YU46054B - Postupak za dobijanje imidazohinolinskih derivata - Google Patents

Postupak za dobijanje imidazohinolinskih derivata

Info

Publication number
YU46054B
YU46054B YU116787A YU116787A YU46054B YU 46054 B YU46054 B YU 46054B YU 116787 A YU116787 A YU 116787A YU 116787 A YU116787 A YU 116787A YU 46054 B YU46054 B YU 46054B
Authority
YU
Yugoslavia
Prior art keywords
formula
alkyl
hydrogen
alkoxy
halogen
Prior art date
Application number
YU116787A
Other languages
English (en)
Serbo-Croatian (sh)
Other versions
YU116787A (en
Inventor
N.A. Meanwell
J.J. Wright
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from YU66086A external-priority patent/YU45321B/xx
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Priority to YU116787A priority Critical patent/YU46054B/sh
Publication of YU116787A publication Critical patent/YU116787A/xx
Publication of YU46054B publication Critical patent/YU46054B/sh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
YU116787A 1985-04-25 1987-06-23 Postupak za dobijanje imidazohinolinskih derivata YU46054B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
YU116787A YU46054B (sh) 1985-04-25 1987-06-23 Postupak za dobijanje imidazohinolinskih derivata

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents
YU66086A YU45321B (en) 1985-04-25 1986-04-22 Process for obtaining imidazocquinolinic derivatives
YU116787A YU46054B (sh) 1985-04-25 1987-06-23 Postupak za dobijanje imidazohinolinskih derivata

Publications (2)

Publication Number Publication Date
YU116787A YU116787A (en) 1988-04-30
YU46054B true YU46054B (sh) 1992-12-21

Family

ID=27111398

Family Applications (1)

Application Number Title Priority Date Filing Date
YU116787A YU46054B (sh) 1985-04-25 1987-06-23 Postupak za dobijanje imidazohinolinskih derivata

Country Status (32)

Country Link
US (1) US4668686A (2)
KR (1) KR940000828B1 (2)
CN (1) CN1016175B (2)
AT (1) AT390257B (2)
AU (1) AU592983B2 (2)
BE (1) BE904671A (2)
CA (1) CA1298836C (2)
CH (1) CH675722A5 (2)
CY (1) CY1641A (2)
DE (1) DE3614132A1 (2)
DK (3) DK164868C (2)
EG (1) EG18104A (2)
ES (3) ES8708229A1 (2)
FI (1) FI83316C (2)
FR (1) FR2581065B1 (2)
GB (1) GB2174987B (2)
GR (1) GR861086B (2)
HK (1) HK64492A (2)
HU (1) HU195813B (2)
IL (1) IL78581A0 (2)
IT (1) IT1215651B (2)
LU (1) LU86406A1 (2)
MY (1) MY102086A (2)
NL (1) NL8601053A (2)
NO (1) NO163406C (2)
NZ (1) NZ215885A (2)
OA (1) OA08242A (2)
PT (1) PT82460B (2)
SE (1) SE461468B (2)
SG (1) SG29092G (2)
SU (3) SU1450746A3 (2)
YU (1) YU46054B (2)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
RU2131876C1 (ru) * 1993-07-06 1999-06-20 Пфайзер Инк. Бициклические тетрагидропиразолпиридины или их фармацевтически приемлемые соли, фармацевтическая композиция, способ ингибирования фосфодиэстеразы, способ лечения
TW530047B (en) * 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
BRPI0413558A (pt) 2003-08-12 2006-10-17 3M Innovative Properties Co compostos contendo imidazo substituìdo por hidroxilamina
MXPA06002199A (es) 2003-08-27 2006-05-22 3M Innovative Properties Co Imidazoquinolinas sustituidas con grupos ariloxi o arilalquilenoxi.
CA2537763A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for cd5+ b cell lymphoma
CA2540541C (en) * 2003-10-03 2012-03-27 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
WO2005048945A2 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
US7897767B2 (en) 2003-11-14 2011-03-01 3M Innovative Properties Company Oxime substituted imidazoquinolines
WO2005051317A2 (en) 2003-11-25 2005-06-09 3M Innovative Properties Company Substituted imidazo ring systems and methods
JP2007517035A (ja) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
EP1699788A2 (en) 2003-12-30 2006-09-13 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl and imidazonaphthyridinyl sulfonamides
WO2005094531A2 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US20080213308A1 (en) * 2004-09-14 2008-09-04 Nicholas Valiante Imidazoquinoline Compounds
AU2005326708C1 (en) 2004-12-30 2012-08-30 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
JP5543068B2 (ja) 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合[1,2]イミダゾ[4,5−c]環状化合物
WO2006084251A2 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
CA2597587A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
JP2008535832A (ja) 2005-04-01 2008-09-04 コーリー ファーマシューティカル グループ,インコーポレイテッド ピラゾロピリジン−1,4−ジアミン、およびそのアナログ
JP2008538550A (ja) 2005-04-01 2008-10-30 コーリー ファーマシューティカル グループ,インコーポレイテッド ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての1−置換ピラゾロ(3,4−c)環状化合物
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
ES2558517T3 (es) 2006-08-02 2016-02-04 Cytokinetics, Inc. Ciertas entidades químicas, composiciones y métodos que comprenden imidazopirimidinas
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
WO2008121333A1 (en) * 2007-03-30 2008-10-09 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
KR101951220B1 (ko) 2011-07-13 2019-02-22 싸이토키네틱스, 인코포레이티드 조합 als 치료법
CN120265631A (zh) * 2023-01-13 2025-07-04 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
ES557552A0 (es) 1988-07-16
SE8601907L (sv) 1986-10-26
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
DK190986D0 (da) 1986-04-24
GR861086B (en) 1986-09-01
CY1641A (en) 1992-11-06
NO163406B (no) 1990-02-12
DK164868B (da) 1992-08-31
FR2581065A1 (fr) 1986-10-31
GB2174987A (en) 1986-11-19
AT390257B (de) 1990-04-10
KR860008177A (ko) 1986-11-12
FI83316C (fi) 1991-06-25
AU592983B2 (en) 1990-02-01
GB2174987B (en) 1989-08-02
ES8801829A1 (es) 1988-02-16
HK64492A (en) 1992-09-04
FI861684L (fi) 1986-10-26
MY102086A (en) 1992-03-31
CH675722A5 (2) 1990-10-31
YU116787A (en) 1988-04-30
SE461468B (sv) 1990-02-19
SG29092G (en) 1992-05-15
NL8601053A (nl) 1986-11-17
CN1016175B (zh) 1992-04-08
FI83316B (fi) 1991-03-15
DK81091D0 (da) 1991-05-01
ES8708229A1 (es) 1987-10-01
EG18104A (en) 1992-09-30
ES557551A0 (es) 1988-02-16
DK80291A (da) 1991-04-30
LU86406A1 (fr) 1986-11-05
BE904671A (fr) 1986-10-24
NO163406C (no) 1990-05-23
NO861617L (no) 1986-10-27
KR940000828B1 (ko) 1994-02-02
NZ215885A (en) 1989-04-26
OA08242A (en) 1987-10-30
DK190986A (da) 1986-10-26
HUT42089A (en) 1987-06-29
FI861684A0 (fi) 1986-04-22
CN86102747A (zh) 1987-02-04
PT82460A (en) 1986-05-01
DK165249C (da) 1993-03-22
AU5641386A (en) 1986-10-30
DK164868C (da) 1993-01-11
SU1470192A3 (ru) 1989-03-30
IT8620206A0 (it) 1986-04-24
IT1215651B (it) 1990-02-22
PT82460B (pt) 1988-11-30
ATA112186A (de) 1989-09-15
SU1560056A3 (ru) 1990-04-23
CA1298836C (en) 1992-04-14
DK165248B (da) 1992-10-26
FR2581065B1 (fr) 1990-02-02
HU195813B (en) 1988-07-28
SU1450746A3 (ru) 1989-01-07
DK165249B (da) 1992-10-26
DK80291D0 (da) 1991-04-30
SE8601907D0 (sv) 1986-04-24
DE3614132A1 (de) 1986-11-27
US4668686A (en) 1987-05-26
GB8610037D0 (en) 1986-05-29
ES8802521A1 (es) 1988-07-16
ES554336A0 (es) 1987-10-01
IL78581A0 (en) 1986-08-31

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