DK1343770T3 - Lithium-komplekser af N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, fremstilling og anvendelse af disse - Google Patents

Lithium-komplekser af N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, fremstilling og anvendelse af disse

Info

Publication number: DK1343770T3
Authority: DK; Denmark
Prior art keywords: triscarboxymethyl; tetraazacyclododecane; dihydroxypropyl; hydroxymethyl; preparation
Prior art date: 2000-12-15

Application number

DK01991788T

Other languages

Danish (da)

English (en)

Inventor

Johannes Platzek

Peter Blaszkiewicz

Orlin Petrov

Holger Hoffmann

Original Assignee

Bayer Schering Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-15

Filing date

2001-12-05

Publication date

2009-08-10

2001-12-05 Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag

2009-08-10 Application granted granted Critical

2009-08-10 Publication of DK1343770T3 publication Critical patent/DK1343770T3/da

Links

JZNZSKXIEDHOBD-UHFFFAOYSA-N 2-[4,10-bis(carboxymethyl)-7-(1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OCC(O)C(CO)N1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 JZNZSKXIEDHOBD-UHFFFAOYSA-N 0.000 title 1
150000002641 lithium Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/02—Lithium compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Epoxy Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK01991788T 2000-12-15 2001-12-05 Lithium-komplekser af N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, fremstilling og anvendelse af disse DK1343770T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10064467A DE10064467C2 (de)	2000-12-15	2000-12-15	Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
PCT/EP2001/014283 WO2002048119A2 (fr)	2000-12-15	2001-12-05	Complexes de lithium du n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, leur fabrication et leur utilisation

Publications (1)

Publication Number	Publication Date
DK1343770T3 true DK1343770T3 (da)	2009-08-10

Family

ID=7668584

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01991788T DK1343770T3 (da)	2000-12-15	2001-12-05	Lithium-komplekser af N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, fremstilling og anvendelse af disse

Country Status (34)

Country	Link
US (1)	US6894151B2 (fr)
EP (1)	EP1343770B1 (fr)
JP (1)	JP4399163B2 (fr)
KR (1)	KR100869627B1 (fr)
CN (1)	CN1229357C (fr)
AR (1)	AR035609A1 (fr)
AT (1)	ATE430737T1 (fr)
AU (2)	AU2002231659B2 (fr)
BG (1)	BG66117B1 (fr)
BR (1)	BR0116219A (fr)
CA (1)	CA2431976C (fr)
CY (1)	CY1109280T1 (fr)
CZ (1)	CZ304573B6 (fr)
DE (2)	DE10064467C2 (fr)
DK (1)	DK1343770T3 (fr)
EC (1)	ECSP034676A (fr)
EE (1)	EE05245B1 (fr)
ES (1)	ES2325982T3 (fr)
HR (1)	HRP20030576B1 (fr)
HU (1)	HU229657B1 (fr)
IL (1)	IL156432A0 (fr)
ME (1)	ME00157B (fr)
MX (1)	MXPA03005240A (fr)
NO (1)	NO324864B1 (fr)
NZ (1)	NZ526478A (fr)
PL (1)	PL204181B1 (fr)
PT (1)	PT1343770E (fr)
RS (1)	RS51862B (fr)
RU (1)	RU2003120513A (fr)
SK (1)	SK287424B6 (fr)
TW (1)	TWI302531B (fr)
UY (1)	UY27056A1 (fr)
WO (1)	WO2002048119A2 (fr)
ZA (1)	ZA200305421B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1635878B1 (fr) *	2003-06-25	2010-12-29	Guerbet	CONJUGUES PEPTIDIQUES POUR IMAGERIE DES Métalloprotéinase matricielle PAR RESONANCE MAGNETIQUE
FR2867473B1 (fr)	2004-03-12	2006-06-23	Guerbet Sa	Compose de porphyrines et utilisation a haut champ en irm
CN1993357B (zh) *	2004-07-02	2011-10-19	伯拉考成像股份公司	用于磁共振成像(mri)的含有具有多羟基化取代基的螯合部分的高弛豫造影剂
CN101400661A (zh)	2006-03-14	2009-04-01	马林克罗特公司	四氮杂大环衍生物的金属络合物
US7777029B2 (en) *	2006-05-02	2010-08-17	San Diego State University (Sdsu) Foundation	Bifunctional chelators for sequestering lanthanides
WO2011054480A1 (fr) *	2009-11-09	2011-05-12	Bayer Schering Pharma Aktiengesellschaft	Préparation de gadobutrol au moyen d'une membrane céramique
DE102009057274B4 (de)	2009-12-02	2011-09-01	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung mittels Trioxobicyclo-octan
DE102009053252B3 (de) *	2009-11-09	2011-09-01	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung mittels keramischer Membran
DE102010013833A1 (de)	2010-03-29	2011-09-29	Bayer Schering Pharma Aktiengesellschaft	Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de)	2010-06-04	2011-12-08	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
EP2699556A1 (fr)	2011-04-21	2014-02-26	Bayer Intellectual Property GmbH	Préparation de gadobutrol de pureté élevée
CN106543094A (zh) *	2016-11-04	2017-03-29	嘉实（湖南）医药科技有限公司	高纯度钆布醇的制备方法
KR101971435B1 (ko) *	2017-08-29	2019-04-24	주식회사 엔지켐생명과학	가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) *	2018-01-19	2019-10-18	주식회사 엔지켐생명과학	가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
CN111039885B (zh) *	2019-12-06	2021-03-05	广州康瑞泰药业有限公司	一种制备高纯度考布曲钙的方法
KR20210112910A (ko) *	2020-03-06	2021-09-15	주식회사 엔지켐생명과학	가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4009119A1 (de) *	1990-03-19	1991-09-26	Schering Ag	1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE19724186C2 (de)	1997-06-02	2002-07-18	Schering Ag	Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe

2000
- 2000-12-15 DE DE10064467A patent/DE10064467C2/de not_active Expired - Lifetime
2001
- 2001-11-07 TW TW090127671A patent/TWI302531B/zh not_active IP Right Cessation
- 2001-12-05 CZ CZ2003-1641A patent/CZ304573B6/cs not_active IP Right Cessation
- 2001-12-05 IL IL15643201A patent/IL156432A0/xx active IP Right Grant
- 2001-12-05 ME MEP-2008-157A patent/ME00157B/fr unknown
- 2001-12-05 BR BRPI0116219-5A patent/BR0116219A/pt not_active IP Right Cessation
- 2001-12-05 CA CA2431976A patent/CA2431976C/fr not_active Expired - Lifetime
- 2001-12-05 EP EP01991788A patent/EP1343770B1/fr not_active Expired - Lifetime
- 2001-12-05 DE DE50114889T patent/DE50114889D1/de not_active Expired - Lifetime
- 2001-12-05 AU AU2002231659A patent/AU2002231659B2/en not_active Expired
- 2001-12-05 MX MXPA03005240A patent/MXPA03005240A/es active IP Right Grant
- 2001-12-05 HU HU0302563A patent/HU229657B1/hu unknown
- 2001-12-05 UY UY27056A patent/UY27056A1/es not_active Application Discontinuation
- 2001-12-05 DK DK01991788T patent/DK1343770T3/da active
- 2001-12-05 JP JP2002549650A patent/JP4399163B2/ja not_active Expired - Lifetime
- 2001-12-05 RS YU48103A patent/RS51862B/sr unknown
- 2001-12-05 AT AT01991788T patent/ATE430737T1/de active
- 2001-12-05 ES ES01991788T patent/ES2325982T3/es not_active Expired - Lifetime
- 2001-12-05 PL PL366141A patent/PL204181B1/pl unknown
- 2001-12-05 KR KR1020037008035A patent/KR100869627B1/ko not_active Expired - Lifetime
- 2001-12-05 HR HR20030576A patent/HRP20030576B1/xx not_active IP Right Cessation
- 2001-12-05 EE EEP200300282A patent/EE05245B1/xx unknown
- 2001-12-05 AU AU3165902A patent/AU3165902A/xx active Pending
- 2001-12-05 PT PT01991788T patent/PT1343770E/pt unknown
- 2001-12-05 SK SK729-2003A patent/SK287424B6/sk not_active IP Right Cessation
- 2001-12-05 NZ NZ526478A patent/NZ526478A/en not_active IP Right Cessation
- 2001-12-05 CN CNB018206808A patent/CN1229357C/zh not_active Expired - Lifetime
- 2001-12-05 RU RU2003120513/04A patent/RU2003120513A/ru not_active Application Discontinuation
- 2001-12-05 WO PCT/EP2001/014283 patent/WO2002048119A2/fr not_active Ceased
- 2001-12-13 US US10/013,840 patent/US6894151B2/en not_active Expired - Lifetime
- 2001-12-14 AR ARP010105797A patent/AR035609A1/es unknown
2003
- 2003-06-04 NO NO20032523A patent/NO324864B1/no not_active IP Right Cessation
- 2003-06-12 BG BG107901A patent/BG66117B1/bg unknown
- 2003-06-26 EC EC2003004676A patent/ECSP034676A/es unknown
- 2003-07-14 ZA ZA200305421A patent/ZA200305421B/en unknown
2009
- 2009-08-06 CY CY20091100837T patent/CY1109280T1/el unknown

Also Published As

Publication number	Publication date
BG107901A (bg)	2004-06-30
NO20032523L (no)	2003-06-04
NZ526478A (en)	2006-04-28
EP1343770A2 (fr)	2003-09-17
JP2004515545A (ja)	2004-05-27
JP4399163B2 (ja)	2010-01-13
CA2431976C (fr)	2010-04-13
RS51862B (sr)	2012-02-29
AU3165902A (en)	2002-06-24
IL156432A0 (en)	2004-01-04
EP1343770B1 (fr)	2009-05-06
CY1109280T1 (el)	2014-07-02
ME00157B (fr)	2010-10-10
KR20030077555A (ko)	2003-10-01
CZ304573B6 (cs)	2014-07-16
CA2431976A1 (fr)	2002-06-20
RU2003120513A (ru)	2004-12-27
DE50114889D1 (de)	2009-06-18
WO2002048119A2 (fr)	2002-06-20
BG66117B1 (bg)	2011-05-31
UY27056A1 (es)	2002-07-31
CN1481371A (zh)	2004-03-10
HUP0302563A2 (hu)	2003-12-29
TWI302531B (en)	2008-11-01
DE10064467A1 (de)	2002-07-11
WO2002048119A3 (fr)	2002-11-07
PL366141A1 (en)	2005-01-24
MXPA03005240A (es)	2003-09-25
HU229657B1 (en)	2014-03-28
HUP0302563A3 (en)	2011-04-28
YU48103A (sh)	2006-05-25
NO20032523D0 (no)	2003-06-04
CZ20031641A3 (cs)	2003-09-17
EE05245B1 (et)	2009-12-15
ZA200305421B (en)	2004-08-27
BR0116219A (pt)	2006-02-21
EE200300282A (et)	2003-10-15
DE10064467C2 (de)	2002-10-31
ES2325982T3 (es)	2009-09-28
PT1343770E (pt)	2009-07-20
MEP15708A (en)	2010-06-10
NO324864B1 (no)	2007-12-17
HRP20030576B1 (en)	2011-09-30
ATE430737T1 (de)	2009-05-15
AU2002231659B2 (en)	2007-07-05
ECSP034676A (es)	2003-08-29
US6894151B2 (en)	2005-05-17
HK1064098A1 (en)	2005-01-21
AR035609A1 (es)	2004-06-16
PL204181B1 (pl)	2009-12-31
CN1229357C (zh)	2005-11-30
KR100869627B1 (ko)	2008-11-21
US20020128472A1 (en)	2002-09-12
HRP20030576A2 (en)	2005-06-30
SK7292003A3 (en)	2003-11-04
SK287424B6 (sk)	2010-09-07

Publication	Publication Date	Title
CY2012009I1 (el)	2015-08-05	Αναστολεις της κυκλοπροπυλ-συντηκωμενης διπεπτυλοπεπτιδασης 4, βασισμενοι σε πυρρολιδινη, και μεθοδοι για την παρασκευη των και την χρηση των
ID29554A (id)	2001-09-06	Celana dalam sekali pakai jenis celana pendek
DK1329456T3 (da)	2006-12-04	Glucopyranosyloxybenzylbenzenderivater og medicinske sammensætninger indeholdende samme
DK1233964T3 (da)	2005-09-19	Ny anvendelse og hidtil ukendte N-azabicycloamidderivater
NO20040469L (no)	2004-04-30	Heterocykliske forbindelser samt fremstilling og anvendelse derav
DK1417175T3 (da)	2013-10-28	Substituerede dihydro-3-halo-1h-pyrazol-5-carboxylater og fremstillingog anvendelse heraf
EP1283707A4 (fr)	2006-01-18	Compositions polymerisables et procedes d'utilisation
DE60043067D1 (de)	2009-11-12	Quadrupol-ionenfalle und zugehöriges verwendungsverfahren
EP1677822A4 (fr)	2009-08-19	4'-thionucleosides et composes d' oligomeres
NO20024742L (no)	2002-11-25	Heterocykliske forbindelser, deres fremstilling og anvendelse
NO20022334L (no)	2002-07-09	Ny sammensetning og anvendelse
NO20030397L (no)	2003-03-24	Amyloid målsökende billeddannende midler og anvendelser av samme
EE200300282A (et)	2003-10-15	N-(1-hüdroksümetüül-2,3-dihüdroksüpropüül)-1,4,7-triskarboksümetüül-1,4,7,10-tetra asatsüklododekaani liitiumikompleksid, nende valmistamine ja kasutamine
EP1423399A4 (fr)	2008-05-07	Chelateurs d'hydroxypyridonate et d'hydroxypyrimidinone
AU2002231659A1 (en)	2002-08-29	Lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, production and use thereof
FR2797298B1 (fr)	2002-10-11	Volume d'echappement
DE60131363D1 (de)	2007-12-27	Blockcopolymer und zusammensetzung daraus
IS6554A (is)	2002-09-19	Ný samsetning af betatálma og kólesteróllækkandi miðli
IS5996A (is)	2001-07-10	Notkun á kólesteról lækkandi miðli
EP1263935A4 (fr)	2004-06-09	Scytonemine et ses procedes d'utilisation
DE50106634D1 (de)	2005-08-04	Filterbeutel
NO20025135D0 (no)	2002-10-25	Antihypertensive midler og anvendelse
NO20032821D0 (no)	2003-06-19	Sea-trosy og beslektede fremgangsmåter
EP1686990A4 (fr)	2009-06-03	Composes de 2-guanidinylimidazolidinedione: procedes de preparation et d'utilisation
FI20001348A0 (fi)	2000-06-06	Kaasukirnu