DK542684D0 - 1h-imidazo(4,5-c)quinolin eller derivat deraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse - Google Patents

1h-imidazo(4,5-c)quinolin eller derivat deraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse

Info

Publication number: DK542684D0
Authority: DK; Denmark
Prior art keywords: imidazo; carbon atoms; quinoline; derivative; procedures
Prior art date: 1983-11-18

Application number

DK542684A

Other languages

English (en)

Other versions

DK542684A (da

DK164280B (da

DK164280C (da

Inventor

John F Gerster

Original Assignee

Riker Laboratories Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-18

Filing date

1984-11-15

Publication date

1984-11-15

1984-11-15 Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc

1984-11-15 Publication of DK542684D0 publication Critical patent/DK542684D0/da

1985-05-19 Publication of DK542684A publication Critical patent/DK542684A/da

1992-06-01 Publication of DK164280B publication Critical patent/DK164280B/da

1992-11-30 Application granted granted Critical

1992-11-30 Publication of DK164280C publication Critical patent/DK164280C/da

Links

ITIRVXDSMXFTPW-UHFFFAOYSA-N 1H-imidazo[4,5-c]quinoline Chemical compound C1=CC=CC2=C(NC=N3)C3=CN=C21 ITIRVXDSMXFTPW-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Physical Water Treatments (AREA)
Macromonomer-Based Addition Polymer (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Alarm Systems (AREA)
Quinoline Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Lubricants (AREA)
Luminescent Compositions (AREA)

DK542684A 1983-11-18 1984-11-15 1h-imidazooe4,5-caaquinolin eller derivat deraf og farmaceutisk praeparat indeholdende en saadan forbindelse DK164280C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US55315883A	1983-11-18	1983-11-18
US55315783A	1983-11-18	1983-11-18
US55315883		1983-11-18
US55315783		1983-11-18

Publications (4)

Publication Number	Publication Date
DK542684D0 true DK542684D0 (da)	1984-11-15
DK542684A DK542684A (da)	1985-05-19
DK164280B DK164280B (da)	1992-06-01
DK164280C DK164280C (da)	1992-11-30

Family

ID=27070262

Family Applications (6)

Application Number	Title	Priority Date	Filing Date
DK542684A DK164280C (da)	1983-11-18	1984-11-15	1h-imidazooe4,5-caaquinolin eller derivat deraf og farmaceutisk praeparat indeholdende en saadan forbindelse
DK135791A DK169179B1 (da)	1983-11-18	1991-07-16	1H-imidazo[4,5-c]quinolin-4-amin, farmaceutisk præparat indeholdende en sådan forbindelse og fremga ngsmåde til fremstilling af en sådan forbindelse
DK135891A DK164455C (da)	1983-11-18	1991-07-16	1h-imidazooe4,5-caaquinolin-4-chlorforbindelser
DK136091A DK164451C (da)	1983-11-18	1991-07-16	3-aminoquinolinderivat
DK135991A DK165921C (da)	1983-11-18	1991-07-16	1h-imidazooe4,5-caaquinolin-5-oxyforbindelser
DK136191A DK164452C (da)	1983-11-18	1991-07-16	3-nitroquinolinderivat

Family Applications After (5)

Application Number	Title	Priority Date	Filing Date
DK135791A DK169179B1 (da)	1983-11-18	1991-07-16	1H-imidazo[4,5-c]quinolin-4-amin, farmaceutisk præparat indeholdende en sådan forbindelse og fremga ngsmåde til fremstilling af en sådan forbindelse
DK135891A DK164455C (da)	1983-11-18	1991-07-16	1h-imidazooe4,5-caaquinolin-4-chlorforbindelser
DK136091A DK164451C (da)	1983-11-18	1991-07-16	3-aminoquinolinderivat
DK135991A DK165921C (da)	1983-11-18	1991-07-16	1h-imidazooe4,5-caaquinolin-5-oxyforbindelser
DK136191A DK164452C (da)	1983-11-18	1991-07-16	3-nitroquinolinderivat

Country Status (15)

Country	Link
EP (2)	EP0310950B1 (da)
JP (1)	JPS60123488A (da)
KR (1)	KR900005657B1 (da)
AT (2)	ATE49763T1 (da)
AU (2)	AU581190B2 (da)
CA (1)	CA1271477A (da)
DE (3)	DE19975027I2 (da)
DK (6)	DK164280C (da)
ES (1)	ES537677A0 (da)
IE (1)	IE57874B1 (da)
IL (2)	IL84537A (da)
NL (2)	NL980041I2 (da)
NO (7)	NO163819C (da)
NZ (1)	NZ210228A (da)
PH (1)	PH22338A (da)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
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US4929624A (en) *	1989-03-23	1990-05-29	Minnesota Mining And Manufacturing Company	Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
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FR2654021B1 (fr) *	1989-11-07	1992-02-28	Simond Jacques	Procede de vitrification de cendres volantes et dispositif pour sa mise en óoeuvre.
GB8928281D0 (en) *	1989-12-14	1990-02-21	Smith Kline French Lab	Compounds
ES2094772T3 (es) *	1990-06-01	1997-02-01	Kyowa Hakko Kogyo Kk	Derivados de imidazonaftiridinas.
DE69229114T2 (de) *	1991-03-01	1999-11-04	Minnesota Mining And Mfg. Co., Saint Paul	1,2-substituierte 1h-imidazo[4,5-c]chinolin-4-amine
US5266575A (en) *	1991-11-06	1993-11-30	Minnesota Mining And Manufacturing Company	2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
IL105325A (en) *	1992-04-16	1996-11-14	Minnesota Mining & Mfg	Immunogen/vaccine adjuvant composition
US5395937A (en) *	1993-01-29	1995-03-07	Minnesota Mining And Manufacturing Company	Process for preparing quinoline amines
US5693811A (en) *	1996-06-21	1997-12-02	Minnesota Mining And Manufacturing Company	Process for preparing tetrahdroimidazoquinolinamines
US6069149A (en) *	1997-01-09	2000-05-30	Terumo Kabushiki Kaisha	Amide derivatives and intermediates for the synthesis thereof
JPH10298181A (ja) *	1997-04-25	1998-11-10	Sumitomo Pharmaceut Co Ltd	タイプ２ヘルパーｔ細胞選択的免疫応答抑制剤
JP2000119271A (ja) *	1998-08-12	2000-04-25	Hokuriku Seiyaku Co Ltd	１ｈ―イミダゾピリジン誘導体
UA74852C2 (en) *	2000-12-08	2006-02-15	3M Innovative Properties Co	Urea-substituted imidazoquinoline ethers
JP4602667B2 (ja) *	2001-10-23	2010-12-22	メルクセローノソシエテアノニム	アゾール誘導体および該アゾール誘導体を含有する医薬組成物
GB0211649D0 (en) *	2002-05-21	2002-07-03	Novartis Ag	Organic compounds
AU2003259226A1 (en)	2002-07-23	2004-02-09	Biogal Gyogyszergyar Rt	Preparation of 1h-imidazo(4,5-c)quinolin-4-amines via1h-imidazo (4,5-c)quinolin-4-phthalimide intermediates
PT1539752E (pt)	2002-07-26	2007-05-31	Teva Gyogyszergyar Zartkoeruen	Preparação de 1h-imidazo [4,5-c] quinolina-4-aminas via novos intermediários imidazo [4,5-c] quinolina-4-ciano e 1h-imidazo [4,5-c] quinolina-4-carboxamida
BRPI0413558A (pt)	2003-08-12	2006-10-17	3M Innovative Properties Co	compostos contendo imidazo substituìdo por hidroxilamina
AU2004268625B2 (en) *	2003-08-27	2011-03-31	3M Innovative Properties Company	Aryloxy and arylalkyleneoxy substituted imidazoquinolines
AU2004270201A1 (en)	2003-09-05	2005-03-17	3M Innovative Properties Company	Treatment for CD5+ B cell lymphoma
EP1668010A2 (en)	2003-10-01	2006-06-14	Taro Pharmaceuticals U.S.A., Inc.	Method of preparing 4-amino-1h -imidazo(4,5- c )quinolines and acid addition salts thereof
AR046046A1 (es) *	2003-10-03	2005-11-23	3M Innovative Properties Co	Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.
US7544697B2 (en)	2003-10-03	2009-06-09	Coley Pharmaceutical Group, Inc.	Pyrazolopyridines and analogs thereof
ITMI20032121A1 (it) *	2003-11-04	2005-05-05	Dinamite Dipharma Spa In Forma Abbr Eviata Dipharm	Procedimento per la preparazione di imiquimod e suoi intermedi
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CA2547020C (en)	2003-11-25	2014-03-25	3M Innovative Properties Company	1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
JP2007517035A (ja)	2003-12-29	2007-06-28	スリーエムイノベイティブプロパティズカンパニー	アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
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WO2006065280A2 (en)	2004-06-18	2006-06-22	3M Innovative Properties Company	Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
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JP5543068B2 (ja)	2004-12-30	2014-07-09	スリーエムイノベイティブプロパティズカンパニー	キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
EP1831221B1 (en)	2004-12-30	2012-08-08	3M Innovative Properties Company	Substituted chiral fused 1,2 imidazo 4,5-c ring compounds
AU2006210392A1 (en)	2005-02-04	2006-08-10	Coley Pharmaceutical Group, Inc.	Aqueous gel formulations containing immune response modifiers
AU2006213746A1 (en)	2005-02-11	2006-08-17	Coley Pharmaceutical Group, Inc.	Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods
EP1869043A2 (en)	2005-04-01	2007-12-26	Coley Pharmaceutical Group, Inc.	Pyrazolopyridine-1,4-diamines and analogs thereof
AU2006232375A1 (en)	2005-04-01	2006-10-12	Coley Pharmaceutical Group, Inc.	1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
CN101304748A (zh)	2005-08-22	2008-11-12	加利福尼亚大学董事会	Tlr激动剂
EP2700638A1 (en)	2006-05-31	2014-02-26	The Regents Of the University of California	Purine analogs
US7906506B2 (en)	2006-07-12	2011-03-15	3M Innovative Properties Company	Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
CN101790380B (zh)	2007-02-07	2013-07-10	加利福尼亚大学董事会	合成tlr激动剂的缀合物及其应用
EP2009002A1 (en) *	2007-06-21	2008-12-31	Institut National De La Sante Et De La Recherche Medicale (Inserm)	New process for the manufacture of 1H-imidazo [4,5-c]-quinoline ring systems
WO2010088924A1 (en)	2009-02-06	2010-08-12	Telormedix Sa	Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
KR20110117705A (ko)	2009-02-11	2011-10-27	더 리전트 오브 더 유니버시티 오브 캘리포니아	톨-유사 수용체 조정제 및 질병의 치료
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US8728486B2 (en)	2011-05-18	2014-05-20	University Of Kansas	Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds
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US3700674A (en) *	1969-04-30	1972-10-24	American Cyanamid Co	4-alkylamino-3-nitroquinolines
IL68495A0 (en) *	1982-05-03	1983-07-31	Lilly Co Eli	2-phenylimidazo(4,5-c)pyridines

1984
- 1984-11-13 CA CA000467706A patent/CA1271477A/en not_active Expired - Lifetime
- 1984-11-14 AU AU35402/84A patent/AU581190B2/en not_active Expired
- 1984-11-15 NO NO844565A patent/NO163819C/no not_active IP Right Cessation
- 1984-11-15 DK DK542684A patent/DK164280C/da not_active IP Right Cessation
- 1984-11-15 ES ES537677A patent/ES537677A0/es active Granted
- 1984-11-16 IE IE2952/84A patent/IE57874B1/en not_active IP Right Cessation
- 1984-11-16 EP EP88116137A patent/EP0310950B1/en not_active Expired - Lifetime
- 1984-11-16 NZ NZ210228A patent/NZ210228A/xx unknown
- 1984-11-16 DE DE1999175027 patent/DE19975027I2/de active Active
- 1984-11-16 EP EP84307974A patent/EP0145340B1/en not_active Expired - Lifetime
- 1984-11-16 AT AT84307974T patent/ATE49763T1/de active
- 1984-11-16 DE DE8888116137T patent/DE3486043T2/de not_active Expired - Lifetime
- 1984-11-16 DE DE8484307974T patent/DE3481124D1/de not_active Expired - Lifetime
- 1984-11-16 IL IL84537A patent/IL84537A/xx not_active IP Right Cessation
- 1984-11-16 AT AT88116137T patent/ATE84525T1/de not_active IP Right Cessation
- 1984-11-16 PH PH31451A patent/PH22338A/en unknown
- 1984-11-17 JP JP59243142A patent/JPS60123488A/ja active Granted
- 1984-11-17 KR KR1019840007224A patent/KR900005657B1/ko not_active Expired
1987
- 1987-11-19 IL IL84537A patent/IL84537A0/xx unknown
1989
- 1989-02-14 AU AU29911/89A patent/AU611997B2/en not_active Expired
- 1989-02-27 NO NO890824A patent/NO165147C/no not_active IP Right Cessation
- 1989-02-27 NO NO890826A patent/NO168705C/no not_active IP Right Cessation
- 1989-02-27 NO NO890823A patent/NO165146C/no not_active IP Right Cessation
- 1989-02-27 NO NO890822A patent/NO165145C/no not_active IP Right Cessation
- 1989-02-27 NO NO890825A patent/NO169437C/no not_active IP Right Cessation
1991
- 1991-07-16 DK DK135791A patent/DK169179B1/da not_active IP Right Cessation
- 1991-07-16 DK DK135891A patent/DK164455C/da not_active IP Right Cessation
- 1991-07-16 DK DK136091A patent/DK164451C/da not_active IP Right Cessation
- 1991-07-16 DK DK135991A patent/DK165921C/da not_active IP Right Cessation
- 1991-07-16 DK DK136191A patent/DK164452C/da not_active IP Right Cessation
1998
- 1998-12-14 NL NL980041C patent/NL980041I2/nl unknown
- 1998-12-14 NL NL980043C patent/NL980043I1/nl unknown
1999
- 1999-07-08 NO NO1999015C patent/NO1999015I1/no unknown

Also Published As

Publication number	Publication date
NO890824L (no)	1985-05-20
EP0145340A2 (en)	1985-06-19
DK542684A (da)	1985-05-19
NO168705B (no)	1991-12-16
AU581190B2 (en)	1989-02-16
NO890825L (no)	1985-05-20
CA1271477A (en)	1990-07-10
DK136191D0 (da)	1991-07-16
NO890826D0 (no)	1989-02-27
DE19975027I2 (de)	2000-09-21
DK164452C (da)	1992-11-09
ATE49763T1 (de)	1990-02-15
NO1999015I1 (no)	1999-07-08
NO169437C (no)	1992-06-24
DK135791A (da)	1991-07-16
NO890824D0 (no)	1989-02-27
IE842952L (en)	1985-05-18
JPS60123488A (ja)	1985-07-02
ATE84525T1 (de)	1993-01-15
DE3486043D1 (de)	1993-02-25
DK164451C (da)	1992-11-09
DK135991D0 (da)	1991-07-16
DK165921C (da)	1993-06-28
NO165146C (no)	1991-01-02
DK135791D0 (da)	1991-07-16
EP0145340A3 (en)	1986-06-11
DK135891A (da)	1991-07-16
NO890823L (no)	1985-05-20
DE3481124D1 (de)	1990-03-01
IL84537A0 (en)	1988-04-29
DK169179B1 (da)	1994-09-05
DK165921B (da)	1993-02-08
AU2991189A (en)	1989-06-15
NL980041I1 (nl)	1999-02-01
DK164280B (da)	1992-06-01
NO163819C (no)	1990-08-01
DK135891D0 (da)	1991-07-16
NO890823D0 (no)	1989-02-27
NO165147C (no)	1991-01-02
DK164280C (da)	1992-11-30
DK164451B (da)	1992-06-29
DK135991A (da)	1991-07-16
NO165147B (no)	1990-09-24
NO163819B (no)	1990-04-17
ES8603477A1 (es)	1985-12-16
EP0310950B1 (en)	1993-01-13
NO165145B (no)	1990-09-24
JPH0586391B2 (da)	1993-12-10
DE3486043T2 (de)	1993-06-03
NO169437B (no)	1992-03-16
NO165146B (no)	1990-09-24
DK136091D0 (da)	1991-07-16
DK136191A (da)	1991-07-16
EP0310950A1 (en)	1989-04-12
DK164452B (da)	1992-06-29
NO890822D0 (no)	1989-02-27
NL980041I2 (nl)	1999-07-01
AU611997B2 (en)	1991-06-27
DK164455B (da)	1992-06-29
NO890825D0 (no)	1989-02-27
EP0145340B1 (en)	1990-01-24
NO165145C (no)	1991-01-02
ES537677A0 (es)	1985-12-16
PH22338A (en)	1988-08-12
NO890822L (no)	1985-05-20
DK164455C (da)	1992-11-16
NL980043I1 (nl)	1999-02-01
NO168705C (no)	1992-03-25
IE57874B1 (en)	1993-05-05
KR850003890A (ko)	1985-06-29
AU3540284A (en)	1985-05-23
KR900005657B1 (ko)	1990-08-03
NO844565L (no)	1985-05-20
NO890826L (no)	1985-05-20
IL84537A (en)	1990-12-23
NZ210228A (en)	1989-01-27
DK136091A (da)	1991-07-16

Legal Events

Date	Code	Title	Description
2004-12-06	PUP	Patent expired