DK3786160T3 - Pyridinderivater og terapeutiske anvendelser deraf som trpc6-inhibitorer - Google Patents

Pyridinderivater og terapeutiske anvendelser deraf som trpc6-inhibitorer Download PDF

Info

Publication number: DK3786160T3
Authority: DK; Denmark
Prior art keywords: therapeutic uses; pyridine derivatives; trpc6; inhibitors; trpc6 inhibitors
Prior art date: 2017-10-27

Application number

DK20197194.2T

Other languages

English (en)

Inventor

Thierry Bouyssou

Dirk Gottschling

Niklas Heine

Keenan Lana Louise Smith

Michael D Lowe

Hossein Razavi

Christopher Ronald Sarko

Simon Surprenant

Hidenori Takahashi

Xinyuan Wu

Michael Robert Turner

Original Assignee

Boehringer Ingelheim Int

Hydra Biosciences Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-10-27

Filing date

2018-10-25

Publication date

2022-08-22

2018-10-25 Application filed by Boehringer Ingelheim Int, Hydra Biosciences Llc filed Critical Boehringer Ingelheim Int

2022-08-22 Application granted granted Critical

2022-08-22 Publication of DK3786160T3 publication Critical patent/DK3786160T3/da

Links

JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
102000003623 TRPC6 Human genes 0.000 title 1
108050001421 Transient receptor potential channel, canonical 6 Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK20197194.2T 2017-10-27 2018-10-25 Pyridinderivater og terapeutiske anvendelser deraf som trpc6-inhibitorer DK3786160T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201762577883P	2017-10-27	2017-10-27
US201862628313P	2018-02-09	2018-02-09
EP18800513.6A EP3700902B8 (en)	2017-10-27	2018-10-25	Pyridine carbonyl derivatives and therapeutic uses thereof as trpc6 inhibitors

Publications (1)

Publication Number	Publication Date
DK3786160T3 true DK3786160T3 (da)	2022-08-22

Family

ID=64270818

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK18800513.6T DK3700902T3 (en)	2017-10-27	2018-10-25	Inhibitorer af trpc6
DK20197194.2T DK3786160T3 (da)	2017-10-27	2018-10-25	Pyridinderivater og terapeutiske anvendelser deraf som trpc6-inhibitorer

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK18800513.6T DK3700902T3 (en)	2017-10-27	2018-10-25	Inhibitorer af trpc6

Country Status (30)

Country	Link
US (4)	US10889568B2 (da)
EP (2)	EP3786160B1 (da)
JP (2)	JP7217273B6 (da)
KR (2)	KR102724066B1 (da)
CN (1)	CN111527078B (da)
AU (2)	AU2018355743B2 (da)
CA (1)	CA3078769A1 (da)
CL (2)	CL2020001097A1 (da)
CY (2)	CY1125488T1 (da)
DK (2)	DK3700902T3 (da)
ES (2)	ES2946274T3 (da)
FI (1)	FI3700902T3 (da)
HR (2)	HRP20220991T1 (da)
HU (2)	HUE059450T2 (da)
IL (2)	IL274039B (da)
LT (2)	LT3786160T (da)
MX (1)	MX387232B (da)
MY (1)	MY202126A (da)
PE (1)	PE20210154A1 (da)
PH (1)	PH12020550503A1 (da)
PL (2)	PL3700902T3 (da)
PT (2)	PT3700902T (da)
RS (2)	RS64271B1 (da)
SA (1)	SA520411843B1 (da)
SG (2)	SG10202011632RA (da)
SI (2)	SI3786160T1 (da)
TW (2)	TWI780246B (da)
UA (1)	UA128474C2 (da)
WO (1)	WO2019081637A1 (da)
ZA (1)	ZA202002372B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI3700902T3 (fi) *	2017-10-27	2023-05-25	Boehringer Ingelheim Int	TRPC6:n inhibiittoreita
EP3752499B1 (en) *	2018-02-15	2024-03-27	Boehringer Ingelheim International GmbH	Inhibitors of trpc6
US11370771B2 (en) *	2018-02-16	2022-06-28	Boehringer Ingelheim International Gmbh	Inhibitors of TRPC6
IL315313A (en) *	2018-08-24	2024-10-01	Xeniopro GmbH	Aromatic molecules for use in the treatment of pathological conditions
US12156874B2 (en) *	2019-04-12	2024-12-03	Boehringer Ingelheim International Gmbh	Inhibitors of TRPC6
WO2021079962A1 (ja) *	2019-10-24	2021-04-29	国立大学法人大阪大学	難聴の予防および／または治療用医薬組成物
EP4103245B1 (en)	2020-02-11	2026-04-01	Klinikum der Technischen Universität München (TUM Klinikum)	Administration of calcium channel trpc6 inhibitors using balloons, stents or other medical devices
AR121846A1 (es) *	2020-04-16	2022-07-13	Teijin Pharma Ltd	Derivado de arilo o heteroarilo
CN115379841A (zh) *	2020-04-16	2022-11-22	勃林格殷格翰国际有限公司	治疗呼吸系统病症的trpc6抑制剂
CN113105318B (zh) *	2021-02-23	2022-05-20	中山大学	一种2,2-二氟环丁烷-1-羧酸的制备方法及应用
AU2022366192A1 (en)	2021-10-15	2024-02-29	Boehringer Ingelheim International Gmbh	Trpc6 inhibitory compounds for treating sepsis
JP2025023360A (ja) *	2021-12-06	2025-02-17	国立大学法人熊本大学	Ｔｒｐｃ６の発現を抑制する方法
AU2024328580A1 (en)	2023-08-18	2026-02-05	Boehringer Ingelheim International Gmbh	Inhibitors of trpc6 for treating focal segmental glomerulosclerosis

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU658134B2 (en)	1989-12-28	1995-04-06	Virginia Commonwealth University	Sigma receptor ligands and the use thereof
JPH06509069A (ja)	1991-06-27	1994-10-13	バージニア・コモンウェルス・ユニバーシティ	シグマレセプターリガンドおよびその用途
BR9307570A (pt)	1992-12-02	1999-05-25	Pfizer	Diéteres de catecol como inibidores seletivos de pdeiv
PL346795A1 (en)	1998-09-22	2002-02-25	Yamanouchi Pharma Co Ltd	Cyanophenyl derivatives
ES2254385T3 (es)	2000-02-29	2006-06-16	Millennium Pharmaceuticals, Inc.	Benzamidas e inhibidores relacionados del factor xa.
WO2002008221A2 (en)	2000-07-20	2002-01-31	Neurogen Corporation	Capsaicin receptor ligands
JP4186518B2 (ja) *	2001-06-15	2008-11-26	アステラス製薬株式会社	フェニルピリジン誘導体
ATE417038T1 (de) *	2001-06-15	2008-12-15	Astellas Pharma Inc	Phenylpyridincarbonyl piperazinderivate
NI200300045A (es)	2002-04-26	2005-07-08	Pfizer Prod Inc	Inhibidores de triariloxiariloxipirimidin-2,4,6-triona de metaloproteinasa.
DE10222291A1 (de)	2002-05-18	2003-11-27	Schlafhorst & Co W	Faserbandzuführeinrichtung
CN1150176C (zh)	2002-05-22	2004-05-19	上海医药工业研究院	芳烷酮哌嗪衍生物及其应用
CA2581745A1 (en)	2004-10-13	2006-04-27	Neurogen Corporation	Aryl substituted 8-azabicyclo[3.2.1]octane compounds as ligands of the melanin concentrating hormone receptor
DE102005044814A1 (de) *	2005-05-19	2006-11-23	Grünenthal GmbH	Substituierte Sprio-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
AR056582A1 (es)	2005-10-28	2007-10-10	Lilly Co Eli	COMPUESTOS DE PIRAZOLIL UREA CON ACTIVIDAD INHIBITORIA DE CINASA P38 Y FORMULACIoN FARMACÉUTICA QUE LO COMPRENDE
EP1976848A2 (en)	2005-12-21	2008-10-08	Schering Corporation	Phenoxypiperidines and analogs thereof useful as histamine h3 antagonists
JP5019768B2 (ja)	2006-03-23	2012-09-05	独立行政法人科学技術振興機構	新規低分子化合物およびその製造方法
EP2137162B1 (en)	2007-03-15	2018-08-01	Novartis AG	Organic compounds and their uses
JP5082538B2 (ja)	2007-03-28	2012-11-28	Ｄｉｃ株式会社	ピペラジン化合物
EP2379524A1 (en)	2008-12-18	2011-10-26	Boehringer Ingelheim International GmbH	Serotonin 5-ht2b receptor inhibitors
US20100234603A1 (en)	2009-03-13	2010-09-16	Xin Linghu	Process for Making Substituted Aryl Sulfone Intermediates
US20110039850A1 (en)	2009-08-12	2011-02-17	Mhairi Copland	Leukemia Treatment
EA201200570A1 (ru)	2009-10-09	2012-11-30	Айрм Ллк	Соединения и композиции в качестве модуляторов активности gpr119
KR20120107962A (ko)	2009-11-18	2012-10-04	노파르티스 아게	고형 종양 및 다른 악성종양의 치료를 위한 방법 및 조성물
KR101939704B1 (ko)	2010-03-01	2019-01-17	지티엑스, 인코포레이티드	암 치료용 화합물
PH12012502112A1 (en)	2010-04-27	2021-06-23	Mitsubishi Tanabe Pharma Corp	Novel amide derivative and use thereof as medicine
NZ603876A (en)	2010-05-13	2015-02-27	Amgen Inc	Nitrogen heterocyclic compounds useful as pde10 inhibitors
KR101764952B1 (ko)	2010-07-29	2017-08-03	리겔 파마슈티칼스, 인크.	Ａｍｐｋ-활성화 헤테로시클릭 화합물 및 그의 사용 방법
WO2012158784A2 (en)	2011-05-16	2012-11-22	Theodore Mark Kamenecka	Modulators of the nuclear hormone receptor ror
JP5800786B2 (ja)	2011-10-26	2015-10-28	田辺三菱製薬株式会社	新規アミド誘導体を有効成分として含有する医薬組成物
WO2013066714A1 (en)	2011-10-31	2013-05-10	Merck Sharp & Dohme Corp.	Inhibitors of the renal outer medullary potassium channel
CN103360343B (zh)	2012-03-30	2017-04-19	凯惠药业(上海)有限公司	一种哌嗪酰胺类化合物的制备方法
WO2014139144A1 (en)	2013-03-15	2014-09-18	Agios Pharmaceuticals, Inc.	Therapeutic compounds and compositions
TWI642668B (zh)	2013-05-27	2018-12-01	赫孚孟拉羅股份公司	新穎３，４－二氫－２ｈ－異喹啉－１－酮及２，３－二氫異吲哚－１－酮化合物
US20150087673A1 (en)	2013-09-26	2015-03-26	Rigel Pharmaceuticals, Inc.	Methods for using and biomarkers for ampk-activating compounds
CA2934700A1 (en)	2014-01-06	2015-07-09	Rhizen Pharmaceuticals Sa	Glutaminase inhibitors
WO2015199206A1 (ja) *	2014-06-27	2015-12-30	塩野義製薬株式会社	Ｔｒｐｖ４阻害活性を有する６員環誘導体
UY36391A (es)	2014-11-05	2016-06-01	Flexus Biosciences Inc	Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
MA41598A (fr) *	2015-02-25	2018-01-02	Constellation Pharmaceuticals Inc	Composés thérapeutiques de pyridazine et leurs utilisations
US20180305334A1 (en)	2015-10-14	2018-10-25	Aquinnah Pharmaceuticals, Inc.	Compounds, compositions and methods of use against stress granules
CN107176927B (zh)	2016-03-12	2020-02-18	福建金乐医药科技有限公司	组蛋白去甲基化酶lsd1抑制剂
EP3429591B1 (en)	2016-03-16	2023-03-15	Kura Oncology, Inc.	Substituted thieno[2,3-d]pyrimidine derivatives as inhibitors of menin-mll and methods of use
AU2017282659A1 (en)	2016-06-20	2019-02-07	Rutgers, The State University Of New Jersey	Therapeutic compounds
CN107540636A (zh)	2016-06-29	2018-01-05	成都贝斯凯瑞生物科技有限公司	一种含氮杂环衍生物及其应用
CN106317050B (zh) *	2016-08-24	2018-11-23	烟台大学	一种苯基噻唑衍生物及其制备方法与应用
JPWO2018159827A1 (ja)	2017-03-03	2020-01-09	国立大学法人京都大学	植物ステロイドホルモン（ブラシノライド）様活性をもつ非ステロイド化合物の創製
TW201902875A (zh)	2017-03-15	2019-01-16	美商亞瑟尼克斯公司	聯芳基哌啶醯胺化合物及其使用方法
FI3700902T3 (fi)	2017-10-27	2023-05-25	Boehringer Ingelheim Int	TRPC6:n inhibiittoreita
CN111491938B (zh) *	2017-11-16	2024-05-24	普林斯匹亚生物制药公司	免疫蛋白酶体抑制剂
EP3752499B1 (en)	2018-02-15	2024-03-27	Boehringer Ingelheim International GmbH	Inhibitors of trpc6
US11370771B2 (en)	2018-02-16	2022-06-28	Boehringer Ingelheim International Gmbh	Inhibitors of TRPC6

2018
- 2018-10-25 FI FIEP18800513.6T patent/FI3700902T3/fi active
- 2018-10-25 CN CN201880070122.4A patent/CN111527078B/zh active Active
- 2018-10-25 PT PT188005136T patent/PT3700902T/pt unknown
- 2018-10-25 AU AU2018355743A patent/AU2018355743B2/en active Active
- 2018-10-25 RS RS20230382A patent/RS64271B1/sr unknown
- 2018-10-25 US US16/170,178 patent/US10889568B2/en active Active
- 2018-10-25 CA CA3078769A patent/CA3078769A1/en active Pending
- 2018-10-25 WO PCT/EP2018/079276 patent/WO2019081637A1/en not_active Ceased
- 2018-10-25 MY MYPI2020001894A patent/MY202126A/en unknown
- 2018-10-25 HR HRP20220991TT patent/HRP20220991T1/hr unknown
- 2018-10-25 US US16/170,154 patent/US10800757B2/en not_active Ceased
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2020
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2021
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2022
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2023
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Also Published As

Publication number	Publication date
USRE49699E1 (en)	2023-10-17
PL3700902T3 (pl)	2023-09-04
RS63535B1 (sr)	2022-09-30
ES2924933T3 (es)	2022-10-11
DK3700902T3 (en)	2023-05-22
KR20200125758A (ko)	2020-11-04
CY1126109T1 (el)	2023-11-15
EP3700902B1 (en)	2023-03-08
ES2946274T3 (es)	2023-07-14
IL274039A (en)	2020-06-30
LT3786160T (lt)	2022-09-26
US10800757B2 (en)	2020-10-13
AU2018355743B2 (en)	2022-04-14
WO2019081637A1 (en)	2019-05-02
RS64271B1 (sr)	2023-07-31
AU2018355743A1 (en)	2020-05-14
EP3700902B8 (en)	2023-08-02
CY1125488T1 (el)	2026-02-25
CL2020001097A1 (es)	2020-08-28
US20210163449A1 (en)	2021-06-03
EP3786160A1 (en)	2021-03-03
CN111527078A (zh)	2020-08-11
BR112020007818A2 (pt)	2020-10-20
US10889568B2 (en)	2021-01-12
LT3700902T (lt)	2023-06-26
HUE059450T2 (hu)	2022-11-28
CL2020002562A1 (es)	2021-01-15
TW201930294A (zh)	2019-08-01
US20190169167A1 (en)	2019-06-06
EP3700902A1 (en)	2020-09-02
HUE062460T2 (hu)	2023-11-28
HRP20220991T1 (hr)	2022-11-11
IL277493B (en)	2022-02-01
UA128474C2 (uk)	2024-07-24
FI3700902T3 (fi)	2023-05-25
ZA202002372B (en)	2023-10-25
MX387232B (es)	2025-03-18
KR20200095467A (ko)	2020-08-10
MY202126A (en)	2024-04-05
PT3700902T (pt)	2023-05-30
NZ763816A (en)	2025-10-31
CN111527078B (zh)	2023-06-02
TWI780246B (zh)	2022-10-11
KR102724066B1 (ko)	2024-10-30
PE20210154A1 (es)	2021-01-26
SG10202011632RA (en)	2021-01-28
MX2020004283A (es)	2021-10-21
SI3700902T1 (sl)	2023-10-30
SA520411843B1 (ar)	2024-01-27
SI3786160T1 (sl)	2022-11-30
JP6979502B2 (ja)	2021-12-15
IL277493A (en)	2020-11-30
JP2021500390A (ja)	2021-01-07
PT3786160T (pt)	2022-08-19
JP7217273B2 (ja)	2023-02-02
JP2021008503A (ja)	2021-01-28
IL274039B (en)	2021-08-31
AU2020250185A1 (en)	2020-11-12
EP3786160B1 (en)	2022-07-13
PH12020550503A1 (en)	2021-03-22
CA3078769A1 (en)	2019-05-02
PL3786160T3 (pl)	2022-10-24
TW202120494A (zh)	2021-06-01
HRP20230502T1 (hr)	2023-09-15
US20190169168A1 (en)	2019-06-06
JP7217273B6 (ja)	2024-02-08
AU2020250185B2 (en)	2022-04-14
SG11202003367TA (en)	2020-05-28
TWI780511B (zh)	2022-10-11

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