ZA9610889B - 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives. - Google Patents

1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives.

Info

Publication number: ZA9610889B
Authority: ZA; South Africa
Prior art keywords: piperidine derivatives; fused imidazole; disubstituted piperidinyl; disubstituted; piperidinyl
Prior art date: 1995-12-27

Application number

ZA9610889A

Other languages

English (en)

Inventor

Frans Eduard Janssens

Yves Emiel Maria Va Roosbroeck

Joseph Elizabeth Leenaerts

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-27

Filing date

1996-12-23

Publication date

1998-06-23

1996-12-23 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1998-06-23 Publication of ZA9610889B publication Critical patent/ZA9610889B/xx

Links

150000002460 imidazoles Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Hospice & Palliative Care (AREA)
Biotechnology (AREA)
Anesthesiology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA9610889A 1995-12-27 1996-12-23 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives. ZA9610889B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP95203652		1995-12-27

Publications (1)

Publication Number	Publication Date
ZA9610889B true ZA9610889B (en)	1998-06-23

Family

ID=8221024

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9610889A ZA9610889B (en)	1995-12-27	1996-12-23	1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives.

Country Status (29)

Country	Link
US (1)	US6251894B1 (da)
EP (1)	EP0843679B1 (da)
JP (1)	JP4097043B2 (da)
KR (1)	KR100485147B1 (da)
CN (1)	CN1066733C (da)
AR (2)	AR005278A1 (da)
AT (1)	ATE208392T1 (da)
AU (1)	AU716071B2 (da)
BR (1)	BR9612307A (da)
CA (1)	CA2238817C (da)
CY (1)	CY2271B1 (da)
CZ (1)	CZ295861B6 (da)
DE (1)	DE69616802T2 (da)
DK (1)	DK0843679T3 (da)
EA (1)	EA001374B1 (da)
ES (1)	ES2167619T3 (da)
HU (1)	HU229766B1 (da)
IL (2)	IL124642A (da)
MY (1)	MY117680A (da)
NO (1)	NO310916B1 (da)
NZ (1)	NZ325845A (da)
PL (1)	PL183767B1 (da)
PT (1)	PT843679E (da)
SI (1)	SI0843679T1 (da)
SK (1)	SK283540B6 (da)
TR (1)	TR199801210T2 (da)
TW (1)	TW382017B (da)
WO (1)	WO1997024356A1 (da)
ZA (1)	ZA9610889B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW527186B (en)	1996-03-19	2003-04-11	Janssen Pharmaceutica Nv	Fused imidazole derivatives as multidrug resistance modulators
US6544979B1 (en)	1997-09-18	2003-04-08	Janssen Pharmaceuticals, N.V.	Fused imidazole derivatives for improving oral bioavailability of pharmaceutical agents
EE04917B1 (et) *	1998-12-19	2007-10-15	Janssen Pharmaceutica N.V.	Antihistamiinsed spirohendid, vahehendid ja farmatseutiline kompositsioon ning nende valmistamismeetodid ja kasutamine
WO2001030348A1 (en) *	1999-10-25	2001-05-03	Janssen Pharmaceutica N.V.	Use of substance p antagonists for influencing the circadian timing system
US7476662B2 (en)	2001-06-12	2009-01-13	Janssen Pharmaceutica N.V.	Substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
US20030083345A1 (en) *	2001-07-10	2003-05-01	Torsten Hoffmann	Method of treatment and/or prevention of brain, spinal or nerve injury
CA2690483C (en) *	2001-11-23	2012-07-24	Janssen Pharmaceutica N.V.	The use of anti-histaminics for acute reduction of elevated intracranial pressure
WO2003050123A1 (en) *	2001-12-10	2003-06-19	Kyorin Pharmaceutical Co., Ltd.	Fused bicyclic pyridine derivatives as tachykinin receptor antagonists
US20050085510A1 (en) *	2002-01-16	2005-04-21	Telefonaktiebolaget Lm Ericsson (Publ)	Prucalopride-n-oxide
CN1297559C (zh)	2002-01-18	2007-01-31	杏林制药株式会社	稠合双环嘧啶衍生物
DE60314238T2 (de) *	2002-03-26	2008-01-31	Kyorin Pharmaceutical Co., Ltd.	Kondensierte, bicyclische pyridinderivate als antagonisten des tachykininrezeptors
JO2696B1 (en)	2002-12-23	2013-03-03	شركة جانسين فارماسوتيكا ان. في	Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
EP1578744B1 (en) *	2002-12-23	2008-07-09	Janssen Pharmaceutica N.V.	Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists
JO2676B1 (en)	2004-04-06	2012-06-17	جانسين فارماسوتيكا ان. في	Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
JO2525B1 (en) *	2004-04-08	2010-03-17	شركة جانسين فارماسوتيكا ان. في	Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin
DE602006014531D1 (de)	2005-03-03	2010-07-08	Janssen Pharmaceutica Nv	Substituierte oxadiazaspiro-ä5.5ü-undecanonderivate und ihre verwendung als neurokininantagonisten
NZ556628A (en)	2005-03-08	2009-09-25	Janssen Pharmaceutica Nv	Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists
JP2010533655A (ja) *	2007-07-19	2010-10-28	アデレイドリサーチアンドイノベーションピーティーワイリミテッド	頭蓋内圧を低下させるための方法
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
WO2013004766A1 (en)	2011-07-04	2013-01-10	Ferrari Giulio	Nk-1 receptor antagonists for treating corneal neovascularisation
US20210015834A1 (en)	2018-02-26	2021-01-21	Ospedale San Raffaele S.R.L.	Nk-1 antagonists for use in the treatment of ocular pain
WO2021180885A1 (en)	2020-03-11	2021-09-16	Ospedale San Raffaele S.R.L.	Treatment of stem cell deficiency

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4329353A (en)	1980-10-22	1982-05-11	Janssen Pharmaceutica, N.V.	1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
DE69110685T2 (de) *	1990-10-10	1995-11-09	Schering Corp	Substituierte imidazobenzazepine und imidazopyridoazepine.
IL101850A (en) *	1991-06-13	1996-01-31	Janssen Pharmaceutica Nv	11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them
IL101851A (en) *	1991-06-13	1996-05-14	Janssen Pharmaceutica Nv	10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor
PT708776E (pt) *	1993-07-13	2001-06-29	Janssen Pharmaceutica Nv	Imidazoazepinas anti-alergicas
US5814636A (en)	1994-07-15	1998-09-29	Meiji Seika Kabushiki Kaisha	Compounds with platelet aggregation inhibitor activity
NZ321575A (en)	1995-10-30	1999-05-28	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives

1996
- 1996-12-13 TW TW085115390A patent/TW382017B/zh not_active IP Right Cessation
- 1996-12-20 WO PCT/EP1996/005885 patent/WO1997024356A1/en not_active Ceased
- 1996-12-20 TR TR1998/01210T patent/TR199801210T2/xx unknown
- 1996-12-20 DK DK96944693T patent/DK0843679T3/da active
- 1996-12-20 CZ CZ19981865A patent/CZ295861B6/cs not_active IP Right Cessation
- 1996-12-20 AT AT96944693T patent/ATE208392T1/de active
- 1996-12-20 KR KR10-1998-0704830A patent/KR100485147B1/ko not_active Expired - Fee Related
- 1996-12-20 BR BR9612307A patent/BR9612307A/pt not_active IP Right Cessation
- 1996-12-20 SK SK830-98A patent/SK283540B6/sk unknown
- 1996-12-20 IL IL12464296A patent/IL124642A/en not_active IP Right Cessation
- 1996-12-20 PL PL96327136A patent/PL183767B1/pl unknown
- 1996-12-20 IL IL12464196A patent/IL124641A/en not_active IP Right Cessation
- 1996-12-20 NZ NZ325845A patent/NZ325845A/xx not_active IP Right Cessation
- 1996-12-20 EP EP96944693A patent/EP0843679B1/en not_active Expired - Lifetime
- 1996-12-20 EA EA199800603A patent/EA001374B1/ru not_active IP Right Cessation
- 1996-12-20 HU HU9903948 patent/HU229766B1/hu not_active IP Right Cessation
- 1996-12-20 CA CA002238817A patent/CA2238817C/en not_active Expired - Fee Related
- 1996-12-20 AU AU13086/97A patent/AU716071B2/en not_active Ceased
- 1996-12-20 ES ES96944693T patent/ES2167619T3/es not_active Expired - Lifetime
- 1996-12-20 CN CN96199396A patent/CN1066733C/zh not_active Expired - Fee Related
- 1996-12-20 JP JP52403397A patent/JP4097043B2/ja not_active Expired - Fee Related
- 1996-12-20 PT PT96944693T patent/PT843679E/pt unknown
- 1996-12-20 SI SI9630419T patent/SI0843679T1/xx unknown
- 1996-12-20 DE DE69616802T patent/DE69616802T2/de not_active Expired - Lifetime
- 1996-12-23 ZA ZA9610889A patent/ZA9610889B/xx unknown
- 1996-12-26 AR ARP960105895A patent/AR005278A1/es active IP Right Grant
- 1996-12-27 MY MYPI96005516A patent/MY117680A/en unknown
1998
- 1998-05-27 NO NO19982405A patent/NO310916B1/no not_active IP Right Cessation
- 1998-06-22 US US09/102,136 patent/US6251894B1/en not_active Expired - Lifetime
2002
- 2002-04-25 CY CY0200023A patent/CY2271B1/xx unknown
2005
- 2005-12-16 AR ARP050105316A patent/AR051817A2/es active IP Right Grant

Also Published As

Publication number	Publication date
ATE208392T1 (de)	2001-11-15
CA2238817A1 (en)	1997-07-10
CN1206417A (zh)	1999-01-27
HK1011206A1 (en)	1999-07-09
TR199801210T2 (xx)	1999-10-21
PL327136A1 (en)	1998-11-23
TW382017B (en)	2000-02-11
AR005278A1 (es)	1999-04-28
BR9612307A (pt)	1999-07-13
PT843679E (pt)	2002-04-29
HUP9903948A3 (hu)	2000-04-28
NZ325845A (en)	1999-06-29
CA2238817C (en)	2006-10-17
HUP9903948A2 (hu)	2000-03-28
EP0843679B1 (en)	2001-11-07
DK0843679T3 (da)	2002-02-25
CY2271B1 (en)	2003-07-04
IL124642A (en)	2002-08-14
EA001374B1 (ru)	2001-02-26
NO982405L (no)	1998-08-19
CZ186598A3 (cs)	1998-11-11
NO310916B1 (no)	2001-09-17
IL124641A (en)	2001-11-25
IL124641A0 (en)	1998-12-06
IL124642A0 (en)	1998-12-06
SI0843679T1 (en)	2002-06-30
ES2167619T3 (es)	2002-05-16
EA199800603A1 (ru)	1998-12-24
KR19990076715A (ko)	1999-10-15
EP0843679A1 (en)	1998-05-27
HU229766B1 (hu)	2014-06-30
JP2000506503A (ja)	2000-05-30
AU1308697A (en)	1997-07-28
AR051817A2 (es)	2007-02-14
JP4097043B2 (ja)	2008-06-04
US6251894B1 (en)	2001-06-26
NO982405D0 (no)	1998-05-27
CZ295861B6 (cs)	2005-11-16
DE69616802D1 (de)	2001-12-13
CN1066733C (zh)	2001-06-06
AU716071B2 (en)	2000-02-17
PL183767B1 (pl)	2002-07-31
KR100485147B1 (ko)	2005-09-13
SK283540B6 (sk)	2003-09-11
DE69616802T2 (de)	2002-07-04
WO1997024356A1 (en)	1997-07-10
MY117680A (en)	2004-07-31
SK83098A3 (en)	1999-01-11

Publication	Publication Date	Title
ZA9610885B (en)	1998-06-23	1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives.
ZA9610889B (en)	1998-06-23	1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives.
ZA969090B (en)	1998-04-29	1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives.
FI943164L (fi)	1995-01-02	2-(1-(1,3-tiatsolin-2-yyli)atsetidin-3-yyli)tiokarbapeneemijohdannaisia
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