１，３－チアゾリジン－２，４－ジオン
ES2926580T3 (es) *	2016-12-23	2022-10-27	Minoryx Therapeutics S L	Proceso para preparar 5-[[4-[2-[5-(1-hidroxietil)-2-piridinil]etoxi]fenil]metil]-2,4-tiazolidindiona y sales de la misma
US11767317B1 (en)	2020-06-30	2023-09-26	Poxel Sa	Methods of synthesizing enantiopure deuterium-enriched pioglitazone
US11319313B2 (en)	2020-06-30	2022-05-03	Poxel Sa	Crystalline forms of deuterium-enriched pioglitazone
WO2024231881A2 (fr) *	2023-05-09	2024-11-14	Minoryx Therapeutics S.L.	Formes polymorphes et formulations de leriglitazone

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5522636A (en) *	1978-08-04	1980-02-18	Takeda Chem Ind Ltd	Thiazoliding derivative
AR240698A1 (es) *	1985-01-19	1990-09-28	Takeda Chemical Industries Ltd	Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales

1992
- 1992-04-06 DE DE69231886T patent/DE69231886T2/de not_active Expired - Lifetime
- 1992-04-06 EP EP92910028A patent/EP0579733B1/fr not_active Expired - Lifetime
- 1992-04-06 DK DK92910028T patent/DK0579733T3/da active
- 1992-04-06 SK SK1099-93A patent/SK109993A3/sk unknown
- 1992-04-06 ES ES92910028T patent/ES2161692T3/es not_active Expired - Lifetime
- 1992-04-06 AT AT92910028T patent/ATE202352T1/de active
- 1992-04-06 FI FI934426A patent/FI934426L/fi not_active Application Discontinuation
- 1992-04-06 WO PCT/US1992/002566 patent/WO1992018501A1/fr not_active Ceased
- 1992-04-06 KR KR1019930703064A patent/KR100249988B1/ko not_active Expired - Lifetime
- 1992-04-06 HU HU9302859A patent/HUT68370A/hu unknown
- 1992-04-06 CZ CS931966A patent/CZ196693A3/cs unknown
- 1992-04-06 CA CA002106967A patent/CA2106967C/fr not_active Expired - Lifetime
- 1992-04-06 AU AU17432/92A patent/AU1743292A/en not_active Abandoned
- 1992-04-07 JP JP08540592A patent/JP3176694B2/ja not_active Expired - Lifetime
- 1992-04-09 MX MX9201637A patent/MX9201637A/es unknown
- 1992-04-09 PT PT100366A patent/PT100366A/pt not_active Application Discontinuation
- 1992-04-11 TW TW081102843A patent/TW209864B/zh active
1993
- 1993-10-08 NO NO933615A patent/NO933615L/no unknown
2001
- 2001-09-17 GR GR20010401481T patent/GR3036623T3/el unknown

Also Published As

Publication number	Publication date
EP0579733A1 (fr)	1994-01-26
FI934426A0 (fi)	1993-10-08
HUT68370A (en)	1995-06-28
FI934426A7 (fi)	1993-10-08
DE69231886D1 (de)	2001-07-26
CA2106967A1 (fr)	1992-10-12
CZ196693A3 (en)	1994-05-18
TW209864B (fr)	1993-07-21
NO933615D0 (no)	1993-10-08
WO1992018501A1 (fr)	1992-10-29
MX9201637A (es)	1993-08-01
FI934426L (fi)	1993-10-08
DE69231886T2 (de)	2002-03-28
KR100249988B1 (ko)	2000-04-01
AU1743292A (en)	1992-11-17
ES2161692T3 (es)	2001-12-16
GR3036623T3 (en)	2001-12-31
SK109993A3 (en)	1994-12-07
JPH0586057A (ja)	1993-04-06
JP3176694B2 (ja)	2001-06-18
EP0579733B1 (fr)	2001-06-20
NO933615L (no)	1993-10-08
CA2106967C (fr)	2003-12-09
PT100366A (pt)	1993-06-30
ATE202352T1 (de)	2001-07-15

Publication	Publication Date	Title
DK0579733T3 (da)	2001-10-15	Thiazolidindionderivater, fremstilling og anvendelse deraf
KR0156747B1 (en)	1998-11-16	Use of 1,3-oxathiolan nucleoside analogues in the treatment of hepatitis-b
TW273550B (fr)	1996-04-01
NO963053L (no)	1996-09-20	Kosmetiske eller farmasöytiske preparater inneholdende mangiferin eller derivater derav
NO944911L (no)	1995-06-22	Ikke-peptid-takykininreseptorantagonister
MY104626A (en)	1994-04-30	A 1-phenylimidazole derivative and its production and use.
DK0613894T3 (da)	1999-11-01	N-Heteroaryl-N'-phenylurinstofderivater, fremstilling og anvendelse deraf
DK0664121T3 (da)	2001-12-03	Anvendelse af raloxifen og dets analoger til fremstilling af et medikament til behandling af aterosclerose og iskæmisk hjertesygdom
AU630777B2 (en)	1992-11-05	2-aminopyrimidine-4-carboxamide derivatives, their preparation and their application in therapeutics
DK0508740T3 (da)	1997-10-20	Thiazolidindionderivater, deres fremstilling og anvendelse.
CA2007771A1 (fr)	1990-07-26	Materiau de lentille oculaire
MY102135A (en)	1992-04-30	A benzoylurea derivative and its production and use.
GB9108629D0 (en)	1991-06-12	Heterocyclic pharmaceutical compounds,preparation and use
IE782185L (en)	1979-05-05	Isothiazole derivatives
IL103826A0 (en)	1993-04-04	Thiazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
EP1156057A4 (fr)	2002-07-03	Derives de malto-oligosaccharide et leurs utilisations
NO941084L (no)	1994-03-24	Neuroleptiske 2-substituerte perhydro-1-H-pyrido[1,2-aÅpyraziner
JPS5419969A (en)	1979-02-15	Proline derivative and its preparation
HU9904686D0 (en)	2000-03-28	New hydroxy-bicyclolactam derivatives, their use and medicaments containing them
DE69131353D1 (de)	1999-07-22	Indolderivate
GB2001635A (en)	1979-02-07	Substituted 3-aminosulphonyl- 4-nitrodiphenyl ether derivatives
AU573062B2 (en)	1988-05-26	Dihydrodithiazine derivatives
GB2009159A (en)	1979-06-13	3'-Methoxyflavylium derivatives
AU9107682A (en)	1983-06-09	3,7alpha-diazacyclohepta(j,k)fluoriene derivatives
SG4595G (en)	1995-06-16	Use of 2-oxo-imidazolidine derivatives in the prophylaxis and treatment of heart failure