DK164868C - Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse - Google Patents

Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse

Info

Publication number
DK164868C
DK164868C DK190986A DK190986A DK164868C DK 164868 C DK164868 C DK 164868C DK 190986 A DK190986 A DK 190986A DK 190986 A DK190986 A DK 190986A DK 164868 C DK164868 C DK 164868C
Authority
DK
Denmark
Prior art keywords
imidazooe4
baaquinolin
derivatives
preparing
procedure
Prior art date
Application number
DK190986A
Other languages
Danish (da)
English (en)
Other versions
DK190986D0 (da
DK164868B (da
DK190986A (da
Inventor
Nicholas A Meanwell
John J Wright
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DK190986D0 publication Critical patent/DK190986D0/da
Publication of DK190986A publication Critical patent/DK190986A/da
Publication of DK164868B publication Critical patent/DK164868B/da
Application granted granted Critical
Publication of DK164868C publication Critical patent/DK164868C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK190986A 1985-04-25 1986-04-24 Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse DK164868C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US72686985 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents
US83221286 1986-02-26

Publications (4)

Publication Number Publication Date
DK190986D0 DK190986D0 (da) 1986-04-24
DK190986A DK190986A (da) 1986-10-26
DK164868B DK164868B (da) 1992-08-31
DK164868C true DK164868C (da) 1993-01-11

Family

ID=27111398

Family Applications (3)

Application Number Title Priority Date Filing Date
DK190986A DK164868C (da) 1985-04-25 1986-04-24 Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK080291A DK165248C (da) 1985-04-25 1991-04-30 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf
DK081091A DK165249C (da) 1985-04-25 1991-05-01 Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK080291A DK165248C (da) 1985-04-25 1991-04-30 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf
DK081091A DK165249C (da) 1985-04-25 1991-05-01 Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Country Status (32)

Country Link
US (1) US4668686A (2)
KR (1) KR940000828B1 (2)
CN (1) CN1016175B (2)
AT (1) AT390257B (2)
AU (1) AU592983B2 (2)
BE (1) BE904671A (2)
CA (1) CA1298836C (2)
CH (1) CH675722A5 (2)
CY (1) CY1641A (2)
DE (1) DE3614132A1 (2)
DK (3) DK164868C (2)
EG (1) EG18104A (2)
ES (3) ES8708229A1 (2)
FI (1) FI83316C (2)
FR (1) FR2581065B1 (2)
GB (1) GB2174987B (2)
GR (1) GR861086B (2)
HK (1) HK64492A (2)
HU (1) HU195813B (2)
IL (1) IL78581A0 (2)
IT (1) IT1215651B (2)
LU (1) LU86406A1 (2)
MY (1) MY102086A (2)
NL (1) NL8601053A (2)
NO (1) NO163406C (2)
NZ (1) NZ215885A (2)
OA (1) OA08242A (2)
PT (1) PT82460B (2)
SE (1) SE461468B (2)
SG (1) SG29092G (2)
SU (3) SU1450746A3 (2)
YU (1) YU46054B (2)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
RU2131876C1 (ru) * 1993-07-06 1999-06-20 Пфайзер Инк. Бициклические тетрагидропиразолпиридины или их фармацевтически приемлемые соли, фармацевтическая композиция, способ ингибирования фосфодиэстеразы, способ лечения
TW530047B (en) * 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
BRPI0413558A (pt) 2003-08-12 2006-10-17 3M Innovative Properties Co compostos contendo imidazo substituìdo por hidroxilamina
MXPA06002199A (es) 2003-08-27 2006-05-22 3M Innovative Properties Co Imidazoquinolinas sustituidas con grupos ariloxi o arilalquilenoxi.
CA2537763A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for cd5+ b cell lymphoma
CA2540541C (en) * 2003-10-03 2012-03-27 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
WO2005048945A2 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
US7897767B2 (en) 2003-11-14 2011-03-01 3M Innovative Properties Company Oxime substituted imidazoquinolines
WO2005051317A2 (en) 2003-11-25 2005-06-09 3M Innovative Properties Company Substituted imidazo ring systems and methods
JP2007517035A (ja) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
EP1699788A2 (en) 2003-12-30 2006-09-13 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl and imidazonaphthyridinyl sulfonamides
WO2005094531A2 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US20080213308A1 (en) * 2004-09-14 2008-09-04 Nicholas Valiante Imidazoquinoline Compounds
AU2005326708C1 (en) 2004-12-30 2012-08-30 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
JP5543068B2 (ja) 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
WO2006084251A2 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
CA2597587A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
JP2008535832A (ja) 2005-04-01 2008-09-04 コーリー ファーマシューティカル グループ，インコーポレイテッド ピラゾロピリジン−１，４−ジアミン、およびそのアナログ
JP2008538550A (ja) 2005-04-01 2008-10-30 コーリー ファーマシューティカル グループ，インコーポレイテッド ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての１−置換ピラゾロ（３，４−ｃ）環状化合物
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
ES2558517T3 (es) 2006-08-02 2016-02-04 Cytokinetics, Inc. Ciertas entidades químicas, composiciones y métodos que comprenden imidazopirimidinas
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
WO2008121333A1 (en) * 2007-03-30 2008-10-09 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
KR101951220B1 (ko) 2011-07-13 2019-02-22 싸이토키네틱스, 인코포레이티드 조합 als 치료법
CN120265631A (zh) * 2023-01-13 2025-07-04 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
ES557552A0 (es) 1988-07-16
SE8601907L (sv) 1986-10-26
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
DK190986D0 (da) 1986-04-24
GR861086B (en) 1986-09-01
CY1641A (en) 1992-11-06
NO163406B (no) 1990-02-12
DK164868B (da) 1992-08-31
FR2581065A1 (fr) 1986-10-31
GB2174987A (en) 1986-11-19
AT390257B (de) 1990-04-10
KR860008177A (ko) 1986-11-12
FI83316C (fi) 1991-06-25
AU592983B2 (en) 1990-02-01
GB2174987B (en) 1989-08-02
ES8801829A1 (es) 1988-02-16
HK64492A (en) 1992-09-04
FI861684L (fi) 1986-10-26
MY102086A (en) 1992-03-31
CH675722A5 (2) 1990-10-31
YU116787A (en) 1988-04-30
SE461468B (sv) 1990-02-19
SG29092G (en) 1992-05-15
NL8601053A (nl) 1986-11-17
CN1016175B (zh) 1992-04-08
FI83316B (fi) 1991-03-15
DK81091D0 (da) 1991-05-01
ES8708229A1 (es) 1987-10-01
EG18104A (en) 1992-09-30
ES557551A0 (es) 1988-02-16
DK80291A (da) 1991-04-30
LU86406A1 (fr) 1986-11-05
BE904671A (fr) 1986-10-24
NO163406C (no) 1990-05-23
NO861617L (no) 1986-10-27
KR940000828B1 (ko) 1994-02-02
NZ215885A (en) 1989-04-26
OA08242A (en) 1987-10-30
DK190986A (da) 1986-10-26
HUT42089A (en) 1987-06-29
FI861684A0 (fi) 1986-04-22
CN86102747A (zh) 1987-02-04
PT82460A (en) 1986-05-01
DK165249C (da) 1993-03-22
AU5641386A (en) 1986-10-30
SU1470192A3 (ru) 1989-03-30
IT8620206A0 (it) 1986-04-24
YU46054B (sh) 1992-12-21
IT1215651B (it) 1990-02-22
PT82460B (pt) 1988-11-30
ATA112186A (de) 1989-09-15
SU1560056A3 (ru) 1990-04-23
CA1298836C (en) 1992-04-14
DK165248B (da) 1992-10-26
FR2581065B1 (fr) 1990-02-02
HU195813B (en) 1988-07-28
SU1450746A3 (ru) 1989-01-07
DK165249B (da) 1992-10-26
DK80291D0 (da) 1991-04-30
SE8601907D0 (sv) 1986-04-24
DE3614132A1 (de) 1986-11-27
US4668686A (en) 1987-05-26
GB8610037D0 (en) 1986-05-29
ES8802521A1 (es) 1988-07-16
ES554336A0 (es) 1987-10-01
IL78581A0 (en) 1986-08-31

Similar Documents

Publication Publication Date Title
DK164868C (da) Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK214090D0 (da) 5-aminosulfonylalkyl-indolderivater, fremgangsmaade og mellemprodukt til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK163991C (da) Dichloranilinderivater, fremgangsmaade til fremstilling af disse, samt farmaceutiske praeparater indeholdende derivaterne
DK359986D0 (da) Phenylethere, fremgangsmaader til fremstilling samt farmaceutiske midler indeholdende disse
DK160492C (da) Pyrimidinderivater, fremgangsmaader til fremstilling heraf samt farmaceutiske praeparater indeholdende disse derivater
DK219387D0 (da) Aminothiazol- og aminooxazolderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK164594C (da) 1,4-dihydro-pyridin-3,5-yl-dicarboxylsyrederivater, farmaceutiske praeparater indeholdende disse derivater samt fremgangsmaade til fremstilling deraf
DK642588A (da) Indanderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK165367C (da) Imidazolylalkylguanidinderivater, fremgangsmaade til fremstilling heraf samt laegemidler indeholdende disse forbindelser
DK163057C (da) Isoindsolinyl-alkyl-piperaziner, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK66086A (da) Dihydropyridiner, fremgangsmaader til fremstilling heraf samt farmaceutiske midler indeholdende disse
DK486789D0 (da) Benzoxazolinonderivater, fremgangsmaader til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK342187D0 (da) 4-pyridin-derivater, fremgangsmaade til fremstilling af saadanne derivater samt farmaceutiske praeparater indeholdende disse
DK469189D0 (da) Substituerede thienopyraner, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK191086D0 (da) Benzisoselenazolonylderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK307085D0 (da) 4-phenyl-2-trifluormethyl-1,3-dioxan-5-ylheptensyrederivater, fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK165885D0 (da) Peptider, fremgangsmaade til fremstilling deraf, samt farmaceutiske praeparater, indeholdende disse peptider
DK2488D0 (da) Dopamin-beta-hydroxylaseinhibitorer, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK160885A (da) Benzazepinderivater, fremgangsmaade til fremstilling deraf samt praeparater indeholdende disse
DK645988D0 (da) Biphenylderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeprater indeholdende samme
DK65986D0 (da) Dihydropyridiner, fremgangsmaader til fremstilling heraf samt farmaceutiske midler indeholdende disse
DK501385A (da) 1,3,4-thiadiazolderivater, fremgangsmaade til fremstilling heraf samt laegemidler indeholdende disse forbindelser
DK379287A (da) 1,3-propandiaminderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK141784A (da) Penemforbindelser, fremgangsmaader til deres fremstilling samt farmaceutiske praeparater indeholdende disse
DK352586D0 (da) 11-methylen-oestr-15-ener, fremgangsmaader til deres fremstilling og farmaceutiske praeparater indeholdende disse oestrener

Legal Events

Date Code Title Description
PBP Patent lapsed