DK173375B1 - LHRH-Antagonister, deres fremstilling og lægemidler der indeholder dem - Google Patents

LHRH-Antagonister, deres fremstilling og lægemidler der indeholder dem Download PDF

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Publication number: DK173375B1
Authority: DK; Denmark
Prior art keywords: phe; peptide; nal; pro; group
Prior art date: 1987-07-17

Application number

DK198803956A

Other languages

Danish (da)

English (en)

Other versions

DK395688A (da

DK395688D0 (da

Inventor

Andrew V Schally

Sandor Bajusz

Original Assignee

Asta Medica Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-17

Filing date

1988-07-15

Publication date

2000-09-11

1988-07-15 Application filed by Asta Medica Ag filed Critical Asta Medica Ag

1988-07-15 Publication of DK395688D0 publication Critical patent/DK395688D0/da

1989-01-18 Publication of DK395688A publication Critical patent/DK395688A/da

2000-09-11 Application granted granted Critical

2000-09-11 Publication of DK173375B1 publication Critical patent/DK173375B1/da

Links

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235000013355 food flavoring agent Nutrition 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
235000019253 formic acid Nutrition 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
239000000499 gel Substances 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
230000002710 gonadal effect Effects 0.000 description 1
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical class C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 1
150000008282 halocarbons Chemical class 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
230000003054 hormonal effect Effects 0.000 description 1
150000003840 hydrochlorides Chemical class 0.000 description 1
238000005984 hydrogenation reaction Methods 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
239000000960 hypophysis hormone Substances 0.000 description 1
235000019239 indanthrene blue RS Nutrition 0.000 description 1
UHOKSCJSTAHBSO-UHFFFAOYSA-N indanthrone blue Chemical compound C1=CC=C2C(=O)C3=CC=C4NC5=C6C(=O)C7=CC=CC=C7C(=O)C6=CC=C5NC4=C3C(=O)C2=C1 UHOKSCJSTAHBSO-UHFFFAOYSA-N 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
239000012442 inert solvent Substances 0.000 description 1
239000007972 injectable composition Substances 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000013067 intermediate product Substances 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000002955 isolation Methods 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000008101 lactose Substances 0.000 description 1
108010000761 leucylarginine Proteins 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
229940040129 luteinizing hormone Drugs 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
150000002688 maleic acid derivatives Chemical class 0.000 description 1
150000004701 malic acid derivatives Chemical class 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000005259 measurement Methods 0.000 description 1
BCVXHSPFUWZLGQ-UHFFFAOYSA-N mecn acetonitrile Chemical compound CC#N.CC#N BCVXHSPFUWZLGQ-UHFFFAOYSA-N 0.000 description 1
239000012528 membrane Substances 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
WXEHBUMAEPOYKP-UHFFFAOYSA-N methylsulfanylethane Chemical compound CCSC WXEHBUMAEPOYKP-UHFFFAOYSA-N 0.000 description 1
239000004005 microsphere Substances 0.000 description 1
SHDMMLFAFLZUEV-UHFFFAOYSA-N n-methyl-1,1-diphenylmethanamine Chemical group C=1C=CC=CC=1C(NC)C1=CC=CC=C1 SHDMMLFAFLZUEV-UHFFFAOYSA-N 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
229960003104 ornithine Drugs 0.000 description 1
239000002245 particle Substances 0.000 description 1
238000005897 peptide coupling reaction Methods 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
125000001557 phthalyl group Chemical group C(=O)(O)C1=C(C(=O)*)C=CC=C1 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
229920005990 polystyrene resin Polymers 0.000 description 1
239000013641 positive control Substances 0.000 description 1
NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
230000002028 premature Effects 0.000 description 1
239000000047 product Substances 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000005855 radiation Effects 0.000 description 1
239000002516 radical scavenger Substances 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
238000001959 radiotherapy Methods 0.000 description 1
239000006215 rectal suppository Substances 0.000 description 1
229940100618 rectal suppository Drugs 0.000 description 1
238000010992 reflux Methods 0.000 description 1
239000003488 releasing hormone Substances 0.000 description 1
238000012552 review Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
238000010186 staining Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
230000001629 suppression Effects 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
150000003892 tartrate salts Chemical class 0.000 description 1
ISHLCKAQWKBMAU-UHFFFAOYSA-N tert-butyl n-diazocarbamate Chemical compound CC(C)(C)OC(=O)N=[N+]=[N-] ISHLCKAQWKBMAU-UHFFFAOYSA-N 0.000 description 1
WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
238000001665 trituration Methods 0.000 description 1
APJYDQYYACXCRM-UHFFFAOYSA-N tryptamine Chemical compound C1=CC=C2C(CCN)=CNC2=C1 APJYDQYYACXCRM-UHFFFAOYSA-N 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
150000003751 zinc Chemical class 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
JPZXHKDZASGCLU-LBPRGKRZSA-N β-(2-naphthyl)-alanine Chemical compound C1=CC=CC2=CC(C[C@H](N)C(O)=O)=CC=C21 JPZXHKDZASGCLU-LBPRGKRZSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/11—Gonadotropin; related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Reproductive Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Gynecology & Obstetrics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK198803956A 1987-07-17 1988-07-15 LHRH-Antagonister, deres fremstilling og lægemidler der indeholder dem DK173375B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/074,126 US4800191A (en)	1987-07-17	1987-07-17	LHRH antagonists
US7412687		1987-07-17

Publications (3)

Publication Number	Publication Date
DK395688D0 DK395688D0 (da)	1988-07-15
DK395688A DK395688A (da)	1989-01-18
DK173375B1 true DK173375B1 (da)	2000-09-11

Family

ID=22117877

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198803956A DK173375B1 (da)	1987-07-17	1988-07-15	LHRH-Antagonister, deres fremstilling og lægemidler der indeholder dem

Country Status (18)

Country	Link
US (2)	US4800191A (fr)
EP (1)	EP0299402B1 (fr)
JP (1)	JP2944669B2 (fr)
AT (1)	ATE90362T1 (fr)
BR (1)	BR1100478A (fr)
CA (1)	CA1339623C (fr)
DE (3)	DE3881592D1 (fr)
DK (1)	DK173375B1 (fr)
ES (1)	ES2054741T3 (fr)
FI (1)	FI91075C (fr)
HK (1)	HK21194A (fr)
HU (1)	HU206376B (fr)
IE (1)	IE62744B1 (fr)
LU (1)	LU90425I2 (fr)
LV (1)	LV5795B4 (fr)
NL (1)	NL990029I2 (fr)
PT (1)	PT87998B (fr)
ZA (1)	ZA885147B (fr)

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US5064939A (en) *	1990-02-06	1991-11-12	The Salk Institute For Biological Studies	Cyclic gnrh antagonists
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US6468959B1 (en) *	1991-12-05	2002-10-22	Alfatec-Pharm Gmbh	Peroral dosage form for peptide containing medicaments, in particular insulin
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US6828415B2 (en)	1993-02-19	2004-12-07	Zentaris Gmbh	Oligopeptide lyophilisate, their preparation and use
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US5550212A (en) *	1993-12-17	1996-08-27	The Administrators Of The Tulane Educational Fund	Analogues of hGH-RH(1-29)NH2 having antagonistic activity
US5843901A (en) *	1995-06-07	1998-12-01	Advanced Research & Technology Institute	LHRH antagonist peptides
US5916582A (en) *	1996-07-03	1999-06-29	Alza Corporation	Aqueous formulations of peptides
US5932547A (en) *	1996-07-03	1999-08-03	Alza Corporation	Non-aqueous polar aprotic peptide formulations
US5981489A (en) *	1996-07-18	1999-11-09	Alza Corporation	Non-aqueous protic peptide formulations
DE19644994A1 (de) *	1996-10-30	1998-05-07	Asta Medica Ag	Diagnostisches Mittel
US5925730A (en)	1997-04-11	1999-07-20	Ferring Bv	GnRH antagonists
US5821230A (en) *	1997-04-11	1998-10-13	Ferring Bv	GnRH antagonist decapeptides
US6407205B1 (en) *	1997-06-04	2002-06-18	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	FSH-releasing peptides
DE19728737C1 (de) *	1997-07-04	1999-02-11	Johannes Christian Groeninghen	Verfahren zur Erkennung und Bestimmung von GnRH-Rezeptoren und die Verwendung von GnRH-Agonisten und GnRH-Antagonisten zur Behandlung eines Tumors ausgehend vom Hirn und/oder Nervensystem und/oder den Hirnhäuten
US5941844A (en) *	1997-11-17	1999-08-24	Alza Corporation	Method and device for controlling mammalian reproductive cycle
US6191115B1 (en) *	1998-08-12	2001-02-20	Abbott Laboratories	C-terminus modified heptapeptide LHRH analogs
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
DE19911771B4 (de) *	1999-03-17	2006-03-30	Zentaris Gmbh	LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung
DE10024451A1 (de) *	2000-05-18	2001-11-29	Asta Medica Ag	Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung
DE10040700A1 (de) *	2000-08-17	2002-02-28	Asta Medica Ag	Salze von biologisch aktiven Peptiden, ihre Herstellung und Verwendung
CN1486141A (zh)	2000-12-15	2004-03-31	Wm・雷格利Jr.公司	包囊的酸混合物和含有该混合物的产品
DE10157628A1 (de) *	2001-11-26	2003-06-12	Zentaris Ag	Injektionslösung eines LHRH-Antagonisten
US7214662B2 (en)	2001-11-27	2007-05-08	Zentaris Gmbh	Injectable solution of an LHRH antagonist
CN101647772A (zh) *	2008-08-12	2010-02-17	中国人民解放军军事医学科学院毒物药物研究所	Lhrh拮抗剂类物质的注射用缓释制剂及其制备
US20120053122A1 (en)	2009-01-22	2012-03-01	Maatschap Interne Geneeskunde Rijnstate	Method for the prophylaxis or treatment of flushing
CN101863960B (zh) *	2009-04-15	2013-03-06	无锡市凯利药业有限公司	西曲瑞克的制备方法
EP2266567A1 (fr)	2009-05-26	2010-12-29	Æterna Zentaris GmbH	Composition pharmaceutique comprenant de Cetrorelix e d'inhibiteurs de PDE V pour le traitement des étas dépendants de l'hormone sexuel
RU2013128357A (ru)	2010-12-06	2015-01-20	Астрон Рисёрч Лимитед	Стабильный готовый к применению инъекционный раствор цетрореликса
BR112021025558A2 (pt)	2019-06-17	2022-03-03	Intas Pharmaceuticals Ltd	Formulação estável de cetrorelix e processo para a preparação de uma formulação estável
CN111875673B (zh) *	2020-07-31	2022-03-11	江苏莱森生物科技研究院有限公司	一种具有抗肿瘤活性的多肽及其用途
CN112175043A (zh) *	2020-10-12	2021-01-05	湖南津安生物科技有限公司	一种改进的鲑鱼促性腺激素释放激素的固相合成方法

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1987
- 1987-07-17 US US07/074,126 patent/US4800191A/en not_active Expired - Lifetime
1988
- 1988-05-23 US US07/197,153 patent/US5198533A/en not_active Expired - Lifetime
- 1988-07-11 AT AT88111031T patent/ATE90362T1/de active
- 1988-07-11 ES ES88111031T patent/ES2054741T3/es not_active Expired - Lifetime
- 1988-07-11 DE DE8888111031T patent/DE3881592D1/de not_active Expired - Lifetime
- 1988-07-11 EP EP88111031A patent/EP0299402B1/fr not_active Expired - Lifetime
- 1988-07-11 DE DE19975052C patent/DE19975052I2/de active Active
- 1988-07-12 DE DE3823590A patent/DE3823590A1/de not_active Withdrawn
- 1988-07-15 IE IE218588A patent/IE62744B1/en not_active IP Right Cessation
- 1988-07-15 HU HU883701A patent/HU206376B/hu unknown
- 1988-07-15 ZA ZA885147A patent/ZA885147B/xx unknown
- 1988-07-15 DK DK198803956A patent/DK173375B1/da not_active IP Right Cessation
- 1988-07-15 FI FI883388A patent/FI91075C/fi active IP Right Grant
- 1988-07-15 PT PT87998A patent/PT87998B/pt not_active IP Right Cessation
- 1988-07-15 CA CA000572236A patent/CA1339623C/fr not_active Expired - Lifetime
- 1988-07-18 JP JP63177288A patent/JP2944669B2/ja not_active Expired - Lifetime
1994
- 1994-03-10 HK HK211/94A patent/HK21194A/xx not_active IP Right Cessation
1996
- 1996-07-22 LV LV960300A patent/LV5795B4/xx unknown
1997
- 1997-05-06 BR BR1100478-9A patent/BR1100478A/pt active IP Right Grant
1999
- 1999-08-04 LU LU90425C patent/LU90425I2/fr unknown
- 1999-09-24 NL NL990029C patent/NL990029I2/nl unknown

Also Published As

Publication number	Publication date
HUT47311A (en)	1989-02-28
FI883388A0 (fi)	1988-07-15
LU90425I2 (fr)	1999-10-04
LV5795B4 (lv)	1997-08-20
PT87998B (pt)	1995-03-01
FI91075C (fi)	1994-05-10
EP0299402B1 (fr)	1993-06-09
ES2054741T3 (es)	1994-08-16
FI91075B (fi)	1994-01-31
PT87998A (pt)	1989-06-30
US4800191A (en)	1989-01-24
JPS6434997A (en)	1989-02-06
DK395688A (da)	1989-01-18
US5198533A (en)	1993-03-30
HU206376B (en)	1992-10-28
ZA885147B (en)	1989-04-26
FI883388L (fi)	1989-01-18
DE3881592D1 (de)	1993-07-15
NL990029I2 (nl)	2000-03-01
DE19975052I2 (de)	2009-01-02
ATE90362T1 (de)	1993-06-15
EP0299402A2 (fr)	1989-01-18
CA1339623C (fr)	1998-01-06
LV5795A4 (lv)	1997-02-20
IE882185L (en)	1989-01-17
NL990029I1 (nl)	1999-12-01
DK395688D0 (da)	1988-07-15
DE3823590A1 (de)	1989-01-26
EP0299402A3 (en)	1990-06-06
IE62744B1 (en)	1995-02-22
HK21194A (en)	1994-03-18
JP2944669B2 (ja)	1999-09-06
BR1100478A (pt)	2000-03-14

Legal Events

Date

Code

Title

Description

2006-09-25

CTFG

Supplementary protection certificate (spc) issued

Free format text: PRODUCT NAME: CETRORELIX ACETAT

Spc suppl protection certif: CA 2000 00017

Filing date: 20000926

2008-08-04

PUP

Patent expired

Publication	Publication Date	Title
DK173375B1 (da)	2000-09-11	LHRH-Antagonister, deres fremstilling og lægemidler der indeholder dem
US5470947A (en)	1995-11-28	CHRH antagonists with low histamine release
DK173544B1 (da)	2001-02-19	Nona- og decapeptider med LHRH antagonist aktivitet, fremgangsmåde til fremstilling heraf og farmaceutiske præparater indeh
AU675274B2 (en)	1997-01-30	Reduced size LHRH analogs
EP0500695B1 (fr)	1998-02-25	ANALOGUES DE GnRH
US5171835A (en)	1992-12-15	LHRH antagonists
AU613878B2 (en)	1991-08-15	Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
NO324991B1 (no)	2008-01-14	GnRH antagonistpeptid samt farmasoytisk preparat inneholdende det samme.
DK167361B1 (da)	1993-10-18	Grf-analoge peptider, farmaceutisk acceptable salte heraf og fremgangsmaader til fremstilling af disse
NZ209357A (en)	1988-04-29	Polypeptides,(44 amino acid residue) having growth hormone releasing properties; growth promoting compositions
US5258492A (en)	1993-11-02	LHRH analogues with cytotoxic moieties at the sixth position
US4721775A (en)	1988-01-26	Effective peptides related to the luteinizing hormone releasing hormone from L-amino acids
EP0125290B1 (fr)	1989-02-08	Peptides agissant sur la fonction gonadique
EP0413839A1 (fr)	1991-02-27	Analogues du GHRH
Fisher et al.	1976	Hypothalamic hormones. 71. Synthesis and some biological activities of the tyrosine-8 analog of substance P
EP0107890B1 (fr)	1986-01-29	PGRF de mammifères
JPH01199997A (ja)	1989-08-11	哺乳動物の脳下垂体に作用するペプチド
US4643989A (en)	1987-02-17	Inhibition of aldosterone secretion
FI101884B (fi)	1998-09-15	Luteinisoivaa hormonia vapauttavan hormonin (LHRH) antagonistipeptidej ä
EP0364819A2 (fr)	1990-04-25	Analogues de LHRH
WO1992002237A1 (fr)	1992-02-20	Analogues d'endotheline
IE892496A1 (en)	1991-02-13	Ghrh analogs