IL135400A0 - Aggregates of human insulin derivatives - Google Patents

Aggregates of human insulin derivatives

Info

Publication number: IL135400A0
Authority: IL; Israel
Prior art keywords: aggregates; derivatives; human insulin; soluble; insulin derivatives
Prior art date: 1997-10-24

Application number

IL13540098A

Other languages

English (en)

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-24

Filing date

1998-10-23

Publication date

2001-05-20

1998-10-23 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2001-05-20 Publication of IL135400A0 publication Critical patent/IL135400A0/xx

Links

PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 2
102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 1
108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000002523 gelfiltration Methods 0.000 abstract 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Immunology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Obesity (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL13540098A 1997-10-24 1998-10-23 Aggregates of human insulin derivatives IL135400A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK121897		1997-10-24
US6417097P	1997-11-04	1997-11-04
PCT/DK1998/000461 WO1999021888A1 (fr)	1997-10-24	1998-10-23	Agregats de derives de l'insuline humaine

Publications (1)

Publication Number	Publication Date
IL135400A0 true IL135400A0 (en)	2001-05-20

Family

ID=26065414

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL13540098A IL135400A0 (en)	1997-10-24	1998-10-23	Aggregates of human insulin derivatives
IL135400A IL135400A (en)	1997-10-24	2000-03-31	Accumulate humane insulin derivatives

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL135400A IL135400A (en)	1997-10-24	2000-03-31	Accumulate humane insulin derivatives

Country Status (20)

Country	Link
EP (1)	EP1025125B1 (fr)
JP (1)	JP2003525846A (fr)
KR (1)	KR100539193B1 (fr)
CN (1)	CN1240718C (fr)
AT (1)	ATE243711T1 (fr)
AU (1)	AU757933B2 (fr)
BR (1)	BR9813128A (fr)
CA (1)	CA2308705A1 (fr)
DE (1)	DE69815877T2 (fr)
DK (1)	DK1025125T3 (fr)
ES (1)	ES2202899T3 (fr)
HU (1)	HUP0004096A3 (fr)
IL (2)	IL135400A0 (fr)
NO (1)	NO20002050L (fr)
PL (1)	PL195845B1 (fr)
PT (1)	PT1025125E (fr)
RU (1)	RU2218349C2 (fr)
UA (1)	UA69393C2 (fr)
WO (1)	WO1999021888A1 (fr)
ZA (1)	ZA989722B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7316999B2 (en)	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
JP2004535401A (ja)	2001-05-21	2004-11-25	ネクターセラピューティックス	化学的に改変されたインスリンの肺投与
US7317000B2 (en)	2001-12-02	2008-01-08	Novo Nordisk A/S	Glucose-dependent insulins
MXPA06001283A (es) *	2003-08-05	2006-04-11	Novo Nordisk As	Derivados de insulina novedosos.
SI2107069T1 (sl) *	2003-08-05	2013-04-30	Novo Nordisk A/S	Novi inzulinski derivati
BRPI0513508B1 (pt) *	2004-07-19	2021-06-01	Biocon Limited	Conjugados de insulina-oligômero, formulações e usos desses
WO2006125765A2 (fr) *	2005-05-26	2006-11-30	Novo Nordisk A/S	Insuline acylee tres pure
JP4808785B2 (ja)	2005-12-28	2011-11-02	ノボ・ノルデイスク・エー／エス	インスリン組成物および組成物の製造方法
EP1991576B1 (fr)	2006-02-27	2010-09-29	Novo Nordisk A/S	Dérivés d'insuline
CA2652989A1 (fr) *	2006-06-08	2007-12-13	Diabecore Medical Inc.	Oligomeres d'insuline derives
ES2542146T3 (es)	2006-07-31	2015-07-31	Novo Nordisk A/S	Insulinas extendidas PEGiladas.
DK2074141T3 (en)	2006-09-22	2016-11-28	Novo Nordisk As	The protease resistant insulin analogues.
US9387176B2 (en)	2007-04-30	2016-07-12	Novo Nordisk A/S	Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US9034818B2 (en)	2007-06-13	2015-05-19	Novo Nordisk A/S	Pharmaceutical formulations comprising an insulin derivative
WO2009112583A2 (fr)	2008-03-14	2009-09-17	Novo Nordisk A/S	Analogues de l’insuline stabilisés une protéase
CN102037008B (zh)	2008-03-18	2016-08-31	诺沃-诺迪斯克有限公司	蛋白酶稳定化的、酰化胰岛素类似物
AU2009309623B9 (en)	2008-10-30	2014-10-02	Novo Nordisk A/S	Treating diabetes melitus using insulin injections with less than daily injection frequency
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
CN103191416A (zh) *	2012-01-05	2013-07-10	四川大学	一种猪胰岛素超分子聚集体及其制备方法
US9481721B2 (en)	2012-04-11	2016-11-01	Novo Nordisk A/S	Insulin formulations
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
AU2014333979B2 (en)	2013-10-07	2018-02-15	Novo Nordisk A/S	Novel derivative of an insulin analogue
AR099569A1 (es)	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
TWI700091B (zh)	2016-12-16	2020-08-01	丹麥商諾佛儂迪克股份有限公司	含胰島素醫藥組成物
HRP20240485T1 (hr)	2017-08-24	2024-07-05	Novo Nordisk A/S	Pripravci glp-1 i njihova upotreba
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation
PE20230819A1 (es)	2020-02-18	2023-05-19	Novo Nordisk As	Composiciones y usos de glp-1

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ287945B6 (cs) *	1993-09-17	2001-03-14	Novo Nordisk A/S	Inzulinový derivát a farmaceutický prostředek s jeho obsahem pro léčení diabetu
US5559094A (en) *	1994-08-02	1996-09-24	Eli Lilly And Company	AspB1 insulin analogs
US6451970B1 (en) *	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives

1998
- 1998-10-23 CN CNB988104458A patent/CN1240718C/zh not_active Expired - Fee Related
- 1998-10-23 CA CA002308705A patent/CA2308705A1/fr not_active Abandoned
- 1998-10-23 DK DK98949960T patent/DK1025125T3/da active
- 1998-10-23 IL IL13540098A patent/IL135400A0/xx not_active IP Right Cessation
- 1998-10-23 PL PL98340032A patent/PL195845B1/pl unknown
- 1998-10-23 UA UA2000042275A patent/UA69393C2/uk unknown
- 1998-10-23 BR BR9813128-1A patent/BR9813128A/pt not_active IP Right Cessation
- 1998-10-23 RU RU2000112882/04A patent/RU2218349C2/ru not_active IP Right Cessation
- 1998-10-23 AU AU96221/98A patent/AU757933B2/en not_active Ceased
- 1998-10-23 PT PT98949960T patent/PT1025125E/pt unknown
- 1998-10-23 HU HU0004096A patent/HUP0004096A3/hu unknown
- 1998-10-23 AT AT98949960T patent/ATE243711T1/de not_active IP Right Cessation
- 1998-10-23 WO PCT/DK1998/000461 patent/WO1999021888A1/fr not_active Ceased
- 1998-10-23 JP JP2000517995A patent/JP2003525846A/ja not_active Withdrawn
- 1998-10-23 ES ES98949960T patent/ES2202899T3/es not_active Expired - Lifetime
- 1998-10-23 DE DE69815877T patent/DE69815877T2/de not_active Expired - Fee Related
- 1998-10-23 EP EP98949960A patent/EP1025125B1/fr not_active Expired - Lifetime
- 1998-10-23 KR KR10-2000-7004229A patent/KR100539193B1/ko not_active Expired - Fee Related
- 1998-10-26 ZA ZA989722A patent/ZA989722B/xx unknown
2000
- 2000-03-31 IL IL135400A patent/IL135400A/en unknown
- 2000-04-18 NO NO20002050A patent/NO20002050L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR100539193B1 (ko)	2005-12-27
CN1240718C (zh)	2006-02-08
EP1025125A1 (fr)	2000-08-09
HUP0004096A3 (en)	2001-12-28
DE69815877T2 (de)	2004-05-19
JP2003525846A (ja)	2003-09-02
ATE243711T1 (de)	2003-07-15
CA2308705A1 (fr)	1999-05-06
NO20002050D0 (no)	2000-04-18
IL135400A (en)	2007-08-19
DK1025125T3 (da)	2003-10-06
UA69393C2 (uk)	2004-09-15
EP1025125B1 (fr)	2003-06-25
HUP0004096A2 (hu)	2001-05-28
WO1999021888A1 (fr)	1999-05-06
RU2218349C2 (ru)	2003-12-10
PL195845B1 (pl)	2007-10-31
AU9622198A (en)	1999-05-17
AU757933B2 (en)	2003-03-13
BR9813128A (pt)	2000-08-15
ES2202899T3 (es)	2004-04-01
CN1281466A (zh)	2001-01-24
KR20010031247A (ko)	2001-04-16
ZA989722B (en)	1999-04-26
DE69815877D1 (de)	2003-07-31
PL340032A1 (en)	2001-01-15
PT1025125E (pt)	2003-11-28
NO20002050L (no)	2000-06-23

Legal Events

Date	Code	Title
2008-01-22	FF	Patent granted
2008-01-22	KB	Patent renewed
2009-12-24	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL135400A0 (en)	2001-05-20	Aggregates of human insulin derivatives
CA2209060A1 (fr)	1997-12-28	Polymeres hydrosolubles ou gonflables dans l'eau
ZA9710290B (en)	1998-06-10	Aqueous dispersion polymers.
WO2002065684A3 (fr)	2002-09-26	Communication de donnees par ligne electrique
CA2119154A1 (fr)	1994-02-03	Derives de cyclodextrines a solubilite aqueuse accrue et leur utilisation
PL331988A1 (en)	1999-08-16	Substitution 6,6-heterobicyclic derivatives
EP1096173A3 (fr)	2001-12-19	Tendeur de chaíne ayant un ressort en forme de lame
ZA972056B (en)	1997-09-22	Substituted 1,2,3,4-tetrahydronaphthalene derivatives.
AU4270596A (en)	1996-07-19	Human phosphodiesterase type ivc, and its production and use
AU6636598A (en)	1998-10-20	Novel 3,4-dialkoxyphenyl derivatives and the use thereof
AU7961900A (en)	2001-05-14	Skin texture-improving agents
AU3657100A (en)	2000-10-04	Use of water-soluble beta-(1,3) glucans as agents for producing therapeutic skintreatment agents
GB2270919B (en)	1996-04-24	Aqueous wax and silicone dispersions,their production and use
MX9803728A (es)	1998-09-30	Agentes floculantes de polimero de alto rendimiento.
AU2894297A (en)	1997-12-05	2,4-diaminopyrimidine derivatives
AU5886500A (en)	2001-01-09	Indolyl-benzimidazole antibacterials, and methods of use thereof
AU7624598A (en)	1998-06-29	1,4-diazabicyclo (2.2.2) Oct-2-ylmethyl derivatives, their preparation and the rapeutic application
ZA971883B (en)	1997-11-10	1,3,5-trisubstituted indazole derivatives.
AU6180896A (en)	1997-01-22	Improved synthesis of 2,4,6,8,10,12-hexabenzyl-2,4,6,8,10,12-hexaazatetracyclo{5.5 .0.05,9.03,11}dodecane
AU3693797A (en)	1998-02-10	1,3-dimethyl-5-fluoro-pyrazole-4-carboxamide derivatives, their preparation and their use as microbicides
AU776463C (en)	2006-01-19	Decorative cosmetic preparations
CA2314716A1 (fr)	1999-06-17	Polysaccharides a reconnaissance biologique modifiee
GB9726130D0 (en)	1998-02-11	2,2'-BI-1H-pyrrole derivatives useful in the treatment of leukemia brought on by HTLV-I
AU2001266137A1 (en)	2002-01-02	Soluble carob
AU4506499A (en)	2000-01-05	Novel 2,4-diaminophenol derivatives and the use thereof