DK1307441T3 - 1,3-dioxolaner med en hostehæmmende virkning - Google Patents

1,3-dioxolaner med en hostehæmmende virkning

Info

Publication number: DK1307441T3
Authority: DK; Denmark
Prior art keywords: dioxolanes; cough; inhibiting effect; preparation; acetals
Prior art date: 2000-07-28

Application number

DK01967203T

Other languages

Danish (da)

English (en)

Inventor

Marcello Allegretti

Maria Candida Cesta

Roberto Curti

Luigi Pellegrini

Gabriella Melillo

Original Assignee

Dompe Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-28

Filing date

2001-07-18

Publication date

2004-08-09

2001-07-18 Application filed by Dompe Spa filed Critical Dompe Spa

2004-08-09 Application granted granted Critical

2004-08-09 Publication of DK1307441T3 publication Critical patent/DK1307441T3/da

Links

125000006091 1,3-dioxolane group Chemical class 0.000 title 1
206010011224 Cough Diseases 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
-1 (S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals Chemical class 0.000 abstract 1
150000001241 acetals Chemical class 0.000 abstract 1
239000003434 antitussive agent Substances 0.000 abstract 1
229940124584 antitussives Drugs 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
PTVWPYVOOKLBCG-ZDUSSCGKSA-N levodropropizine Chemical compound C1CN(C[C@H](O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-ZDUSSCGKSA-N 0.000 abstract 1
229960002265 levodropropizine Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pulmonology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Glass Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK01967203T 2000-07-28 2001-07-18 1,3-dioxolaner med en hostehæmmende virkning DK1307441T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2000MI001734A IT1318650B1 (it)	2000-07-28	2000-07-28	1,3-diossolani ad attivita' antitosse.
PCT/EP2001/008304 WO2002010149A1 (en)	2000-07-28	2001-07-18	1,3-dioxolanes with antitussive activity

Publications (1)

Publication Number	Publication Date
DK1307441T3 true DK1307441T3 (da)	2004-08-09

Family

ID=11445591

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01967203T DK1307441T3 (da)	2000-07-28	2001-07-18	1,3-dioxolaner med en hostehæmmende virkning

Country Status (26)

Country	Link
US (1)	US6835734B2 (cs)
EP (1)	EP1307441B1 (cs)
JP (1)	JP5107497B2 (cs)
KR (1)	KR100781403B1 (cs)
CN (1)	CN1204135C (cs)
AT (1)	ATE266018T1 (cs)
AU (1)	AU2001287638A1 (cs)
BR (1)	BR0112765A (cs)
CZ (1)	CZ301087B6 (cs)
DE (1)	DE60103164T2 (cs)
DK (1)	DK1307441T3 (cs)
EE (1)	EE05178B1 (cs)
ES (1)	ES2219562T3 (cs)
HU (1)	HUP0301497A3 (cs)
IL (2)	IL153515A0 (cs)
IT (1)	IT1318650B1 (cs)
MX (1)	MXPA02012920A (cs)
PL (1)	PL206307B1 (cs)
PT (1)	PT1307441E (cs)
RS (1)	RS50861B (cs)
RU (1)	RU2276149C2 (cs)
SI (1)	SI21040A (cs)
SK (1)	SK286794B6 (cs)
TR (1)	TR200401315T4 (cs)
UA (1)	UA73789C2 (cs)
WO (1)	WO2002010149A1 (cs)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1318651B1 (it) *	2000-07-28	2003-08-27	Dompe Spa	Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.
TWI496776B (zh) *	2007-11-15	2015-08-21	Astrazeneca Ab	製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法
EP2070915A1 (en) *	2007-12-03	2009-06-17	A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A.	New process for the synthesis of moguisteine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4049660A (en) *	1971-06-18	1977-09-20	Delalande S.A.	N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics
IT1203721B (it) *	1983-12-29	1989-02-23	Dompe Farmaceutici Spa	Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
NL8801622A (nl)	1988-06-25	1990-01-16	Stamicarbon	Bereiding van enantiomeren van dropropizine.
IT1226570B (it)	1988-08-01	1991-01-24	Bidachem Spa	Procedimento di preparazione della levo- e destro-dropropizina
DE4041482A1 (de) *	1990-12-22	1992-06-25	Boehringer Ingelheim Kg	Neue pharmazeutische verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine
IT1254452B (it)	1992-02-14	1995-09-25	Dompe Farmaceutici Spa	N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
IT1254993B (it)	1992-06-24	1995-10-11		Procedimento per la preparazione degli enantiomeri della dropropizina
IL111730A (en) *	1993-11-29	1998-12-06	Fujisawa Pharmaceutical Co	Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
IT1318651B1 (it) *	2000-07-28	2003-08-27	Dompe Spa	Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.

2000
- 2000-07-28 IT IT2000MI001734A patent/IT1318650B1/it active
2001
- 2001-07-18 ES ES01967203T patent/ES2219562T3/es not_active Expired - Lifetime
- 2001-07-18 CZ CZ20030268A patent/CZ301087B6/cs not_active IP Right Cessation
- 2001-07-18 JP JP2002515880A patent/JP5107497B2/ja not_active Expired - Fee Related
- 2001-07-18 MX MXPA02012920A patent/MXPA02012920A/es active IP Right Grant
- 2001-07-18 KR KR1020037000945A patent/KR100781403B1/ko not_active Expired - Fee Related
- 2001-07-18 HU HU0301497A patent/HUP0301497A3/hu unknown
- 2001-07-18 AU AU2001287638A patent/AU2001287638A1/en not_active Abandoned
- 2001-07-18 AT AT01967203T patent/ATE266018T1/de active
- 2001-07-18 RU RU2003105691/04A patent/RU2276149C2/ru not_active IP Right Cessation
- 2001-07-18 PT PT01967203T patent/PT1307441E/pt unknown
- 2001-07-18 EP EP01967203A patent/EP1307441B1/en not_active Expired - Lifetime
- 2001-07-18 CN CNB018134564A patent/CN1204135C/zh not_active Expired - Fee Related
- 2001-07-18 IL IL15351501A patent/IL153515A0/xx active IP Right Grant
- 2001-07-18 UA UA2003021767A patent/UA73789C2/uk unknown
- 2001-07-18 TR TR2004/01315T patent/TR200401315T4/xx unknown
- 2001-07-18 US US10/333,979 patent/US6835734B2/en not_active Expired - Fee Related
- 2001-07-18 BR BR0112765-9A patent/BR0112765A/pt not_active Application Discontinuation
- 2001-07-18 SK SK89-2003A patent/SK286794B6/sk not_active IP Right Cessation
- 2001-07-18 SI SI200120036A patent/SI21040A/sl not_active IP Right Cessation
- 2001-07-18 PL PL361172A patent/PL206307B1/pl not_active IP Right Cessation
- 2001-07-18 DK DK01967203T patent/DK1307441T3/da active
- 2001-07-18 WO PCT/EP2001/008304 patent/WO2002010149A1/en not_active Ceased
- 2001-07-18 RS YUP-30/03A patent/RS50861B/sr unknown
- 2001-07-18 DE DE60103164T patent/DE60103164T2/de not_active Expired - Lifetime
- 2001-07-18 EE EEP200300036A patent/EE05178B1/xx not_active IP Right Cessation
2002
- 2002-12-18 IL IL153515A patent/IL153515A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE266018T1 (de)	2004-05-15
BR0112765A (pt)	2004-01-13
JP2004505073A (ja)	2004-02-19
CZ2003268A3 (cs)	2003-06-18
RS50861B (sr)	2010-08-31
MXPA02012920A (es)	2004-04-20
IL153515A0 (en)	2003-07-06
YU3003A (sh)	2006-05-25
EE05178B1 (et)	2009-06-15
IT1318650B1 (it)	2003-08-27
CN1204135C (zh)	2005-06-01
HK1058797A1 (en)	2004-06-04
PT1307441E (pt)	2004-09-30
ITMI20001734A1 (it)	2002-01-28
RU2276149C2 (ru)	2006-05-10
SK286794B6 (sk)	2009-05-07
EP1307441B1 (en)	2004-05-06
HUP0301497A2 (hu)	2003-09-29
EP1307441A1 (en)	2003-05-07
KR20030016425A (ko)	2003-02-26
TR200401315T4 (tr)	2004-07-21
UA73789C2 (en)	2005-09-15
US6835734B2 (en)	2004-12-28
EE200300036A (et)	2004-10-15
ES2219562T3 (es)	2004-12-01
SK892003A3 (en)	2003-09-11
CZ301087B6 (cs)	2009-11-04
WO2002010149A1 (en)	2002-02-07
PL361172A1 (en)	2004-09-20
DE60103164T2 (de)	2005-05-04
SI21040A (sl)	2003-04-30
IL153515A (en)	2006-12-10
KR100781403B1 (ko)	2007-12-03
DE60103164D1 (de)	2004-06-09
CN1444578A (zh)	2003-09-24
AU2001287638A1 (en)	2002-02-13
US20040038989A1 (en)	2004-02-26
PL206307B1 (pl)	2010-07-30
JP5107497B2 (ja)	2012-12-26
ITMI20001734A0 (it)	2000-07-28
HUP0301497A3 (en)	2005-08-29

Publication	Publication Date	Title
PA8514401A1 (es)	2002-02-21	Nuevos derivados de piperazina
DE69015650D1 (de)	1995-02-16	Herstellung von diamantverbundbeschichteten Schneidwerkzeugen.
EA200300429A1 (ru)	2003-10-30	Способ получения порошковых композиций
EA200101156A1 (ru)	2002-06-27	ЛЕКАРСТВЕННЫЕ КОМПОЗИЦИИ НОВОГО ТИПА НА ОСНОВЕ ОБЛАДАЮЩИХ ХОЛИНЕРГИЧЕСКИМ ДЕЙСТВИЕМ СОЕДИНЕНИЙ И β-МИМЕТИКОВ
EA200300527A1 (ru)	2003-08-28	Новые способы лечения синдрома "усталых ног"
DE69709938D1 (de)	2002-02-28	N-benzylpiperidin- und tetrahydropyridin-derivate
DK1129066T3 (da)	2005-03-29	Fremstilling af 2-amino-2-[2-(C2-20alkylphenyl)ethyl]propan-1,3-dioler
NO994822D0 (no)	1999-10-04	Immunotolerant protrombinkomplekspreparat
SE9804002D0 (sv)	1998-11-23	New manufacturing process
AR028743A1 (es)	2003-05-21	DERIVADOS DE N-TRIAZOLILMETIL-PIPERAZINA CON ACCIoN ANTAGONISTA DE RECEPTORES DE NEUROQUININA
EA199901098A1 (ru)	2000-08-28	Новый способ
DK1307441T3 (da)	2004-08-09	1,3-dioxolaner med en hostehæmmende virkning
PL362392A1 (pl)	2004-11-02	Sposób wytwarzania pochodnych taksanu
EA200201003A1 (ru)	2003-02-27	Аморфная модификация торасемида
YU3103A (sh)	2006-05-25	2,2-disupstituisani 1,3-dioksolani kao sredstva protiv kašlja
BR0104738A (pt)	2002-06-25	Beta-hidroxialquilamidas, processo para sua produção e seu uso
EA200100864A1 (ru)	2002-02-28	Способ получения 1,4,7,10-тетраазациклододекана
UY26638A1 (es)	2001-10-25	Nuevos derivados de piperazina
BG106700A (en)	2003-02-28	Sodium 2-(4,6-dimethylpyrimidin-2-yloxy)-3-(2-(3,4-dimethoxyphenyl) ethoxy-3,3-diphenylpropionate and use thereof as endothelin antagonist
DE59002266D1 (de)	1993-09-16	Verwendung von 4-(hydroxydi-phenylmethyl)-1-piperidyl-phenylalkan-derivaten zur herstellung eines antihistaminikums.
EA200100528A1 (ru)	2002-04-25	1,4-диарил-2-фтор-1-бутен-3-ольные производные и их применение для получения 1,4-диарил-2-фтор-1,3-бутадиеновых и 1,4-диарил-2-фтор-2-бутеновых производных
ITMO20020294A1 (it)	2004-04-08	Gruppo fluidodinamico per l'azionamento del percussore