BE904671A - Imidazoquinoleines antithrombogenes cardiotoniques. - Google Patents

Imidazoquinoleines antithrombogenes cardiotoniques.

Info

Publication number: BE904671A
Authority: BE; Belgium
Prior art keywords: imidazoquinoleins; antithrombogenic; cardiotonic; halogen; lower alkoxy
Prior art date: 1985-04-25

Application number

BE0/216585A

Other languages

English (en)

French (fr)

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-25

Filing date

1986-04-24

Publication date

1986-10-24

1986-04-24 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1986-10-24 Publication of BE904671A publication Critical patent/BE904671A/fr

Links

230000002965 anti-thrombogenic effect Effects 0.000 title 1
230000003177 cardiotonic effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052736 halogen Chemical group 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
BINWKEIURMBREF-UHFFFAOYSA-N 1,3-dihydroimidazo[4,5-b]quinolin-2-one Chemical class C1=CC=C2N=C(NC(=O)N3)C3=CC2=C1 BINWKEIURMBREF-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
210000001772 blood platelet Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BE0/216585A 1985-04-25 1986-04-24 Imidazoquinoleines antithrombogenes cardiotoniques. BE904671A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US72686985A	1985-04-25	1985-04-25
US06/832,212 US4668686A (en)	1985-04-25	1986-02-26	Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (1)

Publication Number	Publication Date
BE904671A true BE904671A (fr)	1986-10-24

Family

ID=27111398

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE0/216585A BE904671A (fr)	1985-04-25	1986-04-24	Imidazoquinoleines antithrombogenes cardiotoniques.

Country Status (32)

Country	Link
US (1)	US4668686A (2)
KR (1)	KR940000828B1 (2)
CN (1)	CN1016175B (2)
AT (1)	AT390257B (2)
AU (1)	AU592983B2 (2)
BE (1)	BE904671A (2)
CA (1)	CA1298836C (2)
CH (1)	CH675722A5 (2)
CY (1)	CY1641A (2)
DE (1)	DE3614132A1 (2)
DK (3)	DK164868C (2)
EG (1)	EG18104A (2)
ES (3)	ES8708229A1 (2)
FI (1)	FI83316C (2)
FR (1)	FR2581065B1 (2)
GB (1)	GB2174987B (2)
GR (1)	GR861086B (2)
HK (1)	HK64492A (2)
HU (1)	HU195813B (2)
IL (1)	IL78581A0 (2)
IT (1)	IT1215651B (2)
LU (1)	LU86406A1 (2)
MY (1)	MY102086A (2)
NL (1)	NL8601053A (2)
NO (1)	NO163406C (2)
NZ (1)	NZ215885A (2)
OA (1)	OA08242A (2)
PT (1)	PT82460B (2)
SE (1)	SE461468B (2)
SG (1)	SG29092G (2)
SU (3)	SU1450746A3 (2)
YU (1)	YU46054B (2)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4775674A (en) *	1986-05-23	1988-10-04	Bristol-Myers Company	Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) *	1986-07-08	1987-10-20	Bristol-Myers Company	7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4803210A (en) *	1987-05-29	1989-02-07	Merrell Dow Pharmaceuticals Inc.	Cardiotonic tricyclic oxazolones
US4743607A (en) *	1987-05-29	1988-05-10	Merrell Dow Pharmaceuticals Inc.	Cardiotonic tricyclic imidazolones
US4943573A (en) *	1989-11-01	1990-07-24	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) *	1990-11-10	1996-10-02	Daimler Benz Ag	Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) *	1991-10-30	1998-06-18	Janssen Pharmaceutica Nv	1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5158958A (en) *	1992-04-03	1992-10-27	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5196428A (en) *	1992-04-03	1993-03-23	Bristol-Myers Squibb Company	Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5348960A (en) *	1992-04-03	1994-09-20	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5552267A (en) *	1992-04-03	1996-09-03	The Trustees Of Columbia University In The City Of New York	Solution for prolonged organ preservation
US5208237A (en) *	1992-04-03	1993-05-04	Bristol-Meyers Squibb Company	7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
TW593317B (en) *	1993-06-21	2004-06-21	Janssen Pharmaceutica Nv	Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
RU2131876C1 (ru) *	1993-07-06	1999-06-20	Пфайзер Инк.	Бициклические тетрагидропиразолпиридины или их фармацевтически приемлемые соли, фармацевтическая композиция, способ ингибирования фосфодиэстеразы, способ лечения
TW530047B (en) *	1994-06-08	2003-05-01	Pfizer	Corticotropin releasing factor antagonists
US6664264B2 (en) *	2000-12-08	2003-12-16	3M Innovative Properties Company	Thioether substituted imidazoquinolines
BRPI0413558A (pt)	2003-08-12	2006-10-17	3M Innovative Properties Co	compostos contendo imidazo substituìdo por hidroxilamina
MXPA06002199A (es)	2003-08-27	2006-05-22	3M Innovative Properties Co	Imidazoquinolinas sustituidas con grupos ariloxi o arilalquilenoxi.
CA2537763A1 (en)	2003-09-05	2005-03-17	3M Innovative Properties Company	Treatment for cd5+ b cell lymphoma
CA2540541C (en) *	2003-10-03	2012-03-27	3M Innovative Properties Company	Alkoxy substituted imidazoquinolines
US7544697B2 (en)	2003-10-03	2009-06-09	Coley Pharmaceutical Group, Inc.	Pyrazolopyridines and analogs thereof
WO2005048945A2 (en) *	2003-11-14	2005-06-02	3M Innovative Properties Company	Hydroxylamine substituted imidazo ring compounds
US7897767B2 (en)	2003-11-14	2011-03-01	3M Innovative Properties Company	Oxime substituted imidazoquinolines
WO2005051317A2 (en)	2003-11-25	2005-06-09	3M Innovative Properties Company	Substituted imidazo ring systems and methods
JP2007517035A (ja)	2003-12-29	2007-06-28	スリーエムイノベイティブプロパティズカンパニー	アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
EP1699788A2 (en)	2003-12-30	2006-09-13	3M Innovative Properties Company	Imidazoquinolinyl, imidazopyridinyl and imidazonaphthyridinyl sulfonamides
WO2005094531A2 (en)	2004-03-24	2005-10-13	3M Innovative Properties Company	Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en)	2004-06-15	2011-09-13	3M Innovative Properties Company	Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en)	2004-06-18	2011-09-27	3M Innovative Properties Company	Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US7915281B2 (en)	2004-06-18	2011-03-29	3M Innovative Properties Company	Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
US7897609B2 (en)	2004-06-18	2011-03-01	3M Innovative Properties Company	Aryl substituted imidazonaphthyridines
US20080213308A1 (en) *	2004-09-14	2008-09-04	Nicholas Valiante	Imidazoquinoline Compounds
AU2005326708C1 (en)	2004-12-30	2012-08-30	3M Innovative Properties Company	Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
JP5543068B2 (ja)	2004-12-30	2014-07-09	スリーエムイノベイティブプロパティズカンパニー	キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
WO2006084251A2 (en)	2005-02-04	2006-08-10	Coley Pharmaceutical Group, Inc.	Aqueous gel formulations containing immune reponse modifiers
CA2597587A1 (en)	2005-02-11	2006-08-17	Coley Pharmaceutical Group, Inc.	Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
JP2008535832A (ja)	2005-04-01	2008-09-04	コーリーファーマシューティカルグループ，インコーポレイテッド	ピラゾロピリジン−１，４−ジアミン、およびそのアナログ
JP2008538550A (ja)	2005-04-01	2008-10-30	コーリーファーマシューティカルグループ，インコーポレイテッド	ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての１−置換ピラゾロ（３，４−ｃ）環状化合物
US7906506B2 (en)	2006-07-12	2011-03-15	3M Innovative Properties Company	Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8227603B2 (en)	2006-08-01	2012-07-24	Cytokinetics, Inc.	Modulating skeletal muscle
ES2558517T3 (es)	2006-08-02	2016-02-04	Cytokinetics, Inc.	Ciertas entidades químicas, composiciones y métodos que comprenden imidazopirimidinas
US8299248B2 (en)	2006-08-02	2012-10-30	Cytokinetics, Incorporated	Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
WO2008121333A1 (en) *	2007-03-30	2008-10-09	Cytokinetics, Incorporated	Certain chemical entities, compositions and methods
KR101951220B1 (ko)	2011-07-13	2019-02-22	싸이토키네틱스, 인코포레이티드	조합 als 치료법
CN120265631A (zh) *	2023-01-13	2025-07-04	上海超阳药业有限公司	喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3932407A (en) *	1973-11-19	1976-01-13	Bristol-Myers Company	Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

1986
- 1986-02-26 US US06/832,212 patent/US4668686A/en not_active Expired - Fee Related
- 1986-03-26 CA CA000505136A patent/CA1298836C/en not_active Expired - Fee Related
- 1986-04-18 NZ NZ215885A patent/NZ215885A/xx unknown
- 1986-04-21 AU AU56413/86A patent/AU592983B2/en not_active Ceased
- 1986-04-22 IL IL78581A patent/IL78581A0/xx not_active IP Right Cessation
- 1986-04-22 FI FI861684A patent/FI83316C/fi not_active IP Right Cessation
- 1986-04-23 CN CN86102747A patent/CN1016175B/zh not_active Expired
- 1986-04-23 EG EG237/86A patent/EG18104A/xx active
- 1986-04-24 CH CH1679/86A patent/CH675722A5/de not_active IP Right Cessation
- 1986-04-24 GB GB8610037A patent/GB2174987B/en not_active Expired
- 1986-04-24 DK DK190986A patent/DK164868C/da not_active IP Right Cessation
- 1986-04-24 ES ES554336A patent/ES8708229A1/es not_active Expired
- 1986-04-24 GR GR861086A patent/GR861086B/el unknown
- 1986-04-24 NO NO861617A patent/NO163406C/no unknown
- 1986-04-24 PT PT82460A patent/PT82460B/pt not_active IP Right Cessation
- 1986-04-24 NL NL8601053A patent/NL8601053A/xx not_active Application Discontinuation
- 1986-04-24 FR FR868605966A patent/FR2581065B1/fr not_active Expired - Fee Related
- 1986-04-24 IT IT8620206A patent/IT1215651B/it active
- 1986-04-24 LU LU86406A patent/LU86406A1/fr unknown
- 1986-04-24 BE BE0/216585A patent/BE904671A/fr not_active IP Right Cessation
- 1986-04-24 SU SU864027355A patent/SU1450746A3/ru active
- 1986-04-24 SE SE8601907A patent/SE461468B/sv not_active IP Right Cessation
- 1986-04-25 DE DE19863614132 patent/DE3614132A1/de not_active Ceased
- 1986-04-25 OA OA58845A patent/OA08242A/xx unknown
- 1986-04-25 KR KR1019860003204A patent/KR940000828B1/ko not_active Expired - Lifetime
- 1986-04-25 AT AT0112186A patent/AT390257B/de not_active IP Right Cessation
- 1986-04-25 HU HU861723A patent/HU195813B/hu not_active IP Right Cessation
1987
- 1987-02-27 SU SU874202071A patent/SU1470192A3/ru active
- 1987-05-14 ES ES557552A patent/ES8802521A1/es not_active Expired
- 1987-05-14 ES ES557551A patent/ES8801829A1/es not_active Expired
- 1987-06-23 YU YU116787A patent/YU46054B/sh unknown
- 1987-09-25 SU SU874203391A patent/SU1560056A3/ru active
- 1987-09-29 MY MYPI87002266A patent/MY102086A/en unknown
1991
- 1991-04-30 DK DK080291A patent/DK165248C/da not_active IP Right Cessation
- 1991-05-01 DK DK081091A patent/DK165249C/da not_active IP Right Cessation
1992
- 1992-03-10 SG SG290/92A patent/SG29092G/en unknown
- 1992-08-27 HK HK644/92A patent/HK64492A/xx unknown
- 1992-11-06 CY CY1641A patent/CY1641A/en unknown

Also Published As

Publication number	Publication date
ES557552A0 (es)	1988-07-16
SE8601907L (sv)	1986-10-26
DK165248C (da)	1993-03-22
DK81091A (da)	1991-05-01
DK190986D0 (da)	1986-04-24
GR861086B (en)	1986-09-01
CY1641A (en)	1992-11-06
NO163406B (no)	1990-02-12
DK164868B (da)	1992-08-31
FR2581065A1 (fr)	1986-10-31
GB2174987A (en)	1986-11-19
AT390257B (de)	1990-04-10
KR860008177A (ko)	1986-11-12
FI83316C (fi)	1991-06-25
AU592983B2 (en)	1990-02-01
GB2174987B (en)	1989-08-02
ES8801829A1 (es)	1988-02-16
HK64492A (en)	1992-09-04
FI861684L (fi)	1986-10-26
MY102086A (en)	1992-03-31
CH675722A5 (2)	1990-10-31
YU116787A (en)	1988-04-30
SE461468B (sv)	1990-02-19
SG29092G (en)	1992-05-15
NL8601053A (nl)	1986-11-17
CN1016175B (zh)	1992-04-08
FI83316B (fi)	1991-03-15
DK81091D0 (da)	1991-05-01
ES8708229A1 (es)	1987-10-01
EG18104A (en)	1992-09-30
ES557551A0 (es)	1988-02-16
DK80291A (da)	1991-04-30
LU86406A1 (fr)	1986-11-05
NO163406C (no)	1990-05-23
NO861617L (no)	1986-10-27
KR940000828B1 (ko)	1994-02-02
NZ215885A (en)	1989-04-26
OA08242A (en)	1987-10-30
DK190986A (da)	1986-10-26
HUT42089A (en)	1987-06-29
FI861684A0 (fi)	1986-04-22
CN86102747A (zh)	1987-02-04
PT82460A (en)	1986-05-01
DK165249C (da)	1993-03-22
AU5641386A (en)	1986-10-30
DK164868C (da)	1993-01-11
SU1470192A3 (ru)	1989-03-30
IT8620206A0 (it)	1986-04-24
YU46054B (sh)	1992-12-21
IT1215651B (it)	1990-02-22
PT82460B (pt)	1988-11-30
ATA112186A (de)	1989-09-15
SU1560056A3 (ru)	1990-04-23
CA1298836C (en)	1992-04-14
DK165248B (da)	1992-10-26
FR2581065B1 (fr)	1990-02-02
HU195813B (en)	1988-07-28
SU1450746A3 (ru)	1989-01-07
DK165249B (da)	1992-10-26
DK80291D0 (da)	1991-04-30
SE8601907D0 (sv)	1986-04-24
DE3614132A1 (de)	1986-11-27
US4668686A (en)	1987-05-26
GB8610037D0 (en)	1986-05-29
ES8802521A1 (es)	1988-07-16
ES554336A0 (es)	1987-10-01
IL78581A0 (en)	1986-08-31

Legal Events

Date

Code

Title

Description

1994-10-31

RE

Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 19940430

Publication	Publication Date	Title
BE904671A (fr)	1986-10-24	Imidazoquinoleines antithrombogenes cardiotoniques.
BE1002730A3 (fr)	1991-05-21	Derives d'isoquinoleine, leur preparation et leur utilisation.
FR2592048A1 (fr)	1987-06-26	Inhibiteurs d'ureido-renine, a action therapeutique
BE901880A (fr)	1985-09-05	Derives antipsychotiques de la 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine.
ES8703142A1 (es)	1986-11-16	Proceso para preparar un derivado del bencimidazol.
FI904915A0 (fi)	1990-10-05	Kinolinderivat, deras framstaellning och anvaendning.
BE900192A (fr)	1984-11-16	Nouvelles 1,5-benzothiazepines d'utilite cardiovasculaire, procedes pour leur preparation et compositions pharmaceutiques en contenant.
ES2031892T3 (es)	1996-07-16	Agentes antialergicos y antiinflamatorios.
BE902847A (fr)	1986-01-10	Nouvelles isoindolinylalcoylpiperazines
DE3270525D1 (en)	1986-05-22	Substituted pyrimidin-2-ones and the salts thereof
GR78961B (2)	1984-10-02
SE8302379D0 (sv)	1983-04-27	Ergolinderivat
BE902147A (fr)	1985-07-31	Pesticides.
FI864018A0 (fi)	1986-10-03	Tetrahydro- -karboliner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
ES471895A1 (es)	1979-10-01	Procedimiento para preparar derivados de benzamidina
NO960308L (no)	1996-03-13	Terapeutisk aktive benzoksaziner og benzotioanoner
DE3682599D1 (de)	1992-01-09	1-oxa-1-dethia-cephalosporinverbindungen und sie enthaltendes antibakterielles mittel.
BE902150A (fr)	1985-07-31	Derives de la 1h, 7h-pyrazolo (1,5-a) pyrimidine-7-one et procede pour leur preparation.
DK341988D0 (da)	1988-06-22	Ergolinderivater
NO963307L (no)	1996-10-09	Karbamoylmetylureaderivater
ES8400442A1 (es)	1983-11-01	Un procedimiento para la preparacion de un derivado de furanocremona.
DE3869330D1 (de)	1992-04-23	Bis-indolyl-ethylen-aldehyde.
GR3005034T3 (2)	1993-05-24
AR240920A2 (es)	1991-03-27	"un procedimiento para la preparacion de nuevos derivados de quinolina".
BE900997A (fr)	1985-05-07	Derives de fluorene.