DK1458364T3 - Farmaceutiske kompositioner omfattende metformin og glibenclamid til behandling af type-II diabetes mellitus - Google Patents

Farmaceutiske kompositioner omfattende metformin og glibenclamid til behandling af type-II diabetes mellitus

Info

Publication number: DK1458364T3
Authority: DK; Denmark
Prior art keywords: glibenclamide; metformin; treatment; type; pharmaceutical compositions
Prior art date: 2001-11-29

Application number

DK02791739T

Other languages

Danish (da)

English (en)

Inventor

Alessandro Tosetti

Mauro Guiducci

Giovanni Viti

Original Assignee

Menarini Int Operations Lu Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-29

Filing date

2002-11-29

Publication date

2008-06-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11442301&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1458364(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-11-29 Application filed by Menarini Int Operations Lu Sa filed Critical Menarini Int Operations Lu Sa

2008-06-23 Application granted granted Critical

2008-06-23 Publication of DK1458364T3 publication Critical patent/DK1458364T3/da

Links

229960004580 glibenclamide Drugs 0.000 title 1
ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 title 1
XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title 1
229960003105 metformin Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
208000001072 type 2 diabetes mellitus Diseases 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK02791739T 2001-11-29 2002-11-29 Farmaceutiske kompositioner omfattende metformin og glibenclamid til behandling af type-II diabetes mellitus DK1458364T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001FI000230A ITFI20010230A1 (it)	2001-11-29	2001-11-29	Composizioni farmaceutiche per il trattamento del diabete mellito di tipo ii
PCT/EP2002/013497 WO2003045355A1 (fr)	2001-11-29	2002-11-29	Compositions pharmaceutiques comprenant le glibenclamide et la metformine destinees au traitement du diabete sucre de type ii

Publications (1)

Publication Number	Publication Date
DK1458364T3 true DK1458364T3 (da)	2008-06-23

Family

ID=11442301

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02791739T DK1458364T3 (da)	2001-11-29	2002-11-29	Farmaceutiske kompositioner omfattende metformin og glibenclamid til behandling af type-II diabetes mellitus

Country Status (39)

Country	Link
US (1)	US20050053661A1 (fr)
EP (1)	EP1458364B1 (fr)
JP (1)	JP4474162B2 (fr)
KR (1)	KR20040079898A (fr)
CN (1)	CN1596103B (fr)
AR (1)	AR037407A1 (fr)
AT (1)	ATE387190T1 (fr)
AU (1)	AU2002358061B2 (fr)
BR (1)	BR0214403A (fr)
CA (1)	CA2466677A1 (fr)
CO (1)	CO5590906A2 (fr)
CY (1)	CY1107966T1 (fr)
DE (1)	DE60225331T2 (fr)
DK (1)	DK1458364T3 (fr)
EA (1)	EA006766B1 (fr)
EG (1)	EG24124A (fr)
ES (1)	ES2302862T3 (fr)
HN (1)	HN2002000341A (fr)
HR (1)	HRP20040501A2 (fr)
HU (1)	HUP0402154A3 (fr)
IL (1)	IL162143A0 (fr)
IT (1)	ITFI20010230A1 (fr)
MA (1)	MA27087A1 (fr)
MX (1)	MXPA04004974A (fr)
MY (1)	MY141243A (fr)
NO (1)	NO20042713L (fr)
NZ (1)	NZ533779A (fr)
PA (1)	PA8559801A1 (fr)
PE (1)	PE20030580A1 (fr)
PL (1)	PL206016B1 (fr)
PT (1)	PT1458364E (fr)
RS (1)	RS50937B (fr)
SI (1)	SI1458364T1 (fr)
SV (1)	SV2004001415A (fr)
TN (1)	TNSN04095A1 (fr)
UA (1)	UA81615C2 (fr)
UY (1)	UY27549A1 (fr)
WO (1)	WO2003045355A1 (fr)
ZA (1)	ZA200404880B (fr)

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ATE508738T1 (de) *	2001-01-12	2011-05-15	Sun Pharma Advanced Res Co Ltd	System zur beabstandeten abgabe von arzneimitteln
WO2003105809A1 (fr)	2002-06-17	2003-12-24	Themis Laboratories Private Limited	Comprimes multicouche contenant des thiazolidinediones et des biguanides et procedes de production desdits comprimes
US9060941B2 (en)	2002-09-20	2015-06-23	Actavis, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7785627B2 (en)	2002-09-20	2010-08-31	Watson Pharmaceuticals, Inc.	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
EP1617832B1 (fr)	2003-04-29	2008-03-12	Orexigen Therapeutics, Inc.	Compositions influant sur la perte de poids
PE20061245A1 (es) *	2005-03-30	2007-01-06	Generex Pharm Inc	Composiciones para la transmision transmucosa oral de la metformina
TWI471145B (zh) *	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型
DK2089005T3 (da) *	2006-11-09	2010-07-19	Orexigen Therapeutics Inc	Lagdelte farmaceutiske formuleringer omfattende et hurtigt opløsende mellemlag
ITMI20062254A1 (it) *	2006-11-24	2008-05-25	Acraf	Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
WO2009158114A1 (fr)	2008-05-30	2009-12-30	Orexigen Therapeutics, Inc.	Procédés pour traiter des pathologies des graisses viscérales
CA2638240C (fr)	2008-08-29	2010-02-02	Alexander Macgregor	Methode de traitement des anomalies de la glycemie et des variations de la glycemie
RU2398572C1 (ru) *	2009-05-18	2010-09-10	Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию"	Способ лечения больных сахарным диабетом 2 типа
MX344303B (es)	2010-01-11	2016-12-13	Orexigen Therapeutics Inc	Metodos para proveer terapia de perdida de peso en pacientes con depresion mayor.
RU2483717C2 (ru) *	2010-11-22	2013-06-10	Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН")	Фармацевтическая композиция для лечения диабета (варианты)
US9572784B2 (en)	2011-01-07	2017-02-21	Elcelyx Therapeutics, Inc.	Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
US11759441B2 (en)	2011-01-07	2023-09-19	Anji Pharmaceuticals Inc.	Biguanide compositions and methods of treating metabolic disorders
US9211263B2 (en)	2012-01-06	2015-12-15	Elcelyx Therapeutics, Inc.	Compositions and methods of treating metabolic disorders
US8796338B2 (en)	2011-01-07	2014-08-05	Elcelyx Therapeutics, Inc	Biguanide compositions and methods of treating metabolic disorders
US9480663B2 (en)	2011-01-07	2016-11-01	Elcelyx Therapeutics, Inc.	Biguanide compositions and methods of treating metabolic disorders
HUE051738T2 (hu)	2011-01-07	2021-03-29	Anji Pharma Us Llc	Kemoszenzoros receptorligandum-alapú terápiák
US11974971B2 (en)	2011-01-07	2024-05-07	Anji Pharmaceuticals Inc.	Compositions and methods for treating metabolic disorders
EA033067B1 (ru)	2012-01-06	2019-08-30	Элселикс Терапьютикс, Инк.	Способ лечения метаболических расстройств у пациента, имеющего противопоказание к назначению бигуанидного соединения
KR20200137035A (ko)	2012-01-06	2020-12-08	앤지 파마 유에스 엘엘씨	바이구아나이드 조성물 및 대사 장애를 치료하는 방법
CN110893181A (zh)	2012-06-06	2020-03-20	纳丙药业有限责任公司	治疗超重和肥胖症的方法
BR112017009521A2 (pt)	2014-11-11	2017-12-19	Shionogi & Co	comprimido de múltiplas camadas que contém um fármaco instável à luz
KR101750690B1 (ko) *	2015-10-28	2017-06-27	주식회사 종근당	메트포르민 및 로베글리타존을 포함하는 약제학적 조성물
CN105596339A (zh) *	2015-12-23	2016-05-25	青岛海之源智能技术有限公司	一种二甲双胍阿昔莫司复方组合物及制备方法
SG11202011883RA (en)	2018-05-31	2020-12-30	Hua Medicine Shanghai Ltd	Pharmaceutical combination, composition, and combination formulation containing glucokinase activator and ppar receptor activator, and preparation methods and uses thereof
CN110128305A (zh) *	2019-05-10	2019-08-16	天津大学	二甲双胍-甲苯磺丁脲新盐型、其制备方法及医药用途
JP2021120357A (ja) *	2020-01-30	2021-08-19	サンノーバ株式会社	錠剤
GB2599950A (en) *	2020-10-16	2022-04-20	Zentiva Ks	Pharmaceutical compositions with low amounts of nitrosamine impurities and methods for producing the same
CN113143940A (zh) *	2020-12-30	2021-07-23	成都恒瑞制药有限公司	一种抗糖尿病药物组合物的制备方法

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DE2347531A1 (de) *	1973-09-21	1975-04-30	Hoechst Ag	Arzneizubereitungen zur oralen diabetes-behandlung
IT1276130B1 (it) *	1995-11-14	1997-10-27	Gentili Ist Spa	Associazione glibenclamide-metformina, composizioni farmaceutiche che la contengono e loro uso nel trattamento del diabete mellito di tipo
EP1063973B1 (fr) *	1998-03-19	2016-11-16	Bristol-Myers Squibb Company	Systeme d'apport a liberation lente biphasique destine a des medicaments a solubilite elevee et procede associe
ATE250418T1 (de) *	1998-07-15	2003-10-15	Merck Sante Sas	Tabletten enthaltend eine kombination von glibenclamid und metformin
US6780432B1 (en) *	2000-05-01	2004-08-24	Aeropharm Technology, Inc.	Core formulation
ATE508738T1 (de) *	2001-01-12	2011-05-15	Sun Pharma Advanced Res Co Ltd	System zur beabstandeten abgabe von arzneimitteln

2001
- 2001-11-29 IT IT2001FI000230A patent/ITFI20010230A1/it unknown
2002
- 2002-11-22 AR ARP020104498A patent/AR037407A1/es unknown
- 2002-11-25 MY MYPI20024393A patent/MY141243A/en unknown
- 2002-11-26 PE PE2002001140A patent/PE20030580A1/es not_active Application Discontinuation
- 2002-11-26 UY UY27549A patent/UY27549A1/es not_active Application Discontinuation
- 2002-11-27 EG EG2002111281A patent/EG24124A/xx active
- 2002-11-28 SV SV2002001415A patent/SV2004001415A/es not_active Application Discontinuation
- 2002-11-29 PT PT02791739T patent/PT1458364E/pt unknown
- 2002-11-29 SI SI200230693T patent/SI1458364T1/sl unknown
- 2002-11-29 PA PA20028559801A patent/PA8559801A1/es unknown
- 2002-11-29 CA CA002466677A patent/CA2466677A1/fr not_active Abandoned
- 2002-11-29 WO PCT/EP2002/013497 patent/WO2003045355A1/fr not_active Ceased
- 2002-11-29 BR BR0214403-4A patent/BR0214403A/pt not_active IP Right Cessation
- 2002-11-29 AT AT02791739T patent/ATE387190T1/de not_active IP Right Cessation
- 2002-11-29 CN CN028236920A patent/CN1596103B/zh not_active Expired - Fee Related
- 2002-11-29 ES ES02791739T patent/ES2302862T3/es not_active Expired - Lifetime
- 2002-11-29 HU HU0402154A patent/HUP0402154A3/hu unknown
- 2002-11-29 HR HRP20040501 patent/HRP20040501A2/hr not_active Application Discontinuation
- 2002-11-29 IL IL16214302A patent/IL162143A0/xx not_active IP Right Cessation
- 2002-11-29 EA EA200400664A patent/EA006766B1/ru not_active IP Right Cessation
- 2002-11-29 DE DE60225331T patent/DE60225331T2/de not_active Expired - Lifetime
- 2002-11-29 JP JP2003546858A patent/JP4474162B2/ja not_active Expired - Lifetime
- 2002-11-29 PL PL369851A patent/PL206016B1/pl not_active IP Right Cessation
- 2002-11-29 DK DK02791739T patent/DK1458364T3/da active
- 2002-11-29 MX MXPA04004974A patent/MXPA04004974A/es active IP Right Grant
- 2002-11-29 AU AU2002358061A patent/AU2002358061B2/en not_active Ceased
- 2002-11-29 KR KR10-2004-7006874A patent/KR20040079898A/ko not_active Ceased
- 2002-11-29 NZ NZ533779A patent/NZ533779A/en not_active IP Right Cessation
- 2002-11-29 EP EP02791739A patent/EP1458364B1/fr not_active Expired - Lifetime
- 2002-11-29 US US10/497,022 patent/US20050053661A1/en not_active Abandoned
- 2002-11-29 HN HN2002000341A patent/HN2002000341A/es unknown
- 2002-11-29 UA UA20040504085A patent/UA81615C2/ru unknown
2004
- 2004-05-24 MA MA27696A patent/MA27087A1/fr unknown
- 2004-05-28 TN TNP2004000095A patent/TNSN04095A1/en unknown
- 2004-05-28 RS YUP-473/04A patent/RS50937B/sr unknown
- 2004-06-21 ZA ZA200404880A patent/ZA200404880B/en unknown
- 2004-06-28 NO NO20042713A patent/NO20042713L/no not_active Application Discontinuation
- 2004-06-29 CO CO04061363A patent/CO5590906A2/es not_active Application Discontinuation
2008
- 2008-05-26 CY CY20081100543T patent/CY1107966T1/el unknown

Also Published As

Publication number	Publication date
EP1458364B1 (fr)	2008-02-27
UY27549A1 (es)	2003-06-30
SV2004001415A (es)	2004-05-07
NO20042713L (no)	2004-07-16
DE60225331D1 (de)	2008-04-10
CO5590906A2 (es)	2005-12-30
MY141243A (en)	2010-03-31
IL162143A0 (en)	2005-11-20
EP1458364A1 (fr)	2004-09-22
EA200400664A1 (ru)	2004-10-28
ITFI20010230A1 (it)	2003-05-29
RS50937B (sr)	2010-08-31
HN2002000341A (es)	2009-12-07
RS47304A (sr)	2006-10-27
NZ533779A (en)	2007-02-23
AR037407A1 (es)	2004-11-10
HRP20040501A2 (en)	2004-12-31
PE20030580A1 (es)	2003-09-05
UA81615C2 (ru)	2008-01-25
ZA200404880B (en)	2005-07-29
JP4474162B2 (ja)	2010-06-02
HUP0402154A3 (en)	2008-04-28
AU2002358061B2 (en)	2007-01-11
PT1458364E (pt)	2008-05-26
KR20040079898A (ko)	2004-09-16
US20050053661A1 (en)	2005-03-10
AU2002358061A1 (en)	2003-06-10
ATE387190T1 (de)	2008-03-15
HK1069974A1 (en)	2005-06-10
MXPA04004974A (es)	2004-08-11
TNSN04095A1 (en)	2006-06-01
DE60225331T2 (de)	2009-02-26
BR0214403A (pt)	2004-10-19
PL206016B1 (pl)	2010-06-30
PL369851A1 (en)	2005-05-02
MA27087A1 (fr)	2004-12-20
ES2302862T3 (es)	2008-08-01
WO2003045355A1 (fr)	2003-06-05
CN1596103A (zh)	2005-03-16
EA006766B1 (ru)	2006-04-28
CA2466677A1 (fr)	2003-06-05
JP2005518360A (ja)	2005-06-23
CN1596103B (zh)	2010-06-16
CY1107966T1 (el)	2013-09-04
HUP0402154A2 (hu)	2005-02-28
SI1458364T1 (sl)	2008-08-31
EG24124A (en)	2008-07-07
PA8559801A1 (es)	2003-06-30

Publication	Publication Date	Title
DK1458364T3 (da)	2008-06-23	Farmaceutiske kompositioner omfattende metformin og glibenclamid til behandling af type-II diabetes mellitus
NO20035298D0 (no)	2003-11-28	CDK-inhiberende pyrimider, deres fremstilling og deres anvendelse som legemidler
NO20024175L (no)	2002-10-29	Azetidinderivater, deres fremstilling og farmasöytiske preparater inneholdende forbindelsene
DK1412357T3 (da)	2006-07-17	Beta-aminotetrahydroimidazo-(1,2-a)-pyraziner og tetrahydrotriazolo-(4,3-a)-pyraziner som dipeptidylpeptidaseinhibitorer til behandling eller forebyggelse af diabetes
NO20033566L (no)	2003-10-13	Acylerte 6,7,8,9-tetrehydro-5H-benzocykloheptenyl-aminer og deres anvendelse som farmasöytiske midler
DK1309324T3 (da)	2006-06-12	Antikonvulsive derivater egnede til behandling og forebyggelse af udvikling af type II diabetes mellitus og syndrom X
DK1183020T3 (da)	2006-11-27	(3-trihalogenmethylphenoxy)(4-halogenphenyl) til behandling af insulinresistens og type 2-diabetes
DK1380209T3 (da)	2012-09-24	Sammensætning til et middel til bekæmpelse af skadelige organismer og fremgangsmåde til anvendelse af samme
NO20033726D0 (no)	2003-08-21	Xantin-derivater, fremstilling og anvendelse derav som et medikament
HUP0401665A3 (en)	2008-05-28	Alfa and beta-form crystal of an aminothiazolyl acetanilide derivative, their use and pharmaceutical compositions containing them
DK1572707T3 (da)	2006-08-14	Hidtil ukendte aromatiske fluorglycosidderivater, lægemidler indeholdende disse forbindelser og anvendelse heraf
ATE303802T1 (de)	2005-09-15	3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phen l enthaltendes arzneimittel mit verzögerter wirkstofffreisetzung
DK1484970T3 (da)	2013-10-07	Benzamider og sammensætninger omfattende benzamider til anvendelse som fungicider
DK1423376T3 (da)	2010-06-28	Bicyklisk forbindelse, fremstilling og anvendelse deraf
BRPI0312649A2 (pt)	2017-05-16	compostos, composições farmacêuticas contendo os mesmos, e processos de uso para os mesmos.
ATE296302T1 (de)	2005-06-15	4-(1,3,4-thiadiazolyl-2-yl)-1,4-diazabizyklo- 3.2.2 nonanderivate, ihre herstellung und ihre therapeutische verwendung
NO20042635L (no)	2004-06-23	5-Sulfanyl-ñH-1,2,4-triazol-derivater og deres anvendelse som medisin
NO20006138L (no)	2001-02-01	Substituerte indolinoner, fremstilling og anvendelse derav som medikamenter
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