DK1025125T3 - Aggregater for humane insulinderivater - Google Patents

Aggregater for humane insulinderivater

Info

Publication number: DK1025125T3
Authority: DK; Denmark
Prior art keywords: aggregates; derivatives; human insulin; soluble; insulin derivatives
Prior art date: 1997-10-24

Application number

DK98949960T

Other languages

Danish (da)

English (en)

Inventor

Ib Jonassen

Svend Havelund

Per Balschmidt

Thomas Hoeg-Jensen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-24

Filing date

1998-10-23

Publication date

2003-10-06

1998-10-23 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2003-10-06 Application granted granted Critical

2003-10-06 Publication of DK1025125T3 publication Critical patent/DK1025125T3/da

Links

PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 2
102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 1
108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000002523 gelfiltration Methods 0.000 abstract 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Immunology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Obesity (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK98949960T 1997-10-24 1998-10-23 Aggregater for humane insulinderivater DK1025125T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK121897		1997-10-24
US6417097P	1997-11-04	1997-11-04
PCT/DK1998/000461 WO1999021888A1 (fr)	1997-10-24	1998-10-23	Agregats de derives de l'insuline humaine

Publications (1)

Publication Number	Publication Date
DK1025125T3 true DK1025125T3 (da)	2003-10-06

Family

ID=26065414

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98949960T DK1025125T3 (da)	1997-10-24	1998-10-23	Aggregater for humane insulinderivater

Country Status (20)

Country	Link
EP (1)	EP1025125B1 (fr)
JP (1)	JP2003525846A (fr)
KR (1)	KR100539193B1 (fr)
CN (1)	CN1240718C (fr)
AT (1)	ATE243711T1 (fr)
AU (1)	AU757933B2 (fr)
BR (1)	BR9813128A (fr)
CA (1)	CA2308705A1 (fr)
DE (1)	DE69815877T2 (fr)
DK (1)	DK1025125T3 (fr)
ES (1)	ES2202899T3 (fr)
HU (1)	HUP0004096A3 (fr)
IL (2)	IL135400A0 (fr)
NO (1)	NO20002050L (fr)
PL (1)	PL195845B1 (fr)
PT (1)	PT1025125E (fr)
RU (1)	RU2218349C2 (fr)
UA (1)	UA69393C2 (fr)
WO (1)	WO1999021888A1 (fr)
ZA (1)	ZA989722B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7316999B2 (en)	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
JP2004535401A (ja)	2001-05-21	2004-11-25	ネクターセラピューティックス	化学的に改変されたインスリンの肺投与
US7317000B2 (en)	2001-12-02	2008-01-08	Novo Nordisk A/S	Glucose-dependent insulins
MXPA06001283A (es) *	2003-08-05	2006-04-11	Novo Nordisk As	Derivados de insulina novedosos.
SI2107069T1 (sl) *	2003-08-05	2013-04-30	Novo Nordisk A/S	Novi inzulinski derivati
BRPI0513508B1 (pt) *	2004-07-19	2021-06-01	Biocon Limited	Conjugados de insulina-oligômero, formulações e usos desses
WO2006125765A2 (fr) *	2005-05-26	2006-11-30	Novo Nordisk A/S	Insuline acylee tres pure
JP4808785B2 (ja)	2005-12-28	2011-11-02	ノボ・ノルデイスク・エー／エス	インスリン組成物および組成物の製造方法
EP1991576B1 (fr)	2006-02-27	2010-09-29	Novo Nordisk A/S	Dérivés d'insuline
CA2652989A1 (fr) *	2006-06-08	2007-12-13	Diabecore Medical Inc.	Oligomeres d'insuline derives
ES2542146T3 (es)	2006-07-31	2015-07-31	Novo Nordisk A/S	Insulinas extendidas PEGiladas.
DK2074141T3 (en)	2006-09-22	2016-11-28	Novo Nordisk As	The protease resistant insulin analogues.
US9387176B2 (en)	2007-04-30	2016-07-12	Novo Nordisk A/S	Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US9034818B2 (en)	2007-06-13	2015-05-19	Novo Nordisk A/S	Pharmaceutical formulations comprising an insulin derivative
WO2009112583A2 (fr)	2008-03-14	2009-09-17	Novo Nordisk A/S	Analogues de l’insuline stabilisés une protéase
CN102037008B (zh)	2008-03-18	2016-08-31	诺沃-诺迪斯克有限公司	蛋白酶稳定化的、酰化胰岛素类似物
AU2009309623B9 (en)	2008-10-30	2014-10-02	Novo Nordisk A/S	Treating diabetes melitus using insulin injections with less than daily injection frequency
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
CN103191416A (zh) *	2012-01-05	2013-07-10	四川大学	一种猪胰岛素超分子聚集体及其制备方法
US9481721B2 (en)	2012-04-11	2016-11-01	Novo Nordisk A/S	Insulin formulations
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
AU2014333979B2 (en)	2013-10-07	2018-02-15	Novo Nordisk A/S	Novel derivative of an insulin analogue
AR099569A1 (es)	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
TWI700091B (zh)	2016-12-16	2020-08-01	丹麥商諾佛儂迪克股份有限公司	含胰島素醫藥組成物
HRP20240485T1 (hr)	2017-08-24	2024-07-05	Novo Nordisk A/S	Pripravci glp-1 i njihova upotreba
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation
PE20230819A1 (es)	2020-02-18	2023-05-19	Novo Nordisk As	Composiciones y usos de glp-1

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ287945B6 (cs) *	1993-09-17	2001-03-14	Novo Nordisk A/S	Inzulinový derivát a farmaceutický prostředek s jeho obsahem pro léčení diabetu
US5559094A (en) *	1994-08-02	1996-09-24	Eli Lilly And Company	AspB1 insulin analogs
US6451970B1 (en) *	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives

1998
- 1998-10-23 CN CNB988104458A patent/CN1240718C/zh not_active Expired - Fee Related
- 1998-10-23 CA CA002308705A patent/CA2308705A1/fr not_active Abandoned
- 1998-10-23 DK DK98949960T patent/DK1025125T3/da active
- 1998-10-23 IL IL13540098A patent/IL135400A0/xx not_active IP Right Cessation
- 1998-10-23 PL PL98340032A patent/PL195845B1/pl unknown
- 1998-10-23 UA UA2000042275A patent/UA69393C2/uk unknown
- 1998-10-23 BR BR9813128-1A patent/BR9813128A/pt not_active IP Right Cessation
- 1998-10-23 RU RU2000112882/04A patent/RU2218349C2/ru not_active IP Right Cessation
- 1998-10-23 AU AU96221/98A patent/AU757933B2/en not_active Ceased
- 1998-10-23 PT PT98949960T patent/PT1025125E/pt unknown
- 1998-10-23 HU HU0004096A patent/HUP0004096A3/hu unknown
- 1998-10-23 AT AT98949960T patent/ATE243711T1/de not_active IP Right Cessation
- 1998-10-23 WO PCT/DK1998/000461 patent/WO1999021888A1/fr not_active Ceased
- 1998-10-23 JP JP2000517995A patent/JP2003525846A/ja not_active Withdrawn
- 1998-10-23 ES ES98949960T patent/ES2202899T3/es not_active Expired - Lifetime
- 1998-10-23 DE DE69815877T patent/DE69815877T2/de not_active Expired - Fee Related
- 1998-10-23 EP EP98949960A patent/EP1025125B1/fr not_active Expired - Lifetime
- 1998-10-23 KR KR10-2000-7004229A patent/KR100539193B1/ko not_active Expired - Fee Related
- 1998-10-26 ZA ZA989722A patent/ZA989722B/xx unknown
2000
- 2000-03-31 IL IL135400A patent/IL135400A/en unknown
- 2000-04-18 NO NO20002050A patent/NO20002050L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR100539193B1 (ko)	2005-12-27
CN1240718C (zh)	2006-02-08
EP1025125A1 (fr)	2000-08-09
HUP0004096A3 (en)	2001-12-28
DE69815877T2 (de)	2004-05-19
JP2003525846A (ja)	2003-09-02
IL135400A0 (en)	2001-05-20
ATE243711T1 (de)	2003-07-15
CA2308705A1 (fr)	1999-05-06
NO20002050D0 (no)	2000-04-18
IL135400A (en)	2007-08-19
UA69393C2 (uk)	2004-09-15
EP1025125B1 (fr)	2003-06-25
HUP0004096A2 (hu)	2001-05-28
WO1999021888A1 (fr)	1999-05-06
RU2218349C2 (ru)	2003-12-10
PL195845B1 (pl)	2007-10-31
AU9622198A (en)	1999-05-17
AU757933B2 (en)	2003-03-13
BR9813128A (pt)	2000-08-15
ES2202899T3 (es)	2004-04-01
CN1281466A (zh)	2001-01-24
KR20010031247A (ko)	2001-04-16
ZA989722B (en)	1999-04-26
DE69815877D1 (de)	2003-07-31
PL340032A1 (en)	2001-01-15
PT1025125E (pt)	2003-11-28
NO20002050L (no)	2000-06-23

Publication	Publication Date	Title
DK1025125T3 (da)	2003-10-06	Aggregater for humane insulinderivater
CA2209060A1 (fr)	1997-12-28	Polymeres hydrosolubles ou gonflables dans l'eau
IS4963A (is)	1999-01-29	Setnar 6,5-heteró-bísýklískar afleiður
EP0931788A3 (fr)	1999-08-04	Inhibiteurs de la métalloprotéinase
CA2119154A1 (fr)	1994-02-03	Derives de cyclodextrines a solubilite aqueuse accrue et leur utilisation
AU2002343557A1 (en)	2003-06-10	Substituted aryl 1,4-pyrazine derivatives
PT977741E (pt)	2004-01-30	Derivados de fenilo substituido, sua preparacao e utilizacao
DK0920429T3 (da)	2003-05-12	Substituerede pyrido- eller pyrimidoholdige, 6,6- eller 6,7-bicykliske derivater
DZ2569A1 (fr)	2003-02-15	Dérivés 1,2,3,4-tétrahydronaphtalène substitués.
AP2000001923A0 (en)	2000-09-30	6,9.Disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines
DE69631774D1 (de)	2004-04-08	2,3-dioxo-1,2,3,4-tetrahydro-chinoxalin derivate
MX9803728A (es)	1998-09-30	Agentes floculantes de polimero de alto rendimiento.
TR200002248T2 (tr)	2000-12-21	Yeni dihidroksiheksanoik asit türevleri
DE69931260D1 (de)	2006-06-14	Wässriges künstliches medium
TR199701576T1 (xx)	1998-05-21	N-aril-1,2,4,-triazolin-5-onlar.
TR200001102T2 (tr)	2000-08-21	İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
IT1302243B1 (it)	2000-09-05	Sintesi dell'1,1,1,3,3-pentafluoropropano.
NO980303D0 (no)	1998-01-23	Vandige dispersjoner på basis av vannopplöselige polymerer
DE69628458D1 (de)	2003-07-03	25-hydroxy-16-ene-26,27-bishome-cholecalceriferol derivate
DK0861120T3 (da)	2003-12-15	Oliefri, vandopløselig, flydende hydroxyethylcellulosepolymerdispersion
ATE230592T1 (de)	2003-01-15	Dekorative kosmetische zubereitungen
ATE220674T1 (de)	2002-08-15	12h-dibenzo(d,g)(1,3)dioxocin derivate
ATE202922T1 (de)	2001-07-15	Ophthalmische cromolyn-gelzubereitung
ES1030492Y (es)	1996-07-01	Jamonero perfeccionado.
TR199700219A3 (tr)	1997-10-21	1,25-Dihidroksi-16, 22, 23-Trisdihidro-kolkalsiferol türevleri.