DK583188A - Farmaceutiske praeparater indeholdende ergolin-derivatet pergolid og fremgangsmaade til stabilisering af saadanne praeparater - Google Patents
Farmaceutiske praeparater indeholdende ergolin-derivatet pergolid og fremgangsmaade til stabilisering af saadanne praeparaterInfo
- Publication number
- DK583188A DK583188A DK583188A DK583188A DK583188A DK 583188 A DK583188 A DK 583188A DK 583188 A DK583188 A DK 583188A DK 583188 A DK583188 A DK 583188A DK 583188 A DK583188 A DK 583188A
- Authority
- DK
- Denmark
- Prior art keywords
- preparations
- stabilizing
- pergolid
- ergolin
- derivative
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 230000000087 stabilizing effect Effects 0.000 title 1
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 abstract 2
- IELOKBJPULMYRW-NJQVLOCASA-N D-alpha-Tocopheryl Acid Succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 abstract 1
- 229940099418 d- alpha-tocopherol succinate Drugs 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 abstract 1
- 229960004851 pergolide Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 229940075579 propyl gallate Drugs 0.000 abstract 1
- 235000010388 propyl gallate Nutrition 0.000 abstract 1
- 239000000473 propyl gallate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11236087 | 1987-10-26 | ||
| US07/112,360 US4797405A (en) | 1987-10-26 | 1987-10-26 | Stabilized pergolide compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK583188D0 DK583188D0 (da) | 1988-10-20 |
| DK583188A true DK583188A (da) | 1989-04-27 |
| DK174831B1 DK174831B1 (da) | 2003-12-08 |
Family
ID=22343489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198805831A DK174831B1 (da) | 1987-10-26 | 1988-10-20 | Farmaceutiske præparater indeholdende ergolin-derivatet pergolid og fremgangsmåde til stabiliseringaf sådanne præparater |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4797405A (da) |
| EP (1) | EP0314387B1 (da) |
| JP (1) | JP2747303B2 (da) |
| KR (1) | KR960013284B1 (da) |
| AT (1) | ATE79258T1 (da) |
| AU (1) | AU611494B2 (da) |
| CA (1) | CA1318253C (da) |
| DE (1) | DE3873688T2 (da) |
| DK (1) | DK174831B1 (da) |
| ES (1) | ES2042760T3 (da) |
| GR (1) | GR3005784T3 (da) |
| HU (1) | HU200691B (da) |
| IE (1) | IE61960B1 (da) |
| IL (1) | IL88087A (da) |
| NZ (1) | NZ226650A (da) |
| PH (1) | PH25575A (da) |
| ZA (1) | ZA887805B (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5114948A (en) * | 1989-10-19 | 1992-05-19 | Eli Lilly And Company | Stabilized pergolide compositions |
| US6572879B1 (en) * | 1995-06-07 | 2003-06-03 | Alza Corporation | Formulations for transdermal delivery of pergolide |
| DE19626621A1 (de) * | 1996-07-02 | 1998-01-08 | Hexal Ag | Pflaster zur transdermalen Anwendung von Pergolid |
| US6623752B1 (en) | 1996-07-02 | 2003-09-23 | Hexal Ag | Patch for transdermal application for pergolid |
| WO2001034147A1 (en) * | 1999-11-11 | 2001-05-17 | Kyorin Pharmaceutical Co., Ltd. | Oral solid preparation |
| WO2002011727A1 (en) * | 2000-08-08 | 2002-02-14 | Teva Pharmaceutical Industries Ltd. | Stable pergolide mesylate and process for making same |
| DE10043321B4 (de) * | 2000-08-24 | 2005-07-28 | Neurobiotec Gmbh | Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung |
| DE10341317B4 (de) * | 2003-09-03 | 2008-10-23 | Axxonis Pharma Ag | Transdermales therapeutisches System (TTS) zur Verabreichung von Ergolinverbindungen ausgenommen Pergolid |
| US20070243240A9 (en) * | 2000-08-24 | 2007-10-18 | Fred Windt-Hanke | Transdermal therapeutic system |
| DE10053397A1 (de) * | 2000-10-20 | 2002-05-02 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
| DE10064453A1 (de) * | 2000-12-16 | 2002-07-04 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
| EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
| AU2003215461A1 (en) * | 2002-03-26 | 2003-10-08 | Bernard Charles Sherman | Stable tablets comprising pergolide mesylate |
| KR101302118B1 (ko) * | 2011-04-22 | 2013-08-30 | 한림대학교 산학협력단 | 단백질 수송 도메인과 치료용 단백질이 공유결합한 융합 단백질에 퍼골라이드를 가하여 융합 단백질의 생체 세포 또는 조직 내 도입을 증가시키는 방법 |
| US20190374534A1 (en) * | 2018-06-08 | 2019-12-12 | Boehringer Ingelheim Vetmedica Gmbh | Liquid pharmaceutical compositions comprising pergolide |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2680749A (en) * | 1951-12-01 | 1954-06-08 | Eastman Kodak Co | Water-soluble tocopherol derivatives |
| US3864469A (en) * | 1967-12-16 | 1975-02-04 | Hoechst Ag | Xanthines in pharmaceutical preparations and for stabilization of vitamins |
| US4473565A (en) * | 1976-05-13 | 1984-09-25 | Johnson & Johnson | Topical anti-inflammatory drug therapy |
| JPS5399316A (en) * | 1977-02-04 | 1978-08-30 | Sanpo Seiyaku Kk | Stbilyzing method of leserpine preparation |
| AT362051B (de) * | 1977-04-05 | 1981-04-27 | Sandoz Ag | Verfahren zur herstellung von injektions- praeparaten |
| JPS542316A (en) * | 1977-06-07 | 1979-01-09 | Yamanouchi Pharmaceut Co Ltd | Solid pharmaceutical composition containing nifedipene |
| JPS5446837A (en) * | 1977-09-19 | 1979-04-13 | Kanebo Ltd | Easily absorbable nifedipin composition, its preparation, and anti-stenocardia containing the same |
| US4166182A (en) * | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
| US4202979A (en) * | 1979-01-11 | 1980-05-13 | Eli Lilly And Company | 6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
| US4329366A (en) * | 1979-11-08 | 1982-05-11 | Johnson & Johnson Products, Inc. | Topical acylaminophenols |
| DE3136282A1 (de) * | 1981-09-12 | 1983-03-24 | Hoechst Ag | "verfahren zur stabilisierung photoinstabiler arzneistoffe sowie stabilisierte arzneizubereitungen" |
| JPS58105913A (ja) * | 1981-12-18 | 1983-06-24 | Nippon Chemiphar Co Ltd | ニフエジピン軟カプセル剤 |
| JPS58206533A (ja) * | 1982-05-27 | 1983-12-01 | Teijin Ltd | 活性型ビタミンｄ↓３誘導体組成物及びそれを活性成分とする薬剤 |
| US4547505A (en) * | 1983-03-25 | 1985-10-15 | Degussa Aktiengesellschaft | N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production |
| JPS60155111A (ja) * | 1983-10-20 | 1985-08-15 | Hisamitsu Pharmaceut Co Inc | 安定なケトプロフェン含有外用経皮製剤 |
| DE3424553A1 (de) * | 1984-07-04 | 1986-01-09 | Bayer Ag, 5090 Leverkusen | Feste arzneizubereitungen mit dihydropyridinen und verfahren zu ihrer herstellung |
| JPS6176416A (ja) * | 1984-09-20 | 1986-04-18 | Fujimoto Seiyaku Kk | 活性型ビタミンｄ↓３誘導体のカプセル剤用組成物 |
| JPS6270317A (ja) * | 1985-09-24 | 1987-03-31 | Sawai Seiyaku Kk | 活性型ビタミンｄ↓３類含有製剤 |
| DE3814521A1 (de) * | 1987-05-07 | 1988-11-17 | Sandoz Ag | Neue anwendung von dopaminrezeptor-agonisten |
-
1987
- 1987-10-26 US US07/112,360 patent/US4797405A/en not_active Expired - Lifetime
-
1988
- 1988-10-19 CA CA000580595A patent/CA1318253C/en not_active Expired - Fee Related
- 1988-10-19 IL IL88087A patent/IL88087A/xx not_active IP Right Cessation
- 1988-10-19 ZA ZA887805A patent/ZA887805B/xx unknown
- 1988-10-20 DK DK198805831A patent/DK174831B1/da not_active IP Right Cessation
- 1988-10-20 AU AU24080/88A patent/AU611494B2/en not_active Expired
- 1988-10-20 ES ES88309848T patent/ES2042760T3/es not_active Expired - Lifetime
- 1988-10-20 HU HU885422A patent/HU200691B/hu unknown
- 1988-10-20 EP EP88309848A patent/EP0314387B1/en not_active Expired - Lifetime
- 1988-10-20 AT AT88309848T patent/ATE79258T1/de not_active IP Right Cessation
- 1988-10-20 NZ NZ226650A patent/NZ226650A/xx unknown
- 1988-10-20 JP JP63267000A patent/JP2747303B2/ja not_active Expired - Lifetime
- 1988-10-20 DE DE8888309848T patent/DE3873688T2/de not_active Expired - Lifetime
- 1988-10-20 KR KR1019880013656A patent/KR960013284B1/ko not_active Expired - Lifetime
- 1988-10-21 IE IE319988A patent/IE61960B1/en not_active IP Right Cessation
- 1988-10-21 PH PH37714A patent/PH25575A/en unknown
-
1992
- 1992-09-24 GR GR920402106T patent/GR3005784T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0314387B1 (en) | 1992-08-12 |
| IL88087A0 (en) | 1989-06-30 |
| ATE79258T1 (de) | 1992-08-15 |
| AU611494B2 (en) | 1991-06-13 |
| ES2042760T3 (es) | 1993-12-16 |
| AU2408088A (en) | 1989-04-27 |
| HUT48462A (en) | 1989-06-28 |
| EP0314387A1 (en) | 1989-05-03 |
| DK583188D0 (da) | 1988-10-20 |
| JP2747303B2 (ja) | 1998-05-06 |
| PH25575A (en) | 1991-08-08 |
| DE3873688D1 (de) | 1992-09-17 |
| KR960013284B1 (ko) | 1996-10-02 |
| HU200691B (en) | 1990-08-28 |
| JPH01146821A (ja) | 1989-06-08 |
| US4797405A (en) | 1989-01-10 |
| DE3873688T2 (de) | 1993-03-11 |
| GR3005784T3 (da) | 1993-06-07 |
| NZ226650A (en) | 1990-08-28 |
| IE883199L (en) | 1989-04-26 |
| KR890006238A (ko) | 1989-06-12 |
| IL88087A (en) | 1992-09-06 |
| ZA887805B (en) | 1990-06-27 |
| DK174831B1 (da) | 2003-12-08 |
| IE61960B1 (en) | 1994-11-30 |
| CA1318253C (en) | 1993-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |