ECSP099353A - Composiciones y métodos para modular los receptores - Google Patents

Composiciones y métodos para modular los receptores

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Publication number
ECSP099353A
ECSP099353A EC2009009353A ECSP099353A ECSP099353A EC SP099353 A ECSP099353 A EC SP099353A EC 2009009353 A EC2009009353 A EC 2009009353A EC SP099353 A ECSP099353 A EC SP099353A EC SP099353 A ECSP099353 A EC SP099353A
Authority
EC
Ecuador
Prior art keywords
methods
compounds
raf
pdgfr
abl
Prior art date
Application number
EC2009009353A
Other languages
English (en)
Inventor
Xiaodong Wang
Christopher Cow
Pingda Ren
Shuli You
Taebo Sim
Yun He
Valentina Molteni
Xiaolin Li
Donatella Chianelli
Jon Loren
Juliet Nabakka
Xiaodong Liu
Zuosheng Liu
Songchun Jiang
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39027274&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP099353(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Irm Llc filed Critical Irm Llc
Publication of ECSP099353A publication Critical patent/ECSP099353A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P31/12—Antivirals
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)

Abstract

La invención proporciona los compuestos y las composiciones farmacéuticas, que son útiles como inhibidores de la proteína quinasa, así como los métodos para usar tales compuestos para tratar, mejorar o prevenir una condición asociada con la actividad anormal o desregularizada de la quinasa. En algunas formas de realización, la invención proporciona los métodos para usar tales compuestos para tratar, mejorar o prevenir enfermedades o desórdenes que implican la activación anormal del c-kit, PDGFR?, PDGFR?, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGF , SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2 , BRK, KDR, c-raf o la quinasa b-raf, o sus formas mutantes.
EC2009009353A 2006-10-20 2009-05-20 Composiciones y métodos para modular los receptores ECSP099353A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86243006P 2006-10-20 2006-10-20

Publications (1)

Publication Number Publication Date
ECSP099353A true ECSP099353A (es) 2009-06-30

Family

ID=39027274

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009353A ECSP099353A (es) 2006-10-20 2009-05-20 Composiciones y métodos para modular los receptores

Country Status (25)

Country Link
US (2) US7678792B2 (es)
EP (1) EP2076513A1 (es)
JP (1) JP2010506948A (es)
KR (1) KR101079520B1 (es)
CN (1) CN101528744A (es)
AR (1) AR063343A1 (es)
AU (1) AU2007309279B2 (es)
BR (1) BRPI0718162A2 (es)
CA (1) CA2667010A1 (es)
CL (1) CL2007003005A1 (es)
CO (1) CO6170361A2 (es)
CR (1) CR10717A (es)
EA (1) EA200900573A1 (es)
EC (1) ECSP099353A (es)
IL (1) IL197875A0 (es)
MA (1) MA30888B1 (es)
MX (1) MX2009004141A (es)
NI (1) NI200900061A (es)
NO (1) NO20091949L (es)
PE (1) PE20081262A1 (es)
SM (1) SMP200900027B (es)
TN (1) TN2009000145A1 (es)
TW (1) TW200825081A (es)
WO (1) WO2008051757A1 (es)
ZA (1) ZA200902711B (es)

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