DK1004580T3 - Imider som inhibitorer af TNF-alfa - Google Patents

Imider som inhibitorer af TNF-alfa

Info

Publication number: DK1004580T3
Authority: DK; Denmark
Prior art keywords: imides; tnf; inhibitors; alpha; phthaloylisoglutamine
Prior art date: 1993-07-02

Application number

DK00200491T

Other languages

English (en)

Inventor

George W Muller

Original Assignee

Celgene Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-02

Filing date

1994-07-01

Publication date

2007-04-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22205623&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1004580(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-07-01 Application filed by Celgene Corp filed Critical Celgene Corp

2007-04-23 Application granted granted Critical

2007-04-23 Publication of DK1004580T3 publication Critical patent/DK1004580T3/da

Links

MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 title 1
108060008682 Tumor Necrosis Factor Proteins 0.000 title 1
102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 title 1
150000003949 imides Chemical class 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 abstract 4
ZIMWCUUEMGFXNW-VIFPVBQESA-N 2-[[(1s)-4-amino-1-carboxy-4-oxobutyl]carbamoyl]benzoic acid Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)C1=CC=CC=C1C(O)=O ZIMWCUUEMGFXNW-VIFPVBQESA-N 0.000 abstract 2
JOAOKNHCUKCBBE-VIFPVBQESA-N 2-[[(2s)-1-amino-4-carboxy-1-oxobutan-2-yl]carbamoyl]benzoic acid Chemical compound OC(=O)CC[C@@H](C(=O)N)NC(=O)C1=CC=CC=C1C(O)=O JOAOKNHCUKCBBE-VIFPVBQESA-N 0.000 abstract 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
238000010992 reflux Methods 0.000 abstract 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
229960003433 thalidomide Drugs 0.000 abstract 1

Classifications

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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Cardiology (AREA)
Molecular Biology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Tropical Medicine & Parasitology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Biotechnology (AREA)
Neurology (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
AIDS & HIV (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Transplantation (AREA)

DK00200491T 1993-07-02 1994-07-01 Imider som inhibitorer af TNF-alfa DK1004580T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8751093A	1993-07-02	1993-07-02
PCT/US1994/007411 WO1995001348A2 (en)	1993-07-02	1994-07-01	Imides as inhibitors of tnp alpha

Publications (1)

Publication Number	Publication Date
DK1004580T3 true DK1004580T3 (da)	2007-04-23

Family

ID=22205623

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
DK00200492T DK1004581T3 (da)	1993-07-02	1994-07-01	Fremgangsmåde til fremstilling af thalidomid
DK94921439T DK0706521T3 (da)	1993-07-02	1994-07-01	Imider som TNF-alfa-inhibitorer
DK00200491T DK1004580T3 (da)	1993-07-02	1994-07-01	Imider som inhibitorer af TNF-alfa
DK00200498T DK1004572T3 (da)	1993-07-02	1994-07-01	Aminer som inhibitorer af TNF alpha

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK00200492T DK1004581T3 (da)	1993-07-02	1994-07-01	Fremgangsmåde til fremstilling af thalidomid
DK94921439T DK0706521T3 (da)	1993-07-02	1994-07-01	Imider som TNF-alfa-inhibitorer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK00200498T DK1004572T3 (da)	1993-07-02	1994-07-01	Aminer som inhibitorer af TNF alpha

Country Status (19)

Country	Link
US (1)	US5463063A (da)
EP (5)	EP1004572B1 (da)
JP (5)	JP3971794B2 (da)
KR (1)	KR100401290B1 (da)
AT (4)	ATE348809T1 (da)
AU (1)	AU687843B2 (da)
CA (3)	CA2166315C (da)
CZ (2)	CZ1096A3 (da)
DE (4)	DE69434029T2 (da)
DK (4)	DK1004581T3 (da)
ES (4)	ES2258956T3 (da)
FI (2)	FI114984B (da)
HU (1)	HUT75312A (da)
NZ (3)	NZ329259A (da)
PL (1)	PL180377B1 (da)
PT (4)	PT1004572E (da)
RU (1)	RU2174516C2 (da)
SK (1)	SK166595A3 (da)
WO (1)	WO1995001348A2 (da)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6277969B1 (en) *	1991-03-18	2001-08-21	New York University	Anti-TNF antibodies and peptides of human tumor necrosis factor
US5686436A (en) *	1993-05-13	1997-11-11	Hiv Diagnostics, Inc.	Multi-faceted method to repress reproduction of latent viruses in humans and animals
ATE200621T1 (de) *	1994-12-30	2001-05-15	Celgene Corp	Immunotherapeutische imide/amide und ihre verwendung zur verminderung des tnfalpha-spiegels
US5703098A (en) *	1994-12-30	1997-12-30	Celgene Corporation	Immunotherapeutic imides/amides
US5801195A (en)	1994-12-30	1998-09-01	Celgene Corporation	Immunotherapeutic aryl amides
US6429221B1 (en) *	1994-12-30	2002-08-06	Celgene Corporation	Substituted imides
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- 1994-07-01 ES ES00200491T patent/ES2278574T3/es not_active Expired - Lifetime
- 1994-07-01 JP JP50364895A patent/JP3971794B2/ja not_active Expired - Fee Related
- 1994-07-01 PT PT00200491T patent/PT1004580E/pt unknown
- 1994-07-01 DE DE69434895T patent/DE69434895T2/de not_active Expired - Fee Related
- 1994-07-01 PL PL94312386A patent/PL180377B1/pl not_active IP Right Cessation
- 1994-07-01 SK SK1665-95A patent/SK166595A3/sk unknown
- 1994-07-01 PT PT00200492T patent/PT1004581E/pt unknown
- 1994-07-01 NZ NZ329258A patent/NZ329258A/xx not_active IP Right Cessation
- 1994-07-01 PT PT94921439T patent/PT706521E/pt unknown
1995
- 1995-12-29 FI FI956362A patent/FI114984B/fi not_active IP Right Cessation
2004
- 2004-04-27 FI FI20040593A patent/FI20040593A7/fi not_active Application Discontinuation
2006
- 2006-02-16 JP JP2006039633A patent/JP2006188529A/ja active Pending
- 2006-02-16 JP JP2006039624A patent/JP4461107B2/ja not_active Expired - Fee Related
- 2006-02-16 JP JP2006039629A patent/JP2006131647A/ja active Pending
- 2006-02-16 JP JP2006039637A patent/JP2006188530A/ja active Pending

Also Published As

Publication number	Publication date
ES2226696T3 (es)	2005-04-01
ES2278574T3 (es)	2007-08-16
PT1004581E (pt)	2005-01-31
HK1025765A1 (en)	2000-11-24
DK1004572T3 (da)	2006-07-10
AU687843B2 (en)	1998-03-05
DE69434029T2 (de)	2005-09-22
DE69434645T2 (de)	2006-12-14
FI114984B (fi)	2005-02-15
EP1004581A2 (en)	2000-05-31
HK1025769A1 (en)	2000-11-24
JP4461107B2 (ja)	2010-05-12
DE69434895D1 (de)	2007-02-01
JP2006188529A (ja)	2006-07-20
EP0706521A1 (en)	1996-04-17
DE69434895T2 (de)	2007-08-02
HUT75312A (en)	1997-05-28
AU7216794A (en)	1995-01-24
NZ329258A (en)	1999-08-30
PT1004580E (pt)	2007-02-28
SK166595A3 (en)	1997-01-08
EP1004572A2 (en)	2000-05-31
ATE277036T1 (de)	2004-10-15
JP3971794B2 (ja)	2007-09-05
FI20040593A7 (fi)	2004-04-27
ATE319678T1 (de)	2006-03-15
PT1004572E (pt)	2006-06-30
JPH09500872A (ja)	1997-01-28
WO1995001348A3 (en)	1995-03-09
NZ329259A (en)	1998-07-28
EP1004572B1 (en)	2006-03-08
EP1477486A2 (en)	2004-11-17
WO1995001348A2 (en)	1995-01-12
CA2531868A1 (en)	1995-01-12
JP2006188530A (ja)	2006-07-20
RU2174516C2 (ru)	2001-10-10
EP1004580B1 (en)	2006-12-20
JP2006131647A (ja)	2006-05-25
KR960703891A (ko)	1996-08-31
ES2184765T3 (es)	2003-04-16
EP0706521B1 (en)	2002-10-02
DE69434029D1 (de)	2004-10-28
EP1004581A3 (en)	2002-08-14
DK1004581T3 (da)	2005-01-31
EP1477486A3 (en)	2004-12-15
DE69431480D1 (en)	2002-11-07
FI956362A0 (fi)	1995-12-29
HU9600003D0 (en)	1996-03-28
NZ268812A (en)	1998-04-27
EP1004581B1 (en)	2004-09-22
PL312386A1 (en)	1996-04-15
CZ294444B6 (cs)	2005-01-12
EP1004580A3 (en)	2002-10-02
DE69434645D1 (de)	2006-05-04
JP2006169261A (ja)	2006-06-29
KR100401290B1 (ko)	2005-10-19
CA2166315A1 (en)	1995-01-12
US5463063A (en)	1995-10-31
CA2531868C (en)	2013-08-27
CZ1096A3 (en)	1996-10-16
DE69431480T2 (de)	2003-05-08
ATE225344T1 (de)	2002-10-15
ES2258956T3 (es)	2006-09-16
EP1004572A3 (en)	2002-10-02
PL180377B1 (en)	2001-01-31
FI956362L (fi)	1996-02-26
CA2626178A1 (en)	1995-01-12
CA2166315C (en)	2006-04-04
EP1004580A2 (en)	2000-05-31
HK1025770A1 (en)	2000-11-24
PT706521E (pt)	2003-02-28
ATE348809T1 (de)	2007-01-15
DK0706521T3 (da)	2003-01-27

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