PT1501828E - Piperazinobenzotiazolos como agentes para o tratamento de perturbações isquémicas cerebrais ou perturbações do snc - Google Patents

Piperazinobenzotiazolos como agentes para o tratamento de perturbações isquémicas cerebrais ou perturbações do snc Download PDF

Info

Publication number: PT1501828E
Authority: PT; Portugal
Prior art keywords: disorders; piperazine; treatment; benzothiazoles; agents
Prior art date: 2002-04-25

Application number

PT03727365T

Other languages

English (en)

Inventor

Pierre-Alain Vitte

P Gaillard

Jean-Pierre Gotteland

Original Assignee

Serono Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-25

Filing date

2003-04-25

Publication date

2008-02-11

2003-04-25 Application filed by Serono Lab filed Critical Serono Lab

2008-02-11 Publication of PT1501828E publication Critical patent/PT1501828E/pt

Links

230000002490 cerebral effect Effects 0.000 title abstract 2
230000000302 ischemic effect Effects 0.000 title abstract 2
238000011282 treatment Methods 0.000 title abstract 2
NZORAUGSDRBBBH-UHFFFAOYSA-N 1,3-benzothiazole;piperazine Chemical class C1CNCCN1.C1=CC=C2SC=NC2=C1 NZORAUGSDRBBBH-UHFFFAOYSA-N 0.000 title 1
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
208000015114 central nervous system disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PT03727365T 2002-04-25 2003-04-25 Piperazinobenzotiazolos como agentes para o tratamento de perturbações isquémicas cerebrais ou perturbações do snc PT1501828E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02100417		2002-04-25

Publications (1)

Publication Number	Publication Date
PT1501828E true PT1501828E (pt)	2008-02-11

Family

ID=29265991

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT03727365T PT1501828E (pt)	2002-04-25	2003-04-25	Piperazinobenzotiazolos como agentes para o tratamento de perturbações isquémicas cerebrais ou perturbações do snc

Country Status (22)

Country	Link
US (1)	US7314878B2 (pt)
EP (1)	EP1501828B1 (pt)
JP (1)	JP4523289B2 (pt)
KR (1)	KR100948469B1 (pt)
CN (1)	CN1310911C (pt)
AT (1)	ATE383356T1 (pt)
AU (1)	AU2003233067B2 (pt)
BR (1)	BRPI0309594A8 (pt)
CA (1)	CA2481763C (pt)
CY (1)	CY1107204T1 (pt)
DE (1)	DE60318567T2 (pt)
DK (1)	DK1501828T3 (pt)
EA (1)	EA009682B1 (pt)
ES (1)	ES2297165T3 (pt)
IL (2)	IL164796A (pt)
MX (1)	MXPA04010474A (pt)
PT (1)	PT1501828E (pt)
RS (1)	RS51407B (pt)
SI (1)	SI1501828T1 (pt)
UA (1)	UA78035C2 (pt)
WO (1)	WO2003091249A1 (pt)
ZA (1)	ZA200408023B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4523289B2 (ja)	2002-04-25	2010-08-11	メルクセローノソシエテアノニム	脳虚血障害又はｃｎｓ障害の処置のための薬剤としてのピペラジンベンゾチアゾール
JP5021307B2 (ja) *	2003-09-12	2012-09-05	メルクセローノソシエテアノニム	糖尿病治療のためのベンゾチアゾール誘導体
WO2005118543A1 (ja) *	2004-06-03	2005-12-15	Ono Pharmaceutical Co., Ltd.	キナーゼ阻害薬およびその用途
ATE411817T1 (de) *	2004-11-17	2008-11-15	Ares Trading Sa	Benzothiazolformulierungen und ihre verwendung
US7838522B2 (en)	2004-11-17	2010-11-23	Ares Trading S.A.	Benzothiazole formulations and use thereof
KR20080044836A (ko)	2005-07-15	2008-05-21	라보라뚜와르 세로노 에스. 에이.	자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) *	2005-07-15	2010-12-14	Serono Lab	inibidores de jnk para o tratamento de endometriose
WO2008125518A2 (en) *	2007-04-17	2008-10-23	Merck Serono S.A.	Process for the preparation of piperazine benzothiazoles
ES2392788T3 (es) *	2008-05-16	2012-12-13	F. Hoffmann-La Roche Ag	Inhibidores de las JNK
EP2576537B1 (en) *	2010-06-04	2016-03-16	F.Hoffmann-La Roche Ag	2-amino-pyrimidine derivatives useful as inhibitors of jnk
US8471027B2 (en) *	2011-04-06	2013-06-25	Hoffmann-La Roche Inc.	Adamantyl compounds
CN104903331A (zh) *	2013-01-24	2015-09-09	山东亨利医药科技有限责任公司	Jnk抑制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4153574B2 (ja)	1997-09-10	2008-09-24	トーアエイヨー株式会社	新規なピペリジン誘導体、その製造法およびそれを含有する循環器官用剤
EP1110957A1 (en) *	1999-12-24	2001-06-27	Applied Research Systems ARS Holding N.V.	Benzazole derivatives and their use as JNK modulators
EP1193256A1 (en)	2000-09-27	2002-04-03	Applied Research Systems ARS Holding N.V.	Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins
JP4523289B2 (ja)	2002-04-25	2010-08-11	メルクセローノソシエテアノニム	脳虚血障害又はｃｎｓ障害の処置のための薬剤としてのピペラジンベンゾチアゾール

2003
- 2003-04-25 JP JP2003587807A patent/JP4523289B2/ja not_active Expired - Fee Related
- 2003-04-25 SI SI200331114T patent/SI1501828T1/sl unknown
- 2003-04-25 WO PCT/EP2003/004323 patent/WO2003091249A1/en not_active Ceased
- 2003-04-25 DE DE60318567T patent/DE60318567T2/de not_active Expired - Lifetime
- 2003-04-25 IL IL164796A patent/IL164796A/en not_active IP Right Cessation
- 2003-04-25 EP EP03727365A patent/EP1501828B1/en not_active Expired - Lifetime
- 2003-04-25 MX MXPA04010474A patent/MXPA04010474A/es active IP Right Grant
- 2003-04-25 BR BRPI0309594A patent/BRPI0309594A8/pt not_active IP Right Cessation
- 2003-04-25 UA UA20041008647A patent/UA78035C2/uk unknown
- 2003-04-25 DK DK03727365T patent/DK1501828T3/da active
- 2003-04-25 KR KR1020047016871A patent/KR100948469B1/ko not_active Expired - Fee Related
- 2003-04-25 IL IL16479603A patent/IL164796A0/xx unknown
- 2003-04-25 US US10/511,438 patent/US7314878B2/en not_active Expired - Lifetime
- 2003-04-25 CN CNB03814493XA patent/CN1310911C/zh not_active Expired - Fee Related
- 2003-04-25 PT PT03727365T patent/PT1501828E/pt unknown
- 2003-04-25 AU AU2003233067A patent/AU2003233067B2/en not_active Ceased
- 2003-04-25 CA CA2481763A patent/CA2481763C/en not_active Expired - Fee Related
- 2003-04-25 RS YUP-928/04A patent/RS51407B/sr unknown
- 2003-04-25 ES ES03727365T patent/ES2297165T3/es not_active Expired - Lifetime
- 2003-04-25 EA EA200401423A patent/EA009682B1/ru not_active IP Right Cessation
- 2003-04-25 AT AT03727365T patent/ATE383356T1/de active
2004
- 2004-10-05 ZA ZA2004/08023A patent/ZA200408023B/en unknown
2008
- 2008-02-18 CY CY20081100199T patent/CY1107204T1/el unknown

Also Published As

Publication number	Publication date
EP1501828B1 (en)	2008-01-09
IL164796A0 (en)	2005-12-18
ES2297165T3 (es)	2008-05-01
ZA200408023B (en)	2005-11-30
AU2003233067B2 (en)	2009-01-08
RS51407B (sr)	2011-02-28
EP1501828A1 (en)	2005-02-02
BRPI0309594A8 (pt)	2017-04-11
CY1107204T1 (el)	2012-11-21
WO2003091249A1 (en)	2003-11-06
RS92804A (sr)	2006-12-15
KR100948469B1 (ko)	2010-03-17
US20050261304A1 (en)	2005-11-24
KR20040104572A (ko)	2004-12-10
CA2481763A1 (en)	2003-11-06
UA78035C2 (en)	2007-02-15
MXPA04010474A (es)	2004-12-13
IL164796A (en)	2013-02-28
JP2006504631A (ja)	2006-02-09
AU2003233067A1 (en)	2003-11-10
CN1310911C (zh)	2007-04-18
DE60318567T2 (de)	2009-02-19
HK1075664A1 (en)	2005-12-23
EA009682B1 (ru)	2008-02-28
CN1662528A (zh)	2005-08-31
EA200401423A1 (ru)	2005-04-28
JP4523289B2 (ja)	2010-08-11
CA2481763C (en)	2011-06-14
US7314878B2 (en)	2008-01-01
DK1501828T3 (da)	2008-03-10
BRPI0309594A2 (pt)	2016-11-16
ATE383356T1 (de)	2008-01-15
SI1501828T1 (sl)	2008-04-30
DE60318567D1 (de)	2008-02-21

Publication	Publication Date	Title
CY1107204T1 (el)	2012-11-21	Πιπεραζινοβενζοθειαζολια ως ουσιες για την θεραπευτικη αντιμετωπιση εγκεφαλικων ισχαιμικων διαταραχων ή διαταραχων του κνς
ATE524169T1 (de)	2011-09-15	Therapeutische strategien für die prävention und behandlung der alzeheimer-krankheit
MX2007012374A (es)	2008-02-22	Metodos y composiciones para el tratamiento de condiciones relacionadas con cns.
DE60332604D1 (de)	2010-07-01	Azolylaminoazine als proteinkinasehemmer
DE60314603D1 (de)	2007-08-09	Zusammensetzungen brauchbar als protein-kinase- inhibitoren
MY135841A (en)	2008-07-31	Novel benzodioxoles
ATE466580T1 (de)	2010-05-15	Azolylaminoazine als proteinkinasehemmer
DK1242415T3 (da)	2004-06-01	3-thiazol-4-yl-pyrolidinderivater som AMP-specifikke phosphodiesteraseinhibitorer
DE602004024572D1 (de)	2010-01-21	Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen
MY135856A (en)	2008-07-31	Nicotinamide derivatives useful as pde4 inhibitors
PL377587A1 (pl)	2006-02-06	Pochodne hydroksyetyloaminy do leczenia choroby Alzheimera
MXPA04007031A (es)	2004-10-11	Derivados benzofurano y benzotiofeno utiles en el tratamiento de desordenes hiper-proliferativos.
PL1789398T3 (pl)	2011-03-31	Pochodne 2-amino-chinazoliny użyteczne jako inhibitory ß-sekretazy (BACE)
DE60233350D1 (de)	2009-09-24	IMIDAZOi2,1-B -1,3,4-THIADIAZOLE SULFONAMIDES
BR0209541A (pt)	2004-04-20	Uso das imidazotriazinonas 2-fenil-substituìdas
ECSP055844A (es)	2005-09-20	Nuevos compuestos triciclicos
WO2005117979A3 (en)	2006-03-02	Use of il-17 in the treatment of fertility-related disorders
MXPA05011699A (es)	2006-01-23	Inhibidores de la bomba de protones para el tratamiento de trastornos del abdomen inferior.
MX2007006754A (es)	2007-07-09	Derivados de indenilo y uso de los mismos para el tratamiento de trastornos neurologicos.
GB0407025D0 (en)	2004-04-28	Novel compounds
SG148840A1 (en)	2009-01-29	Indole derivatives useful for the treatment of cns disorders
MY136138A (en)	2008-08-29	Hexacyclic compounds
EA200200750A1 (ru)	2003-02-27	Новое терапевтическое применение еноксапарина
NO20050146L (no)	2005-03-14	N,N-disubstituerte diazocykloalkaner nyttige i behandling av CNS-forstyrrelser grunnet serotonergisk dysfunksjon
TNSN05154A1 (en)	2007-05-14	Use of levocetirizine for the treatment of persistent allergic rhinitis