SU1450746A3 - Способ получени производных 1,3-дигидро-2Н-имидазо/4,5-в/хинолин-2-онов или их фармацевтически приемлемых солей - Google Patents

Способ получени производных 1,3-дигидро-2Н-имидазо/4,5-в/хинолин-2-онов или их фармацевтически приемлемых солей Download PDF

Info

Publication number: SU1450746A3
Authority: SU; USSR - Soviet Union
Prior art keywords: singlet; hydrogen; imidazo; dihydro; halogen
Prior art date: 1985-04-25

Application number

SU864027355A

Other languages

English (en)

Russian (ru)

Inventor

А.Минвел Николас

Дж.Райт Джон

Original Assignee

Бристоль-Мейерз Компани (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-25

Filing date

1986-04-24

Publication date

1989-01-07

1986-04-24 Application filed by Бристоль-Мейерз Компани (Фирма) filed Critical Бристоль-Мейерз Компани (Фирма)

1989-01-07 Application granted granted Critical

1989-01-07 Publication of SU1450746A3 publication Critical patent/SU1450746A3/ru

Links

238000000034 method Methods 0.000 title claims description 7
150000003839 salts Chemical class 0.000 title claims description 3
BINWKEIURMBREF-UHFFFAOYSA-N 1,3-dihydroimidazo[4,5-b]quinolin-2-one Chemical class C1=CC=C2N=C(NC(=O)N3)C3=CC2=C1 BINWKEIURMBREF-UHFFFAOYSA-N 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 23
239000001257 hydrogen Substances 0.000 claims abstract description 20
150000002431 hydrogen Chemical group 0.000 claims abstract description 5
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 5
125000000217 alkyl group Chemical group 0.000 claims abstract 10
125000003545 alkoxy group Chemical group 0.000 claims abstract 9
229910052736 halogen Inorganic materials 0.000 claims abstract 9
150000002367 halogens Chemical group 0.000 claims abstract 9
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 10
230000000694 effects Effects 0.000 claims description 10
230000005764 inhibitory process Effects 0.000 claims description 10
230000008602 contraction Effects 0.000 claims description 8
229940091173 hydantoin Drugs 0.000 claims description 2
150000001469 hydantoins Chemical class 0.000 claims description 2
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239000007800 oxidant agent Substances 0.000 claims 1
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150000001875 compounds Chemical class 0.000 abstract description 35
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125000003118 aryl group Chemical group 0.000 description 30
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 25
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239000007787 solid Substances 0.000 description 19
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 18
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235000019345 sodium thiosulphate Nutrition 0.000 description 12
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239000011541 reaction mixture Substances 0.000 description 10
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
229910000029 sodium carbonate Inorganic materials 0.000 description 9
XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 description 8
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238000000338 in vitro Methods 0.000 description 8
IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 7
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239000000126 substance Substances 0.000 description 6
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IVOMOUWHDPKRLL-UHFFFAOYSA-N UNPD107823 Natural products O1C2COP(O)(=O)OC2C(O)C1N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-UHFFFAOYSA-N 0.000 description 2
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AMQUYLNSYUJEKH-UHFFFAOYSA-N 6,7,8-trimethoxy-1,3-dihydroimidazo[4,5-b]quinolin-2-one Chemical compound C1=C2C(OC)=C(OC)C(OC)=CC2=NC2=C1NC(=O)N2 AMQUYLNSYUJEKH-UHFFFAOYSA-N 0.000 description 1
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IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
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Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
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SU864027355A 1985-04-25 1986-04-24 Способ получени производных 1,3-дигидро-2Н-имидазо/4,5-в/хинолин-2-онов или их фармацевтически приемлемых солей SU1450746A3 (ru)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US72686985A	1985-04-25	1985-04-25
US06/832,212 US4668686A (en)	1985-04-25	1986-02-26	Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (1)

Publication Number	Publication Date
SU1450746A3 true SU1450746A3 (ru)	1989-01-07

Family

ID=27111398

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
SU864027355A SU1450746A3 (ru)	1985-04-25	1986-04-24	Способ получени производных 1,3-дигидро-2Н-имидазо/4,5-в/хинолин-2-онов или их фармацевтически приемлемых солей
SU874202071A SU1470192A3 (ru)	1985-04-25	1987-02-27	Способ получени имидазохинолиновых соединений или их фармацевтически приемлемых солей
SU874203391A SU1560056A3 (ru)	1985-04-25	1987-09-25	Способ получени производных 1,3,9,9 @ -тетрагидро-2Н-имидазо [4,5- @ ]хинолин-2-она или их фармацевтически приемлемых солей

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
SU874202071A SU1470192A3 (ru)	1985-04-25	1987-02-27	Способ получени имидазохинолиновых соединений или их фармацевтически приемлемых солей
SU874203391A SU1560056A3 (ru)	1985-04-25	1987-09-25	Способ получени производных 1,3,9,9 @ -тетрагидро-2Н-имидазо [4,5- @ ]хинолин-2-она или их фармацевтически приемлемых солей

Country Status (32)

Country	Link
US (1)	US4668686A (2)
KR (1)	KR940000828B1 (2)
CN (1)	CN1016175B (2)
AT (1)	AT390257B (2)
AU (1)	AU592983B2 (2)
BE (1)	BE904671A (2)
CA (1)	CA1298836C (2)
CH (1)	CH675722A5 (2)
CY (1)	CY1641A (2)
DE (1)	DE3614132A1 (2)
DK (3)	DK164868C (2)
EG (1)	EG18104A (2)
ES (3)	ES8708229A1 (2)
FI (1)	FI83316C (2)
FR (1)	FR2581065B1 (2)
GB (1)	GB2174987B (2)
GR (1)	GR861086B (2)
HK (1)	HK64492A (2)
HU (1)	HU195813B (2)
IL (1)	IL78581A0 (2)
IT (1)	IT1215651B (2)
LU (1)	LU86406A1 (2)
MY (1)	MY102086A (2)
NL (1)	NL8601053A (2)
NO (1)	NO163406C (2)
NZ (1)	NZ215885A (2)
OA (1)	OA08242A (2)
PT (1)	PT82460B (2)
SE (1)	SE461468B (2)
SG (1)	SG29092G (2)
SU (3)	SU1450746A3 (2)
YU (1)	YU46054B (2)

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RU2131876C1 (ru) *	1993-07-06	1999-06-20	Пфайзер Инк.	Бициклические тетрагидропиразолпиридины или их фармацевтически приемлемые соли, фармацевтическая композиция, способ ингибирования фосфодиэстеразы, способ лечения
RU2304143C2 (ru) *	2001-12-06	2007-08-10	3М Инновейтив Пропертиз Компани	Тиоэфирзамещенные имидазохинолины и фармацевтическая композиция на их основе
RU2412942C2 (ru) *	2003-10-03	2011-02-27	3М Инновейтив Пропертиз Компани	Оксизамещенные имидазохинолины, способные модулировать биосинтез цитокинов
RU2415857C2 (ru) *	2004-09-14	2011-04-10	Новартис Вэксинс Энд Диагностикс Инк.	Имидазохинолиновые соединения

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RU2006105101A (ru)	2003-08-27	2007-10-10	3М Инновейтив Пропертиз Компани (US)	Арилокси и арилалкиленокси замещенные имидазохинолины
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US8598192B2 (en) *	2003-11-14	2013-12-03	3M Innovative Properties Company	Hydroxylamine substituted imidazoquinolines
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AR046781A1 (es)	2003-11-25	2005-12-21	3M Innovative Properties Co	Derivados de imidazoquinolinas. composiciones farmaceuticas.
WO2005066170A1 (en)	2003-12-29	2005-07-21	3M Innovative Properties Company	Arylalkenyl and arylalkynyl substituted imidazoquinolines
CA2551399A1 (en)	2003-12-30	2005-07-21	3M Innovative Properties Company	Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
AU2005228150A1 (en)	2004-03-24	2005-10-13	3M Innovative Properties Company	Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en)	2004-06-15	2005-12-29	3M Innovative Properties Company	Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006038923A2 (en)	2004-06-18	2006-04-13	3M Innovative Properties Company	Aryl substituted imidazonaphthyridines
WO2006065280A2 (en)	2004-06-18	2006-06-22	3M Innovative Properties Company	Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US8026366B2 (en)	2004-06-18	2011-09-27	3M Innovative Properties Company	Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
EP1831226B1 (en)	2004-12-30	2012-08-08	3M Innovative Properties Company	Chiral tetracyclic compounds inducing interferon biosynthesis
AU2005326708C1 (en)	2004-12-30	2012-08-30	3M Innovative Properties Company	Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
AU2006210392A1 (en)	2005-02-04	2006-08-10	Coley Pharmaceutical Group, Inc.	Aqueous gel formulations containing immune response modifiers
CA2597587A1 (en)	2005-02-11	2006-08-17	Coley Pharmaceutical Group, Inc.	Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
US7943636B2 (en)	2005-04-01	2011-05-17	3M Innovative Properties Company	1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
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US7906506B2 (en)	2006-07-12	2011-03-15	3M Innovative Properties Company	Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8227603B2 (en)	2006-08-01	2012-07-24	Cytokinetics, Inc.	Modulating skeletal muscle
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US8299248B2 (en)	2006-08-02	2012-10-30	Cytokinetics, Incorporated	Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
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1986
- 1986-02-26 US US06/832,212 patent/US4668686A/en not_active Expired - Fee Related
- 1986-03-26 CA CA000505136A patent/CA1298836C/en not_active Expired - Fee Related
- 1986-04-18 NZ NZ215885A patent/NZ215885A/xx unknown
- 1986-04-21 AU AU56413/86A patent/AU592983B2/en not_active Ceased
- 1986-04-22 IL IL78581A patent/IL78581A0/xx not_active IP Right Cessation
- 1986-04-22 FI FI861684A patent/FI83316C/fi not_active IP Right Cessation
- 1986-04-23 EG EG237/86A patent/EG18104A/xx active
- 1986-04-23 CN CN86102747A patent/CN1016175B/zh not_active Expired
- 1986-04-24 BE BE0/216585A patent/BE904671A/fr not_active IP Right Cessation
- 1986-04-24 DK DK190986A patent/DK164868C/da not_active IP Right Cessation
- 1986-04-24 PT PT82460A patent/PT82460B/pt not_active IP Right Cessation
- 1986-04-24 GR GR861086A patent/GR861086B/el unknown
- 1986-04-24 SU SU864027355A patent/SU1450746A3/ru active
- 1986-04-24 LU LU86406A patent/LU86406A1/fr unknown
- 1986-04-24 SE SE8601907A patent/SE461468B/sv not_active IP Right Cessation
- 1986-04-24 IT IT8620206A patent/IT1215651B/it active
- 1986-04-24 FR FR868605966A patent/FR2581065B1/fr not_active Expired - Fee Related
- 1986-04-24 NO NO861617A patent/NO163406C/no unknown
- 1986-04-24 ES ES554336A patent/ES8708229A1/es not_active Expired
- 1986-04-24 CH CH1679/86A patent/CH675722A5/de not_active IP Right Cessation
- 1986-04-24 NL NL8601053A patent/NL8601053A/xx not_active Application Discontinuation
- 1986-04-24 GB GB8610037A patent/GB2174987B/en not_active Expired
- 1986-04-25 DE DE19863614132 patent/DE3614132A1/de not_active Ceased
- 1986-04-25 KR KR1019860003204A patent/KR940000828B1/ko not_active Expired - Lifetime
- 1986-04-25 AT AT0112186A patent/AT390257B/de not_active IP Right Cessation
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1987
- 1987-02-27 SU SU874202071A patent/SU1470192A3/ru active
- 1987-05-14 ES ES557552A patent/ES8802521A1/es not_active Expired
- 1987-05-14 ES ES557551A patent/ES8801829A1/es not_active Expired
- 1987-06-23 YU YU116787A patent/YU46054B/sh unknown
- 1987-09-25 SU SU874203391A patent/SU1560056A3/ru active
- 1987-09-29 MY MYPI87002266A patent/MY102086A/en unknown
1991
- 1991-04-30 DK DK080291A patent/DK165248C/da not_active IP Right Cessation
- 1991-05-01 DK DK081091A patent/DK165249C/da not_active IP Right Cessation
1992
- 1992-03-10 SG SG290/92A patent/SG29092G/en unknown
- 1992-08-27 HK HK644/92A patent/HK64492A/xx unknown
- 1992-11-06 CY CY1641A patent/CY1641A/en unknown

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2131876C1 (ru) *	1993-07-06	1999-06-20	Пфайзер Инк.	Бициклические тетрагидропиразолпиридины или их фармацевтически приемлемые соли, фармацевтическая композиция, способ ингибирования фосфодиэстеразы, способ лечения
RU2304143C2 (ru) *	2001-12-06	2007-08-10	3М Инновейтив Пропертиз Компани	Тиоэфирзамещенные имидазохинолины и фармацевтическая композиция на их основе
RU2412942C2 (ru) *	2003-10-03	2011-02-27	3М Инновейтив Пропертиз Компани	Оксизамещенные имидазохинолины, способные модулировать биосинтез цитокинов
RU2415857C2 (ru) *	2004-09-14	2011-04-10	Новартис Вэксинс Энд Диагностикс Инк.	Имидазохинолиновые соединения

Also Published As

Publication number	Publication date
CH675722A5 (2)	1990-10-31
NO861617L (no)	1986-10-27
SE461468B (sv)	1990-02-19
PT82460A (en)	1986-05-01
SU1470192A3 (ru)	1989-03-30
HK64492A (en)	1992-09-04
FI83316B (fi)	1991-03-15
IT8620206A0 (it)	1986-04-24
NZ215885A (en)	1989-04-26
NL8601053A (nl)	1986-11-17
YU116787A (en)	1988-04-30
DK80291A (da)	1991-04-30
DK165248B (da)	1992-10-26
ES557551A0 (es)	1988-02-16
ES8708229A1 (es)	1987-10-01
DK164868C (da)	1993-01-11
ES554336A0 (es)	1987-10-01
DK80291D0 (da)	1991-04-30
AT390257B (de)	1990-04-10
IL78581A0 (en)	1986-08-31
AU592983B2 (en)	1990-02-01
ES557552A0 (es)	1988-07-16
US4668686A (en)	1987-05-26
ES8801829A1 (es)	1988-02-16
MY102086A (en)	1992-03-31
DE3614132A1 (de)	1986-11-27
AU5641386A (en)	1986-10-30
GR861086B (en)	1986-09-01
DK164868B (da)	1992-08-31
YU46054B (sh)	1992-12-21
GB2174987A (en)	1986-11-19
IT1215651B (it)	1990-02-22
NO163406B (no)	1990-02-12
CY1641A (en)	1992-11-06
DK165248C (da)	1993-03-22
DK81091A (da)	1991-05-01
SG29092G (en)	1992-05-15
FI861684A0 (fi)	1986-04-22
DK165249C (da)	1993-03-22
NO163406C (no)	1990-05-23
PT82460B (pt)	1988-11-30
EG18104A (en)	1992-09-30
CN1016175B (zh)	1992-04-08
CA1298836C (en)	1992-04-14
GB8610037D0 (en)	1986-05-29
HUT42089A (en)	1987-06-29
SE8601907D0 (sv)	1986-04-24
DK190986A (da)	1986-10-26
KR860008177A (ko)	1986-11-12
ATA112186A (de)	1989-09-15
OA08242A (en)	1987-10-30
DK165249B (da)	1992-10-26
LU86406A1 (fr)	1986-11-05
FI861684L (fi)	1986-10-26
FR2581065A1 (fr)	1986-10-31
FI83316C (fi)	1991-06-25
ES8802521A1 (es)	1988-07-16
SE8601907L (sv)	1986-10-26
KR940000828B1 (ko)	1994-02-02
BE904671A (fr)	1986-10-24
SU1560056A3 (ru)	1990-04-23
DK190986D0 (da)	1986-04-24
HU195813B (en)	1988-07-28
CN86102747A (zh)	1987-02-04
GB2174987B (en)	1989-08-02
DK81091D0 (da)	1991-05-01
FR2581065B1 (fr)	1990-02-02

Publication	Publication Date	Title
KR940000828B1 (ko)	1994-02-02	항혈전성 강심제 이미다조 퀴놀린의 제조방법
US4256748A (en)	1981-03-17	Imidazo[2,1-b]quinazolin-2(3H)-ones and pharmaceutical compositions for treatment and prophylaxis of cardiac insufficiency and cardiac failure
KR100885308B1 (ko)	2009-02-24	５－ｈｔ6 및／또는 ５－ｈｔ7 세로토닌 수용체의리간드로서 사용되는 ５－할로-트립타민 유도체
CH639847A5 (it)	1983-12-15	Cicloalchiltriazoli.
Monge et al.	1987	Selective thromboxane synthetase inhibitors and antihypertensive agents. New derivatives of 4-hydrazino-5H-pyridazino [4, 5-b] indole, 4-hydrazinotriazino [4, 5-a] indole, and related compounds
PT87051B (pt)	1992-07-31	Processo para a preparacao de agentes anti-arritmicos de indano-sulfonamidas
SU1238732A3 (ru)	1986-06-15	Способ получени 6-хлор-3-метил-2,3,4,5-тетрагидро-1 @ -3-бензазепина или его гидрохлорида
KR100661774B1 (ko)	2006-12-28	광학적 활성 피리딜-4에이치-1,2,4-옥사디아진 유도체 및이것의 혈관 질환의 치료에서의 용도
JPH02180A (ja)	1990-01-05	２，２‐ジメチルクロメン誘導体、その製造方法及びこれを含む薬剤組成物
RU2129554C1 (ru)	1999-04-27	Производные пирролхинолинона, способ их получения, промежуточные соединения для их получения, фармацевтический состав и способ его получения
NO780050L (no)	1978-07-10	Fremgangsmaate ved fremstilling av 4,5,6,7-tetrahydrothieno-(2,3-c) og (3,2-c)pyridiner
NZ207981A (en)	1987-05-29	Pyrimidones and pharmaceutical compositions
NO801843L (no)	1980-12-22	Nye kinazolinderivater og farmasoeytiske preparater
PT87050B (pt)	1992-07-31	Processo para a preparacao de agentes anti-arritmicos de indano-sulfonamidas
JPS5953493A (ja)	1984-03-28	新規なチエノ−チアゾ−ル誘導体
SU1500160A3 (ru)	1989-08-07	Способ получени производных пиперазин-1-ил-эрголина
JPH04230285A (ja)	1992-08-19	利尿作用を有する医薬品およびその製造方法ならびに新規の３，７−ジアザビシクロ〔３．３．１〕ノナン化合物およびその製造方法
PT87049B (pt)	1992-07-31	Processo para a preparacao de agentes anti-arritmicos de benzazepino-sulfonamidas
JPH05506654A (ja)	1993-09-30	１，５―ベンゾチアゼピノン誘導体、その製法および医薬品用途
AU619049B2 (en)	1992-01-16	New 1,4-dihydropyridinederivative, namely (-)-2-{(2- aminoethoxy) ethoxy)-4-(2,3-dichlorophenyl)-3- ethoxycarbonyl-50methoxycarbonyl-6-methyl}-1,4- dihydropyridine, process for preparing it and pharmaceutical compositions containing it
US4224335A (en)	1980-09-23	Tetrahydrocarbazoles and their use
HU196308B (en)	1988-11-28	Process for producing pharmaceutical compositions containing 2-methyl-thiazolo/4,5-c/quinoline as active component
RU1838313C (ru)	1993-08-30	Способ получени спиросоединени азолона или его N-оксидного производного или его основной соли с фармакологически применимым катионом
SU1241993A3 (ru)	1986-06-30	Способ получени бициклических соединений или их гидрохлоридов
EP0312245A2 (en)	1989-04-19	Polycyclic compounds and pharmaceutical compositions thereof

SU1450746A3 - Способ получени производных 1,3-дигидро-2Н-имидазо/4,5-в/хинолин-2-онов или их фармацевтически приемлемых солей - Google Patents

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