DK1397357T3 - Polymorfe former af 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl) piperazinhydrochlorid - Google Patents

Polymorfe former af 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl) piperazinhydrochlorid

Info

Publication number: DK1397357T3
Authority: DK; Denmark
Prior art keywords: carbamoylbenzofuran; cyanoindol; butyl; polymorphic forms; piperazine hydrochloride
Prior art date: 2001-06-19

Application number

DK02754627T

Other languages

English (en)

Inventor

Andreas Bathe

Steffen Neuenfeld

Heike Kniel

Matthias Bartels

Susanne Rudolph

Bernd Helfert

Henning Boettcher

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-19

Filing date

2002-06-05

Publication date

2009-10-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8177643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1397357(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-06-05 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2009-10-05 Application granted granted Critical

2009-10-05 Publication of DK1397357T3 publication Critical patent/DK1397357T3/da

Links

RPZBRGFNBNQSOP-UHFFFAOYSA-N vilazodone hydrochloride Chemical compound Cl.C1=C(C#N)C=C2C(CCCCN3CCN(CC3)C=3C=C4C=C(OC4=CC=3)C(=O)N)=CNC2=C1 RPZBRGFNBNQSOP-UHFFFAOYSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Gynecology & Obstetrics (AREA)
Rheumatology (AREA)
Pregnancy & Childbirth (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Physical Education & Sports Medicine (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Anesthesiology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Nutrition Science (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)

DK02754627T 2001-06-19 2002-06-05 Polymorfe former af 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl) piperazinhydrochlorid DK1397357T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01113647		2001-06-19
PCT/EP2002/006153 WO2002102794A2 (en)	2001-06-19	2002-06-05	Polymorphic forms of 1-'4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride

Publications (1)

Publication Number	Publication Date
DK1397357T3 true DK1397357T3 (da)	2009-10-05

Family

ID=8177643

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02754627T DK1397357T3 (da)	2001-06-19	2002-06-05	Polymorfe former af 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl) piperazinhydrochlorid

Country Status (29)

Country	Link
US (15)	US7381726B2 (da)
EP (1)	EP1397357B9 (da)
JP (3)	JP4624667B2 (da)
KR (1)	KR20040012922A (da)
CN (2)	CN101139345B (da)
AR (1)	AR034595A1 (da)
AT (1)	ATE437871T1 (da)
AU (1)	AU2002320822B2 (da)
BR (1)	BR0210495A (da)
CA (16)	CA2782615A1 (da)
CY (1)	CY1109447T1 (da)
CZ (2)	CZ304471B6 (da)
DE (1)	DE60233133D1 (da)
DK (1)	DK1397357T3 (da)
EC (1)	ECSP044943A (da)
EE (1)	EE05454B1 (da)
ES (1)	ES2330314T3 (da)
HU (1)	HU229601B1 (da)
IL (2)	IL159426A0 (da)
MX (1)	MXPA03011723A (da)
MY (1)	MY151087A (da)
NZ (1)	NZ530642A (da)
PL (1)	PL208708B1 (da)
PT (1)	PT1397357E (da)
RU (1)	RU2303598C2 (da)
SK (2)	SK288334B6 (da)
UA (1)	UA76758C2 (da)
WO (1)	WO2002102794A2 (da)
ZA (1)	ZA200400329B (da)

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UA76758C2 (uk) *	2001-06-19	2006-09-15	Мерк Патент Гмбх	Поліморфні форми гідрохлориду 1-'4-(5-ціаноіндол-3-іл)бутил-4-(2-карбамоїлбензофуран-5-іл)піперазину
DE10259244A1 (de) *	2002-12-17	2004-07-01	Merck Patent Gmbh	N-(Indolethyl-)cycloamin-Verbindungen
DE10326939A1 (de) *	2003-06-16	2005-01-05	Merck Patent Gmbh	Indol-Derivate
DE10326940A1 (de) *	2003-06-16	2005-01-05	Merck Patent Gmbh	Indol-Derivate
US9708300B2 (en)	2011-03-20	2017-07-18	Cadila Healthcare Limited	Amorphous form of vilazodone hydrochloride and process for its preparation
CN102219783B (zh) *	2011-05-05	2013-07-03	天津市汉康医药生物技术有限公司	盐酸维拉佐酮及其组合物
WO2013078361A1 (en)	2011-11-23	2013-05-30	Assia Chemical Industries Ltd.	Solid state forms of vilazodone and vilazodone hydrochloride
US20140378472A1 (en)	2011-12-12	2014-12-25	Ranbaxy Laboratories Limited	Amorphous vilazodone hydrochloride, a process for its preparation and pharmaceutical compositions thereof
WO2013153492A2 (en)	2012-04-12	2013-10-17	Alembic Pharmaceuticals Limited	Process for the preparation of vilazodone hydrochloride and its amorphous form
EP2838894A1 (en) *	2012-04-16	2015-02-25	Ranbaxy Laboratories Limited	Process for the preparation of crystalline vilazodone hydrochloride
WO2013164794A1 (en)	2012-05-04	2013-11-07	Ranbaxy Laboratories Limited	Crystalline forms of vilazodone hydrochloride
WO2013168126A1 (en) *	2012-05-11	2013-11-14	Dr.Reddys Laboratories Limited	Crystalline forms of vilazodone hydrochloride and vilazodone free base
WO2013175361A1 (en)	2012-05-24	2013-11-28	Ranbaxy Laboratories Limited	Process for the preparation of vilazodone hydrochloride
CN102702180A (zh) *	2012-05-25	2012-10-03	吉林三善恩科技开发有限公司	一种维拉佐酮有机药物共晶及其制备方法
US8835635B2 (en) *	2012-06-05	2014-09-16	Symed Labs Limited	Amorphous form of vilazodone hydrochloride substantially free of crystalline forms
WO2013182946A2 (en)	2012-06-06	2013-12-12	Ranbaxy Laboratories Limited	Process for the preparation of vilazodone hydrochloride
AU2013273868A1 (en)	2012-06-13	2015-02-05	Apotex Inc.	Forms of Vilazodone and processes for the preparation thereof
WO2014028473A1 (en)	2012-08-13	2014-02-20	Assia Chemical Industries Ltd.	New salts of vilazodone and solid state forms thereof
WO2014049609A2 (en) *	2012-09-26	2014-04-03	Cadila Healthcare Limited	Novel salts of vilazodone
WO2014049612A2 (en) *	2012-09-27	2014-04-03	Msn Laboratories Limited	Processes and polymorphs of 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-piperazinyl]-2-benzofuran carboxamide and its salts
WO2014064715A2 (en)	2012-10-22	2014-05-01	Cadila Healthcare Limited	Amorphous form of vilazodone hydrochloride and process for preparing thereof
CN103772367B (zh) *	2012-10-24	2016-05-25	杭州和泽医药科技有限公司	盐酸维拉佐酮v晶型的制备方法及其应用
CN103772368B (zh) *	2012-10-24	2016-08-03	杭州和泽医药科技有限公司	盐酸维拉佐酮iv晶型的制备方法及其应用
WO2014087428A1 (en) *	2012-12-07	2014-06-12	Glenmark Pharmaceuticals Limited; Glenmark Generics Limited	Process for preparation of vilazodone and intermediates thereof
CN102977083A (zh) *	2012-12-17	2013-03-20	南京海纳医药科技有限公司	1-[4-(5-氰基吲哚-3-基)丁基]-4-(2-氨甲酰-苯并呋喃-5-基)-哌嗪盐酸盐的新晶型xⅶ及其制备方法
WO2014178013A1 (en)	2013-04-30	2014-11-06	Ranbaxy Laboratories Limited	Vilazodone impurities, process for their preparation, and their use as reference standards
WO2014199313A1 (en)	2013-06-12	2014-12-18	Lupin Limited	Substantially pure vilazodone hydrochloride and a process thereof
EP2824104A1 (en)	2013-07-12	2015-01-14	Sandoz AG	Process for the preparation of form III of Vilazodone hydrochloride
WO2015019256A1 (en)	2013-08-06	2015-02-12	Ranbaxy Laboratories Limited	Pharmaceutical composition of vilazodone and processes of preparation thereof
WO2015019237A1 (en)	2013-08-06	2015-02-12	Ranbaxy Laboratories Limited	Pharmaceutical composition of vilazodone
WO2015037010A1 (en) *	2013-09-13	2015-03-19	Symed Labs Limited	Preparation of vilazodone hydrochloride crystalline form iv
CN104610238A (zh) *	2013-11-01	2015-05-13	北京英科博雅科技有限公司	一种维拉佐酮盐酸盐iii晶型新的制备方法
ITMI20131839A1 (it) *	2013-11-06	2015-05-07	Dipharma Francis Srl	Co-cristallo di un farmaco antidepressivo
WO2015102019A2 (en) *	2013-12-30	2015-07-09	Msn Laboratories Private Limited	Process for the preparation of polymorphs of 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]-1-piperazinyl]-2-benzofuran carboxamide hydrochloride
CN105017233A (zh) *	2014-04-23	2015-11-04	天津药物研究院	一种盐酸维拉佐酮晶体、其制备方法、药物组合物和用途
CN105820157B (zh) *	2015-01-09	2021-05-25	石药集团中奇制药技术（石家庄）有限公司	一种盐酸维拉佐酮晶型及其制备方法
CN106518854A (zh) *	2016-09-21	2017-03-22	北京万全德众医药生物技术有限公司	一种盐酸维拉佐酮晶型ⅳ的制备方法
TR201702104A2 (tr)	2017-02-13	2018-08-27	Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi	Vi̇lazodon hi̇droklorür farmasöti̇k bi̇leşi̇mleri̇
TR201702103A2 (tr)	2017-02-13	2018-08-27	Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi	Vilazodon hi̇droklorürün tablet formlari
CN107098889A (zh) *	2017-03-17	2017-08-29	北京万全德众医药生物技术有限公司	盐酸维拉佐酮药物晶型ⅲ的制备方法
CN109503560A (zh) *	2017-09-14	2019-03-22	北京万全德众医药生物技术有限公司	盐酸维拉佐酮ⅺ晶型的制备方法
US20210393621A1 (en)	2018-10-26	2021-12-23	The Research Foundation For The State University Of New York	Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia

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US1294526A (en) *	1917-09-21	1919-02-18	Gerhard Nicolaas Vis	Manufacture of sodium carbonate and ammonium sulfate from bisulfate of soda.
DE4333254A1 (de) *	1993-09-30	1995-04-06	Merck Patent Gmbh	Piperidine und Piperazine
US5521241A (en) *	1994-08-30	1996-05-28	W. R. Grace & Co.-Conn.	Styrene copolymer-based plastisol containing glycidyl methacrylate
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UA76758C2 (uk) *	2001-06-19	2006-09-15	Мерк Патент Гмбх	Поліморфні форми гідрохлориду 1-'4-(5-ціаноіндол-3-іл)бутил-4-(2-карбамоїлбензофуран-5-іл)піперазину
US7384020B2 (en) *	2006-06-30	2008-06-10	Amtek System Co., Ltd.	Supporting frame structure

2002
- 2002-05-06 UA UA2004010354A patent/UA76758C2/uk unknown
- 2002-06-05 AU AU2002320822A patent/AU2002320822B2/en not_active Expired
- 2002-06-05 ES ES02754627T patent/ES2330314T3/es not_active Expired - Lifetime
- 2002-06-05 HU HU0400236A patent/HU229601B1/hu unknown
- 2002-06-05 CA CA2782615A patent/CA2782615A1/en not_active Abandoned
- 2002-06-05 CA CA2782761A patent/CA2782761A1/en not_active Abandoned
- 2002-06-05 CA CA2782519A patent/CA2782519A1/en not_active Abandoned
- 2002-06-05 CA CA2782791A patent/CA2782791A1/en not_active Abandoned
- 2002-06-05 CA CA2683040A patent/CA2683040C/en not_active Expired - Fee Related
- 2002-06-05 PT PT02754627T patent/PT1397357E/pt unknown
- 2002-06-05 RU RU2004100824/04A patent/RU2303598C2/ru active
- 2002-06-05 CA CA2782865A patent/CA2782865A1/en not_active Abandoned
- 2002-06-05 AT AT02754627T patent/ATE437871T1/de active
- 2002-06-05 CN CN2007101802298A patent/CN101139345B/zh not_active Expired - Lifetime
- 2002-06-05 SK SK5028-2012A patent/SK288334B6/sk unknown
- 2002-06-05 CN CNB028122267A patent/CN100384841C/zh not_active Expired - Lifetime
- 2002-06-05 JP JP2003506267A patent/JP4624667B2/ja not_active Expired - Lifetime
- 2002-06-05 CA CA2782517A patent/CA2782517A1/en not_active Abandoned
- 2002-06-05 CZ CZ2004-26A patent/CZ304471B6/cs not_active IP Right Cessation
- 2002-06-05 KR KR10-2003-7016261A patent/KR20040012922A/ko not_active Ceased
- 2002-06-05 DE DE60233133T patent/DE60233133D1/de not_active Expired - Lifetime
- 2002-06-05 CA CA2782515A patent/CA2782515A1/en not_active Abandoned
- 2002-06-05 PL PL364576A patent/PL208708B1/pl unknown
- 2002-06-05 CA CA2782623A patent/CA2782623A1/en not_active Abandoned
- 2002-06-05 MX MXPA03011723A patent/MXPA03011723A/es active IP Right Grant
- 2002-06-05 US US10/481,270 patent/US7381726B2/en not_active Expired - Lifetime
- 2002-06-05 CA CA2782868A patent/CA2782868A1/en not_active Abandoned
- 2002-06-05 CA CA2782862A patent/CA2782862A1/en not_active Abandoned
- 2002-06-05 CA CA2782494A patent/CA2782494A1/en not_active Abandoned
- 2002-06-05 EE EEP200400019A patent/EE05454B1/xx unknown
- 2002-06-05 CA CA2782857A patent/CA2782857A1/en not_active Abandoned
- 2002-06-05 CZ CZ2013-141A patent/CZ305220B6/cs not_active IP Right Cessation
- 2002-06-05 EP EP02754627A patent/EP1397357B9/en not_active Expired - Lifetime
- 2002-06-05 CA CA2451028A patent/CA2451028C/en not_active Expired - Fee Related
- 2002-06-05 WO PCT/EP2002/006153 patent/WO2002102794A2/en not_active Ceased
- 2002-06-05 CA CA2782521A patent/CA2782521A1/en not_active Abandoned
- 2002-06-05 CA CA2782628A patent/CA2782628A1/en not_active Abandoned
- 2002-06-05 SK SK16-2004A patent/SK288162B6/sk unknown
- 2002-06-05 IL IL15942602A patent/IL159426A0/xx unknown
- 2002-06-05 NZ NZ530642A patent/NZ530642A/en not_active IP Right Cessation
- 2002-06-05 DK DK02754627T patent/DK1397357T3/da active
- 2002-06-05 BR BR0210495-4A patent/BR0210495A/pt not_active Application Discontinuation
- 2002-06-13 MY MYPI20022214 patent/MY151087A/en unknown
- 2002-06-19 AR ARP020102289A patent/AR034595A1/es not_active Application Discontinuation
2003
- 2003-12-17 IL IL159426A patent/IL159426A/en active IP Right Grant
2004
- 2004-01-15 EC EC2004004943A patent/ECSP044943A/es unknown
- 2004-01-15 ZA ZA2004/00329A patent/ZA200400329B/en unknown
2008
- 2008-04-28 US US12/110,704 patent/US7834020B2/en not_active Expired - Lifetime
2009
- 2009-09-25 US US12/566,835 patent/US7981894B2/en not_active Expired - Fee Related
- 2009-09-30 CY CY20091101023T patent/CY1109447T1/el unknown
2010
- 2010-02-08 JP JP2010025039A patent/JP5714824B2/ja not_active Expired - Lifetime
- 2010-02-08 JP JP2010025038A patent/JP5411734B2/ja not_active Expired - Lifetime
- 2010-11-12 US US12/945,272 patent/US8193195B2/en not_active Expired - Fee Related
- 2010-11-12 US US12/945,260 patent/US20110183994A1/en not_active Abandoned
2011
- 2011-04-12 US US13/085,117 patent/US8318744B2/en not_active Expired - Fee Related
- 2011-05-04 US US13/100,948 patent/US8236804B2/en not_active Expired - Fee Related
- 2011-05-04 US US13/100,911 patent/US20110294824A1/en not_active Abandoned
2012
- 2012-10-23 US US13/658,088 patent/US8927552B2/en not_active Expired - Fee Related
2013
- 2013-09-19 US US14/032,183 patent/US8673921B2/en not_active Expired - Fee Related
2014
- 2014-05-30 US US14/291,931 patent/US8921375B2/en not_active Expired - Fee Related
- 2014-11-21 US US14/549,779 patent/US9624204B2/en not_active Expired - Fee Related
2017
- 2017-03-09 US US15/454,642 patent/US20170182037A1/en not_active Abandoned
2019
- 2019-03-18 US US16/355,982 patent/US20190343831A1/en not_active Abandoned
2020
- 2020-12-01 US US17/108,101 patent/US20210251986A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20110294825A1 (en)	2011-12-01
UA76758C2 (uk)	2006-09-15
HK1066003A1 (zh)	2005-03-11
JP4624667B2 (ja)	2011-02-02
CA2782791A1 (en)	2002-12-27
US20140024658A1 (en)	2014-01-23
US9624204B2 (en)	2017-04-18
CA2782865A1 (en)	2002-12-27
CA2451028C (en)	2012-07-17
CZ305220B6 (cs)	2015-06-17
IL159426A (en)	2011-12-29
EE05454B1 (et)	2011-08-15
JP2004534803A (ja)	2004-11-18
CA2782761A1 (en)	2002-12-27
US20110190317A1 (en)	2011-08-04
CA2782517A1 (en)	2002-12-27
PL208708B1 (pl)	2011-05-31
EE200400019A (et)	2004-04-15
ATE437871T1 (de)	2009-08-15
PL364576A1 (en)	2004-12-13
RU2303598C2 (ru)	2007-07-27
US8318744B2 (en)	2012-11-27
CA2683040A1 (en)	2002-12-27
JP2010132687A (ja)	2010-06-17
EP1397357B1 (en)	2009-07-29
HUP0400236A2 (hu)	2004-06-28
SK288162B6 (sk)	2014-03-04
AR034595A1 (es)	2004-03-03
JP5714824B2 (ja)	2015-05-07
CA2782515A1 (en)	2002-12-27
CA2782628A1 (en)	2002-12-27
US20100016332A1 (en)	2010-01-21
US20150080411A1 (en)	2015-03-19
US20130102616A1 (en)	2013-04-25
CA2782519A1 (en)	2002-12-27
US20170182037A1 (en)	2017-06-29
US8673921B2 (en)	2014-03-18
CY1109447T1 (el)	2014-08-13
US8236804B2 (en)	2012-08-07
JP5411734B2 (ja)	2014-02-12
HU229601B1 (en)	2014-02-28
JP2010132688A (ja)	2010-06-17
SK162004A3 (en)	2004-04-06
EP1397357B9 (en)	2009-11-18
WO2002102794A3 (en)	2003-02-20
CA2782857A1 (en)	2002-12-27
ZA200400329B (en)	2005-06-29
EP1397357A2 (en)	2004-03-17
CZ200426A3 (cs)	2004-04-14
US8193195B2 (en)	2012-06-05
CA2451028A1 (en)	2002-12-27
US20140275115A1 (en)	2014-09-18
ES2330314T3 (es)	2009-12-09
US20110312971A1 (en)	2011-12-22
KR20040012922A (ko)	2004-02-11
BR0210495A (pt)	2004-08-17
US7834020B2 (en)	2010-11-16
CA2782862A1 (en)	2002-12-27
US20190343831A1 (en)	2019-11-14
PT1397357E (pt)	2009-11-03
CA2782521A1 (en)	2002-12-27
US8927552B2 (en)	2015-01-06
US20090023749A1 (en)	2009-01-22
ECSP044943A (es)	2004-02-26
US7981894B2 (en)	2011-07-19
RU2004100824A (ru)	2005-06-20
HUP0400236A3 (en)	2010-06-28
CN101139345B (zh)	2012-07-11
US20110294824A1 (en)	2011-12-01
MXPA03011723A (es)	2004-03-19
WO2002102794A2 (en)	2002-12-27
CA2782623A1 (en)	2002-12-27
CN100384841C (zh)	2008-04-30
US8921375B2 (en)	2014-12-30
US7381726B2 (en)	2008-06-03
CZ304471B6 (cs)	2014-05-21
HK1116165A1 (en)	2008-12-19
CA2782868A1 (en)	2002-12-27
CA2782494A1 (en)	2002-12-27
AU2002320822B2 (en)	2007-11-15
IL159426A0 (en)	2004-06-01
NZ530642A (en)	2006-09-29
CA2683040C (en)	2012-09-25
CN101139345A (zh)	2008-03-12
CA2782615A1 (en)	2002-12-27
US20210251986A1 (en)	2021-08-19
US20040147528A1 (en)	2004-07-29
MY151087A (en)	2014-04-15
SK288334B6 (sk)	2016-02-02
DE60233133D1 (de)	2009-09-10
CN1516699A (zh)	2004-07-28
US20110183994A1 (en)	2011-07-28

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