DK168794B1 - Hybridinterferonpolypeptid, fremgangsmåde til fremstilling deraf, farmaceutisk præparat med indhold deraf, hybridvektor indeholdende en DNA sekvens som koder for hybridinterferonpolypeptidet, samt vært transformeret med en ekspressionsvektor indeholdende DNA sekvensen - Google Patents

Hybridinterferonpolypeptid, fremgangsmåde til fremstilling deraf, farmaceutisk præparat med indhold deraf, hybridvektor indeholdende en DNA sekvens som koder for hybridinterferonpolypeptidet, samt vært transformeret med en ekspressionsvektor indeholdende DNA sekvensen Download PDF

Info

Publication number
DK168794B1
DK168794B1 DK272986A DK272986A DK168794B1 DK 168794 B1 DK168794 B1 DK 168794B1 DK 272986 A DK272986 A DK 272986A DK 272986 A DK272986 A DK 272986A DK 168794 B1 DK168794 B1 DK 168794B1
Authority
DK
Denmark
Prior art keywords
leu
glu
ser
gln
asp
Prior art date
Application number
DK272986A
Other languages
Danish (da)
English (en)
Other versions
DK272986A (da
DK272986D0 (da
Inventor
Franqois Meyer
Albert Hinnen
Andreas Meister
Markus Gerhard Gruetter
Sefik Alkan
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858514726A external-priority patent/GB8514726D0/en
Priority claimed from GB858514722A external-priority patent/GB8514722D0/en
Priority claimed from GB858514724A external-priority patent/GB8514724D0/en
Priority claimed from GB858514723A external-priority patent/GB8514723D0/en
Priority claimed from GB858514725A external-priority patent/GB8514725D0/en
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK272986D0 publication Critical patent/DK272986D0/da
Publication of DK272986A publication Critical patent/DK272986A/da
Application granted granted Critical
Publication of DK168794B1 publication Critical patent/DK168794B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249—Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/142—Interferon

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK272986A 1985-06-11 1986-06-10 Hybridinterferonpolypeptid, fremgangsmåde til fremstilling deraf, farmaceutisk præparat med indhold deraf, hybridvektor indeholdende en DNA sekvens som koder for hybridinterferonpolypeptidet, samt vært transformeret med en ekspressionsvektor indeholdende DNA sekvensen DK168794B1 (da)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB858514726A GB8514726D0 (en) 1985-06-11 1985-06-11 Hybrid polypeptides
GB8514726 1985-06-11
GB8514724 1985-06-11
GB858514722A GB8514722D0 (en) 1985-06-11 1985-06-11 Hybrid interferon
GB8514723 1985-06-11
GB8514722 1985-06-11
GB858514724A GB8514724D0 (en) 1985-06-11 1985-06-11 Hybrid alpha-interferon
GB858514723A GB8514723D0 (en) 1985-06-11 1985-06-11 Hybrid alpha-interferon
GB8514725 1985-06-11
GB858514725A GB8514725D0 (en) 1985-06-11 1985-06-11 Hybrid polypeptide

Publications (3)

Publication Number Publication Date
DK272986D0 DK272986D0 (da) 1986-06-10
DK272986A DK272986A (da) 1986-12-12
DK168794B1 true DK168794B1 (da) 1994-06-13

Family

ID=27516593

Family Applications (1)

Application Number Title Priority Date Filing Date
DK272986A DK168794B1 (da) 1985-06-11 1986-06-10 Hybridinterferonpolypeptid, fremgangsmåde til fremstilling deraf, farmaceutisk præparat med indhold deraf, hybridvektor indeholdende en DNA sekvens som koder for hybridinterferonpolypeptidet, samt vært transformeret med en ekspressionsvektor indeholdende DNA sekvensen

Country Status (20)

Country Link
US (2) US4885166A (fr)
EP (1) EP0205404B1 (fr)
JP (2) JPH0655759B2 (fr)
KR (1) KR920002267B1 (fr)
AT (1) ATE78262T1 (fr)
AU (1) AU598196B2 (fr)
CA (1) CA1285507C (fr)
CY (1) CY1842A (fr)
DE (1) DE3685996T2 (fr)
DK (1) DK168794B1 (fr)
FI (1) FI90983C (fr)
GR (1) GR861497B (fr)
HK (1) HK99895A (fr)
HU (1) HU203255B (fr)
IE (1) IE57865B1 (fr)
IL (1) IL79085A (fr)
NO (1) NO175602C (fr)
NZ (1) NZ216485A (fr)
PT (1) PT82736B (fr)
SG (1) SG25195G (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5359035A (en) * 1985-12-21 1994-10-25 Hoechst Aktiengesellschaft Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF)
DE3607835A1 (de) * 1986-03-10 1987-09-24 Boehringer Ingelheim Int Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung
GB8803365D0 (en) * 1988-02-13 1988-03-16 Ciba Geigy Ag Antiviral combination
EP0331635A3 (fr) * 1988-02-29 1990-02-28 The Board of Regents of the University of Texas System Préparation pour le traitement du cancer de la vessie
US5273889A (en) * 1990-08-22 1993-12-28 University Of Saskatchewan Gamma-iterferon-leukotoxin gene fusions and uses thereof
US5594107A (en) * 1990-08-22 1997-01-14 University Of Saskatchewan Chimeric protein comprising an RTX-family cytotoxin and interferon-2 or interferon
DK0546124T4 (da) * 1990-08-29 2003-05-19 Inst Genetics Llc Hæmatopoiese-stimulatorer med flere domæner
US5372808A (en) † 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
DK0548012T3 (da) * 1991-12-16 1998-04-14 Ciba Geigy Ag Endoplasmatisk reticulum-placeret rekombinant dibasisk endoprotease samt dens anvendelse
US5676942A (en) * 1992-02-10 1997-10-14 Interferon Sciences, Inc. Composition containing human alpha interferon species proteins and method for use thereof
WO1993018139A1 (fr) * 1992-03-10 1993-09-16 La Jolla Cancer Research Foundation Phosphatase alcaline intestinale recombinee du veau
TW218846B (fr) * 1992-04-07 1994-01-11 Ciba Geigy
JPH078215A (ja) * 1993-04-30 1995-01-13 Kawasaki Steel Corp ドコサヘキサエン酸含有海洋性微細藻類食品素材およびその製造方法
TW249202B (fr) * 1993-08-13 1995-06-11 Ciba Gerigy Corp
US5981227A (en) 1995-02-09 1999-11-09 Movartis Ag Process for the production of proteins
TW442492B (en) * 1995-07-26 2001-06-23 Novartis Ag Process for the enrichment of interferon
US6685933B1 (en) 1998-07-28 2004-02-03 The United States Of America As Represented By The Department Of Health And Human Services Interferon α hybrids
DK1656952T3 (da) 1998-10-16 2014-01-20 Biogen Idec Inc Polyalkylenglycolkonjugater af interferon beta-1A og anvendelser deraf
US6514729B1 (en) * 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
US20020197235A1 (en) 2000-11-03 2002-12-26 Moran Stanford Mark Method for short-term and long-term drug dosimetry
US7087726B2 (en) 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
FR2821625B1 (fr) * 2001-03-01 2003-05-16 Genodyssee Nouveaux polynucleotides comportant un polymorphisme de type snp fonctionnel dans la sequence nucleotidique du gene ifn-alpha-2 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) * 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
CA2466228A1 (fr) * 2001-11-09 2003-08-07 Biomedicines, Inc. Methode de traitement de maladies faisant appel a l'interferon omega
US20040175359A1 (en) * 2002-11-12 2004-09-09 Desjarlais John Rudolph Novel proteins with antiviral, antineoplastic, and/or immunomodulatory activity
US7314613B2 (en) * 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
US20040219131A1 (en) * 2002-11-18 2004-11-04 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
CA2566247A1 (fr) * 2004-05-19 2005-12-01 Maxygen, Inc. Polypeptides et conjugues interferon-alpha
AU2005260664A1 (en) * 2004-06-30 2006-01-12 Egen Corporation Pegylated interferon alpha-1b
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (fr) 2005-02-03 2006-08-10 Alza Corporation Solutions de solvant/polymere utilisees comme vehicules de suspension
MX2007014524A (es) * 2005-05-18 2008-02-07 Maxygen Inc Polipeptidos desarrollados de interferon-alfa.
KR101106510B1 (ko) 2006-05-30 2012-01-20 인타르시아 세라퓨틱스 인코포레이티드 투피스, 내부채널 삼투압 전달 시스템 유동 조절기
BRPI0714347A2 (pt) 2006-07-14 2013-05-07 Dsm Ip Assets Bv processo aperfeiÇoado para o cultivo de cÉlulas
CA2670821C (fr) 2006-08-09 2012-05-15 Intarcia Therapeutics, Inc. Systemes d'administration osmotiques et ensembles pistons
JP2010512315A (ja) 2006-12-06 2010-04-22 メディミューン，エルエルシー インターフェロンα誘導性薬力学的マーカー
CA2683610C (fr) 2007-04-23 2013-01-08 Intarcia Therapeutics, Inc. Formulations en suspension de peptides insulinotropes et leurs utilisations
KR20100019467A (ko) * 2007-05-02 2010-02-18 암브룩스, 인코포레이티드 변형된 인터페론 베타 폴리펩티드 및 그의 용도
CA2685147A1 (fr) 2007-05-03 2008-11-13 Medimmune, Llc Marqueurs d'auto-anticorps de maladie auto-immune
US7625555B2 (en) * 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
BRPI0819195A2 (pt) 2007-11-05 2017-05-23 Medimmune Llc métodos para tratar escleroderma em um paciente em necessidade de tal tratamento e para aliviar um ou mais dos sintomas associados com escleroderma em um paciente em necessidade de tal tratamento.
MX2010008698A (es) 2008-02-08 2010-12-20 Medimmune Llc Marcadores de enfermedad y usos de los mismos.
WO2009102467A2 (fr) 2008-02-13 2009-08-20 Intarcia Therapeutics, Inc. Dispositifs, formulations et méthodes d’administration de plusieurs agents bénéfiques
AU2010289383B2 (en) 2009-09-03 2015-04-16 Medimmune, Llc Type 1 interferon diagnostic
MX378797B (es) 2009-09-28 2025-03-10 Intarcia Therapeutics Inc Establecimiento y/o terminacion rapidos de suministro de estado estable sustancial de farmaco.
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
WO2012125809A1 (fr) 2011-03-15 2012-09-20 Biogen Idec Inc. Procédé de réduction de symptômes pseudogrippaux associés à administration intramusculaire d'interféron à l'aide de protocole d'administration de doses croissantes à titrage rapide
US8729236B2 (en) * 2011-05-23 2014-05-20 Hal S. Padgett Selection and characterization of novel plant-derived recombinant human interferons with broad spectrum activity
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
CN113598842A (zh) 2015-06-03 2021-11-05 因塔西亚制药公司 植入物放置和移除系统
KR102574993B1 (ko) 2016-05-16 2023-09-06 인타르시아 세라퓨틱스 인코포레이티드 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
WO2018129058A1 (fr) 2017-01-03 2018-07-12 Intarcia Therapeutics, Inc. Méthodes comprenant l'administration continue d'un agoniste du récepteur glp-1 et la co-adminstration d'un médicament
SG11202108679PA (en) 2019-02-15 2021-09-29 Astrazeneca Ab Type i interferon-mediated disorders
KR102570958B1 (ko) * 2023-06-14 2023-08-25 (주) 신성하이스킬 화재방지 4축 파쇄장치
KR102594862B1 (ko) * 2023-06-14 2023-10-27 (주) 신성하이스킬 화재방지 파쇄 시스템

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1346A (en) * 1980-01-08 1987-01-16 Biogen Nv Dna sequences,recombinant dna molecules and processes for producing human interferon-like polypeptides
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
US4456748A (en) * 1981-02-23 1984-06-26 Genentech, Inc. Hybrid human leukocyte interferons
US4414150A (en) * 1980-11-10 1983-11-08 Genentech, Inc. Hybrid human leukocyte interferons
GB2108510B (en) * 1981-10-03 1984-12-12 Ciba Geigy Ag Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof
IT1167610B (it) * 1982-01-19 1987-05-13 Cetus Corp Interfreron ibrido multiclasse, composizione farmaceutica che lo contiene e procedimento di produzione
GB8315980D0 (en) * 1983-06-10 1983-07-13 Biogen Nv Producing hybrid dna sequences
GB8317880D0 (en) * 1983-07-01 1983-08-03 Searle & Co Structure and synthesis of interferons
EP0146903A3 (fr) * 1983-12-19 1987-07-22 Schering Corporation Production d'un vecteur qui encode un interféron hybride
GB8412564D0 (en) * 1984-05-17 1984-06-20 Searle & Co Structure and properties
EP0173935A1 (fr) * 1984-08-31 1986-03-12 University Patents, Inc. Interférons humains d'hybrides de lymphoblastoides-leucocytes
US4716217A (en) * 1984-08-31 1987-12-29 University Patents, Inc. Hybrid lymphoblastoid-leukocyte human interferons

Also Published As

Publication number Publication date
DK272986A (da) 1986-12-12
IE861542L (en) 1986-12-11
NZ216485A (en) 1991-06-25
NO175602C (no) 1994-11-02
FI862461A0 (fi) 1986-06-09
HK99895A (en) 1995-06-30
JPH05308973A (ja) 1993-11-22
JPH0736757B2 (ja) 1995-04-26
FI862461L (fi) 1986-12-12
NO862313L (no) 1986-12-12
EP0205404A3 (en) 1987-10-21
DE3685996T2 (de) 1993-01-14
CY1842A (en) 1996-03-08
PT82736B (pt) 1988-12-15
HUT41846A (en) 1987-05-28
EP0205404A2 (fr) 1986-12-17
PT82736A (en) 1986-07-01
KR870000427A (ko) 1987-02-18
ATE78262T1 (de) 1992-08-15
AU598196B2 (en) 1990-06-21
JPS626000A (ja) 1987-01-12
NO175602B (no) 1994-07-25
NO862313D0 (no) 1986-06-10
KR920002267B1 (ko) 1992-03-20
JPH0655759B2 (ja) 1994-07-27
IL79085A0 (en) 1986-09-30
HU203255B (en) 1991-06-28
IL79085A (en) 1992-03-29
DK272986D0 (da) 1986-06-10
CA1285507C (fr) 1991-07-02
FI90983B (fi) 1994-01-14
DE3685996D1 (de) 1992-08-20
AU5849986A (en) 1986-12-18
US4885166A (en) 1989-12-05
IE57865B1 (en) 1993-05-05
GR861497B (en) 1986-10-10
EP0205404B1 (fr) 1992-07-15
SG25195G (en) 1995-08-18
US5071761A (en) 1991-12-10
FI90983C (fi) 1994-04-25

Similar Documents

Publication Publication Date Title
US4885166A (en) Hybrid interferons
US7635466B1 (en) DNA sequences, recombinant DNA molecules and processes for producing human fibroblast interferon-like polypeptides
CA1339776C (fr) Interferon gamma de cheval
US5702920A (en) DNAS encoding human macrophage migration inhibition factor related peptides
DK170714B1 (da) Rekombinant DNA-vektor, fremgangsmåde til fremstilling deraf, værter transformeret dermed, fremgangsmåde til fremstilling af transformeret vært samt fremgangsmåde til fremstilling af et lymfoblastoidtalfa-interferon
US5554514A (en) Production of recombinant human interferon beta2.sbsb.B
EP0491878B1 (fr) Compositions pour l'inhibition de la formation d'hormones proteiques et emplois de celles-ci
JP2567195B2 (ja) 新規なヒトｉ型インターフェロン
US5739290A (en) Monoclonal antibody against an interferon-induced human protein in pure form
EP0290516A1 (fr) Proteines associees a des agents tensioactifs hydrophobes pulmonaires
EP0242329B1 (fr) Anticörps monoclonaux contre protéine humaine induite par l'interféron sous forme purifiée, et trousses d'essai contenant ces anticorps
EP0174143A1 (fr) Famille distincte d'interférons de leucocytes humains, compositions les contenant, méthodes pour leur production et ADN et hôtes transfectés pour ces méthodes
US6518045B1 (en) Feline cytokine protein
US6407209B1 (en) Interferon-induced human protein in pure form, monoclonal antibodies thereto and test kits containing these antibodies
KR100345467B1 (ko) B형 간염바이러스의 표면항원 s에 대한 인간화 항체 및 이의제조방법
NZ227372A (en) Murine monoclonal antibodies to human ifnalpha
JPS6034994A (ja) 新規ポリペプチドおよびその用途
DD251996A5 (de) Verfahren zur Herstellung von Hybrid-Interferonen

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired