DZ3326A1 - Composés nouveaux modulateurs de chimiokine ccr5, et compositions pharmaceutiques les contenant. - Google Patents

Composés nouveaux modulateurs de chimiokine ccr5, et compositions pharmaceutiques les contenant.

Info

Publication number: DZ3326A1
Authority: DZ; Algeria
Prior art keywords: ccr5; pharmaceutical compositions; compositions containing; modulator compounds; novel chemokine
Prior art date: 1998-12-23

Application number

DZ010081A

Other languages

English (en)

Inventor

Duncan Robert Armour

David Anthony Price

Blanda Luzia C Stammen

Anthony Wood

Manoussos Perros

Martin Paul Edwards

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-23

Filing date

2001-11-19

Publication date

2005-05-29

1998-12-23 Priority claimed from GBGB9828420.1A external-priority patent/GB9828420D0/en

1999-09-10 Priority claimed from GBGB9921375.3A external-priority patent/GB9921375D0/en

2001-11-19 Application filed by Pfizer filed Critical Pfizer

2005-05-29 Application granted granted Critical

2005-05-29 Publication of DZ3326A1 publication Critical patent/DZ3326A1/fr

Links

102000019034 Chemokines Human genes 0.000 title 1
108010012236 Chemokines Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DZ010081A 1998-12-23 2001-11-19 Composés nouveaux modulateurs de chimiokine ccr5, et compositions pharmaceutiques les contenant. DZ3326A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9828420.1A GB9828420D0 (en)	1998-12-23	1998-12-23	CCR5 antagonists useful as anti-hiv agents
GBGB9921375.3A GB9921375D0 (en)	1999-09-10	1999-09-10	CCR5 Modulators
DZ990279A DZ2979A1 (fr)	1998-12-23	1999-12-22	Composés nouveaux modulateurs de chimiokine ccr5, et compositions pharmaceutiques les contenant.

Publications (1)

Publication Number	Publication Date
DZ3326A1 true DZ3326A1 (fr)	2005-05-29

Family

ID=26314899

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DZ990279A DZ2979A1 (fr)	1998-12-23	1999-12-22	Composés nouveaux modulateurs de chimiokine ccr5, et compositions pharmaceutiques les contenant.
DZ010081A DZ3326A1 (fr)	1998-12-23	2001-11-19	Composés nouveaux modulateurs de chimiokine ccr5, et compositions pharmaceutiques les contenant.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DZ990279A DZ2979A1 (fr)	1998-12-23	1999-12-22	Composés nouveaux modulateurs de chimiokine ccr5, et compositions pharmaceutiques les contenant.

Country Status (48)

Country	Link
US (1)	US6586430B1 (fr)
EP (1)	EP1140085B1 (fr)
JP (1)	JP3602795B2 (fr)
KR (1)	KR100425612B1 (fr)
CN (1)	CN1331591A (fr)
AP (1)	AP1697A (fr)
AR (1)	AR024233A1 (fr)
AT (1)	ATE505190T1 (fr)
AU (1)	AU763644B2 (fr)
BG (1)	BG65448B1 (fr)
BR (1)	BRPI9917007B8 (fr)
CA (1)	CA2350073C (fr)
CO (1)	CO5300387A1 (fr)
CR (2)	CR6392A (fr)
CU (1)	CU23344A3 (fr)
CY (1)	CY1111504T1 (fr)
CZ (1)	CZ300926B6 (fr)
DE (1)	DE69943352D1 (fr)
DK (1)	DK1140085T3 (fr)
DZ (2)	DZ2979A1 (fr)
EA (1)	EA004988B1 (fr)
EE (1)	EE05170B1 (fr)
EG (1)	EG24400A (fr)
GC (1)	GC0000117A (fr)
GE (1)	GEP20033131B (fr)
HK (1)	HK1039902A1 (fr)
HR (2)	HRP20010468B1 (fr)
HU (1)	HU228754B1 (fr)
ID (1)	ID28965A (fr)
IL (2)	IL143512A0 (fr)
IS (1)	IS5944A (fr)
MA (1)	MA26714A1 (fr)
ME (1)	ME00513B (fr)
NO (1)	NO330677B1 (fr)
NZ (1)	NZ511794A (fr)
OA (1)	OA11735A (fr)
PA (1)	PA8487201A1 (fr)
PE (1)	PE20001420A1 (fr)
PL (1)	PL201875B1 (fr)
PT (1)	PT1140085E (fr)
RS (1)	RS51701B (fr)
SI (1)	SI1140085T1 (fr)
SK (1)	SK287020B6 (fr)
TN (1)	TNSN99252A1 (fr)
TR (1)	TR200101793T2 (fr)
TW (1)	TW577888B (fr)
UA (1)	UA72750C2 (fr)
WO (1)	WO2000038680A1 (fr)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7217714B1 (en) *	1998-12-23	2007-05-15	Agouron Pharmaceuticals, Inc.	CCR5 modulators
EP1013276A1 (fr) *	1998-12-23	2000-06-28	Pfizer Inc.	Aminoazacycloalcanes comme modulateurs de CCR5
US6399619B1 (en)	1999-04-06	2002-06-04	Merck & Co., Inc.	Pyrrolidine modulators of chemokine receptor activity
US6248755B1 (en)	1999-04-06	2001-06-19	Merck & Co., Inc.	Pyrrolidine modulators of chemokine receptor activity
SE9903544D0 (sv)	1999-10-01	1999-10-01	Astra Pharma Prod	Novel compounds
EP1118858A3 (fr) *	2000-01-12	2003-07-09	Pfizer Limited	Méthode d'essai
GB2359081A (en)	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active thiazolopyrimidines
GB2359078A (en)	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB2359551A (en)	2000-02-23	2001-08-29	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en)	2000-03-10	2000-05-03	Astrazeneca Uk Ltd	Chemical compounds
US6667314B2 (en) *	2000-05-26	2003-12-23	Pfizer, Inc.	Tropane derivatives useful in therapy
RS50904B (sr) *	2000-05-26	2010-08-31	Pfizer Inc.	Derivati tropana i njihova primena
GB0015562D0 (en) *	2000-06-23	2000-08-16	Pfizer Ltd	Heterocycles
US6531484B2 (en)	2000-10-11	2003-03-11	Merck & Co., Inc.	Pyrrolidine modulators of CCR5 chemokine receptor activity
US6511994B2 (en)	2000-10-11	2003-01-28	Merck & Co., Inc.	Modulators of CCR5 chemokine receptor activity
SE0003828D0 (sv)	2000-10-20	2000-10-20	Astrazeneca Ab	Novel compounds
CA2432527A1 (fr) *	2000-12-22	2002-07-04	Takeda Chemical Industries, Ltd.	Compositions medicinales s'administrant par voie orale
SE0101322D0 (sv)	2001-04-12	2001-04-12	Astrazeneca Ab	Novel compounds
SE0103818D0 (sv) *	2001-11-15	2001-11-15	Astrazeneca Ab	Chemical compounds
AR041786A1 (es) *	2002-03-15	2005-06-01	Novartis Ag	Derivados de azetidina como antagonistas del receptor ccr-3, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la elaboracion de un medicamento
US6855724B2 (en)	2002-04-08	2005-02-15	Agouron Pharmaceuticals, Inc.	Tropane derivatives useful in therapy
EP1492789B1 (fr) *	2002-04-08	2006-06-07	Pfizer Limited	Derives de tropane utilises comme modulateur de ccr5
WO2003100427A1 (fr) *	2002-05-23	2003-12-04	Pfizer Limited	Procede d'identification d'un ligand faisant appel a la mesure du temps de sejour sur le recepteur
GB0221828D0 (en)	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
US7202259B2 (en) *	2002-11-18	2007-04-10	Euro-Celtique S.A.	Therapeutic agents useful for treating pain
WO2004052862A1 (fr) *	2002-12-10	2004-06-24	Ono Pharmaceutical Co., Ltd.	Composes heterocycliques contenant de l'azote et leur utilisation medicale
US7569579B2 (en)	2002-12-13	2009-08-04	Smithkline Beecham Corporation	Cyclopropyl compounds as ccr5 antagonists
BR0317230A (pt)	2002-12-13	2005-10-25	Smithkline Beecham Corp	Composto, composição, métodos de antagonizar uma atividade do receptor de quimiocina ccr-5, e de tratar uma infecção viral em um paciente, e, uso de um composto
WO2004080966A1 (fr)	2003-03-14	2004-09-23	Ono Pharmaceutical Co., Ltd.	Derives heterocycliques renfermant de l'azote et medicaments contenant ces derives comme principe actif
US7498323B2 (en)	2003-04-18	2009-03-03	Ono Pharmaceuticals Co., Ltd.	Spiro-piperidine compounds and medicinal use thereof
ATE361911T1 (de) *	2003-07-31	2007-06-15	Astrazeneca Ab	Piperidinderivate als ccr5-rezeptormodulatoren
US7220772B2 (en)	2003-09-05	2007-05-22	Pfizer, Inc.	Pyrazole derivatives
EP1786816A4 (fr)	2003-09-10	2009-11-04	Virochem Pharma Inc	Composes de spirohydantoine et procedes de modulation de l'activite des recepteurs de chimiokine
EP1682545B1 (fr) *	2003-10-03	2007-12-12	Pfizer Limited	Derives de tropane a substitution imidazopyridine en tant qu'antagonistes des recepteurs ccr5 pour le traitement du vih et de l'inflammation
GB0323236D0 (en) *	2003-10-03	2003-11-05	Pfizer Ltd	Chemical compounds
GB0328243D0 (en)	2003-12-05	2004-01-07	Astrazeneca Ab	Methods
CA2552087C (fr) *	2004-01-30	2011-01-25	Euro-Celtique S.A.	Procedes d'elaboration de composes de 4-tetrazolyl-4-phenylpiperidine
TW200533348A (en)	2004-02-18	2005-10-16	Theravance Inc	Indazole-carboxamide compounds as 5-ht4 receptor agonists
WO2005100322A1 (fr) *	2004-04-14	2005-10-27	Pfizer Limited	Composes d'imidazole a liaison souphre pour le traitement du vih
TW200610761A (en) *	2004-04-23	2006-04-01	Astrazeneca Ab	Chemical compounds
RU2006146608A (ru)	2004-06-09	2008-07-20	Ф.Хоффманн-Ля Рош Аг (Ch)	ОКТАГИДРОПИРРОЛО[3,4-с]-ПРОИЗВОДНЫЕ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПРОТИВОВИРУСНЫХ АГЕНТОВ
EP1790637B1 (fr)	2004-09-13	2014-01-29	Ono Pharmaceutical Co., Ltd.	Dérivés de N-4-piperidylurée et medicaments les contenant comme principe actif
KR20070116867A (ko) *	2005-04-08	2007-12-11	뉴로서치 에이/에스	(+)- 및(-)-8-알킬-3-(트리플루오르알킬설포닐옥시)-8-아자바이사이클(3.2.1)옥트-2-엔
US7462639B2 (en)	2005-04-14	2008-12-09	Hoffmann-La Roche Inc.	Aminopyrazole derivatives
US20110052612A1 (en)	2005-05-31	2011-03-03	Ono Pharmaceutical Co., Ltd.	Spiropiperidine compound and medicinal use thereof
US7665658B2 (en)	2005-06-07	2010-02-23	First Data Corporation	Dynamic aggregation of payment transactions
ES2277745B1 (es) *	2005-06-14	2008-06-01	Laboratorios Almirall S.A.	Derivados n-amida de 8-azabiciclo /3.2.1/oct-3-ilo como antagonistas de ccr1.
PT1942108E (pt)	2005-10-28	2013-10-24	Ono Pharmaceutical Co	Composto com um grupo básico e a sua utilização
WO2007058322A1 (fr)	2005-11-18	2007-05-24	Ono Pharmaceutical Co., Ltd.	Composé contenant un groupe basique et son utilisation
KR20090008217A (ko)	2006-03-10	2009-01-21	오노 야꾸힝 고교 가부시키가이샤	질소 함유 복소환 유도체 및 이들을 유효 성분으로 하는 약제
US20080015833A1 (en) *	2006-07-13	2008-01-17	Searete Llc, A Limited Liability Corporation Of The State Of Delaware	Methods and systems for molecular inhibition of protein misfolding
US20080014572A1 (en) *	2006-07-13	2008-01-17	Searete Llc, A Limited Liability Corporation Of The State Of Delaware	Methods and systems for molecular inhibition
US20080015835A1 (en) *	2006-07-13	2008-01-17	Searete Llc, A Limited Liability Corporation Of The State Of Delaware	Methods and systems for treating disease
US20090082344A1 (en) *	2006-07-13	2009-03-26	Searete Llc	Methods and systems for treating disease
WO2008016006A1 (fr)	2006-07-31	2008-02-07	Ono Pharmaceutical Co., Ltd.	Composé auquel un groupe cyclique est lié par une liaison spiro et son utilisation
US20080146605A1 (en) *	2006-12-19	2008-06-19	Auspex Pharmaceuticals, Inc.	Preparation and utility of ccr5 inhibitors
TW201322983A (zh) *	2007-08-31	2013-06-16	Purdue Pharma Lp	經取代之喹□啉型哌啶化合物及其用途
WO2010129351A1 (fr)	2009-04-28	2010-11-11	Schepens Eye Research Institute	Procédé pour identifier et pour traiter une dégénérescence maculaire liée à l'âge
WO2011011652A1 (fr)	2009-07-24	2011-01-27	Glaxosmithkline Llc	Composés thérapeutiques
EP2552429A1 (fr)	2010-04-02	2013-02-06	Phivco-1 LLC	Traitement d'association comprenant un antagoniste du récepteur ccr5, un inhibiteur de la protéase du vih-1 et un accélérateur pharmacocinétique
BR112013023050A8 (pt)	2011-03-09	2018-09-25	G Pestell Richard	antagonista de ccr5, método para determinar se um indivíduo humano tendo câncer de próstata está sofrendo de ou sob o risco de desenvolver metástase, para identificar um antagonista de ccr5, método para determinar se um indivíduo humano tendo câncer de próstata está sofrendo de ou sob o risco de desenvolver metástase, para identificar um composto candidato, para produzir in vitro células epiteliais primárias, para diagnosticar câncer de próstata, para selecionar um tratamento para um indivíduo tendo um câncer/tumor de próstata, linhagem de célula, e, modelo animal
EP2741777B1 (fr)	2011-08-12	2017-01-18	INSERM - Institut National de la Santé et de la Recherche Médicale	Procédés et compositions pharmaceutiques pour le traitement de l'hypertension pulmonaire
AU2013262977A1 (en) *	2012-05-14	2015-01-22	Prostagene, Llc	Using modulators of CCR5 for treating cancer
US9090618B2 (en)	2012-12-27	2015-07-28	Purdue Pharma L.P.	Substituted benzimidazole-type piperidine compounds and uses thereof
EP3826659B1 (fr) *	2018-07-10	2024-06-19	Rush University Medical Center	Immunomodulateur destiné à être utilisé dans le traitement d'une infection bactérienne
AU2021222441A1 (en)	2020-02-19	2022-09-22	Ichilov Tech Ltd.	Improved antidepressant therapy
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
JP2023530319A (ja)	2020-06-17	2023-07-14	メルク・シャープ・アンド・ドーム・エルエルシー	Ｎａｖ１．８阻害剤としての２－オキソ－オキサゾリジン－５－カルボキサミド
BR112022024476A2 (pt) *	2020-06-17	2022-12-27	Merck Sharp & Dohme Llc	5-oxopirrolidino-3-carboxamidas como inibidores de nav1.8
WO2025064788A2 (fr) *	2023-09-20	2025-03-27	Cidara Therapeutics, Inc.	Conjugués ccr5 et leurs utilisations

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9125900D0 (en)	1991-12-05	1992-02-05	Wyeth John & Brother Ltd	Piperazine derivatives
PH30413A (en)	1992-03-26	1997-05-09	Boehringer Ingelheim Italia	Crystalline forms of endo-2,3-dihydro-n-(8-methyl)-8-azabicyclo-(3,2,1)oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamides
GB9310713D0 (en) *	1993-05-24	1993-07-07	Zeneca Ltd	Aryl substituted heterocycles
FR2728166A1 (fr)	1994-12-19	1996-06-21	Oreal	Composition topique contenant un antagoniste de substance p
DE19500120A1 (de) *	1995-01-04	1996-07-11	Bayer Ag	Neue acylierte Pseudopeptide mit trifluormethyl-subsstituiertem 2-Azabicyclooctan
GB9502644D0 (en) *	1995-02-10	1995-03-29	Zeneca Ltd	Heterocyclic derivatives
GB9523526D0 (en) *	1995-11-17	1996-01-17	Zeneca Ltd	Therapeutic compounds
AU1208397A (en) *	1995-12-28	1997-07-28	Takeda Chemical Industries Ltd.	Diphenylmethane derivatives as mip-1alpha/rantes receptor antagonists
PT891332E (pt) *	1996-03-29	2004-07-30	Pfizer	Derivados de 6-fenilpiridil-2-amina
JP2000516210A (ja) *	1996-07-12	2000-12-05	ロイコサイト，インコーポレーテッド	ケモカインレセプターアンタゴニストとその使用方法
US6323206B1 (en) *	1996-07-12	2001-11-27	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
CA2261633A1 (fr) *	1996-07-29	1998-02-05	Banyu Pharmaceutical Co., Ltd.	Antagonistes de recepteurs de chemokines
WO1998025605A1 (fr)	1996-12-13	1998-06-18	Merck & Co., Inc.	Azacycles spiro-substitues utilises comme modulateurs de l'activite des recepteurs de la chemokine
AU5604998A (en)	1996-12-13	1998-07-03	Merck & Co., Inc.	Spiro-substituted azacycles as modulators of chemokine receptor activity
AU5522498A (en)	1996-12-13	1998-07-03	Merck & Co., Inc.	Substituted aryl piperazines as modulators of chemokine receptor activity
EP1003743A4 (fr)	1997-01-21	2001-04-11	Merck & Co Inc	Piperidines 3,3-disubstituees utilisees comme modulateurs de l'activite de recepteurs de chemokines
WO1999004794A1 (fr)	1997-07-25	1999-02-04	Merck & Co., Inc.	Amines cycliques modulant l'activite des recepteurs de chimiokines
IL125658A0 (en) *	1997-08-18	1999-04-11	Hoffmann La Roche	Ccr-3 receptor antagonists
EP1009405A4 (fr)	1997-08-28	2001-05-09	Merck & Co Inc	Modulateurs de pyrrolidine et de piperidine de l'activite du recepteur de chemokine
AR013669A1 (es) *	1997-10-07	2001-01-10	Smithkline Beecham Corp	Compuestos y metodos
US6433165B1 (en) *	1998-01-21	2002-08-13	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor

1999
- 1999-11-29 PE PE1999001190A patent/PE20001420A1/es not_active IP Right Cessation
- 1999-11-30 AR ARP990106086A patent/AR024233A1/es active IP Right Grant
- 1999-12-01 US US09/452,578 patent/US6586430B1/en not_active Expired - Lifetime
- 1999-12-02 TW TW088121100A patent/TW577888B/zh not_active IP Right Cessation
- 1999-12-02 CO CO99075874A patent/CO5300387A1/es not_active Application Discontinuation
- 1999-12-10 PA PA19998487201A patent/PA8487201A1/es unknown
- 1999-12-14 EG EG159299A patent/EG24400A/xx active
- 1999-12-21 GC GCP1999452 patent/GC0000117A/xx active
- 1999-12-22 ID IDW00200101366A patent/ID28965A/id unknown
- 1999-12-22 MA MA25868A patent/MA26714A1/fr unknown
- 1999-12-22 DZ DZ990279A patent/DZ2979A1/fr active
- 1999-12-22 TN TNTNSN99252A patent/TNSN99252A1/fr unknown
- 1999-12-23 AP APAP/P/2001/002186A patent/AP1697A/en active
- 1999-12-23 HR HRP20010468AA patent/HRP20010468B1/xx not_active IP Right Cessation
- 1999-12-23 DE DE69943352T patent/DE69943352D1/de not_active Expired - Lifetime
- 1999-12-23 IL IL14351299A patent/IL143512A0/xx unknown
- 1999-12-23 KR KR10-2001-7008122A patent/KR100425612B1/ko not_active Expired - Lifetime
- 1999-12-23 PT PT99959624T patent/PT1140085E/pt unknown
- 1999-12-23 BR BRPI9917007A patent/BRPI9917007B8/pt not_active IP Right Cessation
- 1999-12-23 EE EEP200100345A patent/EE05170B1/xx unknown
- 1999-12-23 CA CA002350073A patent/CA2350073C/fr not_active Expired - Lifetime
- 1999-12-23 GE GEAP19995958A patent/GEP20033131B/en unknown
- 1999-12-23 AT AT99959624T patent/ATE505190T1/de active
- 1999-12-23 PL PL349495A patent/PL201875B1/pl unknown
- 1999-12-23 EA EA200100589A patent/EA004988B1/ru not_active IP Right Cessation
- 1999-12-23 RS YU38801A patent/RS51701B/sr unknown
- 1999-12-23 JP JP2000590634A patent/JP3602795B2/ja not_active Expired - Lifetime
- 1999-12-23 WO PCT/IB1999/002048 patent/WO2000038680A1/fr not_active Ceased
- 1999-12-23 UA UA2001064397A patent/UA72750C2/uk unknown
- 1999-12-23 HU HU0104795A patent/HU228754B1/hu unknown
- 1999-12-23 TR TR2001/01793T patent/TR200101793T2/xx unknown
- 1999-12-23 OA OA1200100164A patent/OA11735A/en unknown
- 1999-12-23 HR HRP20120132AA patent/HRP20120132B1/hr not_active IP Right Cessation
- 1999-12-23 SK SK875-2001A patent/SK287020B6/sk not_active IP Right Cessation
- 1999-12-23 EP EP99959624A patent/EP1140085B1/fr not_active Expired - Lifetime
- 1999-12-23 CZ CZ20012298A patent/CZ300926B6/cs not_active IP Right Cessation
- 1999-12-23 ME MEP-2008-837A patent/ME00513B/fr unknown
- 1999-12-23 CN CN99815033A patent/CN1331591A/zh active Pending
- 1999-12-23 SI SI9931056T patent/SI1140085T1/sl unknown
- 1999-12-23 NZ NZ511794A patent/NZ511794A/en not_active IP Right Cessation
- 1999-12-23 DK DK99959624.0T patent/DK1140085T3/da active
- 1999-12-23 AU AU16751/00A patent/AU763644B2/en not_active Expired
- 1999-12-23 HK HK02101507.2A patent/HK1039902A1/zh unknown
2001
- 2001-05-15 IS IS5944A patent/IS5944A/is unknown
- 2001-05-31 IL IL143512A patent/IL143512A/en not_active IP Right Cessation
- 2001-06-14 CR CR6392A patent/CR6392A/es unknown
- 2001-06-14 CR CR9879A patent/CR9879A/es unknown
- 2001-06-22 CU CU20010145A patent/CU23344A3/es unknown
- 2001-06-25 NO NO20013183A patent/NO330677B1/no not_active IP Right Cessation
- 2001-07-20 BG BG105721A patent/BG65448B1/bg unknown
- 2001-11-19 DZ DZ010081A patent/DZ3326A1/fr active
2011
- 2011-05-17 CY CY20111100484T patent/CY1111504T1/el unknown

Also Published As

Publication number	Publication date
CA2350073C (fr)	2007-04-17
NO20013183L (no)	2001-08-08
JP3602795B2 (ja)	2004-12-15
CR6392A (es)	2006-08-09
HRP20120132A2 (hr)	2012-03-31
KR20010089701A (ko)	2001-10-08
CZ300926B6 (cs)	2009-09-09
BRPI9917007B8 (pt)	2021-05-25
UA72750C2 (en)	2005-04-15
HRP20010468B1 (hr)	2012-06-30
TW577888B (en)	2004-03-01
HRP20120132A8 (hr)	2017-11-03
AP2001002186A0 (en)	2001-06-30
PL349495A1 (en)	2002-07-29
EP1140085B1 (fr)	2011-04-13
EG24400A (en)	2009-04-29
CO5300387A1 (es)	2003-07-31
MA26714A1 (fr)	2004-12-20
EA004988B1 (ru)	2004-10-28
CU23344A3 (es)	2009-02-20
EE200100345A (et)	2002-12-16
IL143512A0 (en)	2002-04-21
EP1140085A1 (fr)	2001-10-10
YU38801A (sh)	2005-06-10
EE05170B1 (et)	2009-06-15
SK287020B6 (sk)	2009-09-07
PA8487201A1 (es)	2002-02-21
HUP0104795A3 (en)	2002-05-28
WO2000038680A1 (fr)	2000-07-06
HUP0104795A2 (hu)	2002-04-29
DE69943352D1 (de)	2011-05-26
EA200100589A1 (ru)	2002-02-28
CY1111504T1 (el)	2015-08-05
PT1140085E (pt)	2011-06-16
SI1140085T1 (sl)	2011-08-31
PL201875B1 (pl)	2009-05-29
ID28965A (id)	2001-07-19
CZ20012298A3 (cs)	2002-09-11
HRP20010468A2 (en)	2003-02-28
US6586430B1 (en)	2003-07-01
GC0000117A (en)	2005-06-29
BR9917007A (pt)	2001-10-30
BG65448B1 (bg)	2008-08-29
CR9879A (es)	2008-06-20
OA11735A (en)	2005-05-12
TNSN99252A1 (fr)	2005-11-10
BRPI9917007B1 (pt)	2016-07-26
NO20013183D0 (no)	2001-06-25
IL143512A (en)	2013-06-27
HU228754B1 (en)	2013-05-28
AU763644B2 (en)	2003-07-31
HRP20120132B1 (hr)	2018-01-26
NO330677B1 (no)	2011-06-06
AU1675100A (en)	2000-07-31
ATE505190T1 (de)	2011-04-15
AP1697A (en)	2006-12-22
BG105721A (en)	2002-02-28
CN1331591A (zh)	2002-01-16
RS51701B (sr)	2011-10-31
JP2002533393A (ja)	2002-10-08
SK8752001A3 (en)	2003-02-04
CA2350073A1 (fr)	2000-07-06
TR200101793T2 (tr)	2001-12-21
NZ511794A (en)	2003-10-31
KR100425612B1 (ko)	2004-04-01
ME00513B (fr)	2011-10-10
HK1039902A1 (zh)	2002-05-17
GEP20033131B (en)	2003-12-25
IS5944A (is)	2001-05-15
AR024233A1 (es)	2002-09-25
DZ2979A1 (fr)	2005-01-30
DK1140085T3 (da)	2011-06-27
PE20001420A1 (es)	2000-12-18

Publication	Publication Date	Title
DZ3326A1 (fr)	2005-05-29	Composés nouveaux modulateurs de chimiokine ccr5, et compositions pharmaceutiques les contenant.
DZ2978A1 (fr)	2004-07-04	Composés chimiques nouveaux modulateurs de ccr5, et compositions pharmaceutiques les contenant.
DZ2964A1 (fr)	2004-03-15	Diphénylurées substituées nouvelles, et compositions pharmaceutiques les contenant.
DZ1916A1 (fr)	2002-02-17	Composés nouveaux et compostions pharmaceutiques les contenant.
DZ2086A1 (fr)	2002-07-22	Benzylaminopipéridines substituées et compositionspharmaceutiques les contenant.
DZ2594A1 (fr)	2003-02-22	Dérivés de 2-aminopyridine nouveaux et compositions pharmaceutiques les contenant.
DZ2887A1 (fr)	2003-12-15	Dérivés d'azétidine, leur préparation et les médicaments les contenant.
MA24529A1 (fr)	1998-12-31	Pyrazolopyrimidinones nouvelles, procede pour leur preparation et compositions les contenant .
MA26490A1 (fr)	2004-12-20	Derives de tetrahydroisoquinoleine nouveaux, procedes pour leur preparation et compositions pharmaceutiques les contenant.
MA26551A1 (fr)	2004-12-20	Agonistes de prostaglandines nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.
DZ2890A1 (fr)	2003-12-15	4-Carboxamino-2-substitué-1,2,3,4-tétrahydroquinoléines, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2461A1 (fr)	2003-01-18	Dérivés d'arylkylamines nouveaux et composition pharmaceutiques les contenant.
FR2732967B1 (fr)	1997-07-04	1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
DZ2009A1 (fr)	2002-10-23	Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
DZ2745A1 (fr)	2003-09-08	BicycloÄ2.2.1Üheptanes nouveaux procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ3191A1 (fr)	2001-01-11	Composés d'indazole et compositions pharmaceutiques inhibant les protéines kinases, et procédés d'utilisation de ceux-ci.
MA26472A1 (fr)	2004-12-20	Derives de n-hydroxy-b-sulfonylpropionamide, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26630A1 (fr)	2004-12-20	4-phenylpyperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant
DZ2479A1 (fr)	2003-02-01	Composés inhibiteurs sélectifs de cox-2 anti-inflammatoires et compositions pharmaceutiques les contenant.
FR2708606B1 (fr)	1995-10-27	Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
CH689805A8 (fr)	2000-02-29	Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
DZ2188A1 (fr)	2002-12-02	Dérivés de quinoxalinedone, procédés et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant.
MA26558A1 (fr)	2004-12-20	Derives nouveaux de 6-0-methylerythromycine a, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26514A1 (fr)	2004-12-20	Agonistes de prostaglandines, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26707A1 (fr)	2004-12-20	Azalides nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.