DD232498A5 - Verfahren zur herstellung von desulfatohirudinen - Google Patents

Verfahren zur herstellung von desulfatohirudinen Download PDF

Info

Publication number: DD232498A5
Authority: DD; German Democratic Republic
Prior art keywords: gly; glu; cys; asn; gln
Prior art date: 1983-11-22

Application number

DD84269667A

Other languages

German (de)

English (en)

Inventor

Hans Fritz

Johannes Dodt

Ursula Seemueller

Ernst Fink

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-22

Filing date

1984-11-20

Publication date

1986-01-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6214920&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD232498(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1984-11-20 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1986-01-29 Publication of DD232498A5 publication Critical patent/DD232498A5/de

Links

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235000015165 citric acid Nutrition 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
239000013256 coordination polymer Substances 0.000 description 1
239000007857 degradation product Substances 0.000 description 1
230000000593 degrading effect Effects 0.000 description 1
238000006477 desulfuration reaction Methods 0.000 description 1
230000023556 desulfurization Effects 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
230000029087 digestion Effects 0.000 description 1
229940079919 digestives enzyme preparation Drugs 0.000 description 1
238000007865 diluting Methods 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
208000009190 disseminated intravascular coagulation Diseases 0.000 description 1
125000004494 ethyl ester group Chemical group 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
229940093915 gynecological organic acid Drugs 0.000 description 1
230000000025 haemostatic effect Effects 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
-1 hydrochloric acid) Chemical class 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
230000001771 impaired effect Effects 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000006210 lotion Substances 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
239000005445 natural material Substances 0.000 description 1
230000017570 negative regulation of blood coagulation Effects 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
238000010647 peptide synthesis reaction Methods 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
230000026731 phosphorylation Effects 0.000 description 1
238000006366 phosphorylation reaction Methods 0.000 description 1
102000040430 polynucleotide Human genes 0.000 description 1
108091033319 polynucleotide Proteins 0.000 description 1
239000002157 polynucleotide Substances 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
230000024715 positive regulation of secretion Effects 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000002953 preparative HPLC Methods 0.000 description 1
238000004321 preservation Methods 0.000 description 1
235000019833 protease Nutrition 0.000 description 1
230000017854 proteolysis Effects 0.000 description 1
229940005657 pyrophosphoric acid Drugs 0.000 description 1
239000012429 reaction media Substances 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
230000000284 resting effect Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
229940035044 sorbitan monolaurate Drugs 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000008522 spreadable oils and fats Nutrition 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
108091005994 sulfated proteins Proteins 0.000 description 1
230000019635 sulfation Effects 0.000 description 1
238000005670 sulfation reaction Methods 0.000 description 1
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000010414 supernatant solution Substances 0.000 description 1
230000008961 swelling Effects 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
239000003868 thrombin inhibitor Substances 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
102000035160 transmembrane proteins Human genes 0.000 description 1
108091005703 transmembrane proteins Proteins 0.000 description 1
150000003668 tyrosines Chemical class 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Tropical Medicine & Parasitology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DD84269667A 1983-11-22 1984-11-20 Verfahren zur herstellung von desulfatohirudinen DD232498A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19833342139 DE3342139A1 (de)	1983-11-22	1983-11-22	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel

Publications (1)

Publication Number	Publication Date
DD232498A5 true DD232498A5 (de)	1986-01-29

Family

ID=6214920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD84269667A DD232498A5 (de)	1983-11-22	1984-11-20	Verfahren zur herstellung von desulfatohirudinen

Country Status (19)

Country	Link
US (3)	US4654302A (da)
EP (1)	EP0142860B1 (da)
JP (1)	JP2551551B2 (da)
AT (1)	ATE56021T1 (da)
AU (1)	AU578050B2 (da)
CA (1)	CA1239606A (da)
CY (1)	CY1737A (da)
DD (1)	DD232498A5 (da)
DE (3)	DE3342139A1 (da)
DK (1)	DK165696C (da)
HK (1)	HK121293A (da)
IE (1)	IE57885B1 (da)
IL (1)	IL73570A (da)
LU (1)	LU90192I2 (da)
MX (1)	MX9203370A (da)
NL (1)	NL970045I2 (da)
NZ (1)	NZ210275A (da)
PH (1)	PH23831A (da)
ZA (1)	ZA849068B (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3342139A1 (de) *	1983-11-22	1985-05-30	Ciba-Geigy Ag, Basel	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
US5705355A (en) *	1984-03-27	1998-01-06	Transgene, S.A.	Hirudin, pharmaceutical compositions comprising it and their use
FR2562088B1 (fr) *	1984-03-27	1987-11-13	Transgene Sa	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
DE3438296A1 (de) *	1984-04-18	1985-11-07	Hoechst Ag, 6230 Frankfurt	Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3583361D1 (de) *	1984-06-14	1991-08-08	Ucp Gen Pharma Ag	Verfahren zur herstellung von thrombin-inhibitoren.
DE3429430A1 (de) *	1984-08-10	1986-02-20	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3506992A1 (de) *	1985-02-27	1986-08-28	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
JPS6229997A (ja) *	1985-04-08	1987-02-07	Sankyo Co Ltd	Ｃ末端にプロリンアミドを有するペプチドの製法
DE3738541A1 (de) *	1987-11-13	1989-05-24	Hoechst Ag	Verfahren zur isolierung und reinigung von hirudin
EP0209061B1 (de) *	1985-07-17	1994-01-12	Hoechst Aktiengesellschaft	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
MY101203A (en) *	1985-12-12	1991-08-17	Ucp Gen Pharma Ag	Production of thrombin iinhibitors.
US5789540A (en) *	1987-01-23	1998-08-04	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
US6005071A (en) *	1987-01-23	1999-12-21	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
US5192745A (en) *	1987-05-21	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
US5236898A (en) *	1987-05-21	1993-08-17	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
US5256559A (en) *	1988-03-04	1993-10-26	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation
EP0333356A3 (en) *	1988-03-04	1990-12-19	Biogen, Inc.	Hirudin peptides
AU614121B2 (en) *	1988-05-04	1991-08-22	Novartis Ag	Improvements in the production of polypeptides
US4971953A (en) *	1988-05-10	1990-11-20	Merrell Dow Pharmaceuticals	Anticoagulant peptide alcohols
US5268296A (en) *	1988-06-11	1993-12-07	Ciba-Geigy Corporation	DNA vector and recombinant host cell for production of hirullin P6 and P18
ES2052062T3 (es) *	1988-06-11	1994-07-01	Ciba Geigy Ag	Nuevos polipeptidos con actividad anticoagulante.
US5167960A (en) *	1988-08-03	1992-12-01	New England Deaconess Hospital Corporation	Hirudin-coated biocompatible substance
US5112615A (en) *	1988-08-03	1992-05-12	New England Deaconess Hospital Corporation	Soluble hirudin conjugates
GB8822147D0 (en) *	1988-09-21	1988-10-26	Ciba Geigy Ag	Pharmaceutically active combination
JPH04500802A (ja) *	1988-09-29	1992-02-13	バイオジェンインコーポレイテッド	ヒルジンペプチド
US4994367A (en) *	1988-10-07	1991-02-19	East Carolina University	Extended shelf life platelet preparations and process for preparing the same
DE3835815A1 (de) *	1988-10-21	1990-04-26	Hoechst Ag	Neue isohirudine
FI904329A0 (fi) *	1988-12-05	1990-09-03	Biogen Inc	Foerfaranden och kompositioner foer inhibering av tronbocytaggregation.
US4861865A (en) *	1989-01-23	1989-08-29	Washington University	Novel antithrombin peptide
US5179196A (en) *	1989-05-04	1993-01-12	Sri International	Purification of proteins employing ctap-iii fusions
US6239101B1 (en) *	1989-07-05	2001-05-29	Oklahoma Medical Research Foundation	Thrombin binding polypeptides
US5192747A (en) *	1989-10-03	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
AU641215B2 (en) *	1990-02-13	1993-09-16	Merrell Dow Pharmaceuticals Inc.	Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
US5118790A (en) *	1990-07-24	1992-06-02	Sri International	Analogs of hirudin
US5837808A (en) *	1991-08-20	1998-11-17	Baxter International Inc.	Analogs of hirudin
DE4209110A1 (de) *	1991-11-26	1993-05-27	Basf Ag	Neue thrombininhibitorische proteine aus landblutegeln
DE4140381A1 (de) *	1991-12-07	1993-06-09	Hoechst Ag, 6230 Frankfurt, De	Neue synthetische isohirudine mit verbesserter stabilitaet
GB9401447D0 (en)	1994-01-26	1994-03-23	Ciba Geigy Ag	Pharmaceutical compositions
DE4404168A1 (de) *	1994-02-10	1995-08-17	Hoechst Ag	Hirudinderivate und Verfahren zu deren Herstellung
DE19607239A1 (de)	1996-02-27	1997-08-28	Behringwerke Ag	Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
EP0998942A4 (en) *	1997-01-20	2006-08-16	Japan Energy Corp	METHOD FOR STABILIZING PEPTIDES AND FREEZERED MEDICINAL COMPOSITIONS THEREOF
DE19755682A1 (de) *	1997-12-15	1999-06-17	Knoll Ag	Verfahren zur Ermittlung eines Dosierungschemas für Thrombininhibitoren
DE10149678A1 (de)	2001-10-09	2009-03-12	Novel Science International Gmbh	Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
DE10301255A1 (de)	2003-01-15	2004-07-29	Cpi Creative Pharma International Gmbh	Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3342139A1 (de) *	1983-11-22	1985-05-30	Ciba-Geigy Ag, Basel	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3438296A1 (de) *	1984-04-18	1985-11-07	Hoechst Ag, 6230 Frankfurt	Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel

1983
- 1983-11-22 DE DE19833342139 patent/DE3342139A1/de not_active Withdrawn
1984
- 1984-11-20 DD DD84269667A patent/DD232498A5/de not_active IP Right Cessation
- 1984-11-20 DE DE8484114038T patent/DE3483085D1/de not_active Expired - Lifetime
- 1984-11-20 CA CA000468216A patent/CA1239606A/en not_active Expired
- 1984-11-20 IL IL73570A patent/IL73570A/xx not_active IP Right Cessation
- 1984-11-20 DE DE1997175096 patent/DE19775096I2/de active Active
- 1984-11-20 AT AT84114038T patent/ATE56021T1/de active
- 1984-11-20 EP EP84114038A patent/EP0142860B1/de not_active Expired - Lifetime
- 1984-11-21 JP JP59244681A patent/JP2551551B2/ja not_active Expired - Lifetime
- 1984-11-21 US US06/673,952 patent/US4654302A/en not_active Expired - Lifetime
- 1984-11-21 NZ NZ210275A patent/NZ210275A/xx unknown
- 1984-11-21 AU AU35759/84A patent/AU578050B2/en not_active Expired
- 1984-11-21 IE IE2979/84A patent/IE57885B1/en not_active IP Right Cessation
- 1984-11-21 ZA ZA849068A patent/ZA849068B/xx unknown
- 1984-11-21 DK DK552684A patent/DK165696C/da not_active IP Right Cessation
1986
- 1986-11-13 US US06/929,710 patent/US4745177A/en not_active Expired - Lifetime
- 1986-11-20 PH PH31466A patent/PH23831A/en unknown
1988
- 1988-01-19 US US07/145,023 patent/US4801576A/en not_active Expired - Lifetime
1992
- 1992-06-25 MX MX9203370A patent/MX9203370A/es unknown
1993
- 1993-11-04 HK HK1212/93A patent/HK121293A/xx not_active IP Right Cessation
1995
- 1995-10-20 CY CY173795A patent/CY1737A/xx unknown
1997
- 1997-12-19 NL NL970045C patent/NL970045I2/nl unknown
- 1997-12-31 LU LU90192C patent/LU90192I2/fr unknown

Also Published As

Publication number	Publication date
ZA849068B (en)	1985-07-31
JP2551551B2 (ja)	1996-11-06
IE842979L (en)	1985-05-22
IL73570A0 (en)	1985-02-28
DE3483085D1 (de)	1990-10-04
DK165696C (da)	1993-05-24
EP0142860B1 (de)	1990-08-29
NL970045I1 (nl)	1998-03-02
IE57885B1 (en)	1993-05-05
US4801576A (en)	1989-01-31
AU3575984A (en)	1985-05-30
DE19775096I2 (de)	2002-07-04
JPS60136597A (ja)	1985-07-20
CA1239606A (en)	1988-07-26
DK165696B (da)	1993-01-04
CY1737A (en)	1995-10-20
PH23831A (en)	1989-11-23
EP0142860A2 (de)	1985-05-29
EP0142860A3 (en)	1987-03-11
IL73570A (en)	1988-05-31
US4654302A (en)	1987-03-31
NZ210275A (en)	1988-08-30
HK121293A (en)	1993-11-12
MX9203370A (es)	1992-09-01
AU578050B2 (en)	1988-10-13
NL970045I2 (nl)	1998-08-03
DK552684A (da)	1985-05-23
LU90192I2 (fr)	1998-03-02
DK552684D0 (da)	1984-11-21
ATE56021T1 (de)	1990-09-15
DE3342139A1 (de)	1985-05-30
US4745177A (en)	1988-05-17

Legal Events

Date	Code	Title	Description
1999-10-14	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
EP0142860B1 (de)	1990-08-29	Desulfatohirudine, Verfahren zu ihrer Herstellung und pharmazeutische Mittel
EP0207956B1 (de)	1990-07-04	Hirudin-pa und dessen derivate, verfahren zu deren herstellung und deren verwendung
EP0209061B1 (de)	1994-01-12	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
EP0158986B1 (de)	1993-09-15	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
EP0134479B1 (de)	1988-03-02	Modifizierte Protease-Inhibitoren, Verfahren zu ihrer Herstellung und daraus bereitete pharmazeutische Mittel
DE69434448T2 (de)	2006-06-08	Polymer-peptid konjugate
DE3855970T2 (de)	1998-01-29	Verwendung von Amylin oder CGRP zur Behandlung des Diabetes mellitus
EP1161452B1 (de)	2009-04-15	Kovalent verbrückte insulindimere
EP0193175A2 (de)	1986-09-03	Modifizierte Hirudine, Verfahren zu deren Herstellung und pharmazeutische Mittel, die diese Wirkstoffe enthalten
EP0500602B1 (de)	1995-03-29	Mittel zur neutralisierung der tumorzellen-assoziierten prokoagulant-aktivität
DE2201993A1 (de)	1972-08-10	Enzympraeparat und Verfahren zu dessen Herstellung
EP0625908B1 (de)	1997-12-17	Antidot für hirudin und synthetische thrombininhibitoren
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