DK594588A - Fremgangsmaade til fremstilling af et kimaerisk antistofmolekyle - Google Patents

Fremgangsmaade til fremstilling af et kimaerisk antistofmolekyle

Info

Publication number
DK594588A
DK594588A DK594588A DK594588A DK594588A DK 594588 A DK594588 A DK 594588A DK 594588 A DK594588 A DK 594588A DK 594588 A DK594588 A DK 594588A DK 594588 A DK594588 A DK 594588A
Authority
DK
Denmark
Prior art keywords
preparing
procedure
antibody molecule
chemical antibody
chemical
Prior art date
Application number
DK594588A
Other languages
English (en)
Other versions
DK174339B1 (da
DK594588D0 (da
Inventor
Kim R Folger Bruce
Jr Henry Perry Fell
Original Assignee
Oncogen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen filed Critical Oncogen
Publication of DK594588D0 publication Critical patent/DK594588D0/da
Publication of DK594588A publication Critical patent/DK594588A/da
Application granted granted Critical
Publication of DK174339B1 publication Critical patent/DK174339B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
DK198805945A 1987-10-27 1988-10-26 Fremgangsmåde samt målvektor til fremstilling af kimæriske antistoffer ved homolog rekombination DK174339B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11380087A 1987-10-27 1987-10-27
US11380087 1987-10-27
US07/243,873 US5204244A (en) 1987-10-27 1988-09-14 Production of chimeric antibodies by homologous recombination
US24387388 1988-09-14

Publications (3)

Publication Number Publication Date
DK594588D0 DK594588D0 (da) 1988-10-26
DK594588A true DK594588A (da) 1989-04-28
DK174339B1 DK174339B1 (da) 2002-12-16

Family

ID=26811495

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198805945A DK174339B1 (da) 1987-10-27 1988-10-26 Fremgangsmåde samt målvektor til fremstilling af kimæriske antistoffer ved homolog rekombination

Country Status (17)

Country Link
US (1) US5204244A (da)
EP (1) EP0315062B1 (da)
JP (1) JP2624314B2 (da)
CN (1) CN1033290A (da)
AU (1) AU607013B2 (da)
CA (1) CA1334177C (da)
CY (1) CY1778A (da)
DE (1) DE3887085T2 (da)
DK (1) DK174339B1 (da)
ES (1) ES2061598T3 (da)
FI (1) FI97303C (da)
HK (1) HK63094A (da)
IE (1) IE61733B1 (da)
IL (1) IL88149A (da)
NO (1) NO178234C (da)
NZ (1) NZ226695A (da)
PT (1) PT88858B (da)

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DE3887085T2 (de) 1994-05-19
FI884907L (fi) 1989-04-28
PT88858B (pt) 1993-01-29
IL88149A0 (en) 1989-06-30
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IL88149A (en) 1993-06-10
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HK63094A (en) 1994-07-01
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JP2624314B2 (ja) 1997-06-25
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NO884771L (no) 1989-04-28
CN1033290A (zh) 1989-06-07
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DK174339B1 (da) 2002-12-16
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FI97303C (fi) 1996-11-25
DK594588D0 (da) 1988-10-26
US5204244A (en) 1993-04-20
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