ATE415963T1 - Zusammensetzungen aus dmxaa und anderen antikrebsmittel - Google Patents

Zusammensetzungen aus dmxaa und anderen antikrebsmittel

Info

Publication number
ATE415963T1
ATE415963T1 AT02758562T AT02758562T ATE415963T1 AT E415963 T1 ATE415963 T1 AT E415963T1 AT 02758562 T AT02758562 T AT 02758562T AT 02758562 T AT02758562 T AT 02758562T AT E415963 T1 ATE415963 T1 AT E415963T1
Authority
AT
Austria
Prior art keywords
dmxaa
compositions
combinations
anticancer agents
topoisomerase
Prior art date
Application number
AT02758562T
Other languages
German (de)
English (en)
Inventor
William Wilson
Bronwyn Siim
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Application granted granted Critical
Publication of ATE415963T1 publication Critical patent/ATE415963T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/475Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pyrane Compounds (AREA)
AT02758562T 2001-09-03 2002-09-03 Zusammensetzungen aus dmxaa und anderen antikrebsmittel ATE415963T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0121285.1A GB0121285D0 (en) 2001-09-03 2001-09-03 Anti-cancer combinations

Publications (1)

Publication Number Publication Date
ATE415963T1 true ATE415963T1 (de) 2008-12-15

Family

ID=9921418

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02758562T ATE415963T1 (de) 2001-09-03 2002-09-03 Zusammensetzungen aus dmxaa und anderen antikrebsmittel

Country Status (23)

Country Link
US (6) US7863322B2 (2)
EP (3) EP1423105B9 (2)
JP (3) JP2005509599A (2)
CN (5) CN101596186A (2)
AT (1) ATE415963T1 (2)
AU (1) AU2002324143B2 (2)
BR (1) BR0212258A (2)
CA (1) CA2458459A1 (2)
CY (1) CY1110426T1 (2)
DE (1) DE60230159D1 (2)
DK (1) DK1423105T3 (2)
EA (3) EA010857B1 (2)
ES (1) ES2321283T3 (2)
GB (1) GB0121285D0 (2)
IL (1) IL160178A0 (2)
IS (1) IS7144A (2)
MX (1) MXPA04002004A (2)
NO (1) NO20040591L (2)
NZ (5) NZ567456A (2)
PT (1) PT1423105E (2)
SI (1) SI1423105T1 (2)
WO (1) WO2003020259A2 (2)
ZA (1) ZA200401078B (2)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
JP4638098B2 (ja) * 1999-06-14 2011-02-23 キャンサー・リサーチ・テクノロジー・リミテッド 癌治療
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
AU2001282717A1 (en) 2000-07-28 2002-02-13 Cancer Research Technology Limited Cancer treatment by combination therapy
GB0121285D0 (en) 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB2386836B (en) 2002-03-22 2006-07-26 Cancer Res Ventures Ltd Anti-cancer combinations
GB2394658A (en) 2002-11-01 2004-05-05 Cancer Rec Tech Ltd Oral anti-cancer composition
GB0321999D0 (en) * 2003-09-19 2003-10-22 Cancer Rec Tech Ltd Anti-cancer combinations
DE602004016376D1 (de) 2003-11-13 2008-10-16 Pharma Mar Sau Kombination von et-743 mit 5-fluorouracil pro-drugs zur behandlung von krebs
RS50510B (sr) 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal Formulacije koje sadrže ekteinascidin i disaharid
GB0517387D0 (en) * 2005-08-26 2005-10-05 Antisoma Res Ltd Combinations for the treatment of cancer
CA2620436A1 (en) * 2005-08-26 2007-03-01 Antisoma Plc Combinations comprising dmxaa for the treatment of cancer
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
CA2708149A1 (en) * 2007-12-13 2009-06-18 Novartis Ag Combinations of therapeutic agents for treating cancer
CN101279967B (zh) * 2008-05-29 2010-11-10 武汉远大制药集团有限公司 一种治疗癌症的三甲基呫吨酮-4-乙酸药物组合物及其用途
CN102203132A (zh) 2008-08-25 2011-09-28 安普利穆尼股份有限公司 Pd-1拮抗剂的组合物和使用方法
US20100068302A1 (en) * 2008-09-17 2010-03-18 Traslational Cancer Drugs Pharma, S.L. Methods and compositions for the treatment of cancer
US20120129895A1 (en) * 2009-08-11 2012-05-24 Colleen Conway Methods of treatment
DK3327148T3 (da) 2010-06-18 2021-04-12 Myriad Genetics Inc Fremgangsmåder til forudsigelse af status for brca1- og brca2-gener i en cancercelle
ES2704303T3 (es) 2010-08-24 2019-03-15 Dana Farber Cancer Inst Inc Procedimientos para la predicción de una respuesta contra el cáncer
CN102786509B (zh) * 2011-05-16 2016-06-01 杭州民生药业有限公司 2-(5,6-二甲基呫吨酮-4-基)-乙酸的衍生物及其制备方法和用途
EP4563709A3 (en) 2011-06-17 2025-09-03 Myriad Genetics, Inc. Methods and materials for assessing allelic imbalance
CN107267598B (zh) 2011-12-21 2022-03-25 美瑞德生物工程公司 用于评估杂合性丢失的方法与材料
EP2617421A1 (en) * 2012-01-20 2013-07-24 Isofol Medical AB Tetrahydrofolates in combination with EGFR-inhibitors in the use of treating cancer
WO2013130347A1 (en) 2012-02-23 2013-09-06 The Children's Hospital Corporation Methods for predicting anti-cancer response
ES2658867T3 (es) 2012-06-07 2018-03-12 Institut Curie Métodos para detectar la inactivación de la ruta de recombinación homóloga (BRCA1/2) en tumores humanos
WO2014160080A1 (en) 2013-03-14 2014-10-02 Children's Medical Center Corporation Cancer diagnosis, treatment selection and treatment
DK2981624T3 (da) 2013-04-05 2020-03-02 Myriad Genetics Inc Fremgangsmåder til vurdering af homolog rekombinationsdeficiens og forudsigelse af respons på cancerbehandling
US20160067182A1 (en) * 2013-04-09 2016-03-10 Merrimack Pharmaceuticals, Inc. Methods and compositions for improving outcomes of liposomal chemotherapy
JP2016538344A (ja) * 2013-11-19 2016-12-08 ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago 癌処置としてのstingアゴニストの使用
EP3080292B1 (en) 2013-12-09 2022-02-02 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
EP4234711B1 (en) 2014-08-15 2025-05-28 Myriad Genetics, Inc. Methods and materials for assessing homologous recombination deficiency
EP4141127B1 (en) 2021-08-30 2024-10-09 Zentrum Familiärer Brust- und Eierstockkrebs Universitätsklinik Köln Method for assessing homologous recombination deficiency in ovarian cancer cells
CN115282140B (zh) * 2022-02-07 2024-03-08 南京市儿童医院 Aki治疗剂及dmxaa在制备该治疗剂中的应用

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655470A (en) * 1969-03-29 1972-04-11 Toa Gosei Chem Ind Process for the production of a foamed thermoplastic resin sheet
DE2015265A1 (de) 1969-03-29 1970-10-08 Yoshitomi Pharmaceutical Industries Ltd., Osaka (Japan) Arylalkansäuren und Verfahren zu deren Herstellung
US4565806A (en) * 1981-08-18 1986-01-21 Setaelae Kai M E Composition and method for rational treatment of cancer
FR2516922A1 (fr) * 1981-11-25 1983-05-27 Lipha Acides (oxo-4-4h-(1)-benzopyran-8-yl) alcanoiques, sels et derives, preparation et medicament les contenant
ATE92499T1 (de) * 1984-12-04 1993-08-15 Lilly Co Eli Tumorbehandlung bei saeugetieren.
US4704355A (en) * 1985-03-27 1987-11-03 New Horizons Diagnostics Corporation Assay utilizing ATP encapsulated within liposome particles
US5281620A (en) * 1986-12-23 1994-01-25 Cancer Research Campaign Technology Limited Compounds having antitumor and antibacterial properties
JP2672101B2 (ja) 1986-12-23 1997-11-05 ディーエフシー ニュージーランド リミテッド キサンテノン−4−酢酸誘導体
JPH01193227A (ja) 1988-01-29 1989-08-03 Res Dev Corp Of Japan 癌免疫療法補助剤
US5126129A (en) * 1988-05-23 1992-06-30 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Cancer therapy using interleukin-2 and flavone compounds
US5075287A (en) 1989-03-03 1991-12-24 Nisshin Oil Mills, Inc. Muramyl peptide derivatives and immunoregulating compositions containing them
CA2025907A1 (en) 1989-09-21 1991-03-22 Franklin D. Collins Method of transporting compositions across the blood brain barrier
US5250296A (en) 1990-11-29 1993-10-05 Takeda Chemical Industries, Ltd. Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine
EP0551200A1 (en) 1992-01-07 1993-07-14 National University Of Singapore Protein phosphatase inhibitors for use in therapy
CA2086874E (en) 1992-08-03 2000-01-04 Renzo Mauro Canetta Methods for administration of taxol
GB9308166D0 (en) * 1993-04-20 1993-06-02 Cancer Res Campaign Tech Cancer therapy
GB9320484D0 (en) 1993-10-05 1993-11-24 Wellcome Found Pharmaceutical combinations
DE4417742A1 (de) * 1994-05-20 1995-11-23 Bayer Ag Nicht-systemische Bekämpfung von Parasiten
US5620875A (en) * 1995-02-17 1997-04-15 University Of Portland Transfer of taxol from yew tree cuttings into a culture medium over time
WO1996032418A1 (en) 1995-04-13 1996-10-17 Laboratoires Om S.A. Anti-cd14 antibodies for use in the induction of il-10 secretion
EP0743064A1 (en) 1995-05-17 1996-11-20 Eli Lilly And Company Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease
JPH0940690A (ja) 1995-05-23 1997-02-10 Yutaka Sashita ステロイド配糖体及びこれを有効成分とする医薬
WO1997004761A1 (en) 1995-07-28 1997-02-13 Trustees Of Boston University Methods and compositions for treating cell proliferative disorders
US5977077A (en) 1995-08-28 1999-11-02 Interlab Corporation Xanthone analogs for the treatment of infectious diseases
US5863904A (en) * 1995-09-26 1999-01-26 The University Of Michigan Methods for treating cancers and restenosis with P21
US5817684A (en) * 1996-12-13 1998-10-06 Eli Lilly And Company Leukotriene antagonists for use in the treatment or inhibition of cerebral focal stroke
UA47505C2 (uk) 1996-12-13 2002-07-15 Елі Ліллі Енд Компані Спосіб лікування плоскоклітинного раку ротової порожнини за допомогою антагоністів лейкотриєну
AU5792398A (en) 1996-12-13 1998-07-03 Eli Lilly And Company Leukotriene antagonists for treatment or inhibition of gout
NZ337376A (en) 1997-03-11 2002-02-01 Aeterna Lab Inc Compositions for treating tumors containing shark cartilage extracts and anti-neoplastic agents
AU6572298A (en) 1997-03-21 1998-10-20 Eli Lilly And Company Leukotriene antagonists useful for treating ischemia reperfusion injury
HUP9904672A2 (hu) * 1997-03-21 2000-05-28 Eli Lilly And Co. Szájüregi laphámrák ellen alkalmazható leukotrién antagonisták
AU6764798A (en) 1997-03-21 1998-10-20 Eli Lilly And Company Leukotriene antagonists useful for treating cystic fibrosis
AU6570798A (en) 1997-03-21 1998-10-20 Eli Lilly And Company Leukotriene antagonists useful for treating gingivitis
US5998454A (en) 1997-03-21 1999-12-07 Eli Lilly And Company Leukotriene antagonists useful for treating iritis
WO1998042345A1 (en) 1997-03-21 1998-10-01 Eli Lilly And Company Leukotriene antagonists useful for treating cerebral focal stroke
WO1998042335A1 (en) 1997-03-21 1998-10-01 Eli Lilly And Company Leukotriene antagonists useful for treating gout
US5914340A (en) 1997-03-21 1999-06-22 Eli Lilly And Company Leukotriene antagonists useful for treating dermatoses
DE19721211A1 (de) 1997-05-21 1998-11-26 Lindner Sen Wolfgang Dr Med Kombination von antientzündlichen Wirkstoffen mit immunstimulierenden Agentien und zytotoxischen Agentien zur Behandlung von Tumoren
WO2000010600A2 (en) 1998-08-24 2000-03-02 Maxim Pharmaceuticals, Inc. Activation and protection of t-cells (cd4+ and cd8+) using an h¿2? receptor agonist and other t-cell activating agents
EP1119361A4 (en) 1998-09-10 2006-10-04 Magainin Pharma TREATMENT OF CARCINOMA WITH SQUALAMINE IN COMBINATION WITH OTHER ANTI-TUMOR AGENTS
AUPP609198A0 (en) 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
US6174873B1 (en) * 1998-11-04 2001-01-16 Supergen, Inc. Oral administration of adenosine analogs
GB9903404D0 (en) 1999-02-16 1999-04-07 Angiogene Pharm Ltd Methods of treatment and compositions useful for the treatment of diseases involving angiogenesis
ATE289586T1 (de) * 1999-03-01 2005-03-15 Pfizer Prod Inc Oxamsäuren mit einer cyanogruppe als liganden für den thyroidrezeptor
JP4638098B2 (ja) * 1999-06-14 2011-02-23 キャンサー・リサーチ・テクノロジー・リミテッド 癌治療
US6806257B1 (en) * 1999-10-20 2004-10-19 Board Of Trustees Of Southern Illinois University Flavones as inducible nitric oxide synthase inhibitors, cyclooxygenase-2 inhibitors and potassium channel activators
PL355172A1 (en) 1999-11-11 2004-04-05 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
WO2001034135A2 (en) 1999-11-11 2001-05-17 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
WO2001034197A2 (en) 1999-11-11 2001-05-17 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
WO2001034198A2 (en) 1999-11-11 2001-05-17 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
AU3822701A (en) * 2000-02-17 2001-08-27 Merck & Co., Inc. Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug
JP2001247459A (ja) 2000-03-03 2001-09-11 Oakland Uniservices Ltd 癌の組み合わせ療法
AU2001282717A1 (en) * 2000-07-28 2002-02-13 Cancer Research Technology Limited Cancer treatment by combination therapy
GB0121285D0 (en) * 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
GB2386836B (en) * 2002-03-22 2006-07-26 Cancer Res Ventures Ltd Anti-cancer combinations
GB2394658A (en) 2002-11-01 2004-05-05 Cancer Rec Tech Ltd Oral anti-cancer composition
GB0321999D0 (en) 2003-09-19 2003-10-22 Cancer Rec Tech Ltd Anti-cancer combinations
GT200500186A (es) * 2004-07-07 2006-03-02 Regimenes anticonceptivos con antagonistas del receptor de progesterona y kits
CA2620436A1 (en) 2005-08-26 2007-03-01 Antisoma Plc Combinations comprising dmxaa for the treatment of cancer
GB0517387D0 (en) 2005-08-26 2005-10-05 Antisoma Res Ltd Combinations for the treatment of cancer
CA2702301A1 (en) 2007-10-23 2009-04-30 Antisoma Research Limited Crystalline forms of dmxaa sodium salt

Also Published As

Publication number Publication date
CA2458459A1 (en) 2003-03-13
EP1423105A2 (en) 2004-06-02
US20080070886A1 (en) 2008-03-20
NO20040591L (no) 2004-04-30
EA200601118A1 (ru) 2006-12-29
EA200801611A1 (ru) 2009-06-30
EP1423105B9 (en) 2009-08-12
GB0121285D0 (en) 2001-10-24
SI1423105T1 (sl) 2009-08-31
CN101596187A (zh) 2009-12-09
WO2003020259A3 (en) 2003-04-17
PT1423105E (pt) 2009-03-09
IS7144A (is) 2004-02-06
CY1110426T1 (el) 2015-04-29
US7863322B2 (en) 2011-01-04
EP2236134A1 (en) 2010-10-06
JP2010270124A (ja) 2010-12-02
ZA200401078B (en) 2005-04-15
CN101607087A (zh) 2009-12-23
MXPA04002004A (es) 2005-02-17
US7863321B2 (en) 2011-01-04
DK1423105T3 (da) 2009-03-30
EP1759694A3 (en) 2009-02-18
US20080070848A1 (en) 2008-03-20
US7868040B2 (en) 2011-01-11
NZ554093A (en) 2008-07-31
EP1759694A2 (en) 2007-03-07
US20080070849A1 (en) 2008-03-20
EA200400370A1 (ru) 2004-08-26
AU2002324143B2 (en) 2007-09-13
NZ576925A (en) 2010-07-30
NZ567456A (en) 2009-08-28
EA010857B1 (ru) 2008-12-30
EP1423105B1 (en) 2008-12-03
EA008056B1 (ru) 2007-02-27
CN101596186A (zh) 2009-12-09
US20070060637A1 (en) 2007-03-15
CN100536840C (zh) 2009-09-09
IL160178A0 (en) 2004-07-25
CN1708296A (zh) 2005-12-14
US20040204480A1 (en) 2004-10-14
US20080070847A1 (en) 2008-03-20
US7868039B2 (en) 2011-01-11
BR0212258A (pt) 2004-10-19
JP2005509599A (ja) 2005-04-14
NZ531045A (en) 2006-08-31
JP2009263371A (ja) 2009-11-12
NZ546573A (en) 2007-05-31
DE60230159D1 (de) 2009-01-15
US7863320B2 (en) 2011-01-04
CN1994287A (zh) 2007-07-11
WO2003020259A2 (en) 2003-03-13
ES2321283T3 (es) 2009-06-04

Similar Documents

Publication Publication Date Title
ATE415963T1 (de) Zusammensetzungen aus dmxaa und anderen antikrebsmittel
ATE406893T1 (de) Pharmazeutische zusammensetzung (kit) enthaltend dihydropyridinonverbindungen und eine verbindung mit immunmodulatorischer (oder antiinflammatorischer) wirkung und ihre verwendung
ECSP034642A (es) Derivados de tetralona como agentes antitumorales
DE60227492D1 (de) Hemmstoffe der akt aktivität
ES2193391T3 (es) Antagonistas muscarinicos.
ECSP045004A (es) Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades andrógeno dependientes
ECSP003610A (es) Pirimidina-2,4,6 trionas inhibidores de metaloproteinas
YU1899A (sh) Inhibitori matričnih metaloproteaza na bazi fosfinata
AR030185A1 (es) Glutarimidas sustituidas, su preparacion, medicamentos que las contienen, y uso de las mismas para la fabricacion de medicamentos, especialmente inmunomoduladores, como asi tambien inhibidores de angiopatias y/o enfermedades hematologicas/oncologicas
IL160769A0 (en) Heterocyclic compounds and pharmaceutical compositions containing the same
DE60239218D1 (de) Synergistische zusammensetzungen für die behandlung von saatgut
BR0208017A (pt) Combinação compreendendo combretastatina e agentes anticâncer
BR9916680A (pt) Derivados da 3,3-biarilpiperidina e2,2-biarilmorfolina
CA2461622A1 (en) Substituted benzimidazole compounds and their use for the treatment of cancer
IL151198A0 (en) Tricyclic imidazopyridine derivatives and pharmaceutical compositions containing the same
BR0311970A (pt) Novos compostos, seu uso e preparação
DE60121459D1 (de) Cyanidinmischung zur behandlung von dickdarmkrebs
BR0000901A (pt) Derivados 4-fenil-4-heteroarilpiperidina
BRPI0412554A (pt) pirazolinas como antagonistas par-1 para o tratamento de doenças distúrbios cardiovascular
WO2002016327A8 (en) Benzimidazoles and analogues and their use as neutrophil inhibitors
GB0127568D0 (en) Chemical compounds
ATE311228T1 (de) Antikrebs-kombinationen aus dmxaa und paclitaxel oder docetaxel
DE60213541D1 (de) Discodermolid-Analoga und ihre pharmazeutische Verwendung
ES2112597T3 (es) Nuevos derivados de 17-(3-imino-2-alquil-propenil)-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos.
ES2191430T3 (es) Antraciclinas 13-dihidro-3'-azaridino.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1423105

Country of ref document: EP