DK1539746T3 - N-substituerede 1H-indol-5-propionsyre-forbindelser som PPAR-agonister der er nyttige til behandling af diabetes - Google Patents

N-substituerede 1H-indol-5-propionsyre-forbindelser som PPAR-agonister der er nyttige til behandling af diabetes

Info

Publication number: DK1539746T3
Authority: DK; Denmark
Prior art keywords: indole; diabetes; substituted; treatment; propionic acid
Prior art date: 2002-09-12

Application number

DK03747962T

Other languages

English (en)

Inventor

Hans Iding

Hans-Peter Maerki

Peter Mohr

Alfred Binggeli

Hans Hilpert

Beat Wirz

Uwe Grether

Roland Humm

Bernd Kuhn

Markus Meyer

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-12

Filing date

2003-09-04

Publication date

2007-03-26

2003-09-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2007-03-26 Application granted granted Critical

2007-03-26 Publication of DK1539746T3 publication Critical patent/DK1539746T3/da

Links

QLLLZURKPNGXFF-UHFFFAOYSA-N 3-(1h-indol-5-yl)propanoic acid Chemical class OC(=O)CCC1=CC=C2NC=CC2=C1 QLLLZURKPNGXFF-UHFFFAOYSA-N 0.000 title 1
102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title 1
108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title 1
239000000556 agonist Substances 0.000 title 1
206010012601 diabetes mellitus Diseases 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Obesity (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK03747962T 2002-09-12 2003-09-04 N-substituerede 1H-indol-5-propionsyre-forbindelser som PPAR-agonister der er nyttige til behandling af diabetes DK1539746T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02020477		2002-09-12
PCT/EP2003/009819 WO2004024726A1 (en)	2002-09-12	2003-09-04	N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes

Publications (1)

Publication Number	Publication Date
DK1539746T3 true DK1539746T3 (da)	2007-03-26

Family

ID=31985028

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03747962T DK1539746T3 (da)	2002-09-12	2003-09-04	N-substituerede 1H-indol-5-propionsyre-forbindelser som PPAR-agonister der er nyttige til behandling af diabetes

Country Status (29)

Country	Link
US (1)	US6890947B2 (da)
EP (1)	EP1539746B1 (da)
JP (1)	JP4286782B2 (da)
KR (1)	KR100645684B1 (da)
CN (1)	CN100577660C (da)
AR (1)	AR041218A1 (da)
AT (1)	ATE345340T1 (da)
AU (1)	AU2003267041B2 (da)
BR (1)	BR0314261A (da)
CA (1)	CA2494601C (da)
DE (1)	DE60309719T2 (da)
DK (1)	DK1539746T3 (da)
ES (1)	ES2275105T3 (da)
GT (1)	GT200300194A (da)
HR (1)	HRP20050212A2 (da)
MX (1)	MXPA05002704A (da)
MY (1)	MY135646A (da)
NO (1)	NO20050667L (da)
NZ (1)	NZ537979A (da)
PA (1)	PA8581701A1 (da)
PE (1)	PE20050050A1 (da)
PL (1)	PL375878A1 (da)
PT (1)	PT1539746E (da)
RU (1)	RU2296759C2 (da)
SI (1)	SI1539746T1 (da)
TW (1)	TWI248933B (da)
UY (1)	UY27975A1 (da)
WO (1)	WO2004024726A1 (da)
ZA (1)	ZA200501273B (da)

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NO20083270L (no) *	2008-07-23	2010-01-25	Thia Medica As	Indolforbindelser
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8933024B2 (en)	2010-06-18	2015-01-13	Sanofi	Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en)	2011-09-27	2013-04-04	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

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2003
- 2003-09-04 NZ NZ537979A patent/NZ537979A/en unknown
- 2003-09-04 ES ES03747962T patent/ES2275105T3/es not_active Expired - Lifetime
- 2003-09-04 CA CA002494601A patent/CA2494601C/en not_active Expired - Fee Related
- 2003-09-04 HR HR20050212A patent/HRP20050212A2/hr not_active Application Discontinuation
- 2003-09-04 PT PT03747962T patent/PT1539746E/pt unknown
- 2003-09-04 WO PCT/EP2003/009819 patent/WO2004024726A1/en not_active Ceased
- 2003-09-04 PL PL03375878A patent/PL375878A1/xx not_active Application Discontinuation
- 2003-09-04 DK DK03747962T patent/DK1539746T3/da active
- 2003-09-04 EP EP03747962A patent/EP1539746B1/en not_active Expired - Lifetime
- 2003-09-04 BR BR0314261-2A patent/BR0314261A/pt not_active IP Right Cessation
- 2003-09-04 MX MXPA05002704A patent/MXPA05002704A/es active IP Right Grant
- 2003-09-04 AU AU2003267041A patent/AU2003267041B2/en not_active Ceased
- 2003-09-04 SI SI200330631T patent/SI1539746T1/sl unknown
- 2003-09-04 KR KR1020057004166A patent/KR100645684B1/ko not_active Expired - Fee Related
- 2003-09-04 JP JP2004535427A patent/JP4286782B2/ja not_active Expired - Fee Related
- 2003-09-04 DE DE60309719T patent/DE60309719T2/de not_active Expired - Lifetime
- 2003-09-04 AT AT03747962T patent/ATE345340T1/de not_active IP Right Cessation
- 2003-09-04 CN CN03821483A patent/CN100577660C/zh not_active Expired - Fee Related
- 2003-09-04 RU RU2005110921/04A patent/RU2296759C2/ru not_active IP Right Cessation
- 2003-09-08 TW TW092124737A patent/TWI248933B/zh not_active IP Right Cessation
- 2003-09-09 PA PA20038581701A patent/PA8581701A1/es unknown
- 2003-09-10 PE PE2003000917A patent/PE20050050A1/es not_active Application Discontinuation
- 2003-09-10 US US10/659,664 patent/US6890947B2/en not_active Expired - Fee Related
- 2003-09-10 MY MYPI20033416A patent/MY135646A/en unknown
- 2003-09-10 GT GT200300194A patent/GT200300194A/es unknown
- 2003-09-10 AR ARP030103266A patent/AR041218A1/es unknown
- 2003-09-11 UY UY27975A patent/UY27975A1/es not_active Application Discontinuation
2005
- 2005-02-08 NO NO20050667A patent/NO20050667L/no not_active Application Discontinuation
- 2005-02-11 ZA ZA200501273A patent/ZA200501273B/en unknown

Also Published As

Publication number	Publication date
UY27975A1 (es)	2004-03-31
ZA200501273B (en)	2006-08-30
PT1539746E (pt)	2007-02-28
ES2275105T3 (es)	2007-06-01
AR041218A1 (es)	2005-05-11
WO2004024726A1 (en)	2004-03-25
CA2494601C (en)	2009-09-29
JP2006503029A (ja)	2006-01-26
DE60309719D1 (de)	2006-12-28
CA2494601A1 (en)	2004-03-25
PA8581701A1 (es)	2004-04-23
MXPA05002704A (es)	2005-05-05
AU2003267041B2 (en)	2007-03-29
TW200418845A (en)	2004-10-01
BR0314261A (pt)	2005-07-26
DE60309719T2 (de)	2007-09-20
KR100645684B1 (ko)	2006-11-15
CN1681808A (zh)	2005-10-12
RU2005110921A (ru)	2006-01-20
SI1539746T1 (sl)	2007-04-30
RU2296759C2 (ru)	2007-04-10
PL375878A1 (en)	2005-12-12
CN100577660C (zh)	2010-01-06
HRP20050212A2 (en)	2006-05-31
MY135646A (en)	2008-06-30
PE20050050A1 (es)	2005-02-18
US20040053979A1 (en)	2004-03-18
ATE345340T1 (de)	2006-12-15
EP1539746A1 (en)	2005-06-15
TWI248933B (en)	2006-02-11
JP4286782B2 (ja)	2009-07-01
GT200300194A (es)	2004-04-15
NO20050667L (no)	2005-06-08
US6890947B2 (en)	2005-05-10
NZ537979A (en)	2007-08-31
AU2003267041A1 (en)	2004-04-30
KR20050042809A (ko)	2005-05-10
EP1539746B1 (en)	2006-11-15

Publication	Publication Date	Title
DK1471057T3 (da)	2006-05-15	Pyrimidinyleddikesyrederivater, der er egnede til behandlingen af sygdomme medieret af CRTH2
DK1651622T3 (da)	2007-05-07	Fremgangsmåde til fremstilling af 2-(quinoxalin-5-ylsulfonylamino)-benzamidforbindelser
NO20044654L (no)	2004-10-28	Piperidinoylpiperidiner som 5-HTIF-agonister
CY2016042I1 (el)	2017-03-15	Νεες ετεροκυκλικες ενωσεις δραστικες ως αναστολεις των βητα-λακταμασων
DK1551511T5 (da)	2019-11-11	Heterocykliske aromatiske forbindelser, der er anvendelige som væksthormonsekretagoger
PL1636190T3 (pl)	2012-10-31	Trwały kryształ związku 4-oksochinoliny
DK1756084T3 (da)	2009-03-23	Substituerede aryl- og heteroarylderivater som modulatorer af metabolisme og forebyggelse og behandling af forstyrrelser beslægtet dermed
DK1703909T3 (da)	2009-06-22	1-benzoyl-piperazinderivater som glycinoptagelsesinhibitorer til behandling af psykoser
DK1492785T3 (da)	2009-03-02	2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
DK1678185T3 (da)	2008-12-08	2,3-dihydro-6-nitroimidazo[2,1-b]oxazolforbindelser til behandling af tuberkulose
DK1542977T3 (da)	2007-03-19	2,5-dioxoimidazolidin-4-ylacetamider og analoger som inhibitorer af metalloproteinase MMP12
DE602004026320D1 (de)	2010-05-12	Nichtwässrige flüssige zahnbleichzusammensetzung
DK1617834T3 (da)	2007-02-05	Anvendelse af en farmaceutisk sammensætning indeholdende mælkesyre eller lactat og kalium til behandling af hjerneödem eller hjerneskade
NO20050665L (no)	2005-04-18	Pyrrolidonderivater som MAOE inhibitoere
DK1208095T3 (da)	2004-09-20	Dibenzopyraner som glucocorticoidreceptorantagonister til behandling af diabetes
DK1599452T3 (da)	2007-10-01	3- (2-phenyloxazol- 4-ylmethoxy) - cyclohexylmethoxyeddikesyrederivater og beslægtede forbindelser som PPAR modulatorer til behandling af type 2 diabetes og atherosklerosw
IS7858A (is)	2005-05-23	Samsetning til notkunar í meðferð á athyglisbresti með ofvirkni (ADHD)
DK1954690T3 (da)	2013-07-29	Benzamidforbindelser, der er anvendelige som inhibitorer af histondeacetylase
PL375878A1 (en)	2005-12-12	N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes
DK1954668T3 (da)	2012-01-23	Homo- og heterocykliske forbindelser, der er egnede som CETP-inhibitorer
DK1519928T3 (da)	2014-08-04	Fremgangsmåde til fremstilling af heterocykliske fluoralkenylsulfoner
DK1828166T3 (da)	2009-10-05	Hydantoinderivater, der kan anvendes som metalloproteinase-inhibitorer
DK1856063T3 (da)	2012-03-26	5-phenyl-pentansyrederivater som matrix- metalloproteinaseinhibitorer til behandlingen af astma og andre sygdomme
DK2845594T3 (da)	2022-03-07	Anvendelse af dihydroimidazoloner til behandlingen af hunde.
DK1881830T3 (da)	2009-01-26	4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin-derivater til behandling af infertilitet