DK1847524T3 - Terphenylderivater til behandling af Alzheimers sygdom - Google Patents

Terphenylderivater til behandling af Alzheimers sygdom

Info

Publication number: DK1847524T3
Authority: DK; Denmark
Prior art keywords: alzheimer; disease; treatment; terphenyl derivatives; terphenyl
Prior art date: 2006-04-21

Application number

DK06112934T

Other languages

Danish (da)

English (en)

Inventor

Francis Wilson

Alison Reid

Valerie Reader

Richard John Harrison

Mihiro Sunose

Jeremy Major

Cyrille Boussard

Kathryn Smelt

Adeline Leformal

Svenja Burckhardt

Remedios Hernadez-Perni

Andrew Cansfield

Jess Taylor

Original Assignee

Cellzome Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-21

Filing date

2006-04-21

Publication date

2010-01-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36293499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1847524(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-04-21 Application filed by Cellzome Ltd filed Critical Cellzome Ltd

2010-01-11 Application granted granted Critical

2010-01-11 Publication of DK1847524T3 publication Critical patent/DK1847524T3/da

Links

YJTKZCDBKVTVBY-UHFFFAOYSA-N 1,3-Diphenylbenzene Chemical group C1=CC=CC=C1C1=CC=CC(C=2C=CC=CC=2)=C1 YJTKZCDBKVTVBY-UHFFFAOYSA-N 0.000 title 1
208000024827 Alzheimer disease Diseases 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/33—Polycyclic acids
- C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK06112934T 2006-04-21 2006-04-21 Terphenylderivater til behandling af Alzheimers sygdom DK1847524T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06112934A EP1847524B1 (en)	2006-04-21	2006-04-21	Terphenyl derivatives for treatment of Alzheimer's disease

Publications (1)

Publication Number	Publication Date
DK1847524T3 true DK1847524T3 (da)	2010-01-11

Family

ID=36293499

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06112934T DK1847524T3 (da)	2006-04-21	2006-04-21	Terphenylderivater til behandling af Alzheimers sygdom

Country Status (34)

Country	Link
US (1)	US8106236B2 (pt)
EP (2)	EP1847524B1 (pt)
JP (1)	JP5422827B2 (pt)
KR (1)	KR101494906B1 (pt)
CN (1)	CN101484410B (pt)
AR (1)	AR060621A1 (pt)
AT (1)	ATE445586T1 (pt)
AU (1)	AU2007240382B2 (pt)
BR (1)	BRPI0710632A2 (pt)
CA (1)	CA2649845C (pt)
CR (2)	CR10376A (pt)
CY (1)	CY1109729T1 (pt)
DE (1)	DE602006009764D1 (pt)
DK (1)	DK1847524T3 (pt)
EA (1)	EA016908B1 (pt)
ES (2)	ES2333539T3 (pt)
GE (1)	GEP20115211B (pt)
IL (2)	IL194853A0 (pt)
MA (1)	MA30420B1 (pt)
MX (1)	MX2008013447A (pt)
MY (1)	MY148988A (pt)
NO (1)	NO20084516L (pt)
NZ (1)	NZ572999A (pt)
PE (1)	PE20080267A1 (pt)
PL (1)	PL1847524T3 (pt)
PT (1)	PT1847524E (pt)
SI (1)	SI1847524T1 (pt)
SM (1)	SMP200800062B (pt)
TN (1)	TNSN08414A1 (pt)
TW (1)	TWI435720B (pt)
UA (1)	UA95766C2 (pt)
UY (1)	UY30300A1 (pt)
WO (1)	WO2007124351A1 (pt)
ZA (1)	ZA200809857B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2333539T3 (es)	2006-04-21	2010-02-23	Cellzome Limited	Derivados de terfenilo para el tratamiento de la enfermedad de alzheimer.
WO2009052126A1 (en)	2007-10-19	2009-04-23	Janssen Pharmaceutica, N.V.	PIPERIDINYL AND PIPERAZINYL MODULATORS OF γ-SECRETASE
KR101618068B1 (ko)	2007-10-19	2016-05-04	얀센 파마슈티카 엔.브이.	γ-세크레타아제의 탄소 결합된 조절제
CN101903334A (zh) *	2007-10-19	2010-12-01	詹森药业有限公司	Gsm中间体
CN101903335A (zh)	2007-10-19	2010-12-01	詹森药业有限公司	连接有胺的γ-分泌酶调节剂
US20110092554A1 (en) *	2007-11-19	2011-04-21	Richard Chesworth	1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
AU2008335709A1 (en) *	2007-12-13	2009-06-18	Amgen Inc.	Gamma secretase modulators
WO2009086277A1 (en)	2007-12-20	2009-07-09	Envivo Pharmaceuticals, Inc.	Tetrasubstituted benzenes
CA2718241A1 (en) *	2008-03-11	2009-09-17	Neurosearch A/S	Novel triaryl derivatives useful as modulators of nicotinic acetylcholine receptors
US7968725B2 (en) *	2008-07-22	2011-06-28	Janssen Pharmaceutica N.V.	Pyridinyl modulators of γ-secretase
AU2012222832B2 (en) *	2011-03-03	2017-03-30	Denovamed Inc.	Antimicrobial/adjuvant compounds and methods
CN103012200B (zh) *	2011-09-20	2014-12-17	北京大学	具有β-分泌酶抑制功能的化合物及其制备方法与应用
WO2015109109A1 (en)	2014-01-15	2015-07-23	Forum Pharmaceuticals Inc.	Fused morpholinopyrimidines and methods of use thereof
WO2016201168A1 (en)	2015-06-10	2016-12-15	Forum Pharmceuticals Inc.	Oxadiazine compounds and methods of use thereof
WO2020232256A1 (en)	2019-05-15	2020-11-19	Chemocentryx, Inc.	Triaryl compounds for treatment of pd-l1 diseases
EP4253396A4 (en) *	2020-11-27	2024-09-11	Mirailab Bioscience Inc.	HIGH PURITY BETA-NICOTINAMIDE MONONUCLEOTIDE (NMN) AND PROCESS FOR ITS PRODUCTION

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH08325182A (ja) *	1995-05-31	1996-12-10	Fuji Yakuhin Kogyo Kk	置換テルフェニル誘導体とそれらを含有する抗血栓剤
FR2767525B1 (fr) *	1997-08-21	1999-11-12	Cird Galderma	Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
AU4537400A (en)	1999-05-12	2000-12-05	Neurosearch A/S	Ion channel modulating agents
JP2003530437A (ja)	2000-04-13	2003-10-14	マヨファウンデーションフォーメディカルエデュケーションアンドリサーチ	Ａβ４２低下物質
WO2001081312A2 (en)	2000-04-24	2001-11-01	Merck Frosst Canada & Co.	Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore
EP1366113B1 (en) *	2001-02-20	2011-04-13	Isis Innovation Limited	Metal-containing dendrimers
FR2838439B1 (fr) *	2002-04-11	2005-05-20	Sanofi Synthelabo	Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
WO2004052921A1 (en) *	2002-12-05	2004-06-24	Axys Pharmaceuticals, Inc.	Cyanomethyl derivatives as cysteine protease inhibitors
GB0305918D0 (en)	2003-03-14	2003-04-23	Glaxo Group Ltd	Novel compounds
CA2523336A1 (en) *	2003-04-30	2004-11-11	Merck Frosst Canada Ltd.	8-(3-biaryl)phenylquinoline phosphodiesterase-4-inhibitors
WO2005110963A1 (en) *	2004-05-19	2005-11-24	Cellzome Ag	(biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en)	2004-07-23	2004-08-25	Merck Sharp & Dohme	Therapeutic agents
MX2008002014A (es) *	2005-08-15	2008-03-27	Hoffmann La Roche	Derivados de piperidina y piperazina como antagonistas de p2x3.
EP1937632A1 (en)	2005-10-06	2008-07-02	Astra Zeneca AB	Novel compounds
ES2333539T3 (es)	2006-04-21	2010-02-23	Cellzome Limited	Derivados de terfenilo para el tratamiento de la enfermedad de alzheimer.

2006
- 2006-04-21 ES ES06112934T patent/ES2333539T3/es not_active Expired - Lifetime
- 2006-04-21 DK DK06112934T patent/DK1847524T3/da active
- 2006-04-21 EP EP06112934A patent/EP1847524B1/en not_active Expired - Lifetime
- 2006-04-21 SI SI200630509T patent/SI1847524T1/sl unknown
- 2006-04-21 DE DE602006009764T patent/DE602006009764D1/de not_active Expired - Lifetime
- 2006-04-21 PL PL06112934T patent/PL1847524T3/pl unknown
- 2006-04-21 PT PT06112934T patent/PT1847524E/pt unknown
- 2006-04-21 AT AT06112934T patent/ATE445586T1/de active
2007
- 2007-04-19 US US11/737,475 patent/US8106236B2/en not_active Expired - Fee Related
- 2007-04-19 GE GEAP200710984A patent/GEP20115211B/en unknown
- 2007-04-19 WO PCT/US2007/066951 patent/WO2007124351A1/en not_active Ceased
- 2007-04-19 SM SM200800062T patent/SMP200800062B/it unknown
- 2007-04-19 CA CA2649845A patent/CA2649845C/en not_active Expired - Fee Related
- 2007-04-19 EP EP07760900A patent/EP2016039B1/en active Active
- 2007-04-19 ES ES07760900T patent/ES2392352T3/es active Active
- 2007-04-19 UA UAA200813475A patent/UA95766C2/ru unknown
- 2007-04-19 EA EA200802173A patent/EA016908B1/ru not_active IP Right Cessation
- 2007-04-19 JP JP2009506772A patent/JP5422827B2/ja not_active Expired - Fee Related
- 2007-04-19 MY MYPI20084202A patent/MY148988A/en unknown
- 2007-04-19 CN CN2007800184982A patent/CN101484410B/zh not_active Expired - Fee Related
- 2007-04-19 MX MX2008013447A patent/MX2008013447A/es active IP Right Grant
- 2007-04-19 BR BRPI0710632-7A patent/BRPI0710632A2/pt not_active IP Right Cessation
- 2007-04-19 AU AU2007240382A patent/AU2007240382B2/en not_active Ceased
- 2007-04-19 KR KR1020087028470A patent/KR101494906B1/ko not_active Expired - Fee Related
- 2007-04-19 NZ NZ572999A patent/NZ572999A/en not_active IP Right Cessation
- 2007-04-20 TW TW096114164A patent/TWI435720B/zh not_active IP Right Cessation
- 2007-04-20 PE PE2007000497A patent/PE20080267A1/es not_active Application Discontinuation
- 2007-04-20 UY UY30300A patent/UY30300A1/es unknown
- 2007-04-20 AR ARP070101724A patent/AR060621A1/es not_active Application Discontinuation
2008
- 2008-10-17 TN TNP2008000414A patent/TNSN08414A1/en unknown
- 2008-10-17 CR CR10376A patent/CR10376A/es not_active Application Discontinuation
- 2008-10-22 IL IL194853A patent/IL194853A0/en unknown
- 2008-10-22 IL IL194789A patent/IL194789A0/en not_active IP Right Cessation
- 2008-10-27 NO NO20084516A patent/NO20084516L/no not_active Application Discontinuation
- 2008-11-19 ZA ZA200809857A patent/ZA200809857B/xx unknown
- 2008-11-20 MA MA31394A patent/MA30420B1/fr unknown
- 2008-11-21 CR CR10452A patent/CR10452A/es unknown
2010
- 2010-01-14 CY CY20101100039T patent/CY1109729T1/el unknown

Also Published As

Publication number	Publication date
ES2392352T3 (es)	2012-12-10
EA200802173A1 (ru)	2009-06-30
TNSN08414A1 (en)	2010-04-14
ES2333539T3 (es)	2010-02-23
ZA200809857B (en)	2009-08-26
JP2009538275A (ja)	2009-11-05
UY30300A1 (es)	2007-08-31
PE20080267A1 (es)	2008-05-16
PL1847524T3 (pl)	2010-03-31
CR10452A (es)	2009-02-23
TW200810746A (en)	2008-03-01
KR20090024678A (ko)	2009-03-09
MY148988A (en)	2013-06-28
NO20084516L (no)	2009-01-13
MA30420B1 (fr)	2009-05-04
CN101484410B (zh)	2013-08-21
US20070254957A1 (en)	2007-11-01
CR10376A (es)	2009-02-26
UA95766C2 (ru)	2011-08-25
KR101494906B1 (ko)	2015-02-24
JP5422827B2 (ja)	2014-02-19
IL194853A0 (en)	2009-08-03
SMP200800062B (it)	2009-07-14
AR060621A1 (es)	2008-07-02
US8106236B2 (en)	2012-01-31
BRPI0710632A2 (pt)	2011-08-23
NZ572999A (en)	2012-06-29
EP2016039B1 (en)	2012-08-01
EP2016039A1 (en)	2009-01-21
HK1134923A1 (en)	2010-05-20
SMAP200800062A (it)	2008-11-19
AU2007240382A1 (en)	2007-11-01
CA2649845A1 (en)	2007-11-01
WO2007124351A1 (en)	2007-11-01
ATE445586T1 (de)	2009-10-15
MX2008013447A (es)	2009-03-10
IL194789A0 (en)	2009-08-03
CA2649845C (en)	2014-09-16
SI1847524T1 (sl)	2010-01-29
EA016908B1 (ru)	2012-08-30
CY1109729T1 (el)	2014-09-10
CN101484410A (zh)	2009-07-15
PT1847524E (pt)	2009-12-18
EP1847524A1 (en)	2007-10-24
AU2007240382B2 (en)	2013-05-02
TWI435720B (zh)	2014-05-01
EP1847524B1 (en)	2009-10-14
DE602006009764D1 (de)	2009-11-26
GEP20115211B (en)	2011-04-26

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