ATE383356T1 - Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns- systems - Google Patents

Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns- systems

Info

Publication number: ATE383356T1
Authority: AT; Austria
Prior art keywords: piperazine; treatment; benzothiazoles; ischemia; diseases
Prior art date: 2002-04-25

Application number

AT03727365T

Other languages

English (en)

Inventor

P Gaillard

Jean-Pierre Gotteland

Pierre-Alain Vitte

Original Assignee

Serono Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-25

Filing date

2003-04-25

Publication date

2008-01-15

2003-04-25 Application filed by Serono Lab filed Critical Serono Lab

2008-01-15 Application granted granted Critical

2008-01-15 Publication of ATE383356T1 publication Critical patent/ATE383356T1/de

Links

GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
238000011282 treatment Methods 0.000 title abstract 2
239000004480 active ingredient Substances 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000028867 ischemia Diseases 0.000 title 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000000302 ischemic effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT03727365T 2002-04-25 2003-04-25 Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns- systems ATE383356T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02100417		2002-04-25

Publications (1)

Publication Number	Publication Date
ATE383356T1 true ATE383356T1 (de)	2008-01-15

Family

ID=29265991

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03727365T ATE383356T1 (de)	2002-04-25	2003-04-25	Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns- systems

Country Status (22)

Country	Link
US (1)	US7314878B2 (de)
EP (1)	EP1501828B1 (de)
JP (1)	JP4523289B2 (de)
KR (1)	KR100948469B1 (de)
CN (1)	CN1310911C (de)
AT (1)	ATE383356T1 (de)
AU (1)	AU2003233067B2 (de)
BR (1)	BRPI0309594A8 (de)
CA (1)	CA2481763C (de)
CY (1)	CY1107204T1 (de)
DE (1)	DE60318567T2 (de)
DK (1)	DK1501828T3 (de)
EA (1)	EA009682B1 (de)
ES (1)	ES2297165T3 (de)
IL (2)	IL164796A (de)
MX (1)	MXPA04010474A (de)
PT (1)	PT1501828E (de)
RS (1)	RS51407B (de)
SI (1)	SI1501828T1 (de)
UA (1)	UA78035C2 (de)
WO (1)	WO2003091249A1 (de)
ZA (1)	ZA200408023B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4523289B2 (ja)	2002-04-25	2010-08-11	メルクセローノソシエテアノニム	脳虚血障害又はｃｎｓ障害の処置のための薬剤としてのピペラジンベンゾチアゾール
DE602004010178T2 (de) *	2003-09-12	2008-09-11	Laboratoires Serono S.A., Coinsins	Benzothiazol-derivate zur behandlung von diabetes
WO2005118543A1 (ja) *	2004-06-03	2005-12-15	Ono Pharmaceutical Co., Ltd.	キナーゼ阻害薬およびその用途
US7838522B2 (en)	2004-11-17	2010-11-23	Ares Trading S.A.	Benzothiazole formulations and use thereof
DE602005010604D1 (de) *	2004-11-17	2008-12-04	Ares Trading Sa	Benzothiazolformulierungen und ihre verwendung
BRPI0613042A2 (pt)	2005-07-15	2010-12-14	Serono Lab	inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko)	2005-07-15	2008-05-21	라보라뚜와르 세로노 에스. 에이.	자궁내막증 치료용 ｊｎｋ 억제제
EP2137173A2 (de) *	2007-04-17	2009-12-30	Laboratoires Serono SA	Verfahren zur herstellung von piperazinbenzothiazolen
BRPI0912564A2 (pt) *	2008-05-16	2019-09-24	F. Hoffman-La Roche Ag	inibidores de jnk
RU2572247C2 (ru) *	2010-06-04	2016-01-10	Ф. Хоффманн-Ля Рош Аг	Производные 2-амино-пиримидина в качестве ингибиторов jnk
US8471027B2 (en) *	2011-04-06	2013-06-25	Hoffmann-La Roche Inc.	Adamantyl compounds
WO2014114186A1 (zh) *	2013-01-24	2014-07-31	山东亨利医药科技有限责任公司	Jnk抑制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4153574B2 (ja) *	1997-09-10	2008-09-24	トーアエイヨー株式会社	新規なピペリジン誘導体、その製造法およびそれを含有する循環器官用剤
EP1110957A1 (de) *	1999-12-24	2001-06-27	Applied Research Systems ARS Holding N.V.	Benzazolderivate und ihre Verwendung als JNK Modulatoren
EP1193256A1 (de) *	2000-09-27	2002-04-03	Applied Research Systems ARS Holding N.V.	Pharmazeutisch aktive Benzolsulfonamidderivate als JNK-Proteininhibitoren
JP4523289B2 (ja)	2002-04-25	2010-08-11	メルクセローノソシエテアノニム	脳虚血障害又はｃｎｓ障害の処置のための薬剤としてのピペラジンベンゾチアゾール

2003
- 2003-04-25 JP JP2003587807A patent/JP4523289B2/ja not_active Expired - Fee Related
- 2003-04-25 PT PT03727365T patent/PT1501828E/pt unknown
- 2003-04-25 IL IL164796A patent/IL164796A/en not_active IP Right Cessation
- 2003-04-25 BR BRPI0309594A patent/BRPI0309594A8/pt not_active IP Right Cessation
- 2003-04-25 ES ES03727365T patent/ES2297165T3/es not_active Expired - Lifetime
- 2003-04-25 US US10/511,438 patent/US7314878B2/en not_active Expired - Lifetime
- 2003-04-25 UA UA20041008647A patent/UA78035C2/uk unknown
- 2003-04-25 CA CA2481763A patent/CA2481763C/en not_active Expired - Fee Related
- 2003-04-25 EA EA200401423A patent/EA009682B1/ru not_active IP Right Cessation
- 2003-04-25 WO PCT/EP2003/004323 patent/WO2003091249A1/en not_active Ceased
- 2003-04-25 MX MXPA04010474A patent/MXPA04010474A/es active IP Right Grant
- 2003-04-25 IL IL16479603A patent/IL164796A0/xx unknown
- 2003-04-25 DE DE60318567T patent/DE60318567T2/de not_active Expired - Lifetime
- 2003-04-25 EP EP03727365A patent/EP1501828B1/de not_active Expired - Lifetime
- 2003-04-25 RS YUP-928/04A patent/RS51407B/sr unknown
- 2003-04-25 AU AU2003233067A patent/AU2003233067B2/en not_active Ceased
- 2003-04-25 KR KR1020047016871A patent/KR100948469B1/ko not_active Expired - Fee Related
- 2003-04-25 DK DK03727365T patent/DK1501828T3/da active
- 2003-04-25 CN CNB03814493XA patent/CN1310911C/zh not_active Expired - Fee Related
- 2003-04-25 AT AT03727365T patent/ATE383356T1/de active
- 2003-04-25 SI SI200331114T patent/SI1501828T1/sl unknown
2004
- 2004-10-05 ZA ZA2004/08023A patent/ZA200408023B/en unknown
2008
- 2008-02-18 CY CY20081100199T patent/CY1107204T1/el unknown

Also Published As

Publication number	Publication date
CY1107204T1 (el)	2012-11-21
US20050261304A1 (en)	2005-11-24
KR100948469B1 (ko)	2010-03-17
EP1501828B1 (de)	2008-01-09
HK1075664A1 (en)	2005-12-23
CN1310911C (zh)	2007-04-18
ZA200408023B (en)	2005-11-30
UA78035C2 (en)	2007-02-15
IL164796A (en)	2013-02-28
US7314878B2 (en)	2008-01-01
RS51407B (sr)	2011-02-28
DE60318567D1 (de)	2008-02-21
PT1501828E (pt)	2008-02-11
SI1501828T1 (sl)	2008-04-30
EA009682B1 (ru)	2008-02-28
WO2003091249A1 (en)	2003-11-06
JP4523289B2 (ja)	2010-08-11
CA2481763C (en)	2011-06-14
JP2006504631A (ja)	2006-02-09
DK1501828T3 (da)	2008-03-10
CA2481763A1 (en)	2003-11-06
BRPI0309594A8 (pt)	2017-04-11
IL164796A0 (en)	2005-12-18
RS92804A (sr)	2006-12-15
DE60318567T2 (de)	2009-02-19
KR20040104572A (ko)	2004-12-10
EA200401423A1 (ru)	2005-04-28
AU2003233067A1 (en)	2003-11-10
ES2297165T3 (es)	2008-05-01
EP1501828A1 (de)	2005-02-02
MXPA04010474A (es)	2004-12-13
CN1662528A (zh)	2005-08-31
AU2003233067B2 (en)	2009-01-08
BRPI0309594A2 (pt)	2016-11-16

Legal Events

Date

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Title

Description

2008-05-15

UEP

Publication of translation of european patent specification

Ref document number: 1501828

Country of ref document: EP

2011-04-15

EEFA

Change of the company name

Publication	Publication Date	Title
CY1107204T1 (el)	2012-11-21	Πιπεραζινοβενζοθειαζολια ως ουσιες για την θεραπευτικη αντιμετωπιση εγκεφαλικων ισχαιμικων διαταραχων ή διαταραχων του κνς
NO20053263L (no)	2005-08-31	Hydroksyetylaminderivater for behandling av Alzheimers sykdom.
CY1111086T1 (el)	2015-06-11	Παραγωγα 2-αμινο-κιναζολινης χρησιμα ως αναστολεις της βητα-σεκρετασης (bace)
ATE396973T1 (de)	2008-06-15	Benzylether- und benzylamino-beta-sekretase- hemmer zur behandlung von alzheimer-krankheit
CY1111070T1 (el)	2015-06-11	Παραγωγα 2-αμινο-κουιναζολινης χρησιμα ως αναστολεις της β-σεκρετασης (bace)
ECSP045115A (es)	2004-07-23	INDOL-2-CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa
ATE517861T1 (de)	2011-08-15	Benzylether und benzylaminoverbindungen als inhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
ATE337780T1 (de)	2006-09-15	Indoly-lsulphonyl-verbindungen zur behandlung von störungen des zns
NO20050851L (no)	2005-03-29	Kaspase-inhibitorer og anvendelser derav
ATE388708T1 (de)	2008-03-15	Piperazinderivate und anwendungsverfahren
NO20063137L (no)	2006-08-31	Tricykliske indolhydroksyetylaminderivater og deres anvendelse i behandlingen av Alzheimers sykdom
DE602004010186D1 (de)	2007-12-27	Diazaspiropiperidinderivate als inhibitoren von glycintransporter 1 und glycintransporter 2
EA200200750A1 (ru)	2003-02-27	Новое терапевтическое применение еноксапарина
EP1311486A4 (de)	2004-03-31	Verwendungen von thaliporphin oder seinen derivaten in der behandlung von herzkrankheiten und seine herstellung