DZ2309A1 - Dérivés de pyrrolidinyl-et pyrrolinyl-éthylamine procédé pour leur préparation et compositions pharmaceutiques les contenant. - Google Patents

Dérivés de pyrrolidinyl-et pyrrolinyl-éthylamine procédé pour leur préparation et compositions pharmaceutiques les contenant.

Info

Publication number
DZ2309A1
DZ2309A1 DZ970159A DZ970159A DZ2309A1 DZ 2309 A1 DZ2309 A1 DZ 2309A1 DZ 970159 A DZ970159 A DZ 970159A DZ 970159 A DZ970159 A DZ 970159A DZ 2309 A1 DZ2309 A1 DZ 2309A1
Authority
DZ
Algeria
Prior art keywords
pyrrolinyl
pyrrolidinyl
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
DZ970159A
Other languages
English (en)
Inventor
Ito Fumitaka
Kondo Hiroshi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DZ2309A1 publication Critical patent/DZ2309A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DZ970159A 1996-09-18 1997-09-17 Dérivés de pyrrolidinyl-et pyrrolinyl-éthylamine procédé pour leur préparation et compositions pharmaceutiques les contenant. DZ2309A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IBPCT/IB96/00957 1996-09-18

Publications (1)

Publication Number Publication Date
DZ2309A1 true DZ2309A1 (fr) 2002-12-28

Family

ID=11004480

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ970159A DZ2309A1 (fr) 1996-09-18 1997-09-17 Dérivés de pyrrolidinyl-et pyrrolinyl-éthylamine procédé pour leur préparation et compositions pharmaceutiques les contenant.

Country Status (38)

Country Link
US (7) US6201007B1 (fr)
EP (1) EP0934264B1 (fr)
JP (2) JP3195368B2 (fr)
KR (1) KR100339666B1 (fr)
CN (1) CN1237962A (fr)
AP (1) AP1016A (fr)
AR (1) AR008168A1 (fr)
AT (1) ATE249433T1 (fr)
AU (1) AU719895B2 (fr)
BG (1) BG64194B1 (fr)
BR (1) BR9711506A (fr)
CA (1) CA2266006C (fr)
CO (1) CO4920224A1 (fr)
DE (1) DE69724805T2 (fr)
DK (1) DK0934264T3 (fr)
DZ (1) DZ2309A1 (fr)
EA (1) EA001341B1 (fr)
ES (1) ES2205248T3 (fr)
HR (1) HRP970509A2 (fr)
ID (1) ID19611A (fr)
IL (3) IL147367A0 (fr)
IS (1) IS4992A (fr)
MA (1) MA26441A1 (fr)
NO (1) NO313550B1 (fr)
NZ (1) NZ334439A (fr)
OA (1) OA10996A (fr)
PA (1) PA8437201A1 (fr)
PE (1) PE109998A1 (fr)
PL (1) PL332546A1 (fr)
PT (1) PT934264E (fr)
SK (1) SK32799A3 (fr)
TN (2) TNSN97092A1 (fr)
TR (1) TR199900590T2 (fr)
TW (1) TW432047B (fr)
UA (1) UA60310C2 (fr)
WO (1) WO1998012177A1 (fr)
YU (1) YU13899A (fr)
ZA (1) ZA978358B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020009383A (ko) 1998-04-01 2002-02-01 우에노 도시오 축합 티오펜 유도체 및 이의 유도체를 유효 성분으로 하는약제
EP0982297A3 (fr) * 1998-08-24 2001-08-01 Pfizer Products Inc. Procédé de préparation de dérivés de acide hydroxamique substitués par hydroxy-pyrrolidinyl, qui sont agonistes du récepteur opioid kappa
JP2005508851A (ja) * 2001-04-30 2005-04-07 ファイザー・プロダクツ・インク カッパーアゴニストとして有用なヒドロキシピロリジニルエチルアミン化合物の調製方法
WO2003072544A1 (fr) * 2002-02-28 2003-09-04 Pfizer Products Inc. Sels de benzoate monohydrates et anhydres cristallises de (2's,3s)-3-hydroxy-n-{2-[n-methyl-n-4-(n-propylamino-carbonyl)phenyl]amino-2-phenyl}-ethylpyrrolidine
WO2004039785A1 (fr) * 2002-11-01 2004-05-13 Pfizer Products Inc. Procede servant a preparer des composes de pyrolidinyle ethylamine par l'intermediaire d'une arylamination provoquee par du cuivre
JP2007531753A (ja) * 2004-03-31 2007-11-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 非イミダゾール系複素環式化合物
US7746514B2 (en) * 2004-04-14 2010-06-29 Hung-Yi Hsu Scanner and exposure control method thereof
RU2303448C2 (ru) * 2005-04-28 2007-07-27 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО ПГФА Росздрава) 3-гидрокси-5-(3-нитрофенил)-4-(4-хлорбензоил)-1-(2-диэтиламиноэтил)-3-пирролин-2-она гидрохлорид, проявляющий противовоспалительную активность
WO2007081978A2 (fr) * 2006-01-11 2007-07-19 Angion Biomedica Corporation Modulateurs de l'activite facteur de croissance des hepatocytes / c-met
MX339668B (es) 2006-05-30 2016-06-02 Janssen Pharmaceutica N V * Compuestos de piridil amida sustituidos como moduladores del receptor h3 de la histamina.
CN101511807A (zh) * 2006-06-29 2009-08-19 詹森药业有限公司 组胺h3受体的取代的苯甲酰胺调节剂
CN105712977B (zh) 2007-11-20 2021-06-29 詹森药业有限公司 作为组胺h3受体调节剂的环烷基氧基吡啶化合物和杂环烷基氧基吡啶化合物
RU2413512C1 (ru) * 2009-07-29 2011-03-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" Средство, обладающее каппа-опиоидной агонистической активностью
WO2021163683A1 (fr) 2020-02-14 2021-08-19 President And Fellows Of Harvard College Inhibiteurs de la nicotinamide n-méthyltransférase, compositions et utilisations de ceux-ci

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8801304D0 (en) 1988-01-21 1988-02-17 Ici Plc Diamine compounds
DE3935371A1 (de) 1988-12-23 1990-07-05 Merck Patent Gmbh Stickstoffhaltige ringverbindungen
US5232978A (en) * 1988-12-23 1993-08-03 Merck Patent Gesellschaft Mit Beschrankter Haftung 1-(2-arylethyl)-pyrrolidines
DE4034785A1 (de) 1990-11-02 1992-05-07 Merck Patent Gmbh 1-(2-arylethyl)-pyrrolidine
WO1994018165A1 (fr) * 1993-02-12 1994-08-18 Pfizer Inc. Composes de sulfonamide utilises comme agonistes des recepteurs k d'opioides
IL117440A0 (en) 1995-03-31 1996-07-23 Pfizer Pyrrolidinyl hydroxamic acid compounds and their production process

Also Published As

Publication number Publication date
ZA978358B (en) 1999-03-17
US6201007B1 (en) 2001-03-13
BR9711506A (pt) 1999-08-24
AP9701082A0 (en) 1997-10-31
ID19611A (id) 1998-07-23
US6313302B2 (en) 2001-11-06
IL128959A0 (en) 2000-02-17
KR100339666B1 (ko) 2002-06-05
DE69724805T2 (de) 2004-07-01
US20010009921A1 (en) 2001-07-26
US6307061B2 (en) 2001-10-23
YU13899A (sh) 2000-03-21
TW432047B (en) 2001-05-01
PE109998A1 (es) 1999-01-13
EA001341B1 (ru) 2001-02-26
AU3781297A (en) 1998-04-14
JP2001316344A (ja) 2001-11-13
CO4920224A1 (es) 2000-05-29
US6303602B1 (en) 2001-10-16
JP3195368B2 (ja) 2001-08-06
IL147368A0 (en) 2002-08-14
US20010014683A1 (en) 2001-08-16
US20010011091A1 (en) 2001-08-02
PA8437201A1 (es) 1999-12-27
CN1237962A (zh) 1999-12-08
AP1016A (en) 2001-10-08
ES2205248T3 (es) 2004-05-01
IL147367A0 (en) 2002-08-14
AU719895B2 (en) 2000-05-18
DE69724805D1 (de) 2003-10-16
CA2266006C (fr) 2003-11-04
IS4992A (is) 1999-03-05
CA2266006A1 (fr) 1998-03-26
US20010008890A1 (en) 2001-07-19
NZ334439A (en) 2000-09-29
MA26441A1 (fr) 2004-12-20
BG103239A (en) 1999-09-30
KR20000036225A (ko) 2000-06-26
ATE249433T1 (de) 2003-09-15
US20010020024A1 (en) 2001-09-06
US6294569B2 (en) 2001-09-25
WO1998012177A1 (fr) 1998-03-26
OA10996A (en) 2001-11-06
NO991294L (no) 1999-03-17
TNSN97156A1 (fr) 2005-03-15
DK0934264T3 (da) 2004-01-26
NO313550B1 (no) 2002-10-21
EP0934264A1 (fr) 1999-08-11
US6294557B1 (en) 2001-09-25
EP0934264B1 (fr) 2003-09-10
JP2000516634A (ja) 2000-12-12
BG64194B1 (bg) 2004-04-30
TR199900590T2 (xx) 1999-07-21
NO991294D0 (no) 1999-03-17
AR008168A1 (es) 1999-12-09
SK32799A3 (en) 2000-09-12
TNSN97092A1 (ar) 1999-12-31
HRP970509A2 (en) 1998-08-31
PT934264E (pt) 2004-01-30
UA60310C2 (uk) 2003-10-15
EA199900209A1 (ru) 1999-10-28
US6310061B2 (en) 2001-10-30
PL332546A1 (en) 1999-09-13

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