ECSP066335A - Compuestos de indazol 3,5-disustituidos, composiciones farmacéuticas y métodos para intervenir en o inhibir la proliferación celular - Google Patents

Compuestos de indazol 3,5-disustituidos, composiciones farmacéuticas y métodos para intervenir en o inhibir la proliferación celular

Info

Publication number
ECSP066335A
ECSP066335A EC2006006335A ECSP066335A ECSP066335A EC SP066335 A ECSP066335 A EC SP066335A EC 2006006335 A EC2006006335 A EC 2006006335A EC SP066335 A ECSP066335 A EC SP066335A EC SP066335 A ECSP066335 A EC SP066335A
Authority
EC
Ecuador
Prior art keywords
compounds
cell proliferation
pharmaceutical compositions
inhibit
methods
Prior art date
Application number
EC2006006335A
Other languages
English (en)
Inventor
Susan Elizabeth Kephart
Indrawan James Mcalpine
Siegfried Heinz Reich
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ECSP066335A publication Critical patent/ECSP066335A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describen compuestos de indazol 3,5-disustituidos que modulan y/o inhiben la proliferación celular tal como la actividad de las proteínas cinasa. Estos compuestos y composiciones farmacéuticos que los contienen son capaces de intervenir en enfermedades dependientes de la CDK para modular y/o inhibir la proliferación celular no deseada. La invención también se dirige al uso terapéutico o profiláctico de composiciones farmacéuticos que contienen tales compuestos y a métodos para tratar el cáncer así como otras condiciones patológicas asociadas con angiogénesis y/o proliferación celular, no deseada, tales como: retinopatía, diabética, glaucoma neovascular, artritis reumatoide y soriasis, por administración de cantidades eficaces de tales compuestos.
EC2006006335A 2003-07-30 2006-01-30 Compuestos de indazol 3,5-disustituidos, composiciones farmacéuticas y métodos para intervenir en o inhibir la proliferación celular ECSP066335A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49147403P 2003-07-30 2003-07-30
US49207303P 2003-07-31 2003-07-31

Publications (1)

Publication Number Publication Date
ECSP066335A true ECSP066335A (es) 2006-07-28

Family

ID=34108010

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006335A ECSP066335A (es) 2003-07-30 2006-01-30 Compuestos de indazol 3,5-disustituidos, composiciones farmacéuticas y métodos para intervenir en o inhibir la proliferación celular

Country Status (24)

Country Link
US (2) US7008953B2 (es)
EP (1) EP1658284A1 (es)
JP (1) JP3920914B2 (es)
KR (1) KR20060030914A (es)
AR (1) AR045143A1 (es)
AU (1) AU2004259531A1 (es)
BR (1) BRPI0413051A (es)
CA (1) CA2532908A1 (es)
CO (1) CO5650247A2 (es)
EA (1) EA200600123A1 (es)
EC (1) ECSP066335A (es)
IL (1) IL172924A0 (es)
IS (1) IS8214A (es)
MA (1) MA27937A1 (es)
MX (1) MXPA06001193A (es)
NL (1) NL1026761C2 (es)
NO (1) NO20060319L (es)
OA (1) OA13196A (es)
PA (1) PA8608201A1 (es)
PE (1) PE20050330A1 (es)
TN (1) TNSN06038A1 (es)
TW (1) TW200521124A (es)
UY (1) UY28442A1 (es)
WO (1) WO2005009997A1 (es)

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OA13196A (en) 2006-12-13
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CO5650247A2 (es) 2006-06-30
MXPA06001193A (es) 2006-04-11
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IL172924A0 (en) 2006-06-11
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