|
US5951974A
(en)
*
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
US6057287A
(en)
|
1994-01-11 |
2000-05-02 |
Dyax Corp. |
Kallikrein-binding "Kunitz domain" proteins and analogues thereof
|
|
CN1269805A
(zh)
*
|
1997-07-14 |
2000-10-11 |
博尔德生物技术公司 |
生长激素和相关蛋白的衍生物
|
|
US20080076706A1
(en)
|
1997-07-14 |
2008-03-27 |
Bolder Biotechnology, Inc. |
Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
|
|
US6753165B1
(en)
*
|
1999-01-14 |
2004-06-22 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
|
US7270809B2
(en)
*
|
1997-07-14 |
2007-09-18 |
Bolder Biotechnology, Inc. |
Cysteine variants of alpha interferon-2
|
|
US5985263A
(en)
*
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
CN100480266C
(zh)
|
1998-10-16 |
2009-04-22 |
拜奥根Idec马萨诸塞公司 |
干扰素-β融合蛋白及用途
|
|
DK1656952T3
(da)
|
1998-10-16 |
2014-01-20 |
Biogen Idec Inc |
Polyalkylenglycolkonjugater af interferon beta-1A og anvendelser deraf
|
|
US8288126B2
(en)
|
1999-01-14 |
2012-10-16 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
|
AU3714800A
(en)
*
|
1999-03-02 |
2000-09-21 |
Schering Corporation |
Hiv therapy
|
|
US6362162B1
(en)
|
1999-04-08 |
2002-03-26 |
Schering Corporation |
CML Therapy
|
|
US6923966B2
(en)
*
|
1999-04-08 |
2005-08-02 |
Schering Corporation |
Melanoma therapy
|
|
US6605273B2
(en)
|
1999-04-08 |
2003-08-12 |
Schering Corporation |
Renal cell carcinoma treatment
|
|
US6849254B1
(en)
|
1999-04-19 |
2005-02-01 |
Schering Corporation |
HCV combination therapy
|
|
WO2001026677A1
(fr)
*
|
1999-10-12 |
2001-04-19 |
Santen Pharmaceutical Co., Ltd. |
Complexe a base d'interferon et son utilisation en medecine
|
|
US7230081B1
(en)
|
1999-11-12 |
2007-06-12 |
Maxygen Holdings, Ltd. |
Interferon gamma conjugates
|
|
SK8292002A3
(en)
|
1999-11-12 |
2002-12-03 |
Maxygen Holdings Ltd |
A conjugate exhibiting interferon gamma activity, nucleotide sequence encoding for a polypeptide fraction of conjugate, an expression vector and a host cell containing nucleotide sequence, pharmaceutical composition comprising the same and use thereof
|
|
CA2395713C
(en)
|
2000-01-10 |
2012-04-10 |
Maxygen, Inc. |
G-csf conjugates
|
|
EP1982732A3
(en)
|
2000-02-11 |
2011-06-08 |
Bayer HealthCare LLC |
Factor VII or VIIA-like conjugates
|
|
WO2001066132A2
(en)
*
|
2000-03-09 |
2001-09-13 |
Schering Corporation |
Hiv immune adjuvant therapy
|
|
KR100353392B1
(ko)
*
|
2000-03-13 |
2002-09-18 |
선바이오(주) |
높은 생체 활성도를 갖는 생체 활성 단백질과 peg의결합체 제조방법
|
|
US6476062B2
(en)
|
2000-03-30 |
2002-11-05 |
Schering Corporation |
Chemokine receptor antagonists
|
|
ATE313554T1
(de)
*
|
2000-05-16 |
2006-01-15 |
Lipoxen Technologies Ltd |
Derivatisierung von proteinen in wässrigem lösungsmittel
|
|
US20040067527A1
(en)
*
|
2000-07-26 |
2004-04-08 |
Sara Lavi |
Intracellular delivery system for protein phosphatases and other polypeptides
|
|
US7208167B2
(en)
*
|
2000-08-07 |
2007-04-24 |
Sciclone Pharmaceuticals, Inc. |
Treatment of hepatitis C with thymosin and peptide combination therapy
|
|
US7118737B2
(en)
*
|
2000-09-08 |
2006-10-10 |
Amylin Pharmaceuticals, Inc. |
Polymer-modified synthetic proteins
|
|
ATE500838T1
(de)
*
|
2000-09-08 |
2011-03-15 |
Amylin Pharmaceuticals Inc |
ßPSEUDOß-NATIVE CHEMISCHE LIGATION
|
|
ATE516820T1
(de)
*
|
2000-09-29 |
2011-08-15 |
Schering Corp |
Pegyliertes interleukin 10
|
|
US6867183B2
(en)
*
|
2001-02-15 |
2005-03-15 |
Nobex Corporation |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US7060675B2
(en)
|
2001-02-15 |
2006-06-13 |
Nobex Corporation |
Methods of treating diabetes mellitus
|
|
PL367154A1
(en)
|
2001-02-27 |
2005-02-21 |
Maxygen Aps |
New interferon beta-like molecules
|
|
US7038015B2
(en)
*
|
2001-04-06 |
2006-05-02 |
Maxygen Holdings, Ltd. |
Interferon gamma polypeptide variants
|
|
US6958388B2
(en)
|
2001-04-06 |
2005-10-25 |
Maxygen, Aps |
Interferon gamma polypeptide variants
|
|
US6858580B2
(en)
*
|
2001-06-04 |
2005-02-22 |
Nobex Corporation |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US7713932B2
(en)
*
|
2001-06-04 |
2010-05-11 |
Biocon Limited |
Calcitonin drug-oligomer conjugates, and uses thereof
|
|
US6835802B2
(en)
|
2001-06-04 |
2004-12-28 |
Nobex Corporation |
Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
|
|
US6713452B2
(en)
|
2001-06-04 |
2004-03-30 |
Nobex Corporation |
Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6828297B2
(en)
*
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6828305B2
(en)
*
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US7196059B2
(en)
*
|
2001-09-07 |
2007-03-27 |
Biocon Limited |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US7049285B2
(en)
*
|
2001-10-31 |
2006-05-23 |
Myung-Ok Park |
Biocompatible polymers including peptide spacer
|
|
KR100480430B1
(ko)
*
|
2001-12-04 |
2005-04-06 |
선바이오(주) |
인터페론-베타와 폴리에틸렌글리콜 유도체의 배합체
|
|
KR100480429B1
(ko)
*
|
2001-12-04 |
2005-04-06 |
선바이오(주) |
인터페론-알파와 폴리에틸렌글리콜 유도체의 배합체
|
|
AU2002346686A1
(en)
*
|
2001-12-07 |
2003-06-23 |
Intermune, Inc. |
Compositions and method for treating hepatitis virus infection
|
|
DK3025726T3
(da)
|
2002-01-18 |
2019-12-09 |
Biogen Ma Inc |
Polyalkylenpolymerforbindelser og anvendelser deraf
|
|
EP1490402A4
(en)
*
|
2002-03-20 |
2007-05-02 |
Biopolymed Inc |
PREPARATION OF CYSTEINREST STOCHIOMETRIC WITH BIOKOMPATIBLE POLYMER CONJUGATED G-CSF
|
|
US7153829B2
(en)
|
2002-06-07 |
2006-12-26 |
Dyax Corp. |
Kallikrein-inhibitor therapies
|
|
DK2311432T3
(da)
|
2002-06-07 |
2015-02-02 |
Dyax Corp |
Modificerede Kunitz-domæne-polypeptider og deres anvendelse til reduktion af iskæmi eller indtræden af en systemisk inflammatorisk reaktion i forbindelse med en kirurgisk procedure
|
|
AU2003236521A1
(en)
|
2002-06-13 |
2003-12-31 |
Nobex Corporation |
Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
|
|
BR0311978A
(pt)
|
2002-06-21 |
2005-03-22 |
Novo Nordisk Healthcare Ag |
Preparação, método para preparar a mesma, formulação farmacêutica, métodos para tratar de uma sìndrome responsiva ao fator vii, para prevenir hemorragias indesejáveis, para prevenir coagulação sanguìnea indesejável e para prevenir as reações mediadas pelo fator tecidual, e, uso de uma preparação
|
|
PT1523489E
(pt)
|
2002-06-28 |
2014-06-24 |
Centre Nat Rech Scient |
Profármacos de nucleósido modificado em 2' e 3' para tratamento de infecções por flaviridae
|
|
WO2004005341A2
(en)
*
|
2002-07-03 |
2004-01-15 |
Maxygen Holdings Ltd. |
Full-length interferon gamma polypeptide variants
|
|
TR201900937T4
(tr)
*
|
2002-08-28 |
2019-02-21 |
Dyax Corp |
Organların ve dokuların muhafaza edilmesine yönelik yöntem.
|
|
US20040062748A1
(en)
|
2002-09-30 |
2004-04-01 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
US8129330B2
(en)
*
|
2002-09-30 |
2012-03-06 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
AU2003293668A1
(en)
*
|
2002-11-15 |
2004-06-15 |
F. Hoffmann-La Roche Ag |
Positional isomers of peg ifn alpha 2a
|
|
CN102319437B
(zh)
|
2002-12-26 |
2017-10-13 |
山景医药公司 |
具有增强的生物学效用的干扰素‑β的聚合物缀合物
|
|
AU2003303636B2
(en)
*
|
2002-12-26 |
2010-08-05 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
|
|
US20050079155A1
(en)
*
|
2003-03-20 |
2005-04-14 |
Xencor, Inc. |
Generating protein pro-drugs using reversible PPG linkages
|
|
MXPA05010411A
(es)
*
|
2003-03-28 |
2006-05-31 |
Biopolymed Inc |
Material activo biologicamente conjugado con polimeros biocompatibles con el complejo 1:1, metodo de preparacion del mismo y composicion farmaceutica que lo contienen.
|
|
US20060134736A1
(en)
*
|
2003-03-28 |
2006-06-22 |
Jacobs John W |
Human growth hormone conjugated with biocompatible polymer
|
|
US20050281778A1
(en)
*
|
2003-03-28 |
2005-12-22 |
Myung-Ok Park |
Human growth hormone conjugated with biocompatible polymer
|
|
TW200510454A
(en)
|
2003-04-15 |
2005-03-16 |
Smithkline Beecham Corp |
Conjugates comprising human IL-18 and substitution mutants thereof
|
|
JP2007525188A
(ja)
|
2003-05-16 |
2007-09-06 |
インターミューン インコーポレイテッド |
合成ケモカイン受容体リガンドおよびその使用方法
|
|
BRPI0419345B8
(pt)
|
2003-05-30 |
2021-05-25 |
Gilead Pharmasset Llc |
uso do (2r)-2-desoxi-2-flúor-2-c-metil nucleosídeo e de uma composição farmacêutica que o compreende
|
|
EP1664326A2
(en)
*
|
2003-07-31 |
2006-06-07 |
Anticancer, Inc. |
The use of plp with peg-rmetase in vivo for enhanced efficacy
|
|
EP2263684A1
(en)
|
2003-10-10 |
2010-12-22 |
Novo Nordisk A/S |
IL-21 derivatives
|
|
TW201245229A
(en)
|
2003-10-14 |
2012-11-16 |
Hoffmann La Roche |
Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication
|
|
ES2428358T3
(es)
|
2003-10-17 |
2013-11-07 |
Novo Nordisk A/S |
Terapia de combinación
|
|
WO2005042563A2
(en)
*
|
2003-10-22 |
2005-05-12 |
Akzo Nobel N.V. |
Process for incrasing protein pegylation reaction yields by diafiltration ultrafiltration
|
|
US7407973B2
(en)
*
|
2003-10-24 |
2008-08-05 |
Intermune, Inc. |
Use of pirfenidone in therapeutic regimens
|
|
WO2005067454A2
(en)
*
|
2003-12-23 |
2005-07-28 |
Valeant Pharmaceuticals North America |
Combination therapy for treating hepatitis c virus infection
|
|
AU2005206549B2
(en)
*
|
2004-01-21 |
2011-09-15 |
Nektar Therapeutics |
Method of preparing propionic acid-terminated polymers
|
|
CN103755800B
(zh)
|
2004-02-02 |
2016-02-24 |
Ambrx公司 |
经修饰的人类生长激素多肽与其用途
|
|
AU2005319099B2
(en)
|
2004-02-02 |
2010-09-16 |
Ambrx, Inc. |
Modified human growth hormone
|
|
EP1734988A4
(en)
*
|
2004-03-01 |
2009-08-05 |
Enzon Pharmaceuticals Inc |
INTERFERON BETA-polymer
|
|
JP5460958B2
(ja)
*
|
2004-03-17 |
2014-04-02 |
アンチキャンサー インコーポレーテッド |
タンパク質ポリエチレングリコール(peg)複合体形成を増大させる方法
|
|
EP1586334A1
(en)
*
|
2004-04-15 |
2005-10-19 |
TRASTEC scpa |
G-CSF conjugates with peg
|
|
US20060018875A1
(en)
*
|
2004-06-14 |
2006-01-26 |
Blatt Lawrence M |
Interferon compositions and methods of use thereof
|
|
US20050281872A1
(en)
*
|
2004-06-16 |
2005-12-22 |
Peter Summerville |
Enhanced compliance antiviral medicaments and methods of manufacture and use
|
|
CN102532321B
(zh)
|
2004-06-18 |
2018-10-12 |
Ambrx公司 |
新颖抗原结合多肽和其用途
|
|
CN103223160B
(zh)
|
2004-07-19 |
2015-02-18 |
比奥孔有限公司 |
胰岛素-低聚物共轭物,制剂及其用途
|
|
CN101023094B
(zh)
|
2004-07-21 |
2011-05-18 |
法莫赛特股份有限公司 |
烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
|
|
US7638299B2
(en)
|
2004-07-21 |
2009-12-29 |
Ambrx, Inc. |
Biosynthetic polypeptides utilizing non-naturally encoded amino acids
|
|
JP2008515774A
(ja)
|
2004-08-03 |
2008-05-15 |
ダイアックス コーポレイション |
hK1結合タンパク質
|
|
DE602005022895D1
(de)
|
2004-08-12 |
2010-09-23 |
Schering Corp |
Stabile pegylierte interferon-formulierung
|
|
MX2007003085A
(es)
|
2004-09-14 |
2007-08-02 |
Pharmasset Inc |
Preparacion de 2'-fluoro-2'-alquilo sustituido u otras ribofuranosil pirimidinas y purinas opcionalmente sustituidas y sus derivados.
|
|
US7235530B2
(en)
|
2004-09-27 |
2007-06-26 |
Dyax Corporation |
Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
|
|
AU2005323106B2
(en)
|
2004-12-22 |
2010-07-29 |
Ambrx, Inc. |
Methods for expression and purification of recombinant human growth hormone
|
|
NZ555425A
(en)
|
2004-12-22 |
2010-04-30 |
Ambrx Inc |
Compositions of aminoacyl-tRNA synthetase and uses thereof
|
|
KR101224781B1
(ko)
|
2004-12-22 |
2013-01-21 |
암브룩스, 인코포레이티드 |
비천연적으로 코딩된 아미노산을 포함하는 인간 성장호르몬의 조제물
|
|
US7365127B2
(en)
*
|
2005-02-04 |
2008-04-29 |
Enzon Pharmaceuticals, Inc. |
Process for the preparation of polymer conjugates
|
|
ES2440953T3
(es)
|
2005-03-31 |
2014-01-31 |
The General Hospital Corporation |
Modulación de la actividad de HGF/HGFR para tratar un linfedema
|
|
WO2006133088A2
(en)
|
2005-06-03 |
2006-12-14 |
Ambrx, Inc. |
Improved human interferon molecules and their uses
|
|
WO2006134173A2
(en)
|
2005-06-17 |
2006-12-21 |
Novo Nordisk Health Care Ag |
Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine
|
|
MX2008001706A
(es)
*
|
2005-08-04 |
2008-04-07 |
Nektar Therapeutics Al Corp |
Conjugados de una porcion g-csf y un polimero.
|
|
PL2407486T3
(pl)
|
2005-08-19 |
2018-05-30 |
Wyeth Llc |
Przeciwciała antagonistyczne względem GDF-8 i zastosowania w leczeniu ALS i innych zaburzeń związanych z GDF-8
|
|
EP1951890A4
(en)
|
2005-11-16 |
2009-06-24 |
Ambrx Inc |
PROCESSES AND COMPOSITIONS WITH NON-NATURAL AMINO ACIDS
|
|
CU23556A1
(es)
*
|
2005-11-30 |
2010-07-20 |
Ct Ingenieria Genetica Biotech |
Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico
|
|
DK1985303T3
(da)
|
2006-01-12 |
2013-02-25 |
Kitasato Daiichi Sankyo Vaccine Co Ltd |
Oral sammensætning indeholdende interferon-alpha
|
|
ITMI20060612A1
(it)
*
|
2006-03-30 |
2007-09-30 |
Keryos Spa |
New activaded poly-ethylene glycols-and related polymers and their applications
|
|
US20070231301A1
(en)
*
|
2006-03-31 |
2007-10-04 |
Warren Stephen L |
Parenteral low dose type 1 interferons for bladder cancer
|
|
US20080096819A1
(en)
*
|
2006-05-02 |
2008-04-24 |
Allozyne, Inc. |
Amino acid substituted molecules
|
|
EP2581450B1
(en)
|
2006-05-02 |
2018-08-15 |
MedImmune Limited |
Non-natural amino acid substituted polypeptides
|
|
US20090252720A1
(en)
|
2006-05-24 |
2009-10-08 |
Novo Nordisk Health Care Ag |
Prolonged FIX Analogues and Derivatives
|
|
US20070282170A1
(en)
*
|
2006-05-30 |
2007-12-06 |
Sundaram Ravikumar |
Rake Retractor and Needle Assembly for Minimally Invasive Surgical Applications
|
|
US8008948B2
(en)
*
|
2006-07-06 |
2011-08-30 |
Denso Corporation |
Peak voltage detector circuit and binarizing circuit including the same circuit
|
|
EP1886685A1
(en)
|
2006-08-11 |
2008-02-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition
|
|
JP2010510171A
(ja)
*
|
2006-08-21 |
2010-04-02 |
ユナイテッド セラピューティクス コーポレーション |
ウイルス感染症の治療のための併用療法
|
|
WO2008030558A2
(en)
|
2006-09-08 |
2008-03-13 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and their uses
|
|
PT2064333E
(pt)
|
2006-09-08 |
2014-06-09 |
Ambrx Inc |
Supressor híbrido arnt para células de vertebrados
|
|
CN101678117A
(zh)
*
|
2006-09-29 |
2010-03-24 |
坎吉有限公司 |
基因治疗的方法和组合物
|
|
US8679472B1
(en)
|
2006-10-05 |
2014-03-25 |
Merck, Sharp & Dohme Corp. |
Crystal of human interferon alpha 2B in complex with zinc
|
|
KR101079993B1
(ko)
*
|
2006-11-17 |
2011-11-04 |
동아제약주식회사 |
폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체
|
|
PL2097068T3
(pl)
*
|
2006-11-24 |
2013-12-31 |
Cadila Healthcare Ltd |
Preparaty koniugatów PEG-interferon alfa
|
|
US7964580B2
(en)
|
2007-03-30 |
2011-06-21 |
Pharmasset, Inc. |
Nucleoside phosphoramidate prodrugs
|
|
KR101476472B1
(ko)
|
2007-03-30 |
2015-01-05 |
암브룩스, 인코포레이티드 |
변형된 fgf-21 폴리펩티드 및 그 용도
|
|
KR20100019467A
(ko)
|
2007-05-02 |
2010-02-18 |
암브룩스, 인코포레이티드 |
변형된 인터페론 베타 폴리펩티드 및 그의 용도
|
|
CN101361968B
(zh)
|
2007-08-06 |
2011-08-03 |
健能隆医药技术(上海)有限公司 |
白介素-22在治疗脂肪肝中的应用
|
|
CL2008002399A1
(es)
*
|
2007-08-16 |
2009-01-02 |
Pharmaessentia Corp |
Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c.
|
|
CA2707840A1
(en)
*
|
2007-08-20 |
2009-02-26 |
Allozyne, Inc. |
Amino acid substituted molecules
|
|
CA2698173C
(en)
*
|
2007-09-04 |
2015-02-03 |
Biosteed Gene Expression Tech. Co., Ltd. |
Interferon alpha 2b modified by polyethylene glycol, the preparation and use thereof
|
|
CN101636411B
(zh)
*
|
2007-09-04 |
2013-01-09 |
厦门伯赛基因转录技术有限公司 |
聚乙二醇修饰的干扰素α2a及其制备方法和应用
|
|
US9241908B2
(en)
*
|
2007-10-16 |
2016-01-26 |
Biocon Limited |
Orally administrable solid pharmaceutical composition and a process thereof
|
|
PE20091163A1
(es)
|
2007-11-01 |
2009-08-09 |
Wyeth Corp |
Anticuerpos para gdf8
|
|
ES2632504T3
(es)
|
2007-11-20 |
2017-09-13 |
Ambrx, Inc. |
Polipéptidos de insulina modificados y sus usos
|
|
NZ602170A
(en)
|
2008-02-08 |
2014-03-28 |
Ambrx Inc |
Modified leptin polypeptides and their uses
|
|
TW200946541A
(en)
|
2008-03-27 |
2009-11-16 |
Idenix Pharmaceuticals Inc |
Solid forms of an anti-HIV phosphoindole compound
|
|
JP5675606B2
(ja)
|
2008-07-08 |
2015-02-25 |
ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム |
シグナル伝達性転写因子(stat)の増殖及び活性化の新規の抑制剤
|
|
MX2011000859A
(es)
|
2008-07-23 |
2011-02-24 |
Ambrx Inc |
Polipeptidos g-csf bovinos modificados y sus usos.
|
|
TWI421093B
(zh)
*
|
2008-07-31 |
2014-01-01 |
Pharmaessentia Corp |
胜肽-聚合物綴合物
|
|
WO2010033226A1
(en)
*
|
2008-09-17 |
2010-03-25 |
Nektar Therapeutics |
Oligomer-protease inhibitor conjugates
|
|
PL2342223T3
(pl)
|
2008-09-26 |
2017-09-29 |
Ambrx, Inc. |
Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania
|
|
NO2337846T3
(da)
|
2008-09-26 |
2018-06-16 |
|
|
|
WO2010039801A2
(en)
|
2008-10-02 |
2010-04-08 |
The J. David Gladstone Institutes |
Methods of treating hepatitis c virus infection
|
|
EP3348281B1
(en)
|
2008-12-17 |
2023-07-05 |
Merck Sharp & Dohme Corp. |
Mono- and di-peg il-10 production; and uses
|
|
JP6104504B2
(ja)
|
2008-12-23 |
2017-03-29 |
ギリアド ファーマセット エルエルシー |
ヌクレオシド類似体
|
|
CL2009002206A1
(es)
|
2008-12-23 |
2011-08-26 |
Gilead Pharmasset Llc |
Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
|
|
TW201026715A
(en)
|
2008-12-23 |
2010-07-16 |
Pharmasset Inc |
Nucleoside phosphoramidates
|
|
US8975247B2
(en)
|
2009-03-18 |
2015-03-10 |
The Board Of Trustees Of The Leland Stanford Junion University |
Methods and compositions of treating a flaviviridae family viral infection
|
|
US8618076B2
(en)
|
2009-05-20 |
2013-12-31 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
|
TWI583692B
(zh)
|
2009-05-20 |
2017-05-21 |
基利法瑪席特有限責任公司 |
核苷磷醯胺
|
|
EP2516455A4
(en)
|
2009-12-21 |
2013-05-22 |
Ambrx Inc |
MODIFIED SWINE SOMATOTROPIN POLYPEPTIDES AND THEIR USES
|
|
NZ600361A
(en)
|
2009-12-21 |
2014-06-27 |
Ambrx Inc |
Modified bovine somatotropin polypeptides and their uses
|
|
ES2688093T3
(es)
*
|
2010-01-06 |
2018-10-30 |
Dyax Corp. |
Proteínas de unión a calicreína plasmática
|
|
US9815876B2
(en)
|
2010-03-05 |
2017-11-14 |
Omeros Corporation |
Chimeric inhibitor molecules of complement activation
|
|
CL2011000716A1
(es)
|
2010-03-31 |
2012-04-20 |
Gilead Pharmasset Llc |
Formas cristalinas 1 6 de (s)-isopropil-2-(((s)-(((2r.3r.4r.5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-4-fluoro-3-hidroxi-4-metil tetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato; composicion y combinacion farmaceutica; y su uso para tratar una infeccion por el virus de la hepatitis c.
|
|
US20120135912A1
(en)
|
2010-05-10 |
2012-05-31 |
Perseid Therapeutics Llc |
Polypeptide inhibitors of vla4
|
|
RU2447083C1
(ru)
*
|
2010-07-20 |
2012-04-10 |
Закрытое Акционерное Общество "Биокад" |
НОВЫЙ ФУНКЦИОНАЛЬНО АКТИВНЫЙ ВЫСОКООЧИЩЕННЫЙ СТАБИЛЬНЫЙ КОНЪЮГАТ ИНТЕРФЕРОНА α С ПОЛИЭТИЛЕНГЛИКОЛЕМ, ПРЕДСТАВЛЕННЫЙ ОДНИМ ПОЗИЦИОННЫМ ИЗОМЕРОМ ПЭГ-NαH-ИФН, С УМЕНЬШЕННОЙ ИММУНОГЕННОСТЬЮ, С ПРОЛОНГИРОВАННЫМ БИОЛОГИЧЕСКИМ ДЕЙСТВИЕМ, ПРИГОДНЫЙ ДЛЯ МЕДИЦИНСКОГО ПРИМЕНЕНИЯ, И ИММУНОБИОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
SMT201900495T1
(it)
|
2010-08-17 |
2019-11-13 |
Ambrx Inc |
Polipeptidi di relaxina modificati e loro usi
|
|
CN102380091A
(zh)
|
2010-08-31 |
2012-03-21 |
健能隆医药技术(上海)有限公司 |
白介素-22在治疗病毒性肝炎中的应用
|
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
|
WO2012075140A1
(en)
|
2010-11-30 |
2012-06-07 |
Pharmasset, Inc. |
Compounds
|
|
IL269565B2
(en)
|
2011-01-06 |
2024-06-01 |
Dyax Corp |
Plasma kallikrein binding proteins
|
|
WO2012107589A1
(en)
|
2011-02-11 |
2012-08-16 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment and prevention of hcv infections
|
|
US9382305B2
(en)
|
2011-07-01 |
2016-07-05 |
Bayer Intellectual Property Gmbh |
Relaxin fusion polypeptides and uses thereof
|
|
EP2734640A1
(en)
|
2011-07-20 |
2014-05-28 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Methods for determining treatment response in patients infected with hcv genotype 4
|
|
WO2013024156A2
(en)
|
2011-08-17 |
2013-02-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Combinations of anti-hcv-entry factor antibodies and interferons for the treatment and the prevention of hcv infection
|
|
WO2013024158A1
(en)
|
2011-08-17 |
2013-02-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Combinations of protein kinase inhibitors and interferons or of protein kinase inhibitors and direct acting antivirals for the treatment and the prevention of hcv infection
|
|
US8889159B2
(en)
|
2011-11-29 |
2014-11-18 |
Gilead Pharmasset Llc |
Compositions and methods for treating hepatitis C virus
|
|
AU2012347785B2
(en)
|
2011-12-06 |
2017-03-16 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for treating viral diseases
|
|
WO2013174988A1
(en)
|
2012-05-24 |
2013-11-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for predicting and monitoring treatment response in hcv- and hcv/hiv-infected subjects
|
|
JP6498600B2
(ja)
|
2012-06-08 |
2019-04-10 |
ストロ バイオファーマ インコーポレーテッド |
部位特異的な非天然アミノ酸残基を含む抗体、その調製方法、及びその使用方法
|
|
MY177331A
(en)
|
2012-06-15 |
2020-09-12 |
Pfizer |
Improved antagonist antibodies against gdf-8 and uses therefor
|
|
EP2863955B1
(en)
|
2012-06-26 |
2016-11-23 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
|
DK2890402T3
(da)
|
2012-08-31 |
2019-07-15 |
Sutro Biopharma Inc |
Modificerede aminosyrer omfattende en azidogruppe
|
|
WO2014033266A1
(en)
|
2012-08-31 |
2014-03-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Anti-sr-bi antibodies for the inhibition of hepatitis c virus infection
|
|
EA021643B1
(ru)
*
|
2013-03-28 |
2015-07-30 |
Илья Александрович МАРКОВ |
Монопегилированный интерферон-альфа линейной структуры и фармацевтическая композиция для приготовления лекарственного средства, обладающего активностью интерферона-альфа
|
|
EA023360B1
(ru)
*
|
2013-03-28 |
2016-05-31 |
Илья Александрович МАРКОВ |
Линейный ацилазидный пегилирующий агент, способ его получения и способ получения пегилированного интерферона
|
|
EA021610B1
(ru)
*
|
2013-03-28 |
2015-07-30 |
Илья Александрович МАРКОВ |
Жидкое противовирусное лекарственное средство
|
|
CN105209054A
(zh)
|
2013-04-18 |
2015-12-30 |
阿尔莫生物科技股份有限公司 |
使用白细胞介素-10治疗疾病和病症的方法
|
|
JP2016528879A
(ja)
|
2013-06-17 |
2016-09-23 |
アルモ・バイオサイエンシーズ・インコーポレイテッド |
タンパク質の同一性および安定性を評価する方法
|
|
WO2015006555A2
(en)
|
2013-07-10 |
2015-01-15 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
JP2016529293A
(ja)
|
2013-08-27 |
2016-09-23 |
ギリアド ファーマセット エルエルシー |
2つの抗ウイルス化合物の組合せ製剤
|
|
HK1226308A1
(zh)
|
2013-08-30 |
2017-09-29 |
Armo Biosciences, Inc. |
使用白细胞介素-10治疗疾病和病症的方法
|
|
US9840493B2
(en)
|
2013-10-11 |
2017-12-12 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
CN104623637A
(zh)
|
2013-11-07 |
2015-05-20 |
健能隆医药技术(上海)有限公司 |
Il-22二聚体在制备静脉注射药物中的应用
|
|
US11413332B2
(en)
|
2013-11-11 |
2022-08-16 |
Armo Biosciences, Inc. |
Methods of using interleukin-10 for treating diseases and disorders
|
|
EP3122782A4
(en)
|
2014-03-27 |
2017-09-13 |
Dyax Corp. |
Compositions and methods for treatment of diabetic macular edema
|
|
US10076512B2
(en)
|
2014-05-01 |
2018-09-18 |
Eiger Biopharmaceuticals, Inc. |
Treatment of hepatitis delta virus infection
|
|
US11311519B2
(en)
|
2014-05-01 |
2022-04-26 |
Eiger Biopharmaceuticals, Inc. |
Treatment of hepatitis delta virus infection
|
|
KR102686313B1
(ko)
|
2014-05-01 |
2024-07-17 |
아이거 바이오파마슈티컬스 인코포레이티드 |
델타 간염 바이러스 감염의 치료
|
|
RU2554761C1
(ru)
*
|
2014-05-13 |
2015-06-27 |
Закрытое акционерное общество "Сибирский центр фармакологии и биотехнологии" |
Противоэнтеровирусное и иммуностимулирующее средство
|
|
US10293043B2
(en)
|
2014-06-02 |
2019-05-21 |
Armo Biosciences, Inc. |
Methods of lowering serum cholesterol
|
|
KR101736870B1
(ko)
*
|
2014-08-20 |
2017-05-18 |
한국코러스 주식회사 |
인터페론 접합체를 포함하는 복합체 및 이의 제조방법
|
|
KR20170068553A
(ko)
|
2014-10-14 |
2017-06-19 |
아르모 바이오사이언시스 인코포레이티드 |
인터류킨-15 조성물 및 이의 용도
|
|
JP6675394B2
(ja)
|
2014-10-22 |
2020-04-01 |
アルモ・バイオサイエンシーズ・インコーポレイテッド |
疾患及び障害の治療のためにインターロイキン−10を使用する方法
|
|
BR112017008157A2
(pt)
|
2014-10-24 |
2017-12-19 |
Bristol Myers Squibb Co |
polipeptídeos de fgf-21 modificados e usos dos mesmos
|
|
CA2964390A1
(en)
|
2014-11-06 |
2016-05-12 |
Pharmaessentia Corporation |
Dosage regimen for pegylated interferon
|
|
US10618970B2
(en)
|
2015-02-03 |
2020-04-14 |
Armo Biosciences, Inc. |
Method of treating cancer with IL-10 and antibodies that induce ADCC
|
|
US10835496B2
(en)
|
2015-04-21 |
2020-11-17 |
Eiger Biopharmaceuticals, Inc. |
Pharmaceutical compositions comprising lonafarnib and ritonavir
|
|
US20160361415A1
(en)
|
2015-05-28 |
2016-12-15 |
Armo Biosciences, Inc. |
Methods of Using Interleukin-10 for Treating Diseases and Disorders
|
|
JP7053453B2
(ja)
|
2015-08-25 |
2022-04-12 |
アルモ・バイオサイエンシーズ・インコーポレイテッド |
疾患及び障害を治療するためのインターロイキン10の使用方法
|
|
EP3370723B1
(en)
|
2015-11-04 |
2020-12-16 |
Eiger Biopharmaceuticals, Inc. |
Treatment of hepatitis delta virus infection
|
|
BR112018011622A2
(pt)
|
2015-12-11 |
2018-11-27 |
Dyax Corp |
método para tratar ataque de angioedema hereditário (hae) ou reduzir a taxa de ataque de hae
|
|
ES2930351T3
(es)
|
2016-04-15 |
2022-12-09 |
Evive Biotechnology Shanghai Ltd |
Un dímero de IL-22 para su uso en el tratamiento de enterocolitis necrosante
|
|
CN106539557A
(zh)
*
|
2016-10-08 |
2017-03-29 |
西安交通大学 |
一种基于恒速静脉输入的药代动力学参数的测定方法
|
|
AU2016429272A1
(en)
|
2016-11-14 |
2019-05-02 |
Hangzhou Dac Biotech Co., Ltd. |
Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
|
|
WO2018087345A1
(en)
|
2016-11-14 |
2018-05-17 |
F. Hoffmann-La Roche Ag |
COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON
|
|
EP3570849B1
(en)
|
2017-01-18 |
2024-12-25 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Pharmaceutical compositions for the treatment patients suffering from myeloproliferative disorders
|
|
US10266578B2
(en)
|
2017-02-08 |
2019-04-23 |
Bristol-Myers Squibb Company |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
|
WO2018183671A1
(en)
|
2017-03-29 |
2018-10-04 |
Tdw Group |
Protein conjugates
|
|
WO2019020593A1
(en)
|
2017-07-25 |
2019-01-31 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR MODULATION OF MONOCYTOPOISIS
|
|
RU2678332C1
(ru)
|
2017-09-08 |
2019-01-28 |
Общество с ограниченной ответственностью "Саентифик Фьючер Менеджмент" (ООО "СФМ") |
Пегилированный интерферон лямбда, обладающий высокой биодоступностью при пероральном применении, и способ его получения
|
|
MX2021002575A
(es)
|
2018-09-11 |
2021-06-08 |
Ambrx Inc |
Conjugados de polipeptidos de interleucina-2 y sus usos.
|
|
AU2019361206A1
(en)
|
2018-10-19 |
2021-06-03 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
|
CN119455003A
(zh)
|
2019-02-12 |
2025-02-18 |
Ambrx公司 |
包含抗体-tlr激动剂缀合物的组合物、方法和用途
|
|
AU2020312735A1
(en)
|
2019-07-18 |
2021-12-16 |
Enyo Pharma |
Method for decreasing adverse-effects of interferon
|
|
CA3167336A1
(en)
|
2020-01-13 |
2021-07-22 |
Takeda Pharmaceutical Company Limited |
Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack
|
|
WO2021164744A1
(en)
|
2020-02-19 |
2021-08-26 |
Evive Biotechnology (Shanghai) Ltd |
Methods for treating graft versus host disease
|
|
US20210285000A1
(en)
|
2020-03-05 |
2021-09-16 |
Janssen Pharmaceuticals, Inc. |
Combination therapy for treating hepatitis b virus infection
|
|
WO2021183832A1
(en)
|
2020-03-11 |
2021-09-16 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and methods of use thereof
|
|
WO2021228983A1
(en)
|
2020-05-13 |
2021-11-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
A pharmaceutical composition comprising an arsenic compound, an inductor of type-1 ifn and a protein kinase inhibitor for treating cancer
|
|
EP3912627B1
(en)
|
2020-05-20 |
2022-09-07 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of coronavirus infections
|
|
WO2021263271A1
(en)
|
2020-06-22 |
2021-12-30 |
Janssen Pharmaceuticals, Inc. |
Compositions and methods for treatment of hepatitis d virus infection
|
|
EP3954393A1
(en)
|
2020-08-13 |
2022-02-16 |
Bioasis Technologies Inc. |
Combination therapies for delivery across the blood brain barrier
|
|
AU2021327396A1
(en)
|
2020-08-20 |
2023-03-23 |
Ambrx, Inc. |
Antibody-TLR agonist conjugates, methods and uses thereof
|
|
WO2022043496A2
(en)
|
2020-08-28 |
2022-03-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of mait cells as biomarkers and biotargets in covid-19
|
|
WO2022079205A1
(en)
|
2020-10-15 |
2022-04-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of ifn-alpha polypeptides for the treatment of coronavirus infections
|
|
MX2023011480A
(es)
|
2021-04-03 |
2023-12-06 |
Ambrx Inc |
Conjugados anticuerpo anti-her2-fármaco y usos de estos.
|
|
CN117980327A
(zh)
|
2021-11-03 |
2024-05-03 |
杭州多禧生物科技有限公司 |
抗体的特异性偶联
|
|
WO2026043823A2
(en)
|
2024-08-19 |
2026-02-26 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of preparation and uses thereof
|