DK1503785T3 - Nye vævsfaktor targeted thrombomodklin-fusions-proteiner som antikoagulanter - Google Patents

Nye vævsfaktor targeted thrombomodklin-fusions-proteiner som antikoagulanter

Info

Publication number
DK1503785T3
DK1503785T3 DK03721975.5T DK03721975T DK1503785T3 DK 1503785 T3 DK1503785 T3 DK 1503785T3 DK 03721975 T DK03721975 T DK 03721975T DK 1503785 T3 DK1503785 T3 DK 1503785T3
Authority
DK
Denmark
Prior art keywords
thrombomodeclin
anticoagulants
fusion proteins
tissue factor
new tissue
Prior art date
Application number
DK03721975.5T
Other languages
English (en)
Inventor
David Light
Kirk Mclean
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29401364&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1503785(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Application granted granted Critical
Publication of DK1503785T3 publication Critical patent/DK1503785T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK03721975.5T 2002-05-01 2003-04-30 Nye vævsfaktor targeted thrombomodklin-fusions-proteiner som antikoagulanter DK1503785T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37656602P 2002-05-01 2002-05-01
PCT/US2003/013522 WO2003092602A2 (en) 2002-05-01 2003-04-30 Novel tissue factor targeted thrombomodulin fusion proteins as anticoagulants

Publications (1)

Publication Number Publication Date
DK1503785T3 true DK1503785T3 (da) 2011-02-07

Family

ID=29401364

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03721974T DK1549341T3 (da) 2002-05-01 2003-04-30 Mod vævsfaktor rettede antistoffer som antikoagulanter
DK03721975.5T DK1503785T3 (da) 2002-05-01 2003-04-30 Nye vævsfaktor targeted thrombomodklin-fusions-proteiner som antikoagulanter

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK03721974T DK1549341T3 (da) 2002-05-01 2003-04-30 Mod vævsfaktor rettede antistoffer som antikoagulanter

Country Status (29)

Country Link
US (3) US7250168B2 (da)
EP (2) EP1503785B1 (da)
JP (2) JP4460443B2 (da)
KR (2) KR101013697B1 (da)
CN (2) CN100563709C (da)
AR (1) AR039515A1 (da)
AT (2) ATE484524T1 (da)
AU (2) AU2003225255B2 (da)
BR (2) BR0304660A (da)
CA (2) CA2483910A1 (da)
CR (1) CR7584A (da)
DE (2) DE60326970D1 (da)
DK (2) DK1549341T3 (da)
EC (2) ECSP045468A (da)
ES (2) ES2354419T3 (da)
HK (1) HK1080372A1 (da)
IL (3) IL164733A0 (da)
MX (2) MXPA04010851A (da)
NO (2) NO20035848L (da)
NZ (2) NZ536243A (da)
PE (1) PE20040597A1 (da)
PL (2) PL210582B1 (da)
PT (2) PT1503785E (da)
RS (2) RS102404A (da)
RU (2) RU2320366C2 (da)
TW (1) TWI343388B (da)
UA (2) UA85996C2 (da)
WO (2) WO2003092602A2 (da)
ZA (2) ZA200409692B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2135953B1 (en) 1999-06-02 2014-04-23 Chugai Seiyaku Kabushiki Kaisha Novel hemopoietin receptor protein, Nr. 10
ES2254224T3 (es) * 1999-09-27 2006-06-16 Chugai Seiyaku Kabushiki Kaisha Nueva proteina del receptor de hematopoyetina, nr12.
EP2351855A1 (en) 2000-09-26 2011-08-03 Duke University RNA aptamers and methods for identifying the same
US7579000B2 (en) 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
HK1080372A1 (zh) * 2002-05-01 2006-04-28 Schering Aktiengesellschaft 作为抗凝剂的新型组织因子目标抗体
AU2003256299A1 (en) * 2002-07-01 2004-01-19 Human Genome Sciences, Inc. Antibodies that specifically bind to reg iv
US7425328B2 (en) 2003-04-22 2008-09-16 Purdue Pharma L.P. Tissue factor antibodies and uses thereof
US7833978B2 (en) * 2004-02-20 2010-11-16 Emory University Thrombomodulin derivatives and conjugates
KR101185050B1 (ko) 2004-04-22 2012-10-04 레가도 바이오사이언스, 인코포레이티드 응고 인자의 개선된 모듈레이터
WO2006129849A1 (ja) * 2005-06-03 2006-12-07 Mochida Pharmaceutical Co., Ltd. 抗ｃｄ１４抗体融合蛋白質
WO2008039206A2 (en) * 2005-10-05 2008-04-03 The Trustees Of The University Of Pennsylvania Fusion proteins for inhibition and dissolution of coagulation
DE602007009956D1 (de) * 2006-04-07 2010-12-02 Novo Nordisk Healthcare Ag Kovalenter faktor vii-gewebefaktor-komplex
DK2047863T3 (da) 2006-06-08 2013-09-16 Chugai Pharmaceutical Co Ltd Middel til forebyggelse eller behandling af inflammatoriske sygdomme
WO2008044631A1 (en) * 2006-10-06 2008-04-17 Asahi Kasei Pharma Corporation Therapeutic and/or ameliorating agent for disseminated intravascular coagulation
WO2008121814A1 (en) * 2007-03-28 2008-10-09 Ats Medical, Inc. Method for inhibiting platelet interaction with biomaterial surfaces
AU2008300516A1 (en) * 2007-09-20 2009-03-26 Bracco Imaging Spa Method for the preparation of new oligoclonal antibodies
WO2009072598A1 (ja) 2007-12-05 2009-06-11 Chugai Seiyaku Kabushiki Kaisha 掻痒症治療剤
WO2009086552A1 (en) * 2008-01-02 2009-07-09 The Trustees Of The University Of Pennsylvania Targeting recombinant therapeutics to circulating red blood cells
UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
WO2010019493A1 (en) * 2008-08-14 2010-02-18 Merck Sharp & Dohme Corp. Methods for purifying antibodies using protein a affinity chromatography
WO2010045518A1 (en) * 2008-10-16 2010-04-22 The Trustees Of The University Of Pennsylvania Compositions containing thrombomodulin domains and uses thereof
US20120165244A1 (en) * 2008-10-30 2012-06-28 Hua-Lin Wu Methods for binding lewis y antigen
UA109633C2 (uk) 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
EP2230251A1 (en) * 2009-03-19 2010-09-22 Bracco Imaging S.p.A Antibodies specifically active in the coronary plaque and method for their identification
EP2470201A4 (en) * 2009-08-28 2013-01-30 Bayer Healthcare Llc COFACTORS ENABLING THE THROMBINIC ACTIVATION OF FACTOR VII AND THEIR USES
GB201007356D0 (en) 2010-04-30 2010-06-16 Leverton Licence Holdings Ltd Conjugated factor VIIa
MX348567B (es) * 2010-06-04 2017-06-20 Tiumbio Co Ltd Proteina de fusion que tiene actividad de factor vii.
SMT201700547T1 (it) 2010-06-15 2018-01-11 Genmab As Coniugati di farmaco anticorpo umano contro il fattore tissutale
EP2600891B1 (en) 2010-08-05 2018-01-17 Council of Scientific & Industrial Research Protein fusion constructs possessing thrombolytic and anticoagulant properties
RU2445365C1 (ru) * 2010-11-03 2012-03-20 Общество с ограниченной ответственностью "Инновационный Центр "Новые Технологии и Материалы" (ООО "ИЦ Новтехмат") Штамм гибридных культивируемых клеток mus musculus - продуцент моноклональных антител, специфичных к протеину с человека (варианты)
CA2980992C (en) 2015-04-14 2024-01-23 Akihisa Kaneko Pharmaceutical composition for prevention and/or treatment of atopic dermatitis containing il-31 antagonist as active ingredient
US10954502B2 (en) * 2015-04-28 2021-03-23 Saint Louis University Thrombin-thrombomodulin fusion proteins as protein C activators
WO2017189943A1 (en) * 2016-04-28 2017-11-02 Saint Louis University Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant
WO2018093766A1 (en) * 2016-11-16 2018-05-24 Bayer Healthcare Llc Red blood cell targeted factor viii and method of using the same
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
TWI841554B (zh) 2018-03-21 2024-05-11 丹麥商珍美寶股份有限公司 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法
CA3099547A1 (en) 2018-05-07 2019-11-14 Reshma Abdulla RANGWALA Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate
EP3861127A1 (en) * 2018-10-04 2021-08-11 Thrombosis and Coagulation AB Method for the determination of protein s levels
TWI844571B (zh) 2018-10-30 2024-06-11 丹麥商珍美寶股份有限公司 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法
JP6845973B1 (ja) 2019-11-20 2021-03-24 中外製薬株式会社 抗体含有製剤
CN114686443B (zh) * 2020-12-31 2023-11-03 广州万孚生物技术股份有限公司 杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用
CN114686444B (zh) * 2020-12-31 2024-05-31 广州万孚生物技术股份有限公司 杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208479A (en) * 1977-07-14 1980-06-17 Syva Company Label modified immunoassays
ZA862768B (en) * 1985-04-17 1986-12-30 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
US5589173A (en) * 1986-11-04 1996-12-31 Genentech, Inc. Method and therapeutic compositions for the treatment of myocardial infarction
US5437864A (en) * 1987-03-31 1995-08-01 The Scripps Research Institute Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor
US5223427A (en) * 1987-03-31 1993-06-29 The Scripps Research Institute Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
DK299087D0 (da) 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
US5298599A (en) * 1988-12-30 1994-03-29 Oklahoma Medical Research Foundation Expression and purification of recombinant soluble tissue factor
CA2046906A1 (en) * 1989-02-17 1990-08-18 Michael J. Morser Soluble analogs of thrombomodulin
US5466668A (en) * 1989-04-28 1995-11-14 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
KR930008093B1 (ko) * 1990-08-03 1993-08-25 아사히가세이고오교 가부시끼가이샤 신규 폴리펩티드 및 이를 유효성분으로 하는 의약조성물
US5506134A (en) * 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
US5843442A (en) * 1990-10-22 1998-12-01 Corvas International, Inc. Blood coagulation protein antagonists and uses therefor
JPH0578397A (ja) * 1991-01-29 1993-03-30 Sumitomo Pharmaceut Co Ltd 血栓溶解タンパク質
JPH06133780A (ja) * 1992-10-23 1994-05-17 Sumitomo Pharmaceut Co Ltd 新規なｔ−ＰＡ改変体
US5916874A (en) * 1994-04-20 1999-06-29 Asahi Kasei Kogyo Kabushiki Kaisha Method for treating liver injury
US5736364A (en) * 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
US5986065A (en) 1997-03-10 1999-11-16 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
TR200002885T2 (tr) * 1998-04-03 2000-12-21 Chugai Seiyaku Kabushiki Kaisha İnsan doku faktörüne (TF) karşı insanlaştırılmış antikor
HK1049184A1 (zh) * 2000-03-16 2003-05-02 Genentech, Inc. 具有增强抗凝血效能的抗组织因子抗体
US6632791B1 (en) * 2000-06-21 2003-10-14 Schering Aktiengesellschaft Thrombomodulin analogs for pharmaceutical use
TWI338009B (en) * 2001-10-29 2011-03-01 Genentech Inc Antibodies for inhibiting blood coagulation and methods of use thereof
EP1465998A2 (en) 2002-01-08 2004-10-13 Bayer HealthCare AG Single nucleotide polymorphisms predicting cardiovascular disease and medication efficacy
US7579000B2 (en) 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
HK1080372A1 (zh) 2002-05-01 2006-04-28 Schering Aktiengesellschaft 作为抗凝剂的新型组织因子目标抗体

Also Published As

Publication number Publication date
ATE484524T1 (de) 2010-10-15
BR0304660A (pt) 2005-06-07
AU2003225256B2 (en) 2009-06-04
JP4460443B2 (ja) 2010-05-12
IL164733A0 (en) 2005-12-18
IL164733A (en) 2011-05-31
NZ536243A (en) 2006-06-30
WO2003092602A2 (en) 2003-11-13
NO20035849L (no) 2004-02-27
KR20050045945A (ko) 2005-05-17
US7622122B2 (en) 2009-11-24
CR7584A (es) 2006-05-30
MXPA04010795A (es) 2005-03-07
ES2354419T3 (es) 2011-03-14
RU2345789C2 (ru) 2009-02-10
DK1549341T3 (da) 2009-07-06
DE60326970D1 (de) 2009-05-14
UA81114C2 (en) 2007-12-10
NZ536242A (en) 2006-04-28
NO20035848L (no) 2004-02-27
PT1549341E (pt) 2009-05-29
CN1665526A (zh) 2005-09-07
CN100412090C (zh) 2008-08-20
UA85996C2 (ru) 2009-03-25
EP1503785A2 (en) 2005-02-09
AU2003225255A1 (en) 2003-11-17
US7250168B2 (en) 2007-07-31
JP4567437B2 (ja) 2010-10-20
AU2003225256A1 (en) 2003-11-17
US20040063632A1 (en) 2004-04-01
RU2320366C2 (ru) 2008-03-27
MXPA04010851A (es) 2005-02-14
TW200307043A (en) 2003-12-01
PL210582B1 (pl) 2012-02-29
ZA200409692B (en) 2006-07-26
PL373945A1 (en) 2005-09-19
CA2483909A1 (en) 2003-11-13
EP1503785A4 (en) 2007-02-14
KR20050045944A (ko) 2005-05-17
US20080019985A1 (en) 2008-01-24
AR039515A1 (es) 2005-02-23
CN100563709C (zh) 2009-12-02
WO2003093422A3 (en) 2004-07-15
EP1549341B1 (en) 2009-04-01
TWI343388B (en) 2011-06-11
JP2005532045A (ja) 2005-10-27
DE60334538D1 (de) 2010-11-25
RS102404A (sr) 2006-12-15
IL164732A0 (en) 2005-12-18
ECSP045467A (es) 2005-01-28
KR101013697B1 (ko) 2011-02-10
RS104504A (sr) 2007-02-05
RU2004135306A (ru) 2005-07-10
PL373960A1 (en) 2005-09-19
ZA200409694B (en) 2006-02-22
EP1549341A2 (en) 2005-07-06
RU2004135308A (ru) 2005-08-10
CN1665534A (zh) 2005-09-07
ES2323056T3 (es) 2009-07-06
EP1549341A4 (en) 2006-10-18
JP2005538046A (ja) 2005-12-15
WO2003093422A2 (en) 2003-11-13
US20080020965A1 (en) 2008-01-24
ECSP045468A (es) 2005-01-28
BR0304659A (pt) 2004-09-21
EP1503785B1 (en) 2010-10-13
CA2483910A1 (en) 2003-11-13
ATE427121T1 (de) 2009-04-15
US7622457B2 (en) 2009-11-24
PE20040597A1 (es) 2004-10-06
AU2003225255B2 (en) 2008-07-31
KR101080587B1 (ko) 2011-11-04
HK1080372A1 (zh) 2006-04-28
WO2003092602A3 (en) 2004-08-26
PT1503785E (pt) 2011-01-17

Similar Documents

Publication Publication Date Title
NO20035849L (no) Nye vevsfaktorrettede trombomodulinfusjonsproteiner som antikoagulanter
NO20044588L (no) Nye forbindelser
NO20044432L (no) Nye forbindelser
DE60336213D1 (de) Chirurgisches klammergerät
DK1523493T3 (da) Nye tubulysinanaloge
DE60327227D1 (de) Chirurgische klammersetzvorrichtung
NO20055219D0 (no) Nye forbindelser
DE60302032D1 (de) Künstliche Bandscheibe
DE60333607D1 (de) Chirurgische Klammervorrichtung
DE50310014D1 (de) Mähbalken
FI20020846A7 (fi) Sakset
DE60322421D1 (de) Verbesserter brillenbügel
DE50303208D1 (de) Osteosyntheseeinrichtung
DE60330884D1 (de) Optisch angesteuerter Mikro-aktuator
NO20026285D0 (no) Nye peptider
DE50303886D1 (de) Tragarm
EP1483963A4 (en) FALSE BAIT
NO20043664L (no) Ny fremgangsmate
NO20044098L (no) Nye forbindelser
DE10393352D2 (de) Skalpell
NO20043215L (no) Nye alkansulfonamider som endothelin-antagonister
ITMI20020295A0 (it) Procedimento di pacciamatura
DE60302964D1 (de) Verbesserte Augenlidpositionierung
NO20053512D0 (no) IL-8-liknende proteiner
ITUD20020140A1 (it) Taglia capsule