DK174332B1 - Vævsklæber og fremgangsmåde til fremstilling deraf - Google Patents

Vævsklæber og fremgangsmåde til fremstilling deraf Download PDF

Info

Publication number: DK174332B1
Authority: DK; Denmark
Prior art keywords: per; fibrinogen; prothrombin; solution; liter
Prior art date: 1986-07-05

Application number

DK198703428A

Other languages

Danish (da)

English (en)

Other versions

DK342887A (da

DK342887D0 (da

Inventor

Norbert Heimburger

Peter Fuhge

Hansjoerg Ronneberger

Original Assignee

Aventis Behring Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-05

Filing date

1987-07-03

Publication date

2002-12-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6304482&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK174332(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1987-07-03 Application filed by Aventis Behring Gmbh filed Critical Aventis Behring Gmbh

1987-07-03 Publication of DK342887D0 publication Critical patent/DK342887D0/da

1988-01-06 Publication of DK342887A publication Critical patent/DK342887A/da

2002-12-09 Application granted granted Critical

2002-12-09 Publication of DK174332B1 publication Critical patent/DK174332B1/da

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Surgery (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Materials For Medical Uses (AREA)
Adhesives Or Adhesive Processes (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Glass Compositions (AREA)
Medicinal Preparation (AREA)

DK198703428A 1986-07-05 1987-07-03 Vævsklæber og fremgangsmåde til fremstilling deraf DK174332B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3622642		1986-07-05
DE19863622642 DE3622642A1 (de)	1986-07-05	1986-07-05	Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung

Publications (3)

Publication Number	Publication Date
DK342887D0 DK342887D0 (da)	1987-07-03
DK342887A DK342887A (da)	1988-01-06
DK174332B1 true DK174332B1 (da)	2002-12-09

Family

ID=6304482

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198703428A DK174332B1 (da)	1986-07-05	1987-07-03	Vævsklæber og fremgangsmåde til fremstilling deraf

Country Status (12)

Country	Link
US (2)	US5407671A (pt)
EP (1)	EP0253198B2 (pt)
JP (1)	JP2511462B2 (pt)
AT (1)	ATE56883T1 (pt)
AU (1)	AU610504B2 (pt)
CA (1)	CA1321138C (pt)
DE (2)	DE3622642A1 (pt)
DK (1)	DK174332B1 (pt)
ES (1)	ES2018502T5 (pt)
FI (1)	FI90826C (pt)
GR (2)	GR3001226T3 (pt)
PT (1)	PT85242B (pt)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK475386D0 (da) *	1986-10-03	1986-10-03	Weis Fogh Ulla Sivertsen	Fremgangsmaade og apparat til fremstilling af biologiske stoffer
JPH01216939A (ja) *	1988-02-24	1989-08-30	Hoechst Japan Kk	末熟児頭蓋内出血阻止剤
AT397203B (de) *	1988-05-31	1994-02-25	Immuno Ag	Gewebeklebstoff
US5167960A (en) *	1988-08-03	1992-12-01	New England Deaconess Hospital Corporation	Hirudin-coated biocompatible substance
FR2650508A1 (fr) *	1989-08-01	1991-02-08	Fondation Nale Transfusion San	Colle pasteurisee pour reunir des tissus humain ou animal
US5219328A (en) *	1990-01-03	1993-06-15	Cryolife, Inc.	Fibrin sealant delivery method
US5318524A (en) *	1990-01-03	1994-06-07	Cryolife, Inc.	Fibrin sealant delivery kit
US6117425A (en)	1990-11-27	2000-09-12	The American National Red Cross	Supplemented and unsupplemented tissue sealants, method of their production and use
US6559119B1 (en)	1990-11-27	2003-05-06	Loyola University Of Chicago	Method of preparing a tissue sealant-treated biomedical material
US7229959B1 (en)	1990-11-27	2007-06-12	The American National Red Cross	Supplemented fibrin matrix delivery systems
US6197325B1 (en)	1990-11-27	2001-03-06	The American National Red Cross	Supplemented and unsupplemented tissue sealants, methods of their production and use
US6054122A (en)	1990-11-27	2000-04-25	The American National Red Cross	Supplemented and unsupplemented tissue sealants, methods of their production and use
US6613324B1 (en) *	1991-02-28	2003-09-02	Bristol-Myers Squibb Company	Adhesive for the gluing of biological tissues
US5792835A (en) *	1991-09-05	1998-08-11	Baxter International Inc.	Method of preparing a topical fibrinogen complex
WO1993005822A1 (en) *	1991-09-27	1993-04-01	Octapharma Ag	Tissue glue prepared by using cryoprecipitate
EP0534178B1 (en) *	1991-09-27	2001-04-18	Omrix Biopharmaceuticals S.A.	Improved tissue glue prepared by using cryoprecipitate
DE4202667C1 (pt) *	1992-01-29	1993-05-13	Behringwerke Ag, 3550 Marburg, De
CN1091315A (zh) *	1992-10-08	1994-08-31	E·R·斯奎布父子公司	血纤维蛋白封闭剂组合物及其使用方法
US5395923A (en) *	1993-02-23	1995-03-07	Haemacure-Biotech, Inc.	Process for the obtention of a biological adhesive made of concentrated coagulation factors by "salting-out"
US5585007A (en) *	1994-12-07	1996-12-17	Plasmaseal Corporation	Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
DE19521324C1 (de) *	1995-06-12	1996-10-31	Immuno Ag	Gewebeklebstoff und Verwendung desselben als Hämostyptikum
US5702715A (en) *	1995-10-27	1997-12-30	Drying Technology	Reinforced biological sealants
EP0885020A1 (en) *	1996-02-20	1998-12-23	Cohesion Corporation	Tissue sealant compositions and methods of use thereof
DE19607239A1 (de) *	1996-02-27	1997-08-28	Behringwerke Ag	Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
JP2002514960A (ja)	1997-06-18	2002-05-21	コヘージョンテクノロジーズ，インコーポレイテッド	トロンビンおよびミクロフィブリルコラーゲンを含む組成物、ならびにその調製および使用の方法
AT406120B (de)	1997-08-28	2000-02-25	Immuno Ag	Gewebekleber
US6762336B1 (en)	1998-01-19	2004-07-13	The American National Red Cross	Hemostatic sandwich bandage
DE19851334C2 (de) *	1998-11-06	2000-09-28	Aventis Behring Gmbh	Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung
US6310036B1 (en)	1999-01-09	2001-10-30	Last Chance Tissue Adhesives Corporation	High strength, Bio-compatible tissue adhesive and methods for treating vigorously bleeding surfaces
JP3937423B2 (ja) *	1999-01-19	2007-06-27	ニプロ株式会社	アミノ酸含有アルブミン製剤
AT500670A1 (de) *	1999-05-19	2006-02-15	Bio & Bio Licensing Sa	Arzneimittel zur lokalen anwendung
US6463335B1 (en)	1999-10-04	2002-10-08	Medtronic, Inc.	Temporary medical electrical lead having electrode mounting pad with biodegradable adhesive
DE10204405A1 (de) *	2002-02-04	2003-08-21	Surface Care Gmbh	Plasmagel
AU2003226265A1 (en) *	2002-04-05	2003-10-27	Baxter Healthcare S.A.	Storage stable liquid sealer protein complex
US7179391B2 (en)	2002-05-24	2007-02-20	Biomet Manufacturing Corp.	Apparatus and method for separating and concentrating fluids containing multiple components
US20030205538A1 (en)	2002-05-03	2003-11-06	Randel Dorian	Methods and apparatus for isolating platelets from blood
US7832566B2 (en)	2002-05-24	2010-11-16	Biomet Biologics, Llc	Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7374678B2 (en)	2002-05-24	2008-05-20	Biomet Biologics, Inc.	Apparatus and method for separating and concentrating fluids containing multiple components
US7992725B2 (en)	2002-05-03	2011-08-09	Biomet Biologics, Llc	Buoy suspension fractionation system
US20060278588A1 (en)	2002-05-24	2006-12-14	Woodell-May Jennifer E	Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en)	2002-05-24	2010-12-07	Biomet Biologics, Llc	Apparatus and method for separating and concentrating fluids containing multiple components
DE10261126A1 (de)	2002-08-13	2004-03-04	Aventis Behring Gmbh	Lagerungsstabile, flüssige Fibrinogen-Formulierung
AU2003270401B2 (en)	2002-09-10	2008-03-13	American National Red Cross	Hemostatic dressing
US20040243044A1 (en) *	2003-06-02	2004-12-02	Penegor Stephen A.	Hemostatic wound dressing
FR2857267B1 (fr) *	2003-07-09	2006-03-10	Lab Francais Du Fractionnement	Formulation stabilisante et solubilisante pour les proteines cryoprecipitables.
US20050075718A1 (en)	2003-10-06	2005-04-07	Nguyen Tuoc Tan	Minimally invasive valve replacement system
WO2005046528A1 (en)	2003-10-06	2005-05-26	3F Therapeutics, Inc.	Minimally invasive valve replacement system
JP2005239613A (ja) *	2004-02-25	2005-09-08	Asahi Kasei Medical Co Ltd	フィブリノーゲン組成液及びその製法
KR100624013B1 (ko) *	2004-06-25	2006-09-19	주식회사 녹십자홀딩스	동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제
ES2221817B1 (es) *	2004-07-26	2005-10-01	Probitas Pharma, S.A.	"soluciones de albumina humana terapeutica con baja actividad del activador de precalicreina (pka) y procedimiento de obtencion de las mismas".
EP1848472B1 (en)	2005-02-07	2015-04-01	Hanuman LLC	Platelet rich plasma concentrate apparatus and method
US7866485B2 (en)	2005-02-07	2011-01-11	Hanuman, Llc	Apparatus and method for preparing platelet rich plasma and concentrates thereof
US7708152B2 (en)	2005-02-07	2010-05-04	Hanuman Llc	Method and apparatus for preparing platelet rich plasma and concentrates thereof
FR2894831B1 (fr) *	2005-12-16	2008-02-15	Lab Francais Du Fractionnement	Colle biologique exempte de thrombine et son utilisation comme medicament.
US20070248653A1 (en) *	2006-04-20	2007-10-25	Cochrum Kent C	Hemostatic compositions and methods for controlling bleeding
US8567609B2 (en)	2006-05-25	2013-10-29	Biomet Biologics, Llc	Apparatus and method for separating and concentrating fluids containing multiple components
EP2063831A4 (en)	2006-08-04	2010-10-06	Stb Lifesaving Technologies In	SOLID FIRM FOR THE TREATMENT OF WOUND FABRICS
ES2485901T3 (es) *	2007-03-22	2014-08-14	The Chemo-Sero-Therapeutic Research Institute	Preparación sólida de fibrinógeno
US8328024B2 (en)	2007-04-12	2012-12-11	Hanuman, Llc	Buoy suspension fractionation system
EP2146794B1 (en)	2007-04-12	2016-10-19	Biomet Biologics, LLC	Buoy suspension fractionation system
WO2009020612A1 (en)	2007-08-06	2009-02-12	Stb Lifesaving Technologies, Inc.	Methods and dressing for sealing internal injuries
EP2620139B1 (en)	2008-02-27	2016-07-20	Biomet Biologics, LLC	Interleukin-1 receptor antagonist rich solutions
US8337711B2 (en)	2008-02-29	2012-12-25	Biomet Biologics, Llc	System and process for separating a material
US8012077B2 (en)	2008-05-23	2011-09-06	Biomet Biologics, Llc	Blood separating device
JP2010069031A (ja) *	2008-09-19	2010-04-02	Chemo Sero Therapeut Res Inst	シート状フィブリン糊接着剤
US8187475B2 (en)	2009-03-06	2012-05-29	Biomet Biologics, Llc	Method and apparatus for producing autologous thrombin
US8313954B2 (en)	2009-04-03	2012-11-20	Biomet Biologics, Llc	All-in-one means of separating blood components
US9433700B2 (en)	2009-04-27	2016-09-06	Medibeacon Inc.	Tissue sealant compositions, vascular closure devices, and uses thereof
US9011800B2 (en)	2009-07-16	2015-04-21	Biomet Biologics, Llc	Method and apparatus for separating biological materials
US8591391B2 (en)	2010-04-12	2013-11-26	Biomet Biologics, Llc	Method and apparatus for separating a material
AU2011260258B2 (en)	2010-06-01	2015-07-09	Baxter Healthcare S.A.	Process for making dry and stable hemostatic compositions
US8999376B2 (en)	2012-02-03	2015-04-07	Xcede Technologies, Inc.	Tissue patch
US9642956B2 (en)	2012-08-27	2017-05-09	Biomet Biologics, Llc	Apparatus and method for separating and concentrating fluids containing multiple components
US10016527B2 (en)	2012-10-23	2018-07-10	Orthovita, Inc.	Materials and methods for repair of cartilage defects
US10143725B2 (en)	2013-03-15	2018-12-04	Biomet Biologics, Llc	Treatment of pain using protein solutions
US20140271589A1 (en)	2013-03-15	2014-09-18	Biomet Biologics, Llc	Treatment of collagen defects using protein solutions
US9895418B2 (en)	2013-03-15	2018-02-20	Biomet Biologics, Llc	Treatment of peripheral vascular disease using protein solutions
US10208095B2 (en)	2013-03-15	2019-02-19	Biomet Manufacturing, Llc	Methods for making cytokine compositions from tissues using non-centrifugal methods
US9950035B2 (en)	2013-03-15	2018-04-24	Biomet Biologics, Llc	Methods and non-immunogenic compositions for treating inflammatory disorders
IL230150A0 (en)	2013-12-24	2014-09-30	Omrix Biopharmaceuticals Ltd	One-component fibrin glue containing zymogens
IL230151A0 (en)	2013-12-24	2014-09-30	Omrix Biopharmaceuticals Ltd	One-component fibrin glue containing a polymerization inhibitor
IL231230A0 (en)	2014-02-27	2014-08-31	Omrix Biopharmaceuticals Ltd	Fibrinogen preparation
IL231792A0 (en)	2014-03-27	2014-08-31	Omrix Biopharmaceuticals Ltd	Device and method for the preparation and administration of one-component fibrin glue
CN107427601B (zh)	2015-03-27	2021-08-31	3M创新有限公司	纤维蛋白组合物、方法和伤口用制品
US9713810B2 (en)	2015-03-30	2017-07-25	Biomet Biologics, Llc	Cell washing plunger using centrifugal force
US9757721B2 (en)	2015-05-11	2017-09-12	Biomet Biologics, Llc	Cell washing plunger using centrifugal force
US9540548B1 (en)	2015-08-07	2017-01-10	Xcede Technologies, Inc.	Adhesive compositions and related methods
US9833538B2 (en)	2015-08-07	2017-12-05	Xcede Technologies, Inc.	Adhesive compositions and related methods
US10588998B2 (en)	2015-08-07	2020-03-17	Xcede Technologies, Inc.	Adhesive compositions and related methods
WO2017083248A1 (en) *	2015-11-11	2017-05-18	Ethicon, Inc.	Sealant formulation and uses thereof
IL247786B (en)	2016-09-12	2019-08-29	Plotkin Alexander	Covers the wound with a hemostatic action and method and creates it
US12090247B2 (en)	2016-09-12	2024-09-17	Alexander Plotkin	Water-soluble sealant composition and its preparation
US10940233B2 (en)	2016-10-05	2021-03-09	3M Innovative Properties Company	Fibrinogen composition, method and wound articles
EP3522942B1 (en)	2016-10-05	2023-12-27	3M Innovative Properties Company	Fibrin composition comprising carrier material, method and wound articles
WO2018146235A1 (en)	2017-02-09	2018-08-16	Csl Behring Gmbh	A blood coagulation factor replacement product for use in the treatment or prophyl of bleedings

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5558163A (en) *	1978-10-24	1980-04-30	Unitika Ltd	Material for treating wounded portion
AT359653B (de) *	1979-02-15	1980-11-25	Immuno Ag	Verfahren zur herstellung eines gewebekleb- stoffes
AT359652B (de) *	1979-02-15	1980-11-25	Immuno Ag	Verfahren zur herstellung eines gewebekleb- stoffes
DE2916711A1 (de) *	1979-04-25	1980-11-06	Behringwerke Ag	Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
FR2472390A1 (fr) *	1979-05-04	1981-07-03	Merieux Inst	Procede de preparation de concentres de complexe prothrombinique hautement purifies, et concentres obtenus
JPS56135418A (en) *	1980-03-27	1981-10-22	Green Cross Corp:The	Heat treatment of aqueous solution containing 8 factor of coagulation of blood derived from human
DE3101752A1 (de) *	1981-01-21	1982-08-26	Behringwerke Ag, 3550 Marburg	"verfahren zur reinigung der blutgerinnungsfaktoren ii, vii, ix und/oder x und danach hergestellte praeparationen"
DE3105624A1 (de) *	1981-02-16	1982-09-02	Hormon-Chemie München GmbH, 8000 München	Material zum abdichten und heilen von wunden
ATE20824T1 (de) *	1981-06-25	1986-08-15	Serapharm Gmbh & Co Kg	Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung.
AT369990B (de) *	1981-07-28	1983-02-25	Immuno Ag	Verfahren zur herstellung eines gewebeklebstoffes
JPS5844057A (ja) *	1981-08-28	1983-03-14	ユニチカ株式会社	創傷部治療用材料
DE3203775A1 (de) *	1982-02-04	1983-08-11	Behringwerke Ag, 3550 Marburg	Fibrinogenzubereitung, verfahen zu ihrer herstellungund ihre verwendung
DE3230849A1 (de) *	1982-08-19	1984-02-23	Behringwerke Ag, 3550 Marburg	Pasteurisiertes human-fibrinogen (hf) und verfahren zu dessen herstellung
JPS5980253A (ja) *	1982-10-28	1984-05-09	ユニチカ株式会社	創傷部治療用材料

1986
- 1986-07-05 DE DE19863622642 patent/DE3622642A1/de not_active Withdrawn
1987
- 1987-06-30 AT AT87109374T patent/ATE56883T1/de not_active IP Right Cessation
- 1987-06-30 ES ES87109374T patent/ES2018502T5/es not_active Expired - Lifetime
- 1987-06-30 EP EP87109374A patent/EP0253198B2/de not_active Expired - Lifetime
- 1987-06-30 DE DE8787109374T patent/DE3765194D1/de not_active Expired - Lifetime
- 1987-07-02 FI FI872926A patent/FI90826C/fi not_active IP Right Cessation
- 1987-07-03 CA CA000541231A patent/CA1321138C/en not_active Expired - Lifetime
- 1987-07-03 DK DK198703428A patent/DK174332B1/da not_active IP Right Cessation
- 1987-07-03 AU AU75097/87A patent/AU610504B2/en not_active Ceased
- 1987-07-03 PT PT85242A patent/PT85242B/pt unknown
- 1987-07-03 JP JP62165587A patent/JP2511462B2/ja not_active Expired - Fee Related
1990
- 1990-12-21 GR GR90401037T patent/GR3001226T3/el unknown
1992
- 1992-11-30 US US07/983,613 patent/US5407671A/en not_active Expired - Lifetime
1994
- 1994-10-20 US US08/326,254 patent/US6500427B1/en not_active Expired - Lifetime
1999
- 1999-08-18 GR GR990402067T patent/GR3030989T3/el unknown

Also Published As

Publication number	Publication date
EP0253198B1 (de)	1990-09-26
FI90826C (fi)	1994-04-11
PT85242A (de)	1987-08-01
GR3030989T3 (en)	1999-12-31
DE3622642A1 (de)	1988-01-14
JPS6324951A (ja)	1988-02-02
US6500427B1 (en)	2002-12-31
DE3765194D1 (de)	1990-10-31
PT85242B (pt)	1990-03-30
AU610504B2 (en)	1991-05-23
CA1321138C (en)	1993-08-10
ES2018502T5 (es)	1999-10-01
AU7509787A (en)	1988-01-07
DK342887A (da)	1988-01-06
FI90826B (fi)	1993-12-31
EP0253198B2 (de)	1999-06-23
FI872926L (fi)	1988-01-06
US5407671A (en)	1995-04-18
GR3001226T3 (en)	1992-07-30
DK342887D0 (da)	1987-07-03
ATE56883T1 (de)	1990-10-15
ES2018502B3 (es)	1991-04-16
EP0253198A1 (de)	1988-01-20
JP2511462B2 (ja)	1996-06-26
FI872926A0 (fi)	1987-07-02

Legal Events

Date	Code	Title	Description
2002-12-09	B1	Patent granted (law 1993)
2007-03-05	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
US5407671A (en)	1995-04-18	One-component tissue adhesive and a process for the production thereof
AU2003234743B2 (en)	2008-07-31	Storage-stable, liquid fibrinogen formulation
US5883078A (en)	1999-03-16	Hemostyptic and tissue adhesive
JP3367698B2 (ja)	2003-01-14	安定なフィブリノーゲン溶液
RU2130946C1 (ru)	1999-05-27	Способ получения биологического клея, изготовленного из концентрированных коагулирующих факторов посредством "высаливания"
US10555991B2 (en)	2020-02-11	One component fibrin glue comprising zymogens
US20050136046A1 (en)	2005-06-23	Methods of using therapeutic fibrinogen compositions
PT615454E (pt)	2001-06-29	Processo de preparacao de uma cola biologica enriquecida com factores plaquetarios e aplicacao
SK294292A3 (en)	1994-06-08	Tissue adhesive and method of its production
JP4932082B2 (ja)	2012-05-16	フィブリノーゲンに基づく組織接着剤
US6613324B1 (en)	2003-09-02	Adhesive for the gluing of biological tissues
CN101351220A (zh)	2009-01-21	不含凝血酶的生物粘合剂及其作为药剂的应用
ES2325956T3 (es)	2009-09-25	Farmacos y preparaciones de principios activos farmaceuticas que contienen trombina y que pueden generar trombina.
RS20050051A (sr)	2007-06-04	Farmaceutski aktivni sastojak preparata i medikamenata koji sadrže trombin ili imaju mogućnost stvaranja trombina
AT407834B (de)	2001-06-25	Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung