DK2225231T3 - Aminotriazolderivater som alx-agonister - Google Patents

Aminotriazolderivater som alx-agonister

Info

Publication number: DK2225231T3
Authority: DK; Denmark
Prior art keywords: aminotriazole derivatives; alx; agonists; alx agonists; aminotriazole
Prior art date: 2007-12-18

Application number

DK08862134.7T

Other languages

English (en)

Inventor

Daniel Bur

Olivier Corminboeuf

Sylvaine Cren

Corinna Grisostomi

Xavier Leroy

Sylvia Richard-Bildstein

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-18

Filing date

2008-12-17

Publication date

2011-10-17

2008-12-17 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2011-10-17 Application granted granted Critical

2011-10-17 Publication of DK2225231T3 publication Critical patent/DK2225231T3/da

Links

JSIAIROWMJGMQZ-UHFFFAOYSA-N 2h-triazol-4-amine Chemical class NC1=CNN=N1 JSIAIROWMJGMQZ-UHFFFAOYSA-N 0.000 title 1
239000000556 agonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK08862134.7T 2007-12-18 2008-12-17 Aminotriazolderivater som alx-agonister DK2225231T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IB2007055199		2007-12-18
IB2008054369		2008-10-23
PCT/IB2008/055375 WO2009077990A1 (en)	2007-12-18	2008-12-17	Aminotriazole derivatives as alx agonists

Publications (1)

Publication Number	Publication Date
DK2225231T3 true DK2225231T3 (da)	2011-10-17

Family

ID=40404773

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08862134.7T DK2225231T3 (da)	2007-12-18	2008-12-17	Aminotriazolderivater som alx-agonister

Country Status (25)

Country	Link
US (1)	US8536209B2 (da)
EP (1)	EP2225231B1 (da)
JP (1)	JP4656674B2 (da)
KR (1)	KR101213007B1 (da)
CN (1)	CN101903378B (da)
AR (1)	AR069801A1 (da)
AT (1)	ATE520689T1 (da)
AU (1)	AU2008337097B2 (da)
BR (1)	BRPI0821115A8 (da)
CA (1)	CA2706839C (da)
CY (1)	CY1112465T1 (da)
DK (1)	DK2225231T3 (da)
HR (1)	HRP20110825T1 (da)
IL (1)	IL206399A (da)
MA (1)	MA31949B1 (da)
MX (1)	MX2010006241A (da)
MY (1)	MY153985A (da)
NZ (1)	NZ586735A (da)
PL (1)	PL2225231T3 (da)
PT (1)	PT2225231E (da)
RU (1)	RU2492167C2 (da)
SI (1)	SI2225231T1 (da)
TW (1)	TWI434685B (da)
WO (1)	WO2009077990A1 (da)
ZA (1)	ZA201005080B (da)

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AR069650A1 (es)	2007-12-14	2010-02-10	Actelion Pharmaceuticals Ltd	Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano
KR101724765B1 (ko) *	2009-05-18	2017-04-07	액테리온 파마슈티칼 리미티드	Ａｌｘ 수용체 및/또는 ｆｐｒｌ2 아고니스트로서의 브릿지 스피로［2.4］헵탄 유도체
JP5095035B2 (ja) *	2009-06-09	2012-12-12	アクテリオンファーマシューティカルズリミテッド	フッ素化アミノトリアゾール誘導体
US8674111B2 (en)	2009-06-12	2014-03-18	Actelion Pharmaceuticals Ltd.	Oxazole and thiazole derivatives as ALX receptor agonists
CA2814826C (en)	2010-11-17	2019-02-12	Actelion Pharmaceuticals Ltd	Bridged spiro[2.4]heptane ester derivatives
KR101847672B1 (ko)	2010-12-07	2018-04-10	이도르시아 파마슈티컬스 리미티드	Alx 수용체 작용제로서의 히드록실화 아미노트리아졸 유도체
CA2816376C (en)	2010-12-07	2018-11-20	Actelion Pharmaceuticals Ltd	Oxazolyl-methylether derivatives as alx receptor agonists
BR112013028895A2 (pt)	2011-05-10	2016-08-09	Bayer Ip Gmbh	(tio)carbonilamidinas bicíclicas
WO2013022766A1 (en) *	2011-08-05	2013-02-14	Flynn Gary A	Preparation and methods of use for ortho-aryl 5- membered heteroaryl-carboxamide containing multi-targeted kinase inhibitors
CN102558117B (zh) *	2011-12-15	2014-10-08	北京金骄生物质化工有限公司	一种利用废弃生物质制备5-硝基-2-糠酸酯的方法
MA37618B1 (fr)	2012-05-16	2017-08-31	Actelion Pharmaceuticals Ltd	Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
WO2013171687A1 (en)	2012-05-16	2013-11-21	Actelion Pharmaceuticals Ltd	1-(p-tolyl)cyclopropyl substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists
TWI570120B (zh)	2012-06-04	2017-02-11	艾克泰聯製藥有限公司	苯并咪唑脯胺酸衍生物
AU2013328301A1 (en)	2012-10-10	2015-05-28	Actelion Pharmaceuticals Ltd	Orexin receptor antagonists which are [ortho bi (hetero-)aryl]-[2-(meta bi (hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives
KR20150090249A (ko) *	2012-12-03	2015-08-05	에프. 호프만-라 로슈 아게	치환된 트라이아졸 및 이미다졸 화합물
CN105051040A (zh)	2013-03-12	2015-11-11	埃科特莱茵药品有限公司	作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物
AR096686A1 (es)	2013-06-25	2016-01-27	Actelion Pharmaceuticals Ltd	Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx
ES2639798T3 (es)	2013-07-18	2017-10-30	Idorsia Pharmaceuticals Ltd	Derivados de espiro[2.4]heptano con puente sustituidos con piperazina como agonistas del receptor ALX
AR097279A1 (es)	2013-08-09	2016-03-02	Actelion Pharmaceuticals Ltd	Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
NZ752095A (en)	2013-11-28	2022-07-01	Kyorin Seiyaku Kk	Urea derivative or pharmacologically acceptable salt thereof
KR102330133B1 (ko)	2013-12-04	2021-11-23	이도르시아 파마슈티컬스 리미티드	벤즈이미다졸-프롤린 유도체의 용도
US10858314B2 (en)	2015-05-27	2020-12-08	Kyorin Pharmaceutical Co., Ltd.	Urea derivative or pharmacologically acceptable salt thereof
US10525058B2 (en)	2015-05-27	2020-01-07	Kyorin Pharmaceutical Co., Ltd	Urea derivative or pharmacologically acceptable salt thereof
JP2018538367A (ja) *	2015-11-24	2018-12-27	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	ホルミルペプチド受容体２／リポキシンａ４受容体（ｆｐｒ２／ａｌｘ）の心臓疾患を治療するための標的設定
SG11202008504SA (en)	2018-03-05	2020-10-29	Bristol Myers Squibb Co	Phenylpyrrolidinone formyl peptide 2 receptor agonists
US11629143B2 (en)	2020-10-01	2023-04-18	Vibliome Therapeutics, Llc	HipK4 inhibitors and uses thereof
JP7743010B2 (ja) *	2021-03-12	2025-09-24	国立大学法人長崎大学	ハロカルボニル化合物の製造方法

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JPS62234018A (ja)	1986-04-02	1987-10-14	Rooto Seiyaku Kk	糖尿病併発症治療剤
AU2002359311A1 (en)	2001-10-26	2003-05-06	Government Of The United States Of America, As Represented By The Secretary, Department Of Health An	Amyloid ss is a ligand for fpr class receptors
EP1492552A2 (en)	2002-04-03	2005-01-05	Bayer Aktiengesellschaft	Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1)
EP1692502A2 (en)	2003-11-07	2006-08-23	Acadia Pharmaceuticals Inc.	Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation
AU2005247473A1 (en) *	2004-05-25	2005-12-08	Metabolex, Inc.	Substituted triazoles as modulators of PPAR and methods of their preparation
CN101115728B (zh) *	2004-12-13	2012-12-19	利奥制药有限公司	三唑取代的氨基二苯甲酮化合物
US8026260B2 (en) *	2005-11-03	2011-09-27	Merck Sharp & Dohme Corp.	Histone deacetylase inhibitors with aryl-pyrazolyl-motifs
CA2651072A1 (en) *	2006-05-01	2007-11-08	Pfizer Products Inc.	Substituted 2-amino-fused heterocyclic compounds
ES2545121T3 (es)	2007-08-21	2015-09-08	Senomyx, Inc.	Compuestos que inhiben (bloquean) el sabor amargo en composiciones, y uso de los mismos
AR069650A1 (es)	2007-12-14	2010-02-10	Actelion Pharmaceuticals Ltd	Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano
KR101724765B1 (ko)	2009-05-18	2017-04-07	액테리온 파마슈티칼 리미티드	Ａｌｘ 수용체 및/또는 ｆｐｒｌ2 아고니스트로서의 브릿지 스피로［2.4］헵탄 유도체
JP5095035B2 (ja)	2009-06-09	2012-12-12	アクテリオンファーマシューティカルズリミテッド	フッ素化アミノトリアゾール誘導体
US8674111B2 (en)	2009-06-12	2014-03-18	Actelion Pharmaceuticals Ltd.	Oxazole and thiazole derivatives as ALX receptor agonists

2008
- 2008-12-17 DK DK08862134.7T patent/DK2225231T3/da active
- 2008-12-17 US US12/809,545 patent/US8536209B2/en not_active Expired - Fee Related
- 2008-12-17 MX MX2010006241A patent/MX2010006241A/es active IP Right Grant
- 2008-12-17 KR KR1020107015871A patent/KR101213007B1/ko not_active Expired - Fee Related
- 2008-12-17 EP EP08862134A patent/EP2225231B1/en not_active Not-in-force
- 2008-12-17 SI SI200830412T patent/SI2225231T1/sl unknown
- 2008-12-17 CN CN200880122188.XA patent/CN101903378B/zh not_active Expired - Fee Related
- 2008-12-17 RU RU2010129272/04A patent/RU2492167C2/ru not_active IP Right Cessation
- 2008-12-17 MY MYPI2010002834A patent/MY153985A/en unknown
- 2008-12-17 HR HR20110825T patent/HRP20110825T1/hr unknown
- 2008-12-17 TW TW097149199A patent/TWI434685B/zh not_active IP Right Cessation
- 2008-12-17 BR BRPI0821115A patent/BRPI0821115A8/pt not_active IP Right Cessation
- 2008-12-17 JP JP2010539015A patent/JP4656674B2/ja not_active Expired - Fee Related
- 2008-12-17 PL PL08862134T patent/PL2225231T3/pl unknown
- 2008-12-17 AU AU2008337097A patent/AU2008337097B2/en not_active Ceased
- 2008-12-17 CA CA2706839A patent/CA2706839C/en not_active Expired - Fee Related
- 2008-12-17 NZ NZ586735A patent/NZ586735A/en not_active IP Right Cessation
- 2008-12-17 WO PCT/IB2008/055375 patent/WO2009077990A1/en not_active Ceased
- 2008-12-17 PT PT08862134T patent/PT2225231E/pt unknown
- 2008-12-17 AT AT08862134T patent/ATE520689T1/de active
- 2008-12-18 AR ARP080105522A patent/AR069801A1/es not_active Application Discontinuation
2010
- 2010-06-16 IL IL206399A patent/IL206399A/en not_active IP Right Cessation
- 2010-06-29 MA MA32968A patent/MA31949B1/fr unknown
- 2010-07-16 ZA ZA2010/05080A patent/ZA201005080B/en unknown
2011
- 2011-11-17 CY CY20111101111T patent/CY1112465T1/el unknown

Also Published As

Publication number	Publication date
CN101903378B (zh)	2014-03-12
HRP20110825T1 (hr)	2011-12-31
TWI434685B (zh)	2014-04-21
HK1144158A1 (en)	2011-01-28
JP2011506594A (ja)	2011-03-03
KR101213007B1 (ko)	2012-12-20
ZA201005080B (en)	2011-12-28
PT2225231E (pt)	2011-10-19
US8536209B2 (en)	2013-09-17
MX2010006241A (es)	2010-06-30
IL206399A0 (en)	2010-12-30
EP2225231A1 (en)	2010-09-08
JP4656674B2 (ja)	2011-03-23
BRPI0821115A2 (pt)	2015-06-16
MA31949B1 (fr)	2010-12-01
TW200932216A (en)	2009-08-01
AU2008337097A1 (en)	2009-06-25
RU2492167C2 (ru)	2013-09-10
US20100331378A1 (en)	2010-12-30
CN101903378A (zh)	2010-12-01
IL206399A (en)	2016-03-31
PL2225231T3 (pl)	2012-01-31
NZ586735A (en)	2012-06-29
RU2010129272A (ru)	2012-01-27
CY1112465T1 (el)	2015-12-09
KR20100092516A (ko)	2010-08-20
AU2008337097B2 (en)	2014-03-20
WO2009077990A1 (en)	2009-06-25
BRPI0821115A8 (pt)	2017-12-26
EP2225231B1 (en)	2011-08-17
CA2706839C (en)	2015-10-20
CA2706839A1 (en)	2009-06-25
ATE520689T1 (de)	2011-09-15
AR069801A1 (es)	2010-02-17
SI2225231T1 (sl)	2011-12-30
MY153985A (en)	2015-04-30

Publication	Publication Date	Title
ATE520689T1 (de)	2011-09-15	Aminotriazolderivate als alx-agonisten
DK2125792T3 (da)	2011-03-07	Purinderivater som immunomodulatorer
DK2220070T3 (da)	2011-07-04	2-benzylpyridazinonderivater som Met-kinaseinhibitorer
DK2139892T3 (da)	2011-12-12	Substituerede pyrimidodiazepiner nyttige som PLK1-inhibitorer
DK2164844T3 (da)	2012-08-20	Pyrimidinyl-pyridazinonderivater
DK2209786T3 (da)	2013-06-03	Pyrimidinsubstituerede purinderivater
BRPI0813836A2 (pt)	2015-01-06	Derivados pirazólicos
PL2134685T3 (pl)	2016-02-29	Pochodne indolu niepodstawione w pozycji 7 jako inhibitory Mcl-1
BRPI0820112A2 (pt)	2015-05-05	Derivados de isoxazol-piridina
BRPI0809992A2 (pt)	2014-10-14	Derivados de pirrolopirimidina
BRPI0820113A2 (pt)	2015-05-05	Derivados de isoxazolo-piridazina
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