EA010857B1 - Способ лечения рака, применение dmxaa в противораковых комбинациях, способ их получения и набор - Google Patents

Способ лечения рака, применение dmxaa в противораковых комбинациях, способ их получения и набор Download PDF

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Publication number
EA010857B1
EA010857B1 EA200601118A EA200601118A EA010857B1 EA 010857 B1 EA010857 B1 EA 010857B1 EA 200601118 A EA200601118 A EA 200601118A EA 200601118 A EA200601118 A EA 200601118A EA 010857 B1 EA010857 B1 EA 010857B1
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EA
Eurasian Patent Office
Prior art keywords
pharmaceutically acceptable
acceptable salt
topoisomerase
όμχάά
ester
Prior art date
Application number
EA200601118A
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English (en)
Russian (ru)
Other versions
EA200601118A1 (ru
Inventor
Уилльям Роберт Уилсон
Бронуин Гей Сиим
Original Assignee
Кэнсе Рисёч Технолоджи Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Кэнсе Рисёч Технолоджи Лимитед filed Critical Кэнсе Рисёч Технолоджи Лимитед
Publication of EA200601118A1 publication Critical patent/EA200601118A1/ru
Publication of EA010857B1 publication Critical patent/EA010857B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pyrane Compounds (AREA)
EA200601118A 2001-09-03 2002-09-03 Способ лечения рака, применение dmxaa в противораковых комбинациях, способ их получения и набор EA010857B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0121285.1A GB0121285D0 (en) 2001-09-03 2001-09-03 Anti-cancer combinations

Publications (2)

Publication Number Publication Date
EA200601118A1 EA200601118A1 (ru) 2006-12-29
EA010857B1 true EA010857B1 (ru) 2008-12-30

Family

ID=9921418

Family Applications (3)

Application Number Title Priority Date Filing Date
EA200601118A EA010857B1 (ru) 2001-09-03 2002-09-03 Способ лечения рака, применение dmxaa в противораковых комбинациях, способ их получения и набор
EA200801611A EA200801611A1 (ru) 2001-09-03 2002-09-03 Противораковые комбинации
EA200400370A EA008056B1 (ru) 2001-09-03 2002-09-03 Противораковые комбинации

Family Applications After (2)

Application Number Title Priority Date Filing Date
EA200801611A EA200801611A1 (ru) 2001-09-03 2002-09-03 Противораковые комбинации
EA200400370A EA008056B1 (ru) 2001-09-03 2002-09-03 Противораковые комбинации

Country Status (23)

Country Link
US (6) US7863322B2 (2)
EP (3) EP1423105B9 (2)
JP (3) JP2005509599A (2)
CN (5) CN101596186A (2)
AT (1) ATE415963T1 (2)
AU (1) AU2002324143B2 (2)
BR (1) BR0212258A (2)
CA (1) CA2458459A1 (2)
CY (1) CY1110426T1 (2)
DE (1) DE60230159D1 (2)
DK (1) DK1423105T3 (2)
EA (3) EA010857B1 (2)
ES (1) ES2321283T3 (2)
GB (1) GB0121285D0 (2)
IL (1) IL160178A0 (2)
IS (1) IS7144A (2)
MX (1) MXPA04002004A (2)
NO (1) NO20040591L (2)
NZ (5) NZ567456A (2)
PT (1) PT1423105E (2)
SI (1) SI1423105T1 (2)
WO (1) WO2003020259A2 (2)
ZA (1) ZA200401078B (2)

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Also Published As

Publication number Publication date
CA2458459A1 (en) 2003-03-13
EP1423105A2 (en) 2004-06-02
ATE415963T1 (de) 2008-12-15
US20080070886A1 (en) 2008-03-20
NO20040591L (no) 2004-04-30
EA200601118A1 (ru) 2006-12-29
EA200801611A1 (ru) 2009-06-30
EP1423105B9 (en) 2009-08-12
GB0121285D0 (en) 2001-10-24
SI1423105T1 (sl) 2009-08-31
CN101596187A (zh) 2009-12-09
WO2003020259A3 (en) 2003-04-17
PT1423105E (pt) 2009-03-09
IS7144A (is) 2004-02-06
CY1110426T1 (el) 2015-04-29
US7863322B2 (en) 2011-01-04
EP2236134A1 (en) 2010-10-06
JP2010270124A (ja) 2010-12-02
ZA200401078B (en) 2005-04-15
CN101607087A (zh) 2009-12-23
MXPA04002004A (es) 2005-02-17
US7863321B2 (en) 2011-01-04
DK1423105T3 (da) 2009-03-30
EP1759694A3 (en) 2009-02-18
US20080070848A1 (en) 2008-03-20
US7868040B2 (en) 2011-01-11
NZ554093A (en) 2008-07-31
EP1759694A2 (en) 2007-03-07
US20080070849A1 (en) 2008-03-20
EA200400370A1 (ru) 2004-08-26
AU2002324143B2 (en) 2007-09-13
NZ576925A (en) 2010-07-30
NZ567456A (en) 2009-08-28
EP1423105B1 (en) 2008-12-03
EA008056B1 (ru) 2007-02-27
CN101596186A (zh) 2009-12-09
US20070060637A1 (en) 2007-03-15
CN100536840C (zh) 2009-09-09
IL160178A0 (en) 2004-07-25
CN1708296A (zh) 2005-12-14
US20040204480A1 (en) 2004-10-14
US20080070847A1 (en) 2008-03-20
US7868039B2 (en) 2011-01-11
BR0212258A (pt) 2004-10-19
JP2005509599A (ja) 2005-04-14
NZ531045A (en) 2006-08-31
JP2009263371A (ja) 2009-11-12
NZ546573A (en) 2007-05-31
DE60230159D1 (de) 2009-01-15
US7863320B2 (en) 2011-01-04
CN1994287A (zh) 2007-07-11
WO2003020259A2 (en) 2003-03-13
ES2321283T3 (es) 2009-06-04

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