DK2364996T3 - Optimerede Fc-varianter og fremgangsmåder til dannelse deraf - Google Patents

Optimerede Fc-varianter og fremgangsmåder til dannelse deraf Download PDF

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Publication number
DK2364996T3
DK2364996T3 DK10184742.4T DK10184742T DK2364996T3 DK 2364996 T3 DK2364996 T3 DK 2364996T3 DK 10184742 T DK10184742 T DK 10184742T DK 2364996 T3 DK2364996 T3 DK 2364996T3
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Denmark
Prior art keywords
antibody
protein
variants
antibodies
sequence
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DK10184742.4T
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English (en)
Inventor
Gregory Alan Lazar
Arthur J Chirino
Wei Dang
Stephen Kohn Doberstein
Robert J Hayes
Sher Basudur Karki
Omid Vafa
John Rudolph Desjarlais
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Xencor Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32046075&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2364996(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xencor Inc filed Critical Xencor Inc
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Publication of DK2364996T3 publication Critical patent/DK2364996T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Optical Communication System (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Claims (12)

1. Protein, som omfatter en Fc-variant af et stam-lgG-Fc-polypeptid, hvilken Fc-variant omfatter en aminosyresubstitution i Fc-regionen, hvor aminosyresubstitutionen er 243L, og hvor nummereringen er i overensstemmelse med EU-indekset.
2. Protein ifølge krav 1, hvor proteinet er en Fc-fusion.
3. Protein ifølge krav 1, hvor proteinet er et antistof.
4. Protein ifølge krav 3, hvor antistoffet er valgt fra gruppen bestående af et humant antistof, et humaniseret antistof og et monoklonalt antistof.
5. Protein ifølge krav 3 eller 4, hvor antistoffet omfatter en modificeret glycoform.
6. Protein ifølge et hvilket som helst af kravene 2 til 5, hvor proteinet har specificitet for et målantigen valgt fra gruppen bestående af CD19, CD20, CD22, CD30, CD32, CD33, CD38, CD40, CD40L, CD52, Her2/neu, EGFR, EpCAM, MUC1, GD3, CEA, CA 125, HLA-DR, TNF-alfa, MUC18, prostataspecifikt membranantigen (PSMA) og VEGF.
7. Protein ifølge krav 1, hvor proteinet er en Fc-fusion eller et antistof med specificitet for et målantigen valgt blandt CD32 og CD38.
8. Farmaceutisk sammensætning, som omfatter proteinet ifølge et hvilket som helst af kravene 1 til 7, og yderligere omfatter en farmaceutisk acceptabel bærer.
9. Nukleinsyre, som koder for proteinet ifølge et hvilket som helst af kravene 1 til 7.
10. Ekspressionsvektor, som omfatter nukleinsyren ifølge krav 9.
11. Værtscelle, som omfatter nukleinsyren ifølge krav 9.
12. Anvendelse af proteinet ifølge et hvilket som helst af kravene 3 til 7 til fremstilling af et lægemiddel til behandling afen antistoffølsom sygdom, hvor den antistoffølsomme sygdom er valgt fra gruppen bestående af en autoimmun sygdom, en immunologisk sygdom, en infektionssygdom, en inflammatorisk sygdom, en neurologisk sygdom, en onkologisk sygdom og en neoplastisk sygdom.
DK10184742.4T 2002-09-27 2003-09-26 Optimerede Fc-varianter og fremgangsmåder til dannelse deraf DK2364996T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41443302P 2002-09-27 2002-09-27
US44230103P 2003-01-23 2003-01-23
US46760603P 2003-05-02 2003-05-02
US47783903P 2003-06-12 2003-06-12
EP08020666A EP2042517B1 (en) 2002-09-27 2003-09-26 Optimized FC variants and methods for their generation

Publications (1)

Publication Number Publication Date
DK2364996T3 true DK2364996T3 (da) 2017-02-06

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ID=32046075

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Application Number Title Priority Date Filing Date
DK10184742.4T DK2364996T3 (da) 2002-09-27 2003-09-26 Optimerede Fc-varianter og fremgangsmåder til dannelse deraf
DK03773056.1T DK1553975T3 (da) 2002-09-27 2003-09-26 Optimerede Fc-varianter og fremgangsmåder til generering heraf.
DK10184682.2T DK2345671T3 (da) 2002-09-27 2003-09-26 Optimerede Fc-varianter og fremgangsmåder til dannelse deraf

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK03773056.1T DK1553975T3 (da) 2002-09-27 2003-09-26 Optimerede Fc-varianter og fremgangsmåder til generering heraf.
DK10184682.2T DK2345671T3 (da) 2002-09-27 2003-09-26 Optimerede Fc-varianter og fremgangsmåder til dannelse deraf

Country Status (13)

Country Link
EP (8) EP1553975B8 (da)
JP (2) JP4580340B2 (da)
KR (2) KR100980065B1 (da)
CN (2) CN101987871A (da)
AT (1) ATE541857T1 (da)
AU (2) AU2003279719B8 (da)
BR (1) BRPI0314814C1 (da)
CA (2) CA2499816C (da)
DK (3) DK2364996T3 (da)
ES (1) ES2562177T3 (da)
IL (2) IL167685A (da)
SI (1) SI2345671T1 (da)
WO (1) WO2004029207A2 (da)

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