DK0871642T3 - Nucleinsyremedieret elektronoverførsel - Google Patents

Nucleinsyremedieret elektronoverførsel

Info

Publication number
DK0871642T3
DK0871642T3 DK96919290T DK96919290T DK0871642T3 DK 0871642 T3 DK0871642 T3 DK 0871642T3 DK 96919290 T DK96919290 T DK 96919290T DK 96919290 T DK96919290 T DK 96919290T DK 0871642 T3 DK0871642 T3 DK 0871642T3
Authority
DK
Denmark
Prior art keywords
nucleic acid
complexes
electron transfer
mediated electron
moieties
Prior art date
Application number
DK96919290T
Other languages
Danish (da)
English (en)
Inventor
Thomas J Meade
Jon F Kayyem
Scott E Fraser
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Application granted granted Critical
Publication of DK0871642T3 publication Critical patent/DK0871642T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Composite Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK96919290T 1995-06-07 1996-06-07 Nucleinsyremedieret elektronoverførsel DK0871642T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/475,051 US5824473A (en) 1993-12-10 1995-06-07 Nucleic acid mediated electron transfer
PCT/US1996/009769 WO1996040712A1 (fr) 1995-06-07 1996-06-07 Transfert d'electrons induit par de l'acide nucleique

Publications (1)

Publication Number Publication Date
DK0871642T3 true DK0871642T3 (da) 2003-08-11

Family

ID=23886050

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96919290T DK0871642T3 (da) 1995-06-07 1996-06-07 Nucleinsyremedieret elektronoverførsel

Country Status (9)

Country Link
US (6) US5824473A (fr)
EP (2) EP1340764A3 (fr)
AT (1) ATE238337T1 (fr)
AU (1) AU6166296A (fr)
DE (1) DE69627703T2 (fr)
DK (1) DK0871642T3 (fr)
ES (1) ES2198486T3 (fr)
PT (1) PT871642E (fr)
WO (1) WO1996040712A1 (fr)

Families Citing this family (236)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306348B1 (en) * 1993-11-01 2001-10-23 Nanogen, Inc. Inorganic permeation layer for micro-electric device
US5591578A (en) * 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US6472148B1 (en) 1994-09-26 2002-10-29 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6140045A (en) * 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US5759782A (en) 1995-06-07 1998-06-02 The United States Of America Cellular apoptosis susceptibility protein (CSP) and antisense CSP
AU713667B2 (en) * 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
US6444423B1 (en) 1996-06-07 2002-09-03 Molecular Dynamics, Inc. Nucleosides comprising polydentate ligands
JP3400650B2 (ja) * 1996-06-28 2003-04-28 株式会社日立製作所 電気泳動分離検出方法及び装置
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
AU739375B2 (en) * 1996-11-05 2001-10-11 Clinical Micro Sensors, Inc. Electrodes linked via conductive oligomers to nucleic acids
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7045285B1 (en) * 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US6117973A (en) * 1997-02-24 2000-09-12 Georgia Tech Research Corp. PNA monomers with electron donor or acceptor
US7803528B1 (en) 1997-02-28 2010-09-28 Quest Diagnostics Incorporated Fluorescence energy transfer by competitive hybridization
US6221586B1 (en) * 1997-04-09 2001-04-24 California Institute Of Technology Electrochemical sensor using intercalative, redox-active moieties
US6649350B2 (en) * 1997-04-09 2003-11-18 California Institute Of Technology Electrochemical sensor using intercalative, redox-active moieties
US6699667B2 (en) 1997-05-14 2004-03-02 Keensense, Inc. Molecular wire injection sensors
US6060327A (en) 1997-05-14 2000-05-09 Keensense, Inc. Molecular wire injection sensors
US7220550B2 (en) * 1997-05-14 2007-05-22 Keensense, Inc. Molecular wire injection sensors
AU744503B2 (en) 1997-06-12 2002-02-28 Clinical Micro Sensors, Inc. Electronic methods for the detection of analytes
US6013459A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6203983B1 (en) * 1997-06-16 2001-03-20 Affymetrix, Inc. Method for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners
IL121312A (en) * 1997-07-14 2001-09-13 Technion Res & Dev Foundation Microelectronic components, their manufacture and electronic networks containing them
US6322968B1 (en) * 1997-11-21 2001-11-27 Orchid Biosciences, Inc. De novo or “universal” sequencing array
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
CA2229386A1 (fr) * 1997-12-16 1999-06-16 The University Of Saskatchewan Acides nucleiques contenant du metal conductif
AU1656299A (en) 1997-12-16 1999-07-05 University Of Saskatchewan Conductive metal-containing nucleic acids
US6063573A (en) * 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
WO1999037819A2 (fr) * 1998-01-27 1999-07-29 Clinical Micro Sensors, Inc. Amplification des acides nucleiques par detection electronique
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US20030203394A1 (en) * 1998-05-04 2003-10-30 Yoav Eichen Detection of a target in a sample
CA2331189A1 (fr) * 1998-05-06 1999-11-11 Clinical Micro Sensors, Inc. Procedes electroniques de detection d'analytes mettant en oeuvre des couches simples
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
NL1009871C2 (nl) * 1998-08-14 2000-02-15 Holland Biomaterials Group B V Inrichting voor het onderzoeken van chemische interacties en werkwijze die gebruik maakt van een dergelijke inrichting.
DE19940750A1 (de) 1998-08-28 2000-06-21 Febit Ferrarius Biotech Gmbh Träger für Analytbestimmungsverfahren und Verfahren zur Herstellung des Trägers
US6740518B1 (en) * 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
IL126776A (en) * 1998-10-27 2001-04-30 Technion Res & Dev Foundation A method of investing gold
AU1241000A (en) * 1998-10-27 2000-05-15 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
DE19921940C2 (de) * 1998-11-23 2003-02-06 Friz Biochem Gmbh Verfahren zur elektrochemischen Detektion von Nukleinsäureoligomerhybriden
DE19964220C2 (de) * 1998-11-23 2003-07-03 Friz Biochem Gmbh Verfahren zur Herstellung einer modifizierten leitfähigen Oberfläche
US7160869B2 (en) 1998-12-16 2007-01-09 University Of Saskatchewan Biologically active metal-containing nucleic acids
CA2355875A1 (fr) * 1998-12-30 2000-07-06 Clinical Micro Sensors, Inc. Dispositifs de prelevement de tissu contenant des biocapteurs
US6833267B1 (en) 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US6261780B1 (en) * 1999-01-06 2001-07-17 Fuji Photo Film Co., Ltd. Quantitative analysis of biochemical compound utilizing electrochemical reaction
US6244214B1 (en) 1999-01-06 2001-06-12 Embrex, Inc. Concurrent in ovo injection and detection method and apparatus
US6312906B1 (en) 1999-01-15 2001-11-06 Imperial College Innovations, Ltd. Immobilized nucleic acid hybridization reagent and method
DE19901761A1 (de) * 1999-01-18 1999-07-01 Gerhard Dr Hartwich Verfahren zur elektrochemischen Detektion von Nukleinsäure-Oligomer-Hybridisierungsereignissen
BR0007571A (pt) * 1999-01-18 2001-11-27 Friz Biochem Gmbh OligÈmero de ácido nucléico modificado, processode produção de um oligÈmero de ácido nucléicomodificado, superfìcie condutora modificada,processo de produção de uma superfìciecondutora modificada e processo de detecçãoeletroquìmica de eventos de hibridização deoligÈmero
US6432723B1 (en) 1999-01-22 2002-08-13 Clinical Micro Sensors, Inc. Biosensors utilizing ligand induced conformation changes
CA2367405A1 (fr) * 1999-04-07 2000-10-12 Dennis Michael Connolly Procedes et dispositifs de detection d'adn a haute resolution
US20020177135A1 (en) 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US6821770B1 (en) 1999-05-03 2004-11-23 Gen-Probe Incorporated Polynucleotide matrix-based method of identifying microorganisms
AU768210B2 (en) 1999-05-03 2003-12-04 Gen-Probe Incorporated Polynucleotide probes for detection and quantitation of actinomycetes
EP1177317B1 (fr) 1999-05-03 2006-08-09 Gen-Probe Incorporated SONDES POLYNUCLEOTIDIQUES POUR LA DETECTION exclusive ET LA QUANTIFICATION DE STAPHYLOCOQUES
EP1925678B1 (fr) 1999-05-03 2009-07-22 Gen-Probe Incorporated Procédé à base de matrice de polynucléotides pour identifier des microorganismes
WO2000066785A2 (fr) 1999-05-03 2000-11-09 Gen-Probe Incorporated Sondes polynucleotidiques pour detecter et quantifier les bacteries dans la famille des enterobacteriaceae
US7160996B1 (en) * 1999-06-09 2007-01-09 Bioresearch Technologies, Inc. Fluorescence energy transfer probes with stabilized conformations
DE60027309T2 (de) 1999-07-02 2006-08-31 Symyx Technologies, Inc., Santa Clara Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen
JP2003530822A (ja) * 1999-07-20 2003-10-21 クリニカル・マイクロ・センサーズ・インコーポレイテッド 電子的核酸検出の増幅
ATE417127T1 (de) 1999-07-26 2008-12-15 Clinical Micro Sensors Inc Nukelinsäuresequenzbestimmung mittels elektronischem nachweis
DE19945398A1 (de) * 1999-09-22 2001-04-05 Friz Biochem Gmbh Elektrochemische Detektion von sequenzspezifischen Nukleinsäure-Oligomer-Hybridisierungsereignissen
WO2001023082A2 (fr) * 1999-09-30 2001-04-05 Nanogen, Inc. Sites de fixation biomoleculaire dans des reseaux micro-electroniques et procedes correspondants
DE19950969A1 (de) * 1999-10-22 2001-05-10 Aventis Res & Tech Gmbh & Co Doppelstrang-Nukleinsäure-Sonden und deren Verwendung
US7364920B2 (en) * 1999-10-27 2008-04-29 Technion Research And Development Foundation Ltd. Method for gold deposition
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
DE19957827C2 (de) * 1999-11-25 2003-06-12 Epigenomics Ag Verwendung eines Oligomer-Arrays mit PNA- und/oder DNA-Oligomeren auf einer Oberfläche
GB9928232D0 (en) * 1999-12-01 2000-01-26 Skelton Stephen Detection system
US6518024B2 (en) 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
DE19960076C2 (de) * 1999-12-13 2002-12-05 November Ag Molekulare Medizin Verfahren und Vorrichtung zum Nachweis und zur Quantifizierung von Biomolekülen
US6303082B1 (en) * 1999-12-15 2001-10-16 Nanogen, Inc. Permeation layer attachment chemistry and method
DE10000629C5 (de) * 2000-01-10 2010-06-02 november Aktiengesellschaft, Gesellschaft für Molekulare Medizin Verfahren zur Identifizierung einer auf einen festen Körper aufgebrachten Markierung
US7220541B2 (en) * 2000-01-24 2007-05-22 Ingeneus, Inc. Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions
US6824669B1 (en) * 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US6686461B1 (en) 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
US7102024B1 (en) 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
US20110039341A1 (en) * 2000-06-28 2011-02-17 Jianqin Liu Method for detecting nucleotide polymor-phisms using semiconductor particles
JP4382265B2 (ja) * 2000-07-12 2009-12-09 日本電気株式会社 酸化シリコン膜の形成方法及びその形成装置
US6787339B1 (en) 2000-10-02 2004-09-07 Motorola, Inc. Microfluidic devices having embedded metal conductors and methods of fabricating said devices
DE10049527A1 (de) * 2000-10-06 2001-09-06 Friz Biochem Gmbh Thermostabile,photoinduzierbar redoxaktive Einheit zur elektrochemischen Detektion von Nukleinsäure-Oligomer-Hybridisierungsereignissen
DE10051396A1 (de) 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh Verfahren und Vorrichtung zur integrierten Synthese und Analytbestimmung an einem Träger
ATE386821T1 (de) 2000-10-23 2008-03-15 Gen Probe Inc Zusammensetzungen und methoden zur detektion von humanem immundefizienz virus 2 (hiv-2)
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
AU2002246978A1 (en) * 2001-01-10 2002-07-24 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface
JP3670972B2 (ja) 2001-02-01 2005-07-13 日立ソフトウエアエンジニアリング株式会社 生体高分子検出装置
DE10106654A1 (de) * 2001-02-12 2002-09-05 November Ag Molekulare Medizin Verfahren zum Nachweis und/oder zur Quantifizierung eines Analyten
EP1234887B1 (fr) * 2001-02-27 2005-09-28 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Procédé pour attacher acides nucléiques sur un support
US7310543B2 (en) * 2001-03-26 2007-12-18 Kumetrix, Inc. Silicon microprobe with integrated biosensor
US20030003018A1 (en) * 2001-04-02 2003-01-02 Prolinx Incorporated Systems and apparatus for the analysis of molecular interactions
EP1389350A1 (fr) * 2001-05-24 2004-02-18 University of Saskatchewan Technologies Inc. Procedes et elements pour circuit a acides nucleiques
AU2002339853A1 (en) * 2001-05-24 2002-12-03 Genospectra, Inc. Pairs of nucleic acid probes with interactive signaling moieties and nucleic acid probes with enhanced hybridization efficiency and specificity
US7537571B2 (en) 2001-06-12 2009-05-26 Pelikan Technologies, Inc. Integrated blood sampling analysis system with multi-use sampling module
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
WO2002100461A2 (fr) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Dispositif et procede permettant d'ameliorer le rendement du prelevement de sang capillaire au bout du doigt
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
CA2448902C (fr) 2001-06-12 2010-09-07 Pelikan Technologies, Inc. Autopiqueur a optimisation automatique presentant des moyens d'adaptation aux variations temporelles des proprietes cutanees
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7682318B2 (en) 2001-06-12 2010-03-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
WO2002100460A2 (fr) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Actionneur electrique de lancette
AU2002365115A1 (en) * 2001-07-20 2003-09-02 North Carolina State University Light addressable electrochemical detection of duplex structures
US20030022150A1 (en) * 2001-07-24 2003-01-30 Sampson Jeffrey R. Methods for detecting a target molecule
US10539561B1 (en) * 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
EP1438433A4 (fr) * 2001-10-04 2005-12-21 Wisconsin Alumni Res Found Detection d'hybridisation d'adn sur des surfaces
AU2002360272A1 (en) * 2001-10-10 2003-04-22 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
US7344894B2 (en) 2001-10-16 2008-03-18 Agilent Technologies, Inc. Thermal regulation of fluidic samples within a diagnostic cartridge
DE10155055A1 (de) * 2001-11-09 2003-05-28 Friz Biochem Gmbh Fluoreszenz-Quenchen zur Detektion von Nukleinsäure-Oligomer-Hybridisierungsereignissen bei hohen Salz-Konzentrationen
US6960298B2 (en) * 2001-12-10 2005-11-01 Nanogen, Inc. Mesoporous permeation layers for use on active electronic matrix devices
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US20030203384A1 (en) * 2002-03-08 2003-10-30 Chafin David R. Multiplex detection of biological materials in a sample
US7005268B2 (en) * 2002-03-13 2006-02-28 Agilent Technologies, Inc. Detection of biopolymers utilizing photo-initiated charge separation
US20030198960A1 (en) * 2002-04-01 2003-10-23 Wenhong Fan Signal amplifying targeted reporters for biological and chemical sensor applications
US7374544B2 (en) 2002-04-19 2008-05-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7485128B2 (en) 2002-04-19 2009-02-03 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7524293B2 (en) 2002-04-19 2009-04-28 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7563232B2 (en) 2002-04-19 2009-07-21 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7244265B2 (en) 2002-04-19 2007-07-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7141058B2 (en) 2002-04-19 2006-11-28 Pelikan Technologies, Inc. Method and apparatus for a body fluid sampling device using illumination
AU2003231749A1 (en) 2002-04-19 2003-11-03 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7582099B2 (en) 2002-04-19 2009-09-01 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7410468B2 (en) 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
AU2003253651C1 (en) 2002-06-14 2010-06-03 Gen-Probe Incorporated Compositions and methods for detecting hepatitis B virus
WO2004003551A1 (fr) * 2002-06-28 2004-01-08 Canon Kabushiki Kaisha Support de sonde, procede de construction d'un support de sonde, procede d'evaluation d'un support de sonde et procede de detection d'acides nucleiques cibles au moyen de ce support
DE10232139A1 (de) 2002-07-04 2004-01-22 Technische Universität Dresden Mit Nukleinsäuren und Nukleinsäurederivaten beschichteter metallischer Gegenstand, Verfahren zu dessen Herstellung und dessen Verwendung
US7176036B2 (en) 2002-09-20 2007-02-13 Arrowhead Center, Inc. Electroactive microspheres and methods
CA2957200C (fr) 2002-10-16 2020-05-26 Gen-Probe Incorporated Compositions et methodes de detection du virus du nil occidental
CA2505636A1 (fr) * 2002-11-15 2004-06-03 Applera Corporation Detection de sequences d'acides nucleiques
EP1579516B1 (fr) * 2002-12-23 2007-03-28 University of Saskatchewan Permutation chimique d'elements de circuit d'acides nucleiques
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US20040180369A1 (en) * 2003-01-16 2004-09-16 North Carolina State University Photothermal detection of nucleic acid hybridization
EP2238892A3 (fr) 2003-05-30 2011-02-09 Pelikan Technologies Inc. Appareil pour prendre de fluide du corps
ES2490740T3 (es) 2003-06-06 2014-09-04 Sanofi-Aventis Deutschland Gmbh Aparato para toma de muestras de fluido sanguíneo y detección de analitos
WO2006001797A1 (fr) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Element penetrant peu douloureux
US7604592B2 (en) 2003-06-13 2009-10-20 Pelikan Technologies, Inc. Method and apparatus for a point of care device
WO2005010160A2 (fr) * 2003-07-17 2005-02-03 Wisconsin Alumni Research Foundation Cristaux liquides a toxicite reduite et applications associees
EP1671096A4 (fr) 2003-09-29 2009-09-16 Pelikan Technologies Inc Procede et appareil permettant d'obtenir un dispositif de capture d'echantillons ameliore
JP4321854B2 (ja) * 2003-10-02 2009-08-26 ソニー株式会社 ハイブリダイゼーションその他の相互作用検出部と該検出部を備えるdnaチップその他のバイオアッセイ用基板
EP1680014A4 (fr) 2003-10-14 2009-01-21 Pelikan Technologies Inc Procede et appareil fournissant une interface-utilisateur variable
US20050191651A1 (en) * 2003-10-30 2005-09-01 North Carolina State University Temperature-jump enhanced electrochemical detection of nucleic acid hybridization
WO2005042785A1 (fr) * 2003-10-30 2005-05-12 North Carolina State University Detection electrochimique d'hybridation d'acide nucleique
CA2547750C (fr) 2003-12-19 2014-04-08 Gen-Probe Incorporated Compositions, methodes et trousses destinees a la detection des acides nucleiques du vih 1 et du vih 2
WO2005065414A2 (fr) 2003-12-31 2005-07-21 Pelikan Technologies, Inc. Procede et appareil permettant d'ameliorer le flux fluidique et le prelevement d'echantillons
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
CA2566806A1 (fr) * 2004-05-25 2006-01-19 Helicos Biosciences Corporation Procedes et dispositifs pour la determination de sequence d'acides nucleiques
EP1765194A4 (fr) 2004-06-03 2010-09-29 Pelikan Technologies Inc Procede et appareil pour la fabrication d'un dispositif d'echantillonnage de liquides
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US20060083694A1 (en) 2004-08-07 2006-04-20 Cabot Corporation Multi-component particles comprising inorganic nanoparticles distributed in an organic matrix and processes for making and using same
WO2006083326A2 (fr) * 2004-08-07 2006-08-10 Cabot Corporation Fabrication d'une dispersion gazeuse de nanoparticules, et produits contenant des nanoparticules et traitement de ceux-ci
ES2759991T3 (es) 2004-09-30 2020-05-12 Gen Probe Inc Ensayo para detectar y cuantificar el VIH-1
DE112005002567T5 (de) * 2004-10-19 2007-11-22 Wallac Oy Eine neue Sonde und deren Verwendung in Bioaffinitäts-Analysen
CA2582661C (fr) * 2004-11-09 2015-08-11 Gen-Probe Incorporated Compositions et methode de detection de streptocoques du groupe a
US20060102471A1 (en) 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer
US20060205061A1 (en) * 2004-11-24 2006-09-14 California Institute Of Technology Biosensors based upon actuated desorption
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US20060177859A1 (en) * 2005-02-07 2006-08-10 Gen-Probe Incorporated Compositions and methods for detecting group B streptococci
US20070034513A1 (en) 2005-03-25 2007-02-15 Combimatrix Corporation Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
US9394167B2 (en) 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
US20070065877A1 (en) 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
WO2007111681A2 (fr) * 2005-10-31 2007-10-04 Wisconsin Alumni Research Foundation Dispositif et procédé de détection d'agent biologique à base de cristaux liquides
US20090036315A1 (en) * 2006-02-07 2009-02-05 Antara Biosciences Inc. Device and methods for detecting and quantifying one or more target agents
EP2677039B8 (fr) 2006-05-10 2022-10-05 DxTerity Diagnostics Incorporated Détection de cibles d'acides nucléiques au moyen de sondes oligonucléotidiques chimiquement réactives
US7687103B2 (en) * 2006-08-31 2010-03-30 Gamida For Life B.V. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
US20080269065A1 (en) * 2007-04-30 2008-10-30 Syntrix Biosystems, Inc. Conformationally Constrained Analytical Probes
EP2265324B1 (fr) 2008-04-11 2015-01-28 Sanofi-Aventis Deutschland GmbH Système intégré de mesure d'analytes
EP3957754B1 (fr) 2008-04-21 2026-01-28 Gen-Probe Incorporated Procédé de détection de virus du chikungunya
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
DK2414544T3 (da) 2009-04-01 2014-06-16 Dxterity Diagnostics Inc Probe-amplifikations-afhængig kemisk ligering
US9927434B2 (en) 2010-01-20 2018-03-27 Customarray, Inc. Multiplex microarray of serially deposited biomolecules on a microarray
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP2588629B1 (fr) 2010-06-30 2017-05-17 Gen-Probe Incorporated Methode et appareil pour l'identification d'echantillons contenant un analyte utilisant une determination de l'analyte en lecture simple et des signaux de controle du procede.
EP2625297B1 (fr) 2010-10-04 2018-10-10 Gen-Probe Prodesse, Inc. Compositions, méthodes et kits pour détecter des acides nucléiques adénoviraux
CN106434871B (zh) 2011-05-17 2020-08-18 德克斯特里蒂诊断公司 用于检测目标核酸的方法与组合物
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
EP3427830B1 (fr) 2012-10-24 2021-06-23 Genmark Diagnostics Inc. Analyse de cibles multiplexes intégrées
JP6351702B2 (ja) 2013-03-15 2018-07-04 ジェンマーク ダイアグノスティクス, インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
EP3154696B1 (fr) 2014-06-10 2020-04-08 DxTerity Diagnostics Incorporated Dispositifs et procédés de collecte et de stabilisation d'échantillons biologiques
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
ES3038141T3 (en) 2014-11-11 2025-10-09 Hoffmann La Roche Fluid sample processing cartridge
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US11300578B2 (en) 2016-09-19 2022-04-12 Roche Molecular Systems, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US20190062809A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) Electrochemical detection of bacterial and/or fungal infections
EP3673086B1 (fr) 2017-08-24 2025-04-09 Roche Diagnostics GmbH Détection électrochimique d'infections bactériennes et/ou fongiques
WO2019081680A1 (fr) * 2017-10-25 2019-05-02 Institut Pasteur Immobilisation d'acides nucléiques à l'aide d'un mimétique d'étiquette histidine enzymatique pour des applications de diagnostic
US11009480B2 (en) * 2017-11-07 2021-05-18 Amrita Vishwa Vidyapeetham Lab on a chip device for multi-analyte detection and a method of fabrication thereof
JP7813728B2 (ja) 2020-06-12 2026-02-13 エフ. ホフマン-ラ ロシュ アーゲー 診断装置上のベイを評価するためのシステムおよび方法
AU2023282374A1 (en) 2022-06-07 2024-11-21 F. Hoffmann-La Roche Ag Ferrocene labelled primers for electrochemical detection
EP4658810A1 (fr) 2023-02-02 2025-12-10 University of Strathclyde Biocapteur électrochimique
WO2024235904A1 (fr) 2023-05-16 2024-11-21 Roche Molecular Systems, Inc. Détection d'analytes cibles à l'aide de sondes de signal multimodales

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1219824A (fr) * 1981-04-17 1987-03-31 David C. Ward Nucleotides modifies, leur preparation et leur emploi
US5241060A (en) * 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
US4994373A (en) * 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4840893A (en) 1983-12-16 1989-06-20 Medisense, Inc. Electrochemical assay for nucleic acids and nucleic acid probes
US4849513A (en) * 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US5175269A (en) * 1984-01-30 1992-12-29 Enzo Diagnostics, Inc. Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group
US4707440A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US5002885A (en) * 1984-01-30 1991-03-26 Enzo Biochem, Inc. Detectable molecules, method preparation and use
US4952685A (en) * 1984-01-30 1990-08-28 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US4943523A (en) * 1984-01-30 1990-07-24 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US5013831A (en) * 1984-01-30 1991-05-07 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
CA1260372A (fr) * 1984-04-27 1989-09-26 Elazar Rabbani Methode d'hybridation pour la detection de materiaux genetiques
GB8417301D0 (en) * 1984-07-06 1984-08-08 Serono Diagnostics Ltd Assay
US4755458A (en) * 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US5112974A (en) * 1985-01-18 1992-05-12 The Trustees Of Columbia University In The City Of New York Mixed ligand complexes and uses thereof as binding agents to DNA
GB8507706D0 (en) 1985-03-25 1985-05-01 Genetics Int Inc Magnetic nucleic acid sequences
US5595908A (en) 1985-09-26 1997-01-21 University Of Southern Mississipi Piezoelectric device for detection of polynucleotide hybridization
CA1273552A (fr) * 1985-12-23 1990-09-04 Michael J. Heller Sondes fluorescentes a decalage de stoke pour les determinations d'hybridation des polynucleotides
US4868103A (en) * 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
CA1254945A (fr) * 1986-02-27 1989-05-30 Marco F. Cardosi Application des tetrathiafulvalenes dans des procedes bio-electro-chimiques
US4704193A (en) * 1986-05-14 1987-11-03 Gte Laboratories Incorporated Covalently coupled cofactor modified electrodes and methods of synthesis and use
US4879243A (en) * 1987-05-26 1989-11-07 Eastman Kodak Company Use of substituted ortho-quinones as electron transfer agents in analytical determinations
DE3708767A1 (de) * 1987-03-18 1988-09-29 Hoechst Ag Wasserloesliche azoverbindungen, verfahren zu ihrer herstellung und ihre verwendung als farbstoffe
JPS63238166A (ja) 1987-03-26 1988-10-04 Mitsubishi Electric Corp 有機電子素子材料
US4787963A (en) * 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
US5082830A (en) * 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5089112A (en) * 1989-03-20 1992-02-18 Associated Universities, Inc. Electrochemical biosensor based on immobilized enzymes and redox polymers
US5491097A (en) * 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
CA2033692A1 (fr) * 1990-01-25 1991-07-26 Wilhelm Bannwarth Systemes de transfert d'energie
US5776672A (en) 1990-09-28 1998-07-07 Kabushiki Kaisha Toshiba Gene detection method
DE4039677A1 (de) * 1990-12-12 1992-06-17 Boehringer Mannheim Gmbh Universalbindefilm
US5180968A (en) * 1991-03-01 1993-01-19 Research Foundation Of State University Of New York Method and apparatus for compensation of double layer charging current in electrochemical cells
JPH04278450A (ja) * 1991-03-04 1992-10-05 Adam Heller バイオセンサー及び分析物を分析する方法
RU1794088C (ru) 1991-03-18 1993-02-07 Институт Молекулярной Биологии Ан@ Ссср Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени
JP2778304B2 (ja) * 1991-09-17 1998-07-23 三菱電機株式会社 有機電子素子材料
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
DK0567635T3 (da) * 1991-11-15 2000-09-25 Igen Int Inc Hurtige assays for amplifikationsprodukter
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5565552A (en) * 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5391272A (en) * 1992-03-06 1995-02-21 Andcare, Inc. Electrochemical immunoassay methods
DK0566751T3 (da) * 1992-03-23 1996-03-04 Hoffmann La Roche DNA-påvisningsmetode
US5422244A (en) 1992-05-05 1995-06-06 Athena Neurosciences, Inc. Detection of brain α1-antichymotrypsin
CA2094785A1 (fr) * 1992-05-08 1993-11-09 Jean Gariepy Peptide chelatant le metal
JPH0641183A (ja) 1992-07-23 1994-02-15 Mitsubishi Kasei Corp オリゴヌクレオチド単分子膜
US5601682A (en) * 1992-07-28 1997-02-11 Moore Business Forms, Inc. Method of making reflective decals
IL102930A (en) * 1992-08-25 1997-03-18 Yissum Res Dev Co Electrobiochemical analytical method and electrodes
JPH06121404A (ja) * 1992-10-06 1994-04-28 Hitachi Ltd 電気車の制御装置
US5312527A (en) * 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US5472881A (en) 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
EP0599337B1 (fr) * 1992-11-27 2006-03-08 Canon Kabushiki Kaisha Procédé et sonde pour la détection d'acides nucléiques
JPH06153997A (ja) 1992-11-27 1994-06-03 Canon Inc 検出信号増幅による標的核酸の検出方法
WO1994020841A1 (fr) 1993-03-05 1994-09-15 University Of Wollongong Detection electrochimique pulsee au moyen d'electrodes electroactives en polymere
FR2703359B1 (fr) * 1993-03-31 1995-06-23 Cis Bio Int Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation .
RU2041262C1 (ru) 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель
RU2041263C1 (ru) 1993-08-11 1995-08-09 Геннадий Моисеевич Ершов Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления
RU2041261C1 (ru) 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ изготовления матрицы для детектирования мисматчей
WO1995008626A1 (fr) * 1993-09-20 1995-03-30 The Regents Of The University Of Colorado Strategie de production d'arn a partir de matrices immobilisees
US5824473A (en) * 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) * 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) * 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US5591579A (en) 1993-12-21 1997-01-07 Washington University Indicator cell line for detecting RNA viruses and method therefor
FR2720832A1 (fr) * 1994-04-22 1995-12-08 Francis Garnier Electrodes et membranes électroactives à base de peptides bioactifs, pour la reconnaissance, l'extraction ou le relargage d'espèces biologiquement actives.
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5601982A (en) 1995-02-07 1997-02-11 Sargent; Jeannine P. Method and apparatus for determining the sequence of polynucleotides
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
KR100449615B1 (ko) * 1995-03-10 2004-12-08 메소 스케일 테크놀러지즈, 엘엘시 다-배열,다-특이적전기화학발광시험법
NZ311955A (en) * 1995-06-27 1999-04-29 Univ North Carolina Electrochemical detection of nucleic acid hybridization
US5861247A (en) 1996-01-26 1999-01-19 University Of Chicago Rapid method to detect duplex formation in sequencing by hybridization methods
US5851772A (en) 1996-01-29 1998-12-22 University Of Chicago Microchip method for the enrichment of specific DNA sequences
JP2000513811A (ja) 1996-05-22 2000-10-17 オーストラリアン メンブレイン アンド バイオテクノロジィ リサーチ インスティチュート 核酸センサー
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
AU739375B2 (en) 1996-11-05 2001-10-11 Clinical Micro Sensors, Inc. Electrodes linked via conductive oligomers to nucleic acids
US5905024A (en) 1996-12-17 1999-05-18 University Of Chicago Method for performing site-specific affinity fractionation for use in DNA sequencing
AU5716098A (en) 1996-12-23 1998-07-17 University Of Chicago, The Customized oligonucleotide microchips as multiple biosensors
JP2002524021A (ja) 1997-02-06 2002-07-30 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 分子相互作用の検出および薬剤発見のための電気化学的プローブ
SE9703314D0 (sv) 1997-09-15 1997-09-15 Sangtec Medical Ab Capacity affinity sensor
WO1999037819A2 (fr) 1998-01-27 1999-07-29 Clinical Micro Sensors, Inc. Amplification des acides nucleiques par detection electronique
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes

Also Published As

Publication number Publication date
PT871642E (pt) 2003-08-29
ES2198486T3 (es) 2004-02-01
DE69627703T2 (de) 2004-01-29
DE69627703D1 (de) 2003-05-28
US6291188B1 (en) 2001-09-18
ATE238337T1 (de) 2003-05-15
WO1996040712A1 (fr) 1996-12-19
US7033760B2 (en) 2006-04-25
EP0871642B1 (fr) 2003-04-23
US6177250B1 (en) 2001-01-23
US6265155B1 (en) 2001-07-24
EP1340764A3 (fr) 2004-04-07
EP1340764A2 (fr) 2003-09-03
US20020034759A1 (en) 2002-03-21
US5824473A (en) 1998-10-20
EP0871642A1 (fr) 1998-10-21
US5770369A (en) 1998-06-23
AU6166296A (en) 1996-12-30

Similar Documents

Publication Publication Date Title
ATE215959T1 (de) Nukleinsäurevermittelter elektronentransfer
ATE238337T1 (de) Durch nukleinsäure vermittelter elektronen- transfer
ATE308553T1 (de) Nukleinsäurevermittelter elektronentransfer
FI932144A7 (fi) Nukleiinihappovahvistus kahden entsyymin jatkuvalla sekvenssireplikaat iolla
TW289020B (fr)
NL182936C (nl) Anti-inflammatoire en analgetische zalf, die indomethacine als actieve component bevat.
FI881501A7 (fi) 5-substituerade kinolon- och naftyridonkarboxylsyraderivat.
DE3872937D1 (de) Benzoylaminophenoxybuttersaeure-derivate.
FI861506A7 (fi) Foerfarande foer framstaellning av 1,2-ditiolan-3-pentansyra (tioktsyra).
IT1207155B (it) Derivati di acidi prostanoici 4,5insaturi
TR199700828T1 (xx) .Klavulanik asit tuzlar�.
FI900024A7 (fi) Pyrrolylfenyl-substituerade hydroxamsyraderivat.
FI864900L (fi) Foerfarande foer framstaellning av 5-(2,5-dimetylfenoxi)-2,2-dimetylpentansyra.
FI914149L (fi) Foerfarande foer kontinuerlig omsaettning av kefalosporinderivat till glutaryl-7-aminokefalosporinsyraderivat.
DE69018375D1 (de) Pro-drugs von 6-Mercaptopurin und 6-Thioguanin.
NO883233L (no) Hydrokanelsyrederivater.
FI871316A7 (fi) Foerfarande foer framstaellning av acymmetriska esterderivat av 1,4-dihydropyridin-3,5-dikarboxylsyra.
FI880120A7 (fi) Foerfarande foer framstaellning av nya karbonsyraderivat.
AU527930B2 (en) 1,3,4-thiadiazole-2-carboxylic acid derivatives
FI885053A7 (fi) Fluorerade arakidonsyraderivat.
FI880081A7 (fi) 2,1-bensotiazepin-2,2-dioxid-5 -karboxylsyraderivat.
FI883162A7 (fi) Nukleiinihappojohdannaisia.
AU507074B2 (en) 1, 2-diphneylcyclohex-1-ene carboxylic acid derivatives
ATE101598T1 (de) Carbonsaeure-derivate.
JPS5312492A (en) Oxidation o f steroid by microoganism