DK2996720T3 - Stabile formuleringer af enkelte variable immunoglobulin-domæner og anvendelser deraf - Google Patents

Stabile formuleringer af enkelte variable immunoglobulin-domæner og anvendelser deraf Download PDF

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Publication number
DK2996720T3
DK2996720T3 DK14727433.6T DK14727433T DK2996720T3 DK 2996720 T3 DK2996720 T3 DK 2996720T3 DK 14727433 T DK14727433 T DK 14727433T DK 2996720 T3 DK2996720 T3 DK 2996720T3
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Denmark
Prior art keywords
single variable
immunoglobulin domain
stable formulations
variable immunoglobulin
formulations
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Application number
DK14727433.6T
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English (en)
Inventor
Yves Meyvis
Brabandere Veronique De
Hans Ulrichts
Ann Brige
Filip Callewaert
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Ablynx Nv
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Publication of DK2996720T3 publication Critical patent/DK2996720T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK14727433.6T 2013-05-17 2014-05-16 Stabile formuleringer af enkelte variable immunoglobulin-domæner og anvendelser deraf DK2996720T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361824523P 2013-05-17 2013-05-17
PCT/EP2014/060107 WO2014184352A1 (en) 2013-05-17 2014-05-16 Stable formulations of immunoglobulin single variable domains and uses thereof

Publications (1)

Publication Number Publication Date
DK2996720T3 true DK2996720T3 (da) 2019-06-24

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DK14727433.6T DK2996720T3 (da) 2013-05-17 2014-05-16 Stabile formuleringer af enkelte variable immunoglobulin-domæner og anvendelser deraf

Country Status (25)

Country Link
US (2) US10035862B2 (da)
EP (2) EP3511018B1 (da)
JP (2) JP6433986B2 (da)
KR (1) KR102166399B1 (da)
CN (3) CN110063935B (da)
AU (3) AU2014267222B2 (da)
BR (1) BR112015028411B1 (da)
CA (1) CA2912670A1 (da)
CY (1) CY1122090T1 (da)
DK (1) DK2996720T3 (da)
ES (2) ES2731922T3 (da)
HR (1) HRP20190954T1 (da)
HU (1) HUE044392T2 (da)
LT (1) LT2996720T (da)
MX (2) MX387527B (da)
NL (1) NL1040254C2 (da)
PH (1) PH12015502591B1 (da)
PL (2) PL3511018T3 (da)
PT (2) PT2996720T (da)
RS (1) RS58857B1 (da)
RU (1) RU2671977C2 (da)
SI (1) SI2996720T1 (da)
SM (1) SMT201900359T1 (da)
TR (1) TR201908663T4 (da)
WO (1) WO2014184352A1 (da)

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CN113908254B (zh) * 2021-10-19 2024-05-28 山西锦波生物医药股份有限公司 一种干粉吸入剂及其制备方法和用途
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Publication number Publication date
CN105339003A (zh) 2016-02-17
WO2014184352A1 (en) 2014-11-20
NL1040254C2 (en) 2014-11-24
CN105339003B (zh) 2018-11-20
MX387527B (es) 2025-03-12
CA2912670A1 (en) 2014-11-20
MX2019005269A (es) 2019-09-04
AU2014267222A1 (en) 2015-11-12
US20190010249A1 (en) 2019-01-10
RS58857B1 (sr) 2019-07-31
ES2731922T3 (es) 2019-11-19
CN110063935A (zh) 2019-07-30
EP3511018A1 (en) 2019-07-17
PT3511018T (pt) 2021-10-15
RU2671977C2 (ru) 2018-11-08
PH12015502591A1 (en) 2016-02-29
TR201908663T4 (tr) 2019-07-22
JP6952019B2 (ja) 2021-10-20
HRP20190954T1 (hr) 2019-07-26
JP2016520075A (ja) 2016-07-11
AU2019201307A1 (en) 2019-03-14
JP2019034967A (ja) 2019-03-07
AU2019201307B2 (en) 2021-01-28
MX364664B (es) 2019-05-03
AU2014267222B2 (en) 2018-12-13
RU2018137504A3 (da) 2021-12-28
BR112015028411A2 (pt) 2017-12-12
HK1218258A1 (zh) 2017-02-10
AU2021200035A1 (en) 2021-02-25
ES2895150T3 (es) 2022-02-17
RU2015154214A (ru) 2017-06-22
US20160090424A1 (en) 2016-03-31
BR112015028411B1 (pt) 2023-01-10
PH12015502591B1 (en) 2016-02-29
CY1122090T1 (el) 2020-11-25
KR102166399B1 (ko) 2020-10-16
PT2996720T (pt) 2019-07-04
PL3511018T3 (pl) 2022-01-10
LT2996720T (lt) 2019-07-10
EP2996720B1 (en) 2019-03-27
JP6433986B2 (ja) 2018-12-05
MX2015015722A (es) 2016-03-16
RU2018137504A (ru) 2018-12-14
CN110063935B (zh) 2021-11-09
KR20160007657A (ko) 2016-01-20
US10035862B2 (en) 2018-07-31
SMT201900359T1 (it) 2019-07-11
HUE044392T2 (hu) 2019-10-28
EP3511018B1 (en) 2021-07-28
PL2996720T3 (pl) 2019-09-30
EP2996720A1 (en) 2016-03-23
CN110037983A (zh) 2019-07-23
SI2996720T1 (sl) 2019-07-31

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