DK2805969T3 - Optimerede Fc-varianter - Google Patents

Optimerede Fc-varianter Download PDF

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Publication number
DK2805969T3
DK2805969T3 DK14163605.0T DK14163605T DK2805969T3 DK 2805969 T3 DK2805969 T3 DK 2805969T3 DK 14163605 T DK14163605 T DK 14163605T DK 2805969 T3 DK2805969 T3 DK 2805969T3
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variant
amino acid
variants
region
fcrn
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DK14163605.0T
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English (en)
Inventor
Christian Behrens
Sylvie Jorieux
Abdelhakim Kharrat
Khalil Bouayadi
Philippe Mondon
Céline Monnet-Mars
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Lab Francais Du Fractionnement
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (12)

1. Variant af et moderpolypeptid, der omfatter en Fc-region, hvilken variant fremviser forøget binding til FcRn sammenlignet med moderpolypeptidet og omfatter mindst to aminosyremodifikationer, hvilke mindst to aminosyremodifikationer omfatter: (i) én aminosyremodifikation, som er 434Y, og (ii) mindst én aminosyremodifikation, som er 315D eller 378V, i Fc-regionen, hvor nummereringen af aminosyrerne i Fc-regionen er ifølge EU-indekset som i Rabat.
2. Variant ifølge krav 1, hvilken variant omfatter mindst én kombination af aminosyremodifikationer valgt fra gruppen, der består af 226G/315D/434Y, 230S/315D/434Y, 230T/315D/434Y, 2591/315D/434Y, 307P/378V/434Y, 315D/330V/434Y, 315D/382V/434Y og 378V/383N/434Y, i Fc-regionen sammenlignet med moderpolypeptidet, hvor nummereringen af aminosyrerne i Fc-regionen er ifølge EU-indekset som i Rabat.
3. Variant ifølge krav 2, hvor varianten yderligere omfatter mindst én aminosyremodifikation valgt fra gruppen, der består af 226G, 230S, 230T, 241L, 250A, 256N, 2591, 267R, 290E, 305A, 307P, 307A, 3081, 325S, 327V, 330V, 342R, 361D, 362R, 362E, 378V, 382V, 383N, 386R, 387T, 389T, 389R, 392R, 395A, 397M, 421T, 426T og 428L, i Fc-regionen sammenlignet med moderpolypeptidet, hvor nummereringen af aminosyrerne i Fc-regionen er ifølge EU-indekset som i Rabat.
4. Variant ifølge et hvilket som helst af kravene 1 eller 2, hvor varianten omfatter én kombination af aminosyremodifikationer valgt fra gruppen, der består af 307A/315D/330V/382V/389T/434Y, 256N/378V/383N/434Y, 315D/330V/361D/378V/434Y, 259I/315D/434Y, 230S/315D/428L/434Y, 305A/315D/330V/395A/434Y, 315D/330V/362R/434Y, 305A/315D/330V/389R/434Y, 315D/327V/330V/397M/434Y, 230T/315D/362R/426T/434Y, 226G/315D/330V/434Y, 250A/315D/325S/330V/434Y, 290E/315D/342R/382V/434Y, 241L/315D/33OV/392R/434Y, 230T/315D/362E/434Y, 226G/315D/434Y, 226G/315D/362R/434Y, 308I/315D/330V/382V/434Y, 230T/315D/330V/386K/434Y, 226G/315D/330V/389T/434Y, 267R/307P/378V/421T/434Y og 230S/315D/387T/434Y, i Fc-regionen sammenlignet med moderpolypeptidet, hvor nummereringen af aminosyrerne i Fc-regionen er ifølge EU-indekset som i Rabat
5. Variant ifølge et hvilket som helst af kravene 1 til 4, hvor varianten er et antistof.
6. Variant ifølge krav 5, hvor antistoffet er et IgG-antistof.
7. Farmaceutisk sammensætning, der omfatter en variant ifølge et hvilket som helst af kravene 1 til 6.
8. Isoleret nukleinsyre, der koder for en variant ifølge et hvilket som helst af kravene 1 til 6.
9. Vektor, der omfatter nukleinsyren ifølge krav 8.
10. Værtscelle, der indeholder vektoren ifølge krav 9.
11. Fremgangsmåde til frembringelse af en variant ifølge et hvilket som helst af kravene 1 til 6, som omfatter dyrkning af værtscellen ifølge krav 10, således at nukleinsyren udtrykkes.
12. Variant ifølge et hvilket som helst af kravene 1 til 6 til anvendelse som et medikament.
DK14163605.0T 2009-03-20 2010-03-19 Optimerede Fc-varianter DK2805969T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09305250A EP2233500A1 (en) 2009-03-20 2009-03-20 Optimized Fc variants
EP10709546A EP2408813A2 (en) 2009-03-20 2010-03-19 Optimized fc variants

Publications (1)

Publication Number Publication Date
DK2805969T3 true DK2805969T3 (da) 2019-04-15

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DK20151751.3T DK3674318T3 (da) 2009-03-20 2010-03-19 Optimerede fc-varianter
DK14163605.0T DK2805969T3 (da) 2009-03-20 2010-03-19 Optimerede Fc-varianter

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Country Status (14)

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US (3) USRE46585E1 (da)
EP (6) EP2233500A1 (da)
JP (2) JP5770710B2 (da)
KR (3) KR101781318B1 (da)
CN (2) CN102405231B (da)
AU (1) AU2010224800B2 (da)
BR (2) BRPI1014525B1 (da)
CA (3) CA3069425C (da)
DK (2) DK3674318T3 (da)
ES (2) ES2726625T3 (da)
IL (2) IL215041A (da)
PL (2) PL2805969T3 (da)
TR (1) TR201904385T4 (da)
WO (1) WO2010106180A2 (da)

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US20120009188A1 (en) 2012-01-12
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