ZA200404880B - Pharmaceutical compositions comprising metformine and glibenclamide for the treatment of type-II diabetes mellitus. - Google Patents

Pharmaceutical compositions comprising metformine and glibenclamide for the treatment of type-II diabetes mellitus. Download PDF

Info

Publication number: ZA200404880B
Authority: ZA; South Africa
Prior art keywords: glibenclamide; metformin; layer; pharmaceutical formulations; formulations according
Prior art date: 2001-11-29

Application number

ZA200404880A

Other languages

English (en)

Inventor

Alessandro Tosetti

Mauro Guiducci

Giovanni Viti

Original Assignee

Menarini Int Operations Lu Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-29

Filing date

2004-06-21

Publication date

2005-07-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11442301&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200404880(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-06-21 Application filed by Menarini Int Operations Lu Sa filed Critical Menarini Int Operations Lu Sa

2005-07-29 Publication of ZA200404880B publication Critical patent/ZA200404880B/en

Links

ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 title claims description 160
229960004580 glibenclamide Drugs 0.000 title claims description 157
XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title claims description 135
239000008194 pharmaceutical composition Substances 0.000 title claims description 28
238000011282 treatment Methods 0.000 title claims description 10
208000001072 type 2 diabetes mellitus Diseases 0.000 title description 5
229960003105 metformin Drugs 0.000 claims description 121
239000003826 tablet Substances 0.000 claims description 98
239000000203 mixture Substances 0.000 claims description 74
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 57
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 49
UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 34
238000002360 preparation method Methods 0.000 claims description 33
239000007942 layered tablet Substances 0.000 claims description 30
239000008119 colloidal silica Substances 0.000 claims description 29
239000004480 active ingredient Substances 0.000 claims description 27
239000000546 pharmaceutical excipient Substances 0.000 claims description 26
235000019359 magnesium stearate Nutrition 0.000 claims description 25
239000011734 sodium Substances 0.000 claims description 21
239000011777 magnesium Substances 0.000 claims description 20
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 20
TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims description 19
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 17
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 17
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 17
WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims description 14
239000004407 iron oxides and hydroxides Substances 0.000 claims description 14
JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 14
229960001021 lactose monohydrate Drugs 0.000 claims description 14
239000000377 silicon dioxide Substances 0.000 claims description 14
238000009472 formulation Methods 0.000 claims description 13
229910002012 Aerosil® Inorganic materials 0.000 claims description 12
229920000168 Microcrystalline cellulose Polymers 0.000 claims description 12
229940016286 microcrystalline cellulose Drugs 0.000 claims description 12
235000019813 microcrystalline cellulose Nutrition 0.000 claims description 12
239000008108 microcrystalline cellulose Substances 0.000 claims description 12
239000004094 surface-active agent Substances 0.000 claims description 12
239000002270 dispersing agent Substances 0.000 claims description 11
MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical class CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims description 11
229920002785 Croscarmellose sodium Polymers 0.000 claims description 9
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 9
239000004141 Sodium laurylsulphate Substances 0.000 claims description 9
VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims description 9
229960005168 croscarmellose Drugs 0.000 claims description 9
239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims description 9
235000019333 sodium laurylsulphate Nutrition 0.000 claims description 9
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 8
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 8
206010012601 diabetes mellitus Diseases 0.000 claims description 8
229960001375 lactose Drugs 0.000 claims description 8
239000008101 lactose Substances 0.000 claims description 8
150000003839 salts Chemical class 0.000 claims description 8
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 7
239000000244 polyoxyethylene sorbitan monooleate Chemical class 0.000 claims description 7
229940068968 polysorbate 80 Drugs 0.000 claims description 7
229920000053 polysorbate 80 Chemical class 0.000 claims description 7
239000000454 talc Substances 0.000 claims description 7
229910052623 talc Inorganic materials 0.000 claims description 7
FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims description 6
229920002472 Starch Polymers 0.000 claims description 5
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 5
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 5
239000008107 starch Substances 0.000 claims description 5
235000019698 starch Nutrition 0.000 claims description 5
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 4
239000001828 Gelatine Substances 0.000 claims description 4
235000010980 cellulose Nutrition 0.000 claims description 4
229920002678 cellulose Polymers 0.000 claims description 4
239000001913 cellulose Substances 0.000 claims description 4
229920000159 gelatin Polymers 0.000 claims description 4
235000019322 gelatine Nutrition 0.000 claims description 4
235000011187 glycerol Nutrition 0.000 claims description 4
229960003511 macrogol Drugs 0.000 claims description 4
239000011248 coating agent Substances 0.000 claims description 2
238000000576 coating method Methods 0.000 claims description 2
150000004682 monohydrates Chemical class 0.000 claims description 2
229920001223 polyethylene glycol Polymers 0.000 claims description 2
229910021653 sulphate ion Inorganic materials 0.000 claims description 2
229910002016 Aerosil® 200 Inorganic materials 0.000 claims 4
229920003084 Avicel® PH-102 Polymers 0.000 claims 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
241000206607 Porphyra umbilicalis Species 0.000 claims 2
229910052708 sodium Inorganic materials 0.000 claims 2
BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims 1
238000004090 dissolution Methods 0.000 description 23
238000000034 method Methods 0.000 description 12
239000003814 drug Substances 0.000 description 11
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Substances N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 11
229940079593 drug Drugs 0.000 description 10
OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 description 10
239000000243 solution Substances 0.000 description 10
239000008187 granular material Substances 0.000 description 9
238000002474 experimental method Methods 0.000 description 8
229920002261 Corn starch Polymers 0.000 description 7
239000008120 corn starch Substances 0.000 description 7
238000005469 granulation Methods 0.000 description 7
230000003179 granulation Effects 0.000 description 7
238000002156 mixing Methods 0.000 description 7
229940123208 Biguanide Drugs 0.000 description 6
150000004283 biguanides Chemical class 0.000 description 6
238000007906 compression Methods 0.000 description 6
230000006835 compression Effects 0.000 description 6
229940125396 insulin Drugs 0.000 description 6
238000004519 manufacturing process Methods 0.000 description 6
102000004877 Insulin Human genes 0.000 description 5
108090001061 Insulin Proteins 0.000 description 5
210000004027 cell Anatomy 0.000 description 5
230000000694 effects Effects 0.000 description 5
229960004329 metformin hydrochloride Drugs 0.000 description 5
230000009467 reduction Effects 0.000 description 5
238000010521 absorption reaction Methods 0.000 description 4
238000004040 coloring Methods 0.000 description 4
DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 4
239000000126 substance Substances 0.000 description 4
229920000623 Cellulose acetate phthalate Polymers 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
229940081734 cellulose acetate phthalate Drugs 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
238000007922 dissolution test Methods 0.000 description 3
238000001035 drying Methods 0.000 description 3
230000003628 erosive effect Effects 0.000 description 3
229940095884 glucophage Drugs 0.000 description 3
239000008103 glucose Substances 0.000 description 3
HCEQQASHRRPQFE-UHFFFAOYSA-N 5-chloro-n-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide;3-(diaminomethylidene)-1,1-dimethylguanidine;hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N.COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 HCEQQASHRRPQFE-UHFFFAOYSA-N 0.000 description 2
206010022489 Insulin Resistance Diseases 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
239000000654 additive Substances 0.000 description 2
238000011260 co-administration Methods 0.000 description 2
229940109239 creatinine Drugs 0.000 description 2
230000007812 deficiency Effects 0.000 description 2
238000009509 drug development Methods 0.000 description 2
229940112611 glucovance Drugs 0.000 description 2
230000002440 hepatic effect Effects 0.000 description 2
239000000314 lubricant Substances 0.000 description 2
239000011812 mixed powder Substances 0.000 description 2
229940127017 oral antidiabetic Drugs 0.000 description 2
210000000496 pancreas Anatomy 0.000 description 2
230000002093 peripheral effect Effects 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000007787 solid Substances 0.000 description 2
238000012360 testing method Methods 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
LLJFMFZYVVLQKT-UHFFFAOYSA-N 1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-2-isoquinolinyl)ethyl]phenyl]sulfonylurea Chemical compound C=1C(OC)=CC=C(C(C2=O)(C)C)C=1C(=O)N2CCC(C=C1)=CC=C1S(=O)(=O)NC(=O)NC1CCCCC1 LLJFMFZYVVLQKT-UHFFFAOYSA-N 0.000 description 1
RKWGIWYCVPQPMF-UHFFFAOYSA-N Chloropropamide Chemical compound CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1 RKWGIWYCVPQPMF-UHFFFAOYSA-N 0.000 description 1
101100533387 Homo sapiens SCGB1D1 gene Proteins 0.000 description 1
102100028659 Secretoglobin family 1D member 1 Human genes 0.000 description 1
JLRGJRBPOGGCBT-UHFFFAOYSA-N Tolbutamide Chemical compound CCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1 JLRGJRBPOGGCBT-UHFFFAOYSA-N 0.000 description 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
230000009471 action Effects 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
229940127003 anti-diabetic drug Drugs 0.000 description 1
239000003472 antidiabetic agent Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 1
230000008859 change Effects 0.000 description 1
229960001761 chlorpropamide Drugs 0.000 description 1
238000002648 combination therapy Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000010586 diagram Methods 0.000 description 1
230000037213 diet Effects 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000003292 diminished effect Effects 0.000 description 1
238000010494 dissociation reaction Methods 0.000 description 1
230000005593 dissociations Effects 0.000 description 1
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000029142 excretion Effects 0.000 description 1
230000006870 function Effects 0.000 description 1
229960001381 glipizide Drugs 0.000 description 1
ZJJXGWJIGJFDTL-UHFFFAOYSA-N glipizide Chemical compound C1=NC(C)=CN=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZJJXGWJIGJFDTL-UHFFFAOYSA-N 0.000 description 1
229960003468 gliquidone Drugs 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
201000001421 hyperglycemia Diseases 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000011221 initial treatment Methods 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
230000003907 kidney function Effects 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
230000007774 longterm Effects 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
208000030159 metabolic disease Diseases 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
239000003538 oral antidiabetic agent Substances 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
238000010422 painting Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000003285 pharmacodynamic effect Effects 0.000 description 1
ICFJFFQQTFMIBG-UHFFFAOYSA-N phenformin Chemical compound NC(=N)NC(=N)NCCC1=CC=CC=C1 ICFJFFQQTFMIBG-UHFFFAOYSA-N 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
230000008569 process Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000007873 sieving Methods 0.000 description 1
238000009097 single-agent therapy Methods 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
229960005371 tolbutamide Drugs 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
238000009736 wetting Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA200404880A 2001-11-29 2004-06-21 Pharmaceutical compositions comprising metformine and glibenclamide for the treatment of type-II diabetes mellitus. ZA200404880B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2001FI000230A ITFI20010230A1 (it)	2001-11-29	2001-11-29	Composizioni farmaceutiche per il trattamento del diabete mellito di tipo ii

Publications (1)

Publication Number	Publication Date
ZA200404880B true ZA200404880B (en)	2005-07-29

Family

ID=11442301

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200404880A ZA200404880B (en)	2001-11-29	2004-06-21	Pharmaceutical compositions comprising metformine and glibenclamide for the treatment of type-II diabetes mellitus.

Country Status (39)

Country	Link
US (1)	US20050053661A1 (fr)
EP (1)	EP1458364B1 (fr)
JP (1)	JP4474162B2 (fr)
KR (1)	KR20040079898A (fr)
CN (1)	CN1596103B (fr)
AR (1)	AR037407A1 (fr)
AT (1)	ATE387190T1 (fr)
AU (1)	AU2002358061B2 (fr)
BR (1)	BR0214403A (fr)
CA (1)	CA2466677A1 (fr)
CO (1)	CO5590906A2 (fr)
CY (1)	CY1107966T1 (fr)
DE (1)	DE60225331T2 (fr)
DK (1)	DK1458364T3 (fr)
EA (1)	EA006766B1 (fr)
EG (1)	EG24124A (fr)
ES (1)	ES2302862T3 (fr)
HN (1)	HN2002000341A (fr)
HR (1)	HRP20040501A2 (fr)
HU (1)	HUP0402154A3 (fr)
IL (1)	IL162143A0 (fr)
IT (1)	ITFI20010230A1 (fr)
MA (1)	MA27087A1 (fr)
MX (1)	MXPA04004974A (fr)
MY (1)	MY141243A (fr)
NO (1)	NO20042713L (fr)
NZ (1)	NZ533779A (fr)
PA (1)	PA8559801A1 (fr)
PE (1)	PE20030580A1 (fr)
PL (1)	PL206016B1 (fr)
PT (1)	PT1458364E (fr)
RS (1)	RS50937B (fr)
SI (1)	SI1458364T1 (fr)
SV (1)	SV2004001415A (fr)
TN (1)	TNSN04095A1 (fr)
UA (1)	UA81615C2 (fr)
UY (1)	UY27549A1 (fr)
WO (1)	WO2003045355A1 (fr)
ZA (1)	ZA200404880B (fr)

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KR20190120430A (ko)	2012-01-06	2019-10-23	엘셀릭스 테라퓨틱스 인코포레이티드	바이구아나이드 조성물 및 대사 장애를 치료하는 방법
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2001
- 2001-11-29 IT IT2001FI000230A patent/ITFI20010230A1/it unknown
2002
- 2002-11-22 AR ARP020104498A patent/AR037407A1/es unknown
- 2002-11-25 MY MYPI20024393A patent/MY141243A/en unknown
- 2002-11-26 PE PE2002001140A patent/PE20030580A1/es not_active Application Discontinuation
- 2002-11-26 UY UY27549A patent/UY27549A1/es not_active Application Discontinuation
- 2002-11-27 EG EG2002111281A patent/EG24124A/xx active
- 2002-11-28 SV SV2002001415A patent/SV2004001415A/es not_active Application Discontinuation
- 2002-11-29 KR KR10-2004-7006874A patent/KR20040079898A/ko not_active Ceased
- 2002-11-29 ES ES02791739T patent/ES2302862T3/es not_active Expired - Lifetime
- 2002-11-29 JP JP2003546858A patent/JP4474162B2/ja not_active Expired - Lifetime
- 2002-11-29 US US10/497,022 patent/US20050053661A1/en not_active Abandoned
- 2002-11-29 UA UA20040504085A patent/UA81615C2/ru unknown
- 2002-11-29 PA PA20028559801A patent/PA8559801A1/es unknown
- 2002-11-29 IL IL16214302A patent/IL162143A0/xx not_active IP Right Cessation
- 2002-11-29 CN CN028236920A patent/CN1596103B/zh not_active Expired - Fee Related
- 2002-11-29 DE DE60225331T patent/DE60225331T2/de not_active Expired - Lifetime
- 2002-11-29 MX MXPA04004974A patent/MXPA04004974A/es active IP Right Grant
- 2002-11-29 PT PT02791739T patent/PT1458364E/pt unknown
- 2002-11-29 HU HU0402154A patent/HUP0402154A3/hu unknown
- 2002-11-29 HN HN2002000341A patent/HN2002000341A/es unknown
- 2002-11-29 EP EP02791739A patent/EP1458364B1/fr not_active Expired - Lifetime
- 2002-11-29 AT AT02791739T patent/ATE387190T1/de not_active IP Right Cessation
- 2002-11-29 AU AU2002358061A patent/AU2002358061B2/en not_active Ceased
- 2002-11-29 NZ NZ533779A patent/NZ533779A/en not_active IP Right Cessation
- 2002-11-29 CA CA002466677A patent/CA2466677A1/fr not_active Abandoned
- 2002-11-29 PL PL369851A patent/PL206016B1/pl not_active IP Right Cessation
- 2002-11-29 HR HRP20040501 patent/HRP20040501A2/hr not_active Application Discontinuation
- 2002-11-29 SI SI200230693T patent/SI1458364T1/sl unknown
- 2002-11-29 BR BR0214403-4A patent/BR0214403A/pt not_active IP Right Cessation
- 2002-11-29 EA EA200400664A patent/EA006766B1/ru not_active IP Right Cessation
- 2002-11-29 WO PCT/EP2002/013497 patent/WO2003045355A1/fr not_active Ceased
- 2002-11-29 DK DK02791739T patent/DK1458364T3/da active
2004
- 2004-05-24 MA MA27696A patent/MA27087A1/fr unknown
- 2004-05-28 TN TNP2004000095A patent/TNSN04095A1/en unknown
- 2004-05-28 RS YUP-473/04A patent/RS50937B/sr unknown
- 2004-06-21 ZA ZA200404880A patent/ZA200404880B/en unknown
- 2004-06-28 NO NO20042713A patent/NO20042713L/no not_active Application Discontinuation
- 2004-06-29 CO CO04061363A patent/CO5590906A2/es not_active Application Discontinuation
2008
- 2008-05-26 CY CY20081100543T patent/CY1107966T1/el unknown

Also Published As

Publication number	Publication date
TNSN04095A1 (en)	2006-06-01
PL369851A1 (en)	2005-05-02
EA006766B1 (ru)	2006-04-28
AU2002358061A1 (en)	2003-06-10
EP1458364B1 (fr)	2008-02-27
HUP0402154A2 (hu)	2005-02-28
ES2302862T3 (es)	2008-08-01
EA200400664A1 (ru)	2004-10-28
RS47304A (sr)	2006-10-27
EP1458364A1 (fr)	2004-09-22
EG24124A (en)	2008-07-07
JP4474162B2 (ja)	2010-06-02
PT1458364E (pt)	2008-05-26
HUP0402154A3 (en)	2008-04-28
DK1458364T3 (da)	2008-06-23
ITFI20010230A1 (it)	2003-05-29
DE60225331T2 (de)	2009-02-26
AU2002358061B2 (en)	2007-01-11
UA81615C2 (ru)	2008-01-25
BR0214403A (pt)	2004-10-19
NO20042713L (no)	2004-07-16
HRP20040501A2 (en)	2004-12-31
WO2003045355A1 (fr)	2003-06-05
CN1596103A (zh)	2005-03-16
IL162143A0 (en)	2005-11-20
MA27087A1 (fr)	2004-12-20
PA8559801A1 (es)	2003-06-30
CA2466677A1 (fr)	2003-06-05
MY141243A (en)	2010-03-31
PL206016B1 (pl)	2010-06-30
CO5590906A2 (es)	2005-12-30
MXPA04004974A (es)	2004-08-11
US20050053661A1 (en)	2005-03-10
HK1069974A1 (en)	2005-06-10
CN1596103B (zh)	2010-06-16
ATE387190T1 (de)	2008-03-15
JP2005518360A (ja)	2005-06-23
HN2002000341A (es)	2009-12-07
NZ533779A (en)	2007-02-23
KR20040079898A (ko)	2004-09-16
CY1107966T1 (el)	2013-09-04
SV2004001415A (es)	2004-05-07
UY27549A1 (es)	2003-06-30
PE20030580A1 (es)	2003-09-05
AR037407A1 (es)	2004-11-10
DE60225331D1 (de)	2008-04-10
RS50937B (sr)	2010-08-31
SI1458364T1 (sl)	2008-08-31

Publication	Publication Date	Title
AU2002358061B2 (en)	2007-01-11	Pharmaceutical compositions comprising metformine and glibenclamide for the treatment of type-II diabetes mellitus
CA2303537C (fr)	2005-12-06	Forme posologique orale solide comprenant une combinaison de metformine et de glibenclamide
US7598262B2 (en)	2009-10-06	Method for treating diabetes
TWI280125B (en)	2007-05-01	Pharmaceutical compositions for treating type 2 diabetes in drug naive human patients
US8911781B2 (en)	2014-12-16	Process of manufacture of novel drug delivery system: multilayer tablet composition of thiazolidinedione and biguanides
EP2026787A1 (fr)	2009-02-25	Formulation de comprimé comprenant du répaglinide et de la metformine
MXPA05009633A (es)	2007-03-07	Composicion farmaceutica estable de glimepirida de liberacion inmediata y metformina de liberacion prolongada.
WO2021176096A1 (fr)	2021-09-10	Composition pharmaceutique comprenant un inhibiteur du sglt2
US20040147564A1 (en)	2004-07-29	Combinations of glimepiride and the thiazolidinedione for treatment of diabetes
HK1069974B (en)	2008-08-22	Pharmaceutical compositions comprising metformine and glibenclamide for the treatment of type-ii diabetes mellitus
WO2004069229A1 (fr)	2004-08-19	Medicaments antidiabetiques a double liberation et procede de production de ceux-ci