DK1343770T3 - Lithium-komplekser af N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, fremstilling og anvendelse af disse - Google Patents

Lithium-komplekser af N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, fremstilling og anvendelse af disse

Info

Publication number: DK1343770T3
Authority: DK; Denmark
Prior art keywords: triscarboxymethyl; tetraazacyclododecane; dihydroxypropyl; hydroxymethyl; preparation
Prior art date: 2000-12-15

Application number

DK01991788T

Other languages

Danish (da)

English (en)

Inventor

Johannes Platzek

Peter Blaszkiewicz

Orlin Petrov

Holger Hoffmann

Original Assignee

Bayer Schering Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-15

Filing date

2001-12-05

Publication date

2009-08-10

2001-12-05 Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag

2009-08-10 Application granted granted Critical

2009-08-10 Publication of DK1343770T3 publication Critical patent/DK1343770T3/da

Links

JZNZSKXIEDHOBD-UHFFFAOYSA-N 2-[4,10-bis(carboxymethyl)-7-(1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OCC(O)C(CO)N1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 JZNZSKXIEDHOBD-UHFFFAOYSA-N 0.000 title 1
150000002641 lithium Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/02—Lithium compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK01991788T 2000-12-15 2001-12-05 Lithium-komplekser af N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, fremstilling og anvendelse af disse DK1343770T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10064467A DE10064467C2 (de)	2000-12-15	2000-12-15	Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
PCT/EP2001/014283 WO2002048119A2 (fr)	2000-12-15	2001-12-05	Complexes de lithium du n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, leur fabrication et leur utilisation

Publications (1)

Publication Number	Publication Date
DK1343770T3 true DK1343770T3 (da)	2009-08-10

Family

ID=7668584

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01991788T DK1343770T3 (da)	2000-12-15	2001-12-05	Lithium-komplekser af N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, fremstilling og anvendelse af disse

Country Status (34)

Country	Link
US (1)	US6894151B2 (fr)
EP (1)	EP1343770B1 (fr)
JP (1)	JP4399163B2 (fr)
KR (1)	KR100869627B1 (fr)
CN (1)	CN1229357C (fr)
AR (1)	AR035609A1 (fr)
AT (1)	ATE430737T1 (fr)
AU (2)	AU2002231659B2 (fr)
BG (1)	BG66117B1 (fr)
BR (1)	BR0116219A (fr)
CA (1)	CA2431976C (fr)
CY (1)	CY1109280T1 (fr)
CZ (1)	CZ304573B6 (fr)
DE (2)	DE10064467C2 (fr)
DK (1)	DK1343770T3 (fr)
EC (1)	ECSP034676A (fr)
EE (1)	EE05245B1 (fr)
ES (1)	ES2325982T3 (fr)
HR (1)	HRP20030576B1 (fr)
HU (1)	HU229657B1 (fr)
IL (1)	IL156432A0 (fr)
ME (1)	ME00157B (fr)
MX (1)	MXPA03005240A (fr)
NO (1)	NO324864B1 (fr)
NZ (1)	NZ526478A (fr)
PL (1)	PL204181B1 (fr)
PT (1)	PT1343770E (fr)
RS (1)	RS51862B (fr)
RU (1)	RU2003120513A (fr)
SK (1)	SK287424B6 (fr)
TW (1)	TWI302531B (fr)
UY (1)	UY27056A1 (fr)
WO (1)	WO2002048119A2 (fr)
ZA (1)	ZA200305421B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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JP2007521254A (ja) *	2003-06-25	2007-08-02	ゲルベ	診断画像用化合物
FR2867473B1 (fr)	2004-03-12	2006-06-23	Guerbet Sa	Compose de porphyrines et utilisation a haut champ en irm
JP5106107B2 (ja) *	2004-07-02	2012-12-26	ブラッコ・イメージング・ソシエタ・ペル・アチオニ	ポリヒドロキシル化置換基を有するキレート化部分を含む磁気共鳴画像法（ｍｒｉ）用高緩和能造影剤
CN101400661A (zh)	2006-03-14	2009-04-01	马林克罗特公司	四氮杂大环衍生物的金属络合物
US7777029B2 (en) *	2006-05-02	2010-08-17	San Diego State University (Sdsu) Foundation	Bifunctional chelators for sequestering lanthanides
WO2011054480A1 (fr) *	2009-11-09	2011-05-12	Bayer Schering Pharma Aktiengesellschaft	Préparation de gadobutrol au moyen d'une membrane céramique
DE102009057274B4 (de)	2009-12-02	2011-09-01	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung mittels Trioxobicyclo-octan
DE102009053252B3 (de) *	2009-11-09	2011-09-01	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung mittels keramischer Membran
DE102010013833A1 (de)	2010-03-29	2011-09-29	Bayer Schering Pharma Aktiengesellschaft	Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) *	2010-06-04	2011-12-08	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
US10072027B2 (en) *	2011-04-21	2018-09-11	Bayer Intellectual Property Gmbh	Preparation of high-purity gadobutrol
CN106543094A (zh) *	2016-11-04	2017-03-29	嘉实（湖南）医药科技有限公司	高纯度钆布醇的制备方法
KR101971435B1 (ko) *	2017-08-29	2019-04-24	주식회사 엔지켐생명과학	가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) *	2018-01-19	2019-10-18	주식회사 엔지켐생명과학	가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
CN111039885B (zh) *	2019-12-06	2021-03-05	广州康瑞泰药业有限公司	一种制备高纯度考布曲钙的方法
KR20210112910A (ko) *	2020-03-06	2021-09-15	주식회사 엔지켐생명과학	가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4009119A1 (de) *	1990-03-19	1991-09-26	Schering Ag	1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE19724186C2 (de)	1997-06-02	2002-07-18	Schering Ag	Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe

2000
- 2000-12-15 DE DE10064467A patent/DE10064467C2/de not_active Expired - Lifetime
2001
- 2001-11-07 TW TW090127671A patent/TWI302531B/zh not_active IP Right Cessation
- 2001-12-05 ME MEP-2008-157A patent/ME00157B/fr unknown
- 2001-12-05 CZ CZ2003-1641A patent/CZ304573B6/cs not_active IP Right Cessation
- 2001-12-05 RS YU48103A patent/RS51862B/sr unknown
- 2001-12-05 AT AT01991788T patent/ATE430737T1/de active
- 2001-12-05 NZ NZ526478A patent/NZ526478A/en not_active IP Right Cessation
- 2001-12-05 AU AU2002231659A patent/AU2002231659B2/en not_active Expired
- 2001-12-05 EP EP01991788A patent/EP1343770B1/fr not_active Expired - Lifetime
- 2001-12-05 DK DK01991788T patent/DK1343770T3/da active
- 2001-12-05 WO PCT/EP2001/014283 patent/WO2002048119A2/fr not_active Ceased
- 2001-12-05 BR BRPI0116219-5A patent/BR0116219A/pt not_active IP Right Cessation
- 2001-12-05 EE EEP200300282A patent/EE05245B1/xx unknown
- 2001-12-05 KR KR1020037008035A patent/KR100869627B1/ko not_active Expired - Lifetime
- 2001-12-05 UY UY27056A patent/UY27056A1/es not_active Application Discontinuation
- 2001-12-05 RU RU2003120513/04A patent/RU2003120513A/ru not_active Application Discontinuation
- 2001-12-05 DE DE50114889T patent/DE50114889D1/de not_active Expired - Lifetime
- 2001-12-05 HR HR20030576A patent/HRP20030576B1/xx not_active IP Right Cessation
- 2001-12-05 MX MXPA03005240A patent/MXPA03005240A/es active IP Right Grant
- 2001-12-05 HU HU0302563A patent/HU229657B1/hu unknown
- 2001-12-05 CN CNB018206808A patent/CN1229357C/zh not_active Expired - Lifetime
- 2001-12-05 SK SK729-2003A patent/SK287424B6/sk not_active IP Right Cessation
- 2001-12-05 JP JP2002549650A patent/JP4399163B2/ja not_active Expired - Lifetime
- 2001-12-05 AU AU3165902A patent/AU3165902A/xx active Pending
- 2001-12-05 ES ES01991788T patent/ES2325982T3/es not_active Expired - Lifetime
- 2001-12-05 PL PL366141A patent/PL204181B1/pl unknown
- 2001-12-05 IL IL15643201A patent/IL156432A0/xx active IP Right Grant
- 2001-12-05 PT PT01991788T patent/PT1343770E/pt unknown
- 2001-12-05 CA CA2431976A patent/CA2431976C/fr not_active Expired - Lifetime
- 2001-12-13 US US10/013,840 patent/US6894151B2/en not_active Expired - Lifetime
- 2001-12-14 AR ARP010105797A patent/AR035609A1/es unknown
2003
- 2003-06-04 NO NO20032523A patent/NO324864B1/no not_active IP Right Cessation
- 2003-06-12 BG BG107901A patent/BG66117B1/bg unknown
- 2003-06-26 EC EC2003004676A patent/ECSP034676A/es unknown
- 2003-07-14 ZA ZA200305421A patent/ZA200305421B/en unknown
2009
- 2009-08-06 CY CY20091100837T patent/CY1109280T1/el unknown

Also Published As

Publication number	Publication date
DE10064467C2 (de)	2002-10-31
DE10064467A1 (de)	2002-07-11
HU229657B1 (en)	2014-03-28
NO20032523L (no)	2003-06-04
YU48103A (sh)	2006-05-25
WO2002048119A2 (fr)	2002-06-20
HRP20030576A2 (en)	2005-06-30
WO2002048119A3 (fr)	2002-11-07
AU2002231659B2 (en)	2007-07-05
CN1481371A (zh)	2004-03-10
KR100869627B1 (ko)	2008-11-21
HRP20030576B1 (en)	2011-09-30
JP2004515545A (ja)	2004-05-27
DE50114889D1 (de)	2009-06-18
PT1343770E (pt)	2009-07-20
NZ526478A (en)	2006-04-28
BG66117B1 (bg)	2011-05-31
AR035609A1 (es)	2004-06-16
KR20030077555A (ko)	2003-10-01
ECSP034676A (es)	2003-08-29
CZ20031641A3 (cs)	2003-09-17
NO324864B1 (no)	2007-12-17
ZA200305421B (en)	2004-08-27
CZ304573B6 (cs)	2014-07-16
MXPA03005240A (es)	2003-09-25
IL156432A0 (en)	2004-01-04
SK287424B6 (sk)	2010-09-07
PL366141A1 (en)	2005-01-24
ES2325982T3 (es)	2009-09-28
BG107901A (bg)	2004-06-30
MEP15708A (en)	2010-06-10
EE05245B1 (et)	2009-12-15
ME00157B (fr)	2010-10-10
TWI302531B (en)	2008-11-01
UY27056A1 (es)	2002-07-31
SK7292003A3 (en)	2003-11-04
CA2431976C (fr)	2010-04-13
CY1109280T1 (el)	2014-07-02
EP1343770B1 (fr)	2009-05-06
NO20032523D0 (no)	2003-06-04
EP1343770A2 (fr)	2003-09-17
CN1229357C (zh)	2005-11-30
HUP0302563A2 (hu)	2003-12-29
ATE430737T1 (de)	2009-05-15
JP4399163B2 (ja)	2010-01-13
BR0116219A (pt)	2006-02-21
PL204181B1 (pl)	2009-12-31
US20020128472A1 (en)	2002-09-12
RS51862B (sr)	2012-02-29
RU2003120513A (ru)	2004-12-27
HUP0302563A3 (en)	2011-04-28
US6894151B2 (en)	2005-05-17
AU3165902A (en)	2002-06-24
CA2431976A1 (fr)	2002-06-20
HK1064098A1 (en)	2005-01-21
EE200300282A (et)	2003-10-15

Publication	Publication Date	Title
DK1343770T3 (da)	2009-08-10	Lithium-komplekser af N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, fremstilling og anvendelse af disse
CY2012009I2 (el)	2015-08-05	Αναστολεις της κυκλοπροπυλ-συντηκωμενης διπεπτυλοπεπτιδασης 4, βασισμενοι σε πυρρολιδινη, και μεθοδοι για την παρασκευη των και την χρηση των
ID29554A (id)	2001-09-06	Celana dalam sekali pakai jenis celana pendek
DK1329456T3 (da)	2006-12-04	Glucopyranosyloxybenzylbenzenderivater og medicinske sammensætninger indeholdende samme
DK1233964T3 (da)	2005-09-19	Ny anvendelse og hidtil ukendte N-azabicycloamidderivater
NO20040469L (no)	2004-04-30	Heterocykliske forbindelser samt fremstilling og anvendelse derav
EP1283707A4 (fr)	2006-01-18	Compositions polymerisables et procedes d'utilisation
DE60043067D1 (de)	2009-11-12	Quadrupol-ionenfalle und zugehöriges verwendungsverfahren
DE60031513D1 (de)	2006-12-07	Phenyl- und pyridinyl-derivate verwendbar als neurokinin-1-antagonisten
EP1677822A4 (fr)	2009-08-19	4'-thionucleosides et composes d' oligomeres
FR12C0012I2 (fr)	2012-10-26	Combinaisons d'herbicides et de phytoprotecteurs
ID30590A (id)	2002-01-03	Celana sekali pakai jenis-celana pendek
NO20024742D0 (no)	2002-10-02	Heterocykliske forbindelser, deres fremstilling og anvendelse
NO20022334L (no)	2002-07-09	Ny sammensetning og anvendelse
NO20030397D0 (no)	2003-01-24	Amyloid målsökende billeddannende midler og anvendelser av samme
EP1423399A4 (fr)	2008-05-07	Chelateurs d'hydroxypyridonate et d'hydroxypyrimidinone
NO20025158L (no)	2002-12-06	Lipidpreparat og anvendelse derav
AU2002231659A1 (en)	2002-08-29	Lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, production and use thereof
DE60131363D1 (de)	2007-12-27	Blockcopolymer und zusammensetzung daraus
IS6554A (is)	2002-09-19	Ný samsetning af betatálma og kólesteróllækkandi miðli
EE05084B1 (et)	2008-10-15	N-(heterotskll)benseen- v?i -pridiinsulfoonamiidid kui tromboosi- ja hbimisvastased ained
IS5996A (is)	2001-07-10	Notkun á kólesteról lækkandi miðli
EP1314428A4 (fr)	2006-10-18	Preparations d'oct
NO20025135L (no)	2002-11-27	Antihypertensive midler og anvendelse
NO20032821D0 (no)	2003-06-19	Sea-trosy og beslektede fremgangsmåter