EA200200313A1 - Применение доцетаксела для лечения печеночно-клеточного рака - Google Patents

Применение доцетаксела для лечения печеночно-клеточного рака

Info

Publication number
EA200200313A1
EA200200313A1 EA200200313A EA200200313A EA200200313A1 EA 200200313 A1 EA200200313 A1 EA 200200313A1 EA 200200313 A EA200200313 A EA 200200313A EA 200200313 A EA200200313 A EA 200200313A EA 200200313 A1 EA200200313 A1 EA 200200313A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
docetexela
hepatic
application
cellular cancer
Prior art date
Application number
EA200200313A
Other languages
English (en)
Other versions
EA004804B1 (ru
Inventor
Чинь-Вэнь Чи
Хэн-Лян Линь
Цзун-Юнь Лю
Вин-Ию Луи
Гар-Ян Чао
Original Assignee
Авентис Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фарма С.А. filed Critical Авентис Фарма С.А.
Publication of EA200200313A1 publication Critical patent/EA200200313A1/ru
Publication of EA004804B1 publication Critical patent/EA004804B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

Настоящее изобретение основано на открытии того факта, что доцетаксел является значительно более активным в отношении клеток печеночно-клеточного рака, чем паклитаксел, в концентрациях до 1 мкМ. Соответственно оно предлагает применение доцетаксела или его гидрата в производстве лекарственных средств для применения при лечении печеночно-клеточного рака.Отчет о международном поиске был опубликован 2001.09.20.
EA200200313A 1999-08-31 2000-08-29 Применение доцетаксела для лечения печеночно-клеточного рака EA004804B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9920548.6A GB9920548D0 (en) 1999-08-31 1999-08-31 Treatment of hepatocellular carcinoma
PCT/EP2000/008782 WO2001015675A2 (en) 1999-08-31 2000-08-29 Use of docetaxel for treating hepatocellular carcinoma

Publications (2)

Publication Number Publication Date
EA200200313A1 true EA200200313A1 (ru) 2002-08-29
EA004804B1 EA004804B1 (ru) 2004-08-26

Family

ID=10860081

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200313A EA004804B1 (ru) 1999-08-31 2000-08-29 Применение доцетаксела для лечения печеночно-клеточного рака

Country Status (34)

Country Link
US (2) US20030158249A1 (ru)
EP (1) EP1214061B1 (ru)
JP (1) JP4866522B2 (ru)
KR (1) KR100670416B1 (ru)
CN (1) CN1174748C (ru)
AT (1) ATE269700T1 (ru)
AU (1) AU777583B2 (ru)
BG (1) BG65913B1 (ru)
BR (1) BR0013625A (ru)
CA (1) CA2382294C (ru)
CZ (1) CZ301378B6 (ru)
DE (1) DE60011794T2 (ru)
DK (1) DK1214061T3 (ru)
EA (1) EA004804B1 (ru)
EE (1) EE05124B1 (ru)
ES (1) ES2218223T3 (ru)
GB (1) GB9920548D0 (ru)
HK (1) HK1048944B (ru)
HR (1) HRP20020171A2 (ru)
HU (1) HU228861B1 (ru)
IL (2) IL147489A0 (ru)
ME (1) MEP7809A (ru)
MX (1) MXPA02002041A (ru)
NO (1) NO328527B1 (ru)
NZ (1) NZ517604A (ru)
PL (1) PL212612B1 (ru)
PT (1) PT1214061E (ru)
RS (1) RS50148B (ru)
SI (1) SI1214061T1 (ru)
SK (1) SK286378B6 (ru)
TW (1) TW589180B (ru)
UA (1) UA72927C2 (ru)
WO (1) WO2001015675A2 (ru)
ZA (1) ZA200201408B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
EP1694660B1 (en) * 2003-12-12 2009-04-08 Quiral Quimica Do Brasil Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions
US7449196B2 (en) * 2004-07-09 2008-11-11 Robert Sabin Anti tumor compositions and methods of use
US8034765B2 (en) * 2005-08-31 2011-10-11 Abraxis Bioscience, Llc Compositions and methods for preparation of poorly water soluble drugs with increased stability
BRPI0615265A8 (pt) 2005-08-31 2018-03-06 Abraxis Bioscience Llc composições compreendendo agentes farmacêuticos pouco hidrossoluíveis e agentes antimicrobianos
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
US20080081051A1 (en) * 2006-09-28 2008-04-03 Robert Sabin Method of manufacturing anti-tumor and anti-viral compositions
CA2683712A1 (en) * 2007-04-20 2009-01-15 Sun Pharmaceutical Industries Limited Pharmaceutical compositions
FR2917088B1 (fr) * 2007-06-08 2009-09-04 Aventis Pharma Sa Dissolution directe du docetaxel dans un solvant dans le polysorbate 80
US8541360B2 (en) * 2008-11-19 2013-09-24 Ben Venue Laboratories, Inc. Parenteral formulations comprising sugar-based esters and ethers
CN104784121A (zh) 2010-03-26 2015-07-22 阿布拉科斯生物科学有限公司 治疗肝细胞癌的方法
JP5824511B2 (ja) * 2010-05-03 2015-11-25 テイコク ファーマ ユーエスエー インコーポレーテッド 非水タキサンプロエマルジョン配合物ならびにそれを調製および使用する方法
US8842114B1 (en) 2011-04-29 2014-09-23 Nvidia Corporation System, method, and computer program product for adjusting a depth of displayed objects within a region of a display
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
CA2976912A1 (en) * 2015-02-17 2016-08-25 Mallinckrodt Llc Modified docetaxel liposome formulations and uses thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US5543154A (en) * 1991-12-27 1996-08-06 Merck & Co., Inc. Controlled release nifedipine delivery device
JP3254219B2 (ja) * 1993-01-19 2002-02-04 ワーナー−ランバート・コンパニー 安定な経口用のｃｉ−９８１製剤およびその製法
US5801029A (en) * 1993-02-16 1998-09-01 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
US5436243A (en) * 1993-11-17 1995-07-25 Research Triangle Institute Duke University Aminoanthraquinone derivatives to combat multidrug resistance
FR2718963B1 (fr) * 1994-04-25 1996-05-24 Rhone Poulenc Rorer Sa Nouvelle composition pharmaceutique à base de taxoïdes.
FR2722191B1 (fr) * 1994-07-08 1996-08-23 Rhone Poulenc Rorer Sa Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle
US5968972A (en) 1995-10-26 1999-10-19 Baker Norton Pharmaceuticals, Inc. Method for increasing the oral bioactivity of pharmaceutical agents
US6245805B1 (en) * 1995-10-26 2001-06-12 Baker Norton Pharmaceuticals, Inc. Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
FR2742751B1 (fr) * 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US6503893B2 (en) * 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
BR9713661A (pt) * 1996-12-30 2000-10-24 Battelle Memorial Institute Formulação e método para o tratamento de neoplasmas por inalação
ES2435944T3 (es) * 1997-06-27 2013-12-26 Abraxis Bioscience, Llc Nuevas formulaciones de agentes farmacológicos, métodos para su preparación y métodos para su uso
AU1146099A (en) * 1997-09-18 1999-04-05 Janssen Pharmaceutica N.V. Fused imidazole derivatives for improving oral bioavailability of pharmaceuticalagents
WO1999022728A1 (en) * 1997-10-31 1999-05-14 Arch Development Corporation Methods and compositions for regulation of 5-alpha reductase activity
UA73092C2 (ru) * 1998-07-17 2005-06-15 Брістол-Майерс Сквібб Компані Таблетки с энтеросолюбильным покрытием и способ их получения
CN1398189A (zh) * 1998-12-23 2003-02-19 G.D.西尔公司 用于治疗肿瘤形成的放疗与cox－2抑制剂的联合治疗
GB9909925D0 (en) * 1999-04-29 1999-06-30 Pharmacia & Upjohn Spa Combined preparations comprising anthracycline derivatives
CA2633268A1 (en) * 2005-12-13 2007-06-21 Teva Pharmaceutical Industries Ltd. Crystal form of atorvastatin hemi-calcium and processes for preparation thereof

Also Published As

Publication number Publication date
US20030158249A1 (en) 2003-08-21
NO20020829D0 (no) 2002-02-20
BG106460A (bg) 2002-09-30
PL353198A1 (en) 2003-11-03
CN1174748C (zh) 2004-11-10
GB9920548D0 (en) 1999-11-03
PT1214061E (pt) 2004-09-30
ME00624B (me) 2011-12-20
EP1214061B1 (en) 2004-06-23
WO2001015675A3 (en) 2001-09-20
YU11402A (sh) 2005-07-19
SK2712002A3 (en) 2002-07-02
MXPA02002041A (es) 2002-08-20
EE200200087A (et) 2003-04-15
US20080045584A1 (en) 2008-02-21
EP1214061A2 (en) 2002-06-19
SK286378B6 (sk) 2008-08-05
KR100670416B1 (ko) 2007-01-17
CZ301378B6 (cs) 2010-02-03
RS50148B (sr) 2009-05-06
IL147489A0 (en) 2002-08-14
DE60011794D1 (de) 2004-07-29
CN1372466A (zh) 2002-10-02
TW589180B (en) 2004-06-01
NZ517604A (en) 2004-04-30
CZ2002739A3 (cs) 2002-06-12
HRP20020171A2 (en) 2004-02-29
MEP7809A (en) 2011-12-20
CA2382294A1 (en) 2001-03-08
BR0013625A (pt) 2002-05-14
PL212612B1 (pl) 2012-10-31
CA2382294C (en) 2008-06-03
IL147489A (en) 2006-06-11
EE05124B1 (et) 2009-02-16
ZA200201408B (en) 2003-07-30
JP4866522B2 (ja) 2012-02-01
HU228861B1 (hu) 2013-06-28
UA72927C2 (ru) 2005-05-16
HUP0203197A2 (hu) 2003-01-28
BG65913B1 (bg) 2010-05-31
HUP0203197A3 (en) 2005-01-28
NO20020829L (no) 2002-02-20
ES2218223T3 (es) 2004-11-16
ATE269700T1 (de) 2004-07-15
AU7516800A (en) 2001-03-26
SI1214061T1 (en) 2004-12-31
EA004804B1 (ru) 2004-08-26
KR20020060166A (ko) 2002-07-16
AU777583B2 (en) 2004-10-21
HK1048944B (zh) 2005-04-22
NO328527B1 (no) 2010-03-08
HK1048944A1 (en) 2003-04-25
WO2001015675A2 (en) 2001-03-08
DK1214061T3 (da) 2004-11-01
DE60011794T2 (de) 2005-07-14
JP2003508427A (ja) 2003-03-04

Similar Documents

Publication Publication Date Title
DE60318092D1 (de) Pharmazeutische zusammensetzung enthältend estetrolderivate und anwendung in der krebsbehandlung
CY1106468T1 (el) Υποκατεστημενα παραγωγα κυκλοεξανο-1,4-διαμινης
BR0207378A (pt) Tratamento de câncer
BRPI0113286B8 (pt) pirazóis substituídos e composição farmacêutica compreendendo os mesmos.
CY1110258T1 (el) Υποκατεστημενα παραγωγα c-κυκλοεξυλομεθυλαμινης
DE602004024037D1 (de) Substituierte heterozyklen
NO20031648L (no) Farmasöytiske lösninger av modafinilforbindelser
IS6970A (is) Lyfjablanda á föstu formi sem felur í sér 4-sýanó-tríflúor-3-(4-flúorfenýlsúlfonýl)-2-hýdroxý-2-metýlprópíón-m-tólúidíð og PVP
EE200200087A (et) Kompositsioon hepatotsellulaarse kartsinoomi raviks
BR0307518A (pt) Composição farmacêutica
CY1106319T1 (el) Τοπικη θepαπεια στη μασταλγια
CY1107231T1 (el) Υποκατεστημενα παραγωγα 4-αμινοκυκλοεξανολης
SE0003476D0 (sv) Compounds
TR200402030T4 (tr) İkame edilen I-aminobutan-3-ol-türevleri
TR200402070T4 (tr) Siklobüten-dion türevleri ve bunların damar sertliği tedavisinde kullanımı
EA200501301A1 (ru) Ментоловые растворы лекарственных препаратов
ATE298328T1 (de) Taxan-derivate für die behandlung von krebs
TR200302193T4 (tr) Kombinasyon kemoterapisi.
ATE277622T1 (de) Arzneimittel enthaltend xenogene oligo- oder/und polyribonukleotide
DE50304524D1 (de) Arzneimittel enthaltend substituierte 2,5-diaminomethyl-1h-pyrrole
DE50211461D1 (de) Pharmazeutische zusammensetzung enthaltend bulbophyllum
GR1003969B (el) Σταθερα φαρμακευτικα διαλυματα νιμεσουλιδης.
ECSP003812A (es) Compuestos de dihidropirimidina hererociclicos

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU