DK545686A - Insulinderivater og farmaceutiske praeparater, som indeholder disse derivater - Google Patents

Insulinderivater og farmaceutiske praeparater, som indeholder disse derivater

Info

Publication number: DK545686A
Authority: DK; Denmark
Prior art keywords: derivatives; pct; pharmaceutical preparations; preparations containing; insulin
Prior art date: 1985-03-15

Application number

DK545686A

Other languages

English (en)

Other versions

DK545686D0 (da

Inventor

Per Balschmidt

Finn Benned Hansen

Original Assignee

Nordisk Gentofte

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-15

Filing date

1986-11-14

Publication date

1986-11-14

1986-11-14 Application filed by Nordisk Gentofte filed Critical Nordisk Gentofte

1986-11-14 Priority to DK545686A priority Critical patent/DK545686D0/da

1986-11-14 Publication of DK545686A publication Critical patent/DK545686A/da

1986-11-14 Publication of DK545686D0 publication Critical patent/DK545686D0/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 3
239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
125000000539 amino acid group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK545686A 1985-03-15 1986-11-14 Insulinderivater og farmaceutiske praeparater, som indeholder disse derivater DK545686D0 (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK545686A DK545686D0 (da)	1985-03-15	1986-11-14	Insulinderivater og farmaceutiske praeparater, som indeholder disse derivater

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK119785A DK119785D0 (da)	1985-03-15	1985-03-15	Insulinpraeparat
PCT/DK1986/000022 WO1986005496A1 (en)	1985-03-15	1986-03-14	Novel insulin derivatives and pharmaceutical preparations containing these derivatives
DK545686A DK545686D0 (da)	1985-03-15	1986-11-14	Insulinderivater og farmaceutiske praeparater, som indeholder disse derivater

Publications (2)

Publication Number	Publication Date
DK545686A true DK545686A (da)	1986-11-14
DK545686D0 DK545686D0 (da)	1986-11-14

Family

ID=8102063

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK119785A DK119785D0 (da)	1985-03-15	1985-03-15	Insulinpraeparat
DK545686A DK545686D0 (da)	1985-03-15	1986-11-14	Insulinderivater og farmaceutiske praeparater, som indeholder disse derivater
DK545786A DK159856C (da)	1985-03-15	1986-11-14	Humaninsulinderivater og farmaceutiske praeparater, som indeholder disse derivater

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK119785A DK119785D0 (da)	1985-03-15	1985-03-15	Insulinpraeparat

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK545786A DK159856C (da)	1985-03-15	1986-11-14	Humaninsulinderivater og farmaceutiske praeparater, som indeholder disse derivater

Country Status (11)

Country	Link
US (1)	US5028586A (da)
EP (2)	EP0216833B1 (da)
JP (2)	JPS62502196A (da)
AT (2)	ATE56022T1 (da)
AU (2)	AU596968B2 (da)
DE (2)	DE3673737D1 (da)
DK (3)	DK119785D0 (da)
FI (2)	FI864559L (da)
IL (2)	IL78161A0 (da)
NO (2)	NO864555D0 (da)
WO (2)	WO1986005497A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK347086D0 (da) *	1986-07-21	1986-07-21	Novo Industri As	Novel peptides
DK113585D0 (da) *	1985-03-12	1985-03-12	Novo Industri As	Nye peptider
US5157021A (en) *	1985-03-15	1992-10-20	Novo Nordisk A/S	Insulin derivatives and pharmaceutical preparations containing these derivatives
DK437786D0 (da) *	1986-09-12	1986-09-12	Nordisk Gentofte	Insulinprecursorer
DE3880346T2 (de) *	1987-02-25	1993-07-29	Novonordisk As	Insulinderivate.
BR8803346A (pt) *	1988-06-30	1990-02-13	Biobras Bioquimica Do Brasil S	Processo aperfeicoado para producao em larga escala de cristais de insulina purificada
BR8803345A (pt) *	1988-06-30	1990-02-13	Biobras Bioquimica Do Brasil S	Processo aperfeicoado para producao em larga escala de cristais de insulina humana purificada
KR900701842A (ko) *	1988-07-20	1990-12-04	헨리 브뢰늄	인간 인슐린 동족체와 그를 포함하는 제제
US5716927A (en) *	1988-12-23	1998-02-10	Novo Nordisk A/S	Insulin analogs having a modified B-chain
DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
WO1992010284A2 (en)	1990-12-07	1992-06-25	Cnc Development, Inc.	Catalytic chemical reactor
DK33591D0 (da) *	1991-02-27	1991-02-27	Novo Nordisk As
CA2109794A1 (en) *	1991-05-24	1992-11-26	Timothy J. Rink	Amylin and possibly insulin containing composition for the treatment of anorexia and related states
US5461031A (en) *	1994-06-16	1995-10-24	Eli Lilly And Company	Monomeric insulin analog formulations
AUPO269996A0 (en) *	1996-10-01	1996-10-24	Walter And Eliza Hall Institute Of Medical Research, The	A method of prophylaxis and treatment
US5898067A (en) *	1997-02-07	1999-04-27	Novo Nordisk A/S	Crystallization of proteins
KR20050075373A (ko) *	2002-11-01	2005-07-20	앤태어스 파머, 인코퍼레이티드	분사식 주사에 의한 인슐린 투여
ES2642214T3 (es)	2004-01-21	2017-11-15	Novo Nordisk Health Care Ag	Conjugación de péptidos mediante transglutaminasa
US7833513B2 (en)	2004-12-03	2010-11-16	Rhode Island Hospital	Treatment of Alzheimer's Disease
EP1991575A1 (en) *	2006-02-21	2008-11-19	Novo Nordisk A/S	Single-chain insulin analogues and pharmaceutical formulations thereof
WO2009099763A1 (en) *	2008-01-30	2009-08-13	Indiana University Research And Technology Corporation	Ester-based peptide prodrugs
KR20110114568A (ko) *	2008-12-19	2011-10-19	인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션	디펩티드 링크된 약효 물질
RU2550696C2 (ru)	2008-12-19	2015-05-10	Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн	Основанные на амидах пролекарства пептидов глюкагонового надсемейства
CA2803164C (en)	2010-06-24	2018-08-21	Indiana University Research And Technology Corporation	Amide-based insulin prodrugs
CN104114183A (zh)	2011-12-20	2014-10-22	印第安纳大学研究及科技有限公司	用于治疗糖尿病的基于ctp的胰岛素类似物
CN108383902A (zh)	2012-09-26	2018-08-10	印第安纳大学研究及科技有限公司	胰岛素类似物二聚体
JP6538645B2 (ja)	2013-03-14	2019-07-03	インディアナユニバーシティーリサーチアンドテクノロジーコーポレーションＩｎｄｉａｎａＵｎｉｖｅｒｓｉｔｙＲｅｓｅａｒｃｈＡｎｄＴｅｃｈｎｏｌｏｇｙＣｏｒｐｏｒａｔｉｏｎ	インスリン‐インクレチン複合物
CN107001441A (zh)	2014-09-24	2017-08-01	印第安纳大学研究及科技有限公司	脂质化的基于酰胺的胰岛素前药
US10232020B2 (en)	2014-09-24	2019-03-19	Indiana University Research And Technology Corporation	Incretin-insulin conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3903068A (en) *	1972-12-26	1975-09-02	Us Health Education & Welfare	Facile synthesis of human insulin by modification of porcine insulin
NO153061C (no) *	1979-04-13	1986-01-08	Shionogi & Co	Fremgangsmaate for fremstilling av et b30-threonininsulin
JPS55138393A (en) *	1979-04-13	1980-10-29	Shionogi & Co Ltd	Semisynthesis of insulin
JPS55138391A (en) *	1979-04-13	1980-10-29	Shionogi & Co Ltd	New synthetic method of peptide derivative
DK147437A (en) *	1980-02-11	1900-01-01		Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
US4421685A (en) *	1980-03-27	1983-12-20	Eli Lilly And Company	Process for producing an insulin
DK319780A (da) *	1980-07-24	1982-01-25	Forenede Bryggerier As	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
IE52768B1 (en) *	1981-04-06	1988-02-17	Boots Co Ltd	1-arylcyclobutylalkylamine compounds useful as therapeutic agents
DE3327709A1 (de) *	1983-07-29	1985-02-07	Hoechst Ag, 6230 Frankfurt	Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DK113585D0 (da) *	1985-03-12	1985-03-12	Novo Industri As	Nye peptider

1985
- 1985-03-15 DK DK119785A patent/DK119785D0/da not_active Application Discontinuation
1986
- 1986-03-14 IL IL78161A patent/IL78161A0/xx unknown
- 1986-03-14 FI FI864559A patent/FI864559L/fi not_active IP Right Cessation
- 1986-03-14 JP JP61501710A patent/JPS62502196A/ja active Pending
- 1986-03-14 WO PCT/DK1986/000023 patent/WO1986005497A1/en not_active Ceased
- 1986-03-14 DE DE8686901826T patent/DE3673737D1/de not_active Expired - Lifetime
- 1986-03-14 WO PCT/DK1986/000022 patent/WO1986005496A1/en not_active Ceased
- 1986-03-14 AT AT86901826T patent/ATE56022T1/de not_active IP Right Cessation
- 1986-03-14 IL IL78160A patent/IL78160A/xx not_active IP Right Cessation
- 1986-03-14 US US07/002,672 patent/US5028586A/en not_active Expired - Fee Related
- 1986-03-14 DE DE8686901827T patent/DE3687500T2/de not_active Expired - Fee Related
- 1986-03-14 EP EP86901827A patent/EP0216833B1/en not_active Expired - Lifetime
- 1986-03-14 AU AU56227/86A patent/AU596968B2/en not_active Ceased
- 1986-03-14 AU AU56226/86A patent/AU5622686A/en not_active Abandoned
- 1986-03-14 JP JP61501709A patent/JPS62502538A/ja active Pending
- 1986-03-14 AT AT86901827T patent/ATE84546T1/de not_active IP Right Cessation
- 1986-03-14 EP EP86901826A patent/EP0216832B1/en not_active Expired - Lifetime
- 1986-11-10 FI FI864560A patent/FI93460C/fi not_active IP Right Cessation
- 1986-11-14 DK DK545686A patent/DK545686D0/da not_active Application Discontinuation
- 1986-11-14 NO NO864555A patent/NO864555D0/no unknown
- 1986-11-14 DK DK545786A patent/DK159856C/da not_active IP Right Cessation
- 1986-11-14 NO NO864556A patent/NO174278C/no unknown

Also Published As

Publication number	Publication date
DK159856C (da)	1991-05-06
NO864555L (no)	1986-11-14
FI864559A0 (fi)	1986-11-10
FI93460B (fi)	1994-12-30
EP0216833B1 (en)	1993-01-13
IL78160A0 (en)	1986-07-31
FI864559A7 (fi)	1986-11-10
AU5622686A (en)	1986-10-13
DK545786A (da)	1986-11-14
US5028586A (en)	1991-07-02
DE3687500D1 (de)	1993-02-25
AU5622786A (en)	1986-10-13
WO1986005496A1 (en)	1986-09-25
ATE56022T1 (de)	1990-09-15
NO864556D0 (no)	1986-11-14
DK119785D0 (da)	1985-03-15
NO174278B (no)	1994-01-03
FI864560A0 (fi)	1986-11-10
DK159856B (da)	1990-12-17
IL78161A0 (en)	1986-07-31
DE3687500T2 (de)	1993-07-01
AU596968B2 (en)	1990-05-24
FI864559L (fi)	1986-11-10
IL78160A (en)	1991-06-10
NO864555D0 (no)	1986-11-14
EP0216832A1 (en)	1987-04-08
FI93460C (fi)	1995-04-10
DK545786D0 (da)	1986-11-14
EP0216832B1 (en)	1990-08-29
NO864556L (no)	1986-11-14
DE3673737D1 (de)	1990-10-04
FI864560L (fi)	1986-11-10
JPS62502196A (ja)	1987-08-27
DK545686D0 (da)	1986-11-14
WO1986005497A1 (en)	1986-09-25
ATE84546T1 (de)	1993-01-15
EP0216833A1 (en)	1987-04-08
JPS62502538A (ja)	1987-10-01
NO174278C (no)	1994-04-13

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Legal Events

Date	Code	Title	Description
1991-04-08	AHS	Application shelved for other reasons than non-payment