NO174278C - Fremgangsmåte ved fremstilling av insulinderivat - Google Patents

Fremgangsmåte ved fremstilling av insulinderivat

Info

Publication number
NO174278C
NO174278C NO864556A NO864556A NO174278C NO 174278 C NO174278 C NO 174278C NO 864556 A NO864556 A NO 864556A NO 864556 A NO864556 A NO 864556A NO 174278 C NO174278 C NO 174278C
Authority
NO
Norway
Prior art keywords
pct
insulin derivatives
preparation
sec
date
Prior art date
Application number
NO864556A
Other languages
English (en)
Norwegian (no)
Other versions
NO174278B (no
NO864556D0 (no
NO864556L (no
Inventor
Per Balschmidt
Finn Benned Hansen
Original Assignee
Novo Nordisk As
Nordisk Gentofte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As, Nordisk Gentofte filed Critical Novo Nordisk As
Publication of NO864556D0 publication Critical patent/NO864556D0/no
Publication of NO864556L publication Critical patent/NO864556L/no
Publication of NO174278B publication Critical patent/NO174278B/no
Publication of NO174278C publication Critical patent/NO174278C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO864556A 1985-03-15 1986-11-14 Fremgangsmåte ved fremstilling av insulinderivat NO174278C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK119785A DK119785D0 (da) 1985-03-15 1985-03-15 Insulinpraeparat
PCT/DK1986/000023 WO1986005497A1 (en) 1985-03-15 1986-03-14 Novel insulin derivatives and pharmaceutical preparations containing these derivatives

Publications (4)

Publication Number Publication Date
NO864556D0 NO864556D0 (no) 1986-11-14
NO864556L NO864556L (no) 1986-11-14
NO174278B NO174278B (no) 1994-01-03
NO174278C true NO174278C (no) 1994-04-13

Family

ID=8102063

Family Applications (2)

Application Number Title Priority Date Filing Date
NO864556A NO174278C (no) 1985-03-15 1986-11-14 Fremgangsmåte ved fremstilling av insulinderivat
NO864555A NO864555L (no) 1985-03-15 1986-11-14 Fremgangsmaate ved fremstilling av insulinpreparat.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO864555A NO864555L (no) 1985-03-15 1986-11-14 Fremgangsmaate ved fremstilling av insulinpreparat.

Country Status (11)

Country Link
US (1) US5028586A (da)
EP (2) EP0216832B1 (da)
JP (2) JPS62502196A (da)
AT (2) ATE84546T1 (da)
AU (2) AU596968B2 (da)
DE (2) DE3687500T2 (da)
DK (3) DK119785D0 (da)
FI (2) FI864559A7 (da)
IL (2) IL78161A0 (da)
NO (2) NO174278C (da)
WO (2) WO1986005496A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
US5157021A (en) * 1985-03-15 1992-10-20 Novo Nordisk A/S Insulin derivatives and pharmaceutical preparations containing these derivatives
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
ES2053723T3 (es) * 1987-02-25 1994-08-01 Novo Nordisk As Nuevos derivados de insulina.
BR8803346A (pt) * 1988-06-30 1990-02-13 Biobras Bioquimica Do Brasil S Processo aperfeicoado para producao em larga escala de cristais de insulina purificada
BR8803345A (pt) * 1988-06-30 1990-02-13 Biobras Bioquimica Do Brasil S Processo aperfeicoado para producao em larga escala de cristais de insulina humana purificada
WO1990001038A1 (en) * 1988-07-20 1990-02-08 Nordisk Gentofte A/S Human insulin analogs and preparations containing them
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
WO1992010284A2 (en) 1990-12-07 1992-06-25 Cnc Development, Inc. Catalytic chemical reactor
DK33591D0 (da) * 1991-02-27 1991-02-27 Novo Nordisk As
ES2108122T3 (es) * 1991-05-24 1997-12-16 Amylin Pharmaceuticals Inc Composicion a base de amilina o de un analogo de amilina conteniendo opcionalmente insulina, para el tratamiento de la anorexia y de las patologias asociadas.
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
AUPO269996A0 (en) * 1996-10-01 1996-10-24 Walter And Eliza Hall Institute Of Medical Research, The A method of prophylaxis and treatment
US5898067A (en) * 1997-02-07 1999-04-27 Novo Nordisk A/S Crystallization of proteins
WO2004041331A1 (en) * 2002-11-01 2004-05-21 Antares Pharma, Inc. Administration of insulin by jet injection
EP2033662B1 (en) 2004-01-21 2012-10-17 Novo Nordisk Health Care AG Transglutaminase mediated conjugation of peptides
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
WO2007096332A1 (en) * 2006-02-21 2007-08-30 Novo Nordisk A/S Single-chain insulin analogues and pharmaceutical formulations thereof
US20110065633A1 (en) * 2008-01-30 2011-03-17 Indiana University Research And Technology Corporation Ester-based peptide prodrugs
JP2012512898A (ja) * 2008-12-19 2012-06-07 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション ジペプチド結合薬用剤
EP2376097A4 (en) 2008-12-19 2012-10-03 Univ Indiana Res & Tech Corp PEPTIDE PRODRUGS OF AMIDE-BASED GLUCAGON SUPERFAMILY
CA2803164C (en) 2010-06-24 2018-08-21 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
CN104114183A (zh) 2011-12-20 2014-10-22 印第安纳大学研究及科技有限公司 用于治疗糖尿病的基于ctp的胰岛素类似物
CN108383902A (zh) 2012-09-26 2018-08-10 印第安纳大学研究及科技有限公司 胰岛素类似物二聚体
JP6538645B2 (ja) 2013-03-14 2019-07-03 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン‐インクレチン複合物
CN108271356A (zh) 2014-09-24 2018-07-10 印第安纳大学研究及科技有限公司 肠降血糖素-胰岛素缀合物
EP3197912B1 (en) 2014-09-24 2023-01-04 Indiana University Research & Technology Corporation Lipidated amide-based insulin prodrugs

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903068A (en) * 1972-12-26 1975-09-02 Us Health Education & Welfare Facile synthesis of human insulin by modification of porcine insulin
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
NO153061C (no) * 1979-04-13 1986-01-08 Shionogi & Co Fremgangsmaate for fremstilling av et b30-threonininsulin
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
US4421685A (en) * 1980-03-27 1983-12-20 Eli Lilly And Company Process for producing an insulin
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
IE52768B1 (en) * 1981-04-06 1988-02-17 Boots Co Ltd 1-arylcyclobutylalkylamine compounds useful as therapeutic agents
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider

Also Published As

Publication number Publication date
FI864560L (fi) 1986-11-10
EP0216833B1 (en) 1993-01-13
DE3673737D1 (de) 1990-10-04
NO174278B (no) 1994-01-03
FI864560A0 (fi) 1986-11-10
DK545686D0 (da) 1986-11-14
DK159856B (da) 1990-12-17
NO864556D0 (no) 1986-11-14
FI93460B (fi) 1994-12-30
JPS62502196A (ja) 1987-08-27
IL78161A0 (en) 1986-07-31
DK159856C (da) 1991-05-06
DK545786D0 (da) 1986-11-14
IL78160A (en) 1991-06-10
DE3687500T2 (de) 1993-07-01
EP0216832B1 (en) 1990-08-29
FI864559L (fi) 1986-11-10
FI93460C (fi) 1995-04-10
IL78160A0 (en) 1986-07-31
NO864555D0 (no) 1986-11-14
EP0216833A1 (en) 1987-04-08
AU5622686A (en) 1986-10-13
JPS62502538A (ja) 1987-10-01
DK545786A (da) 1986-11-14
WO1986005497A1 (en) 1986-09-25
DK119785D0 (da) 1985-03-15
DE3687500D1 (de) 1993-02-25
DK545686A (da) 1986-11-14
FI864559A0 (fi) 1986-11-10
WO1986005496A1 (en) 1986-09-25
US5028586A (en) 1991-07-02
NO864555L (no) 1986-11-14
AU5622786A (en) 1986-10-13
AU596968B2 (en) 1990-05-24
ATE84546T1 (de) 1993-01-15
FI864559A7 (fi) 1986-11-10
EP0216832A1 (en) 1987-04-08
ATE56022T1 (de) 1990-09-15
NO864556L (no) 1986-11-14

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