DK175200B1 - Broforbundne bicycliske imider med en 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butylgruppe knyttet til imidnitrogenatomer og antipsykotisk farmaceutiske præparater indeholdende disse - Google Patents

Broforbundne bicycliske imider med en 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butylgruppe knyttet til imidnitrogenatomer og antipsykotisk farmaceutiske præparater indeholdende disse Download PDF

Info

Publication number
DK175200B1
DK175200B1 DK198904563A DK456389A DK175200B1 DK 175200 B1 DK175200 B1 DK 175200B1 DK 198904563 A DK198904563 A DK 198904563A DK 456389 A DK456389 A DK 456389A DK 175200 B1 DK175200 B1 DK 175200B1
Authority
DK
Denmark
Prior art keywords
piperazinyl
benzisothiazolyl
antipsychotic
formula
bridged bicyclic
Prior art date
Application number
DK198904563A
Other languages
Danish (da)
English (en)
Other versions
DK456389D0 (da
DK456389A (da
Inventor
Gene Michael Bright
Adams Lowe John Iii
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK456389D0 publication Critical patent/DK456389D0/da
Publication of DK456389A publication Critical patent/DK456389A/da
Application granted granted Critical
Publication of DK175200B1 publication Critical patent/DK175200B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK198904563A 1988-09-16 1989-09-15 Broforbundne bicycliske imider med en 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butylgruppe knyttet til imidnitrogenatomer og antipsykotisk farmaceutiske præparater indeholdende disse DK175200B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1988/003230 WO1990002552A1 (en) 1988-09-16 1988-09-16 Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides
US8803230 1988-09-16

Publications (3)

Publication Number Publication Date
DK456389D0 DK456389D0 (da) 1989-09-15
DK456389A DK456389A (da) 1990-03-17
DK175200B1 true DK175200B1 (da) 2004-07-05

Family

ID=22208913

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198904563A DK175200B1 (da) 1988-09-16 1989-09-15 Broforbundne bicycliske imider med en 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butylgruppe knyttet til imidnitrogenatomer og antipsykotisk farmaceutiske præparater indeholdende disse

Country Status (20)

Country Link
US (1) US5077295A (de)
EP (1) EP0364091B1 (de)
JP (1) JPH0631231B2 (de)
KR (1) KR930002568B1 (de)
AT (1) ATE92063T1 (de)
AU (1) AU607354B2 (de)
CA (1) CA1339314C (de)
DE (1) DE68907845T2 (de)
DK (1) DK175200B1 (de)
ES (1) ES2058542T3 (de)
FI (1) FI911285A0 (de)
HU (1) HUT61760A (de)
IE (1) IE61413B1 (de)
IL (1) IL91552A (de)
MY (1) MY104207A (de)
NO (1) NO911042L (de)
NZ (1) NZ230672A (de)
PT (1) PT91703B (de)
WO (1) WO1990002552A1 (de)
ZA (1) ZA897049B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235283A (en) * 1991-02-07 1993-08-10 Siemens Aktiengesellschaft Gradient coil system for a nuclear magnetic resonance tomography apparatus which reduces acoustic noise
DK0790236T3 (da) * 1996-02-13 2004-02-23 Pfizer Prolægemidler af 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chlor-1,3-dihydro-2H-indol-2-on
US6084097A (en) * 1997-10-20 2000-07-04 Council Of Scientific & Industrial Research Methods for preparing 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl] propanes
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4507303A (en) * 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4423049A (en) * 1981-12-28 1983-12-27 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
JPS5995267A (ja) * 1982-11-25 1984-06-01 Eisai Co Ltd カルボン酸イミド誘導体およびその製造方法
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4562255A (en) * 1984-03-30 1985-12-31 American Home Products Corporation Substituted bi-alicyclic imides
US4585773A (en) * 1984-07-11 1986-04-29 Bristol-Myers Company Isoindolinyl-alkyl-piperazines
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
US4656173A (en) * 1985-04-24 1987-04-07 Bristol-Myers Company Antipsychotic benzisothiazole S-oxide compound
NL8601494A (nl) * 1985-06-22 1987-01-16 Sandoz Ag Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten.
US4732984A (en) * 1985-10-17 1988-03-22 American Home Products Corporation Piperazinoisothiazolones with psychotropic activity
JPS6310786A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd 新規イミド誘導体およびその製造法
JPS6310760A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd イミド誘導体の新規製造法
DD263531A5 (de) * 1986-10-21 1989-01-04 ������@���Kk�� Verfahren zur herstellung von verbrueckten bicyclischen imidverbindungen
US4748240A (en) * 1987-04-03 1988-05-31 American Home Products Corporation Psychotropic bicyclic imides
US4883795A (en) * 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds
JPH0310760A (ja) * 1989-06-09 1991-01-18 Nippon Spindle Mfg Co Ltd 結晶質脆性材料切断用ワイヤソー

Also Published As

Publication number Publication date
PT91703A (pt) 1990-03-30
IL91552A0 (en) 1990-04-29
FI911285A7 (fi) 1991-03-15
KR930002568B1 (ko) 1993-04-03
IE61413B1 (en) 1994-11-02
MY104207A (en) 1994-02-28
CA1339314C (en) 1997-08-19
WO1990002552A1 (en) 1990-03-22
AU607354B2 (en) 1991-02-28
KR900004730A (ko) 1990-04-12
IE892949L (en) 1990-03-16
EP0364091A1 (de) 1990-04-18
NO911042L (no) 1991-05-15
PT91703B (pt) 1995-07-18
FI911285A0 (fi) 1991-03-15
HUT61760A (en) 1993-03-01
JPH02121986A (ja) 1990-05-09
ES2058542T3 (es) 1994-11-01
DK456389D0 (da) 1989-09-15
US5077295A (en) 1991-12-31
NZ230672A (en) 1990-12-21
DK456389A (da) 1990-03-17
ZA897049B (en) 1991-04-24
DE68907845D1 (de) 1993-09-02
ATE92063T1 (de) 1993-08-15
AU4150689A (en) 1990-03-22
EP0364091B1 (de) 1993-07-28
IL91552A (en) 1994-02-27
JPH0631231B2 (ja) 1994-04-27
DE68907845T2 (de) 1993-11-11
NO911042D0 (no) 1991-03-15

Similar Documents

Publication Publication Date Title
US4748182A (en) Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents
KR0123441B1 (ko) 아릴 피페라지닐-헤테로사이클릭 화합물의 제조방법
DK163304B (da) Glutarimidderivat, fremgangsmaade til dets fremstilling og dets anvendelse som angstdaempende og antihypertensivt middel
DK160939B (da) Analogifremgangsmaade til fremstilling af benzisothiazol- og benzisoxazolpiperazinderivater, samt mellemprodukter til anvendelse ved fremgangsmaaden
HU214032B (en) Process for producing benzoisothiazole and benzoisoxazole-3-carboxamide derivatives and pharmaceutical compositions comprising such compounds as active ingredient
HU206709B (en) Process for producing new 3-/4-/1-substituted-4-piperazinyl/-butyl/-4-thiazolidinone derivatives and pharmaceutical compositions containing them
JPH01249769A (ja) 向精神性ヘテロビシクロアルキルピペラジン誘導体
DK148688B (da) Analogifremgangsmaade til fremstilling af basisk substituerede 7-alkylteofyllinderivater eller salte deraf med farmaceutisk acceptable syrer
US5059601A (en) Imidazolone derivatives with activity on central nervous system and antihypertensive activity, preparation methods thereof, and pharmaceutical compositions containing them
KR900000371B1 (ko) 피페라지노이소티아졸론 및 이의 제조방법
AU665172B2 (en) 1,4-disubstituted piperazines
CA1327575C (en) 1,4-benzoxazine and 1,4-benzothiazine derivatives and process for their preparation
DK166584B1 (da) Substituerede 4-benzyl-1h-imidazoler, fremgangsmaade til deres fremstilling samt farmaceutiske praeparater indeholdende dem
AU642570B2 (en) New benzisoxazole and benzisothiazole compounds, process for the preparation thereof, and pharmaceutical compositions containing them
CA1079277A (en) 10(.omega.-(BENZOYLPIPERIDINYL)ALKYL) PHENOTHIAZINES
DK170441B1 (da) Diazinylpiperidinderivater af cykliske amider og imider, samt fremgangsmåde til fremstilling deraf
NO309477B1 (no) Nye heterocykliske aminometylforbindelser, fremgangsmåte ved fremstilling av dem og farmasöytiske sammensetninger som inneholder dem
DK165745B (da) Pyridinylpiperazinderivater med kondenseret ringsystem, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende forbindelserne.
JPS58128384A (ja) ベンゾジオキシン化合物、その製造方法、および精神作用障害治療用医薬組成物
DK149947B (da) Analogifremgangsmaade til fremstilling af 1,5-diphenylpyrazolin-3-on-forbindelser eller syreadditionssalte deraf
KR930002568B1 (ko) 정신병 치료제인 4-[4-(3-벤즈이소티아졸릴)-1-피페라지닐]부틸 가교 결합된 이환상 이미드
DK156059B (da) Analogifremgangsmaade til fremstilling af guanidinderivater
EP0375536B1 (de) 1,7'-[Imidazo-[1,2-a]pyridin]5'-(6'H)one-Derivate und Verfahren zu deren Herstellung
NO177962B (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 1-oxa-2-oxo-8-azaspiro[4,5Ådecan-derivater
JPH0357903B2 (de)

Legal Events

Date Code Title Description
PBP Patent lapsed

Country of ref document: DK