DK0917874T3 - Fremgangsmåde til den langsigtede reduktion af legemsfedtdepoter, insulinresistens, hyperinsulimia og hypoglykæmi hos hvirveldyr - Google Patents

Fremgangsmåde til den langsigtede reduktion af legemsfedtdepoter, insulinresistens, hyperinsulimia og hypoglykæmi hos hvirveldyr

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Publication number
DK0917874T3
DK0917874T3 DK98110831T DK98110831T DK0917874T3 DK 0917874 T3 DK0917874 T3 DK 0917874T3 DK 98110831 T DK98110831 T DK 98110831T DK 98110831 T DK98110831 T DK 98110831T DK 0917874 T3 DK0917874 T3 DK 0917874T3
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DK
Denmark
Prior art keywords
insulin resistance
long term
treatment
peak
body fat
Prior art date
Application number
DK98110831T
Other languages
English (en)
Inventor
Anthony Cincotta
Albert Meier
Original Assignee
Univ Louisiana State
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Publication date
Application filed by Univ Louisiana State filed Critical Univ Louisiana State
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Publication of DK0917874T3 publication Critical patent/DK0917874T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
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    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/47—Quinolines; Isoquinolines
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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DK98110831T 1990-01-10 1991-01-07 Fremgangsmåde til den langsigtede reduktion af legemsfedtdepoter, insulinresistens, hyperinsulimia og hypoglykæmi hos hvirveldyr DK0917874T3 (da)

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Application Number Priority Date Filing Date Title
US46332790A 1990-01-10 1990-01-10

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DK0917874T3 true DK0917874T3 (da) 2008-07-28

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DK98110831T DK0917874T3 (da) 1990-01-10 1991-01-07 Fremgangsmåde til den langsigtede reduktion af legemsfedtdepoter, insulinresistens, hyperinsulimia og hypoglykæmi hos hvirveldyr
DK91300083T DK0440333T3 (da) 1990-01-10 1991-01-07 Anvendelse af prolactin-inhiberende forbindelser til genindstilling af prolactin-døgnrytmen

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DK91300083T DK0440333T3 (da) 1990-01-10 1991-01-07 Anvendelse af prolactin-inhiberende forbindelser til genindstilling af prolactin-døgnrytmen

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Country Link
US (2) US5496803A (da)
EP (2) EP0917874B1 (da)
JP (2) JP2896939B2 (da)
AT (2) ATE391506T1 (da)
CA (1) CA2030174C (da)
DE (2) DE69130651T2 (da)
DK (2) DK0917874T3 (da)
ES (2) ES2306465T3 (da)
GR (1) GR3029276T3 (da)

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US5731287A (en) * 1988-05-10 1998-03-24 Louisiana State University And Agricultural And Mechanical College Process for the long term reduction of body fat stores, insulin resistance, and hyperinsulinemia in vertebrates
US5744477A (en) * 1988-05-10 1998-04-28 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method for treatment of obesity using prolactin modulators and diet
US5344832A (en) * 1990-01-10 1994-09-06 The Board Of Supervisors Of Louisiana University And Agricultural And Mechanical College Method for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hyperglycemia in vertebrates
US5792748A (en) * 1995-06-07 1998-08-11 The General Hospital Corporation Method for inhibiting neoplastic disease in mammals
WO1996040132A1 (en) * 1995-06-07 1996-12-19 Ergo Science Incorporated Method for inhibiting neoplastic disease in mammals
ATE243513T1 (de) * 1996-05-01 2003-07-15 Gen Hospital Corp Wachstumshemmung und abtoetung solider tumore unter verwendung eines prolaktin-modulators und eines photosensitizers
US5866546A (en) * 1997-04-18 1999-02-02 Hadasit Medical Research Services And Development Company Ltd. Treatment for diabetes
AR019727A1 (es) 1998-06-30 2002-03-13 Takeda Chemical Industries Ltd Composicion farmaceutica
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US5866584A (en) 1999-02-02
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EP0440333B1 (en) 1998-12-23
EP0917874B1 (en) 2008-04-09
DE69133595D1 (de) 2008-05-21
ATE391506T1 (de) 2008-04-15
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US5496803A (en) 1996-03-05
DE69133595T2 (de) 2009-06-10
ATE174793T1 (de) 1999-01-15
CA2030174A1 (en) 1991-07-11
ES2306465T3 (es) 2008-11-01
EP0440333A2 (en) 1991-08-07
DK0440333T3 (da) 1999-08-23
DE69130651D1 (de) 1999-02-04
EP0440333A3 (en) 1992-06-17
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EP0917874A1 (en) 1999-05-26
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