DK439884D0 - Insulinderivater eller salte deraf, deres fremstilling og anvendelse - Google Patents

Insulinderivater eller salte deraf, deres fremstilling og anvendelse

Info

Publication number: DK439884D0
Authority: DK; Denmark
Prior art keywords: aminoacid; radical; aminoacids; neutral; alpha
Prior art date: 1983-09-17

Application number

DK439884A

Other languages

English (en)

Other versions

DK172462B1 (da

DK439884A (da

Inventor

Rainer Obermeier

Rolf Geiger

Ulrich Grau

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-09-17

Filing date

1984-09-14

Publication date

1984-09-14

1984-09-14 Application filed by Hoechst Ag filed Critical Hoechst Ag

1984-09-14 Publication of DK439884D0 publication Critical patent/DK439884D0/da

1985-03-18 Publication of DK439884A publication Critical patent/DK439884A/da

1998-08-31 Application granted granted Critical

1998-08-31 Publication of DK172462B1 publication Critical patent/DK172462B1/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 5
150000001371 alpha-amino acids Chemical class 0.000 abstract 4
235000008206 alpha-amino acids Nutrition 0.000 abstract 4
230000007935 neutral effect Effects 0.000 abstract 4
125000000962 organic group Chemical group 0.000 abstract 4
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
102000005593 Endopeptidases Human genes 0.000 abstract 1
108010059378 Endopeptidases Proteins 0.000 abstract 1
239000004026 insulin derivative Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000001810 trypsinlike Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Toxicology (AREA)
General Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Plant Pathology (AREA)
Pharmacology & Pharmacy (AREA)
Physics & Mathematics (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK198404398A 1983-09-17 1984-09-14 Fremgangsmåde til fremstilling af et insulinderivat DK172462B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19833333640 DE3333640A1 (de)	1983-09-17	1983-09-17	Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3333640		1983-09-17

Publications (3)

Publication Number	Publication Date
DK439884D0 true DK439884D0 (da)	1984-09-14
DK439884A DK439884A (da)	1985-03-18
DK172462B1 DK172462B1 (da)	1998-08-31

Family

ID=6209365

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198404398A DK172462B1 (da)	1983-09-17	1984-09-14	Fremgangsmåde til fremstilling af et insulinderivat

Country Status (19)

Country	Link
US (1)	US5015728A (da)
EP (1)	EP0140084B1 (da)
JP (1)	JPH0691834B2 (da)
KR (1)	KR850002282A (da)
AT (1)	ATE53590T1 (da)
AU (1)	AU577801B2 (da)
CA (1)	CA1246478A (da)
DE (2)	DE3333640A1 (da)
DK (1)	DK172462B1 (da)
ES (1)	ES8600218A1 (da)
FI (1)	FI82838C (da)
GR (1)	GR80366B (da)
HU (1)	HU194282B (da)
IL (1)	IL72966A (da)
NO (1)	NO843664L (da)
NZ (1)	NZ209545A (da)
PH (1)	PH22422A (da)
PT (1)	PT79201B (da)
ZA (1)	ZA847258B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3326472A1 (de) *	1983-07-22	1985-02-14	Hoechst Ag, 6230 Frankfurt	Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327928A1 (de) *	1983-08-03	1985-02-21	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten
DE3334407A1 (de) *	1983-09-23	1985-04-04	Hoechst Ag, 6230 Frankfurt	In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DK347086D0 (da) *	1986-07-21	1986-07-21	Novo Industri As	Novel peptides
DK113585D0 (da) *	1985-03-12	1985-03-12	Novo Industri As	Nye peptider
FI882921A7 (fi) *	1986-10-20	1988-06-17	Novo Ind A/S	Protamiinisinkki-insuliinivalmisteet.
DE3717370A1 (de) *	1987-05-22	1988-12-01	Hoechst Ag	Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus
DE3827533A1 (de) *	1988-08-13	1990-02-15	Hoechst Ag	Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3936876A1 (de) *	1989-11-06	1991-05-23	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
ATE203998T1 (de) *	1993-04-27	2001-08-15	Hoechst Ag	Amorphe monosphärische formen von insulinderivaten
US6444641B1 (en)	1997-10-24	2002-09-03	Eli Lilly Company	Fatty acid-acylated insulin analogs
US6323311B1 (en)	1999-09-22	2001-11-27	University Of Utah Research Foundation	Synthesis of insulin derivatives
CZ2004710A3 (cs) *	2001-12-20	2005-02-16	Eli Lilly And Company	Inzulínová sloučenina s protrahovaným účinkem
EP1620465A2 (en) *	2003-04-29	2006-02-01	Eli Lilly And Company	Insulin analogs having protracted time action
DE102006031962A1 (de) *	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Amidiertes Insulin Glargin
DE102006031955A1 (de) *	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
RS59913B1 (sr)	2008-10-17	2020-03-31	Sanofi Aventis Deutschland	Kombinacija insulina i glp-1-agonista
CN102596175A (zh)	2009-07-06	2012-07-18	赛诺菲-安万特德国有限公司	含有甲硫氨酸的水性胰岛素制备物
PT3345593T (pt)	2009-11-13	2023-11-27	Sanofi Aventis Deutschland	Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina
MY180661A (en)	2009-11-13	2020-12-04	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine
PL2611458T3 (pl)	2010-08-30	2017-02-28	Sanofi-Aventis Deutschland Gmbh	Zastosowanie AVE0010 do produkcji leku do leczenia cukrzycy typu 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es)	2011-08-29	2014-04-09	Sanofi Aventis Deutschland	Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
EP3229828B1 (en)	2014-12-12	2023-04-05	Sanofi-Aventis Deutschland GmbH	Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EG10440A (en) *	1970-02-07	1977-09-30	Hoechst Ag	Process for the preparation of des-phenylalamin b1-insuli
DE2460753A1 (de) *	1974-12-21	1976-06-24	Hoechst Ag	Verfahren zur herstellung von humaninsulin
JPS55138391A (en) *	1979-04-13	1980-10-29	Shionogi & Co Ltd	New synthetic method of peptide derivative
NO153061C (no) *	1979-04-13	1986-01-08	Shionogi & Co	Fremgangsmaate for fremstilling av et b30-threonininsulin
JPS55138393A (en) *	1979-04-13	1980-10-29	Shionogi & Co Ltd	Semisynthesis of insulin
DK319780A (da) *	1980-07-24	1982-01-25	Forenede Bryggerier As	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DE3033127A1 (de) *	1980-09-03	1982-04-08	Hoechst Ag, 6000 Frankfurt	Neue analoga des insulins
DE3101382A1 (de) *	1981-01-17	1982-09-02	Hoechst Ag, 6000 Frankfurt	"verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
DK149824C (da) *	1982-01-22	1987-03-16	Carlsberg Biotechnology Ltd	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
DE3209184A1 (de) *	1982-03-13	1983-09-15	Hoechst Ag, 6230 Frankfurt	Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
NL8201650A (nl) *	1982-04-21	1983-11-16	Akzo Nv	Semisynthetische bereiding van humane insuline.
DE3326472A1 (de) *	1983-07-22	1985-02-14	Hoechst Ag, 6230 Frankfurt	Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327928A1 (de) *	1983-08-03	1985-02-21	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten
DE3334407A1 (de) *	1983-09-23	1985-04-04	Hoechst Ag, 6230 Frankfurt	In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus

1983
- 1983-09-17 DE DE19833333640 patent/DE3333640A1/de not_active Withdrawn
1984
- 1984-03-17 PH PH31214A patent/PH22422A/en unknown
- 1984-09-10 HU HU843416A patent/HU194282B/hu not_active IP Right Cessation
- 1984-09-11 AT AT84110813T patent/ATE53590T1/de not_active IP Right Cessation
- 1984-09-11 DE DE8484110813T patent/DE3482470D1/de not_active Expired - Fee Related
- 1984-09-11 EP EP84110813A patent/EP0140084B1/de not_active Expired - Lifetime
- 1984-09-13 CA CA000463076A patent/CA1246478A/en not_active Expired
- 1984-09-13 FI FI843593A patent/FI82838C/fi not_active IP Right Cessation
- 1984-09-13 JP JP59190727A patent/JPH0691834B2/ja not_active Expired - Fee Related
- 1984-09-14 AU AU33072/84A patent/AU577801B2/en not_active Ceased
- 1984-09-14 NZ NZ209545A patent/NZ209545A/xx unknown
- 1984-09-14 ZA ZA847258A patent/ZA847258B/xx unknown
- 1984-09-14 GR GR80366A patent/GR80366B/el unknown
- 1984-09-14 NO NO843664A patent/NO843664L/no unknown
- 1984-09-14 PT PT79201A patent/PT79201B/pt not_active IP Right Cessation
- 1984-09-14 ES ES535916A patent/ES8600218A1/es not_active Expired
- 1984-09-14 DK DK198404398A patent/DK172462B1/da not_active IP Right Cessation
- 1984-09-15 KR KR1019840005641A patent/KR850002282A/ko not_active Withdrawn
- 1984-09-17 IL IL72966A patent/IL72966A/xx not_active IP Right Cessation
1988
- 1988-03-23 US US07/172,236 patent/US5015728A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI843593L (fi)	1985-03-18
EP0140084B1 (de)	1990-06-13
ES535916A0 (es)	1985-10-01
US5015728A (en)	1991-05-14
PT79201A (de)	1984-10-01
HU194282B (en)	1988-01-28
PT79201B (de)	1986-09-10
DE3333640A1 (de)	1985-04-25
AU577801B2 (en)	1988-10-06
ES8600218A1 (es)	1985-10-01
FI843593A0 (fi)	1984-09-13
DE3482470D1 (de)	1990-07-19
FI82838B (fi)	1991-01-15
KR850002282A (ko)	1985-05-10
PH22422A (en)	1988-09-12
CA1246478A (en)	1988-12-13
GR80366B (en)	1985-01-11
JPS6094998A (ja)	1985-05-28
EP0140084A1 (de)	1985-05-08
IL72966A (en)	1989-08-15
AU3307284A (en)	1985-03-21
HUT36144A (en)	1985-08-28
ATE53590T1 (de)	1990-06-15
IL72966A0 (en)	1984-12-31
NO843664L (no)	1985-03-18
DK172462B1 (da)	1998-08-31
FI82838C (fi)	1991-04-25
JPH0691834B2 (ja)	1994-11-16
DK439884A (da)	1985-03-18
ZA847258B (en)	1985-05-29
NZ209545A (en)	1989-02-24

Legal Events

Date	Code	Title	Description
1998-08-31	B1	Patent granted (law 1993)
2004-05-10	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK439884A (da)	1985-03-18	Insulinderivater eller salte deraf, deres fremstilling og anvendelse
JPS55135595A (en)	1980-10-22	Preparation of dipeptide
BG46451A3 (en)	1989-12-15	Herbicide means
BG32269A3 (bg)	1982-06-15	Метод за получаване на производни на тиазолидин-(тиазан)-карбонови киселини
BG50164A3 (en)	1992-05-15	Method for preparing of amicacine
FI843045A0 (fi)	1984-08-01	Foerfarande foer framstaellning av insulinderivat.
BG38489A3 (en)	1985-12-16	Method for preparing oxazophosphorine- 6, 4- thiolcalsulphonic acids and their neutral salts
ZA831693B (en)	1983-11-30	A process for converting preproinsulin analogs into insulins
KR860007286A (ko)	1986-10-10	Grf 유도체의 제조방법
SE8602523D0 (sv)	1986-06-04	2-alkyl- eller -aralkyltio-1-cykloalken-1-karboxamider och deras sulfoxider, sett for deras framstellning och deras anvendning for syntes av tri- och 4,5-tetrametylen-4-isotiazolin-3-oner
DE3061077D1 (en)	1982-12-23	Solubilized thymidine composition and method of producing same
PT83837A (de)	1986-12-01	Verfahren zur herstellung von peptiden unter der verwendung von perchloraten
BG34456A3 (bg)	1983-09-15	Метод за получаване на производни на 7 бета- аминотиазолилацетамидо- 3- цефем- 4- карбоновата киселина
JPS5412369A (en)	1979-01-30	Preparation of thienylacetic acid
BG29874A3 (bg)	1981-02-16	Метод за получаване на производни на метил-2-фенокси -2-пропио- нови киселини
FR2425426A1 (fr)	1979-12-07	Peptides apparentes a la somatostatine
ES8200091A1 (es)	1981-10-16	Procedimiento para la produccion de n-((2s)-3-mercapto-2-me-tilpropionil)-l-prolina
ES8704185A1 (es)	1987-03-16	Procedimiento para preparar derivados de aminoacidos