BR0108435A - Formulação e uso de entecavir de baixa dose - Google Patents

Formulação e uso de entecavir de baixa dose

Info

Publication number
BR0108435A
BR0108435A BR0108435-6A BRPI0108435A BR0108435A BR 0108435 A BR0108435 A BR 0108435A BR PI0108435 A BRPI0108435 A BR PI0108435A BR 0108435 A BR0108435 A BR 0108435A
Authority
BR
Brazil
Prior art keywords
entecavir
low dose
formulation
treatment
low
Prior art date
Application number
BR0108435-6A
Other languages
English (en)
Inventor
Richard J Colonno
Omar L Sprockerl
Abizer Harianawala
Divyakant Desai
Micael G Fakes
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26881354&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0108435(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR0108435A publication Critical patent/BR0108435A/pt
Publication of BRPI0108435B1 publication Critical patent/BRPI0108435B1/pt
Publication of BRPI0108435B8 publication Critical patent/BRPI0108435B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

"FORMULAçãO E USO DE ENTECAVIR DE BAIXA DOSE" Composições contendo uma baixa dose de entecavir são administradas em uma base diária para tratar infecção e/ou coinfecções pelo vírus da hepatite B. São fornecidas formulações para administração oral de uma baixa dose de entecavir. Outras substâncias farmaceuticamente ativas podem ser incluidas na composição do entecavir, ou podem ser administradas separadamente para o tratamento de infecção pelo vírus da hepatite B ou para o tratamento de pacientes coinfectados.
BR0108435-6 2000-02-29 2001-01-26 formulação e uso de entecavir de baixa dose BRPI0108435B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18567200P 2000-02-29 2000-02-29
US22131300P 2000-07-28 2000-07-28
PCT/US2001/002630 WO2001064221A1 (en) 2000-02-29 2001-01-26 Low dose entecavir formulation and use

Publications (3)

Publication Number Publication Date
BR0108435A true BR0108435A (pt) 2004-06-15
BRPI0108435B1 BRPI0108435B1 (pt) 2019-02-05
BRPI0108435B8 BRPI0108435B8 (pt) 2021-05-25

Family

ID=26881354

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108435-6 BRPI0108435B8 (pt) 2000-02-29 2001-01-26 formulação e uso de entecavir de baixa dose

Country Status (35)

Country Link
US (1) US6627224B2 (pt)
EP (2) EP1642582A1 (pt)
JP (3) JP5140222B2 (pt)
KR (1) KR100757155B1 (pt)
AR (1) AR027965A1 (pt)
AT (1) ATE312613T1 (pt)
AU (1) AU2001229775A1 (pt)
BG (1) BG65815B1 (pt)
BR (1) BRPI0108435B8 (pt)
CA (1) CA2401569C (pt)
CO (1) CO5261593A1 (pt)
CZ (1) CZ303395B6 (pt)
DE (1) DE60115870T3 (pt)
DK (1) DK1267880T4 (pt)
EA (1) EA006181B1 (pt)
EE (1) EE05442B1 (pt)
EG (1) EG24408A (pt)
ES (1) ES2253403T5 (pt)
GE (1) GEP20053504B (pt)
HK (1) HK1048771A1 (pt)
HR (1) HRP20020649A2 (pt)
HU (1) HU230698B1 (pt)
IL (1) IL150447A0 (pt)
MX (1) MXPA02008359A (pt)
MY (1) MY127422A (pt)
NO (1) NO324014B1 (pt)
NZ (1) NZ520024A (pt)
PE (1) PE20020770A1 (pt)
PL (1) PL201411B1 (pt)
RS (1) RS51561B (pt)
SI (1) SI1267880T2 (pt)
SK (1) SK288008B6 (pt)
TW (1) TWI287988B (pt)
UA (1) UA84534C2 (pt)
WO (1) WO2001064221A1 (pt)

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JP6582000B2 (ja) * 2014-06-20 2019-09-25 シーティーシー バイオ インコーポレイテッド エンテカビルを有効成分として含む薬学製剤及びこの製造方法
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Also Published As

Publication number Publication date
ATE312613T1 (de) 2005-12-15
MXPA02008359A (es) 2003-02-12
HU230698B1 (hu) 2017-09-28
SK11652002A3 (sk) 2003-09-11
HUP0500558A2 (hu) 2005-09-28
EP1642582A1 (en) 2006-04-05
MY127422A (en) 2006-11-30
EP1267880B2 (en) 2010-01-20
KR100757155B1 (ko) 2007-09-07
DE60115870T3 (de) 2010-07-29
GEP20053504B (en) 2005-05-10
HUP0500558A3 (en) 2012-08-28
EP1267880A1 (en) 2003-01-02
BRPI0108435B8 (pt) 2021-05-25
NO20024099L (no) 2002-08-28
AR027965A1 (es) 2003-04-16
KR20020082230A (ko) 2002-10-30
JP5921746B2 (ja) 2016-05-24
EP1267880B1 (en) 2005-12-14
NZ520024A (en) 2005-03-24
CA2401569A1 (en) 2001-09-07
BRPI0108435B1 (pt) 2019-02-05
US6627224B2 (en) 2003-09-30
JP2004503467A (ja) 2004-02-05
JP2012255017A (ja) 2012-12-27
DE60115870T2 (de) 2006-08-17
DK1267880T4 (da) 2010-05-17
IL150447A0 (en) 2002-12-01
RS51561B (sr) 2011-08-31
SI1267880T2 (sl) 2010-04-30
PL366102A1 (en) 2005-01-24
EE200200484A (et) 2004-04-15
PL201411B1 (pl) 2009-04-30
NO324014B1 (no) 2007-07-30
CA2401569C (en) 2009-08-18
DK1267880T3 (da) 2006-03-06
AU2001229775A1 (en) 2001-09-12
ES2253403T3 (es) 2006-06-01
US20010033864A1 (en) 2001-10-25
EG24408A (en) 2009-05-20
CZ303395B6 (cs) 2012-08-29
EE05442B1 (et) 2011-08-15
DE60115870D1 (de) 2006-01-19
CO5261593A1 (es) 2003-03-31
EA200200812A1 (ru) 2003-12-25
ES2253403T5 (es) 2010-04-22
PE20020770A1 (es) 2002-09-06
UA84534C2 (uk) 2008-11-10
SI1267880T1 (sl) 2006-06-30
SK288008B6 (sk) 2012-10-02
EA006181B1 (ru) 2005-10-27
NO20024099D0 (no) 2002-08-28
BG106905A (bg) 2003-04-30
JP2015178523A (ja) 2015-10-08
HK1048771A1 (zh) 2003-04-17
BG65815B1 (bg) 2010-01-29
JP5140222B2 (ja) 2013-02-06
WO2001064221A1 (en) 2001-09-07
HRP20020649A2 (en) 2004-12-31
YU63002A (sh) 2005-03-15
TWI287988B (en) 2007-10-11

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