ECSP11011419A - Compuesto de pirazol - Google Patents
Compuesto de pirazolInfo
- Publication number
- ECSP11011419A ECSP11011419A EC2011011419A ECSP11011419A ECSP11011419A EC SP11011419 A ECSP11011419 A EC SP11011419A EC 2011011419 A EC2011011419 A EC 2011011419A EC SP11011419 A ECSP11011419 A EC SP11011419A EC SP11011419 A ECSP11011419 A EC SP11011419A
- Authority
- EC
- Ecuador
- Prior art keywords
- hydrogen atom
- halogen atom
- compound
- optionally
- pirazol
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención proporciona un compuesto que tiene una excelente acción supresora de la secreción de un ácido, y que exhibe una actividad anti-tumoral y otras. Se describe específicamente, un compuesto representado por la fórmula (I):en donde R1 es un sustituyente, R2 es (i) un átomo de hidrógeno, (ii) un grupo alquilo C1-6 que tiene opcionalmente un átomo de halógeno o (iii) un grupo ciano, R3 es (i) un átomo de hidrógeno, (ii) un átomo de halógeno, (iii) un grupo ciano, (iv) un grupo alquilo C1-6 que tiene opcionalmente un átomo de halógeno o (v) un grupo alcoxi C1-6, que tiene opcionalmente un átomo de halógeno, y uno de R2 y R3 es un átomo de hidrógeno, y el otro es un sustituyente diferente de un átomo de hidrógeno, o una sal del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009077078 | 2009-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP11011419A true ECSP11011419A (es) | 2011-11-30 |
Family
ID=42781069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2011011419A ECSP11011419A (es) | 2009-03-26 | 2011-08-25 | Compuesto de pirazol |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8895588B2 (es) |
| EP (1) | EP2412713B1 (es) |
| JP (1) | JP5552481B2 (es) |
| KR (1) | KR101656906B1 (es) |
| CN (1) | CN102448953B (es) |
| AU (1) | AU2010228220B2 (es) |
| BR (1) | BRPI1009090A2 (es) |
| CA (1) | CA2756086A1 (es) |
| CL (1) | CL2011002351A1 (es) |
| CO (1) | CO6460700A2 (es) |
| CR (1) | CR20110533A (es) |
| DO (1) | DOP2011000296A (es) |
| EA (1) | EA019853B1 (es) |
| EC (1) | ECSP11011419A (es) |
| GE (1) | GEP20156222B (es) |
| IL (1) | IL215235A (es) |
| MA (1) | MA33214B1 (es) |
| MX (1) | MX2011009943A (es) |
| NZ (1) | NZ595890A (es) |
| PE (1) | PE20120618A1 (es) |
| SG (1) | SG174476A1 (es) |
| TN (1) | TN2011000474A1 (es) |
| UA (1) | UA107457C2 (es) |
| WO (1) | WO2010110378A1 (es) |
| ZA (1) | ZA201107435B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6216338B2 (ja) | 2012-06-27 | 2017-10-18 | 武田薬品工業株式会社 | 塩により安定化されたアミンおよび有機酸の液状製剤 |
| CN111419845A (zh) | 2012-09-27 | 2020-07-17 | 阿莱塔纳治疗学股份有限公司 | 应用控制食欲不振的化合物的组合物和方法 |
| US9700591B2 (en) | 2015-01-28 | 2017-07-11 | Aratana Therapeutics, Inc. | Compositions and methods for chronic use of a weight-gaining compound |
| CN105067814A (zh) * | 2015-07-24 | 2015-11-18 | 中国科学院成都生物研究所 | 解旋酶水解atp活性测定方法 |
| KR20210156235A (ko) * | 2020-06-17 | 2021-12-24 | 일동제약(주) | 신규한 산 분비 억제제 및 이의 용도 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3285991A (en) | 1963-03-26 | 1966-11-15 | Union Carbide Corp | Polyepoxides cured with the reaction product of a dihydroxydiphenylsul-fone, an amine, and an aldehyde |
| US4847289A (en) | 1987-06-08 | 1989-07-11 | Merck & Co., Inc. | Thiophene sulfonamide antiglaucoma agents |
| CN1071924A (zh) | 1991-10-29 | 1993-05-12 | 纳幕尔杜邦公司 | 除草的三唑羧酸酰胺 |
| DE69532245T2 (de) | 1994-09-26 | 2004-09-16 | Shionogi & Co., Ltd. | Imidazolderivat |
| JPH0948778A (ja) | 1995-08-04 | 1997-02-18 | Sagami Chem Res Center | ２−置換−３−アルコキシ−５−（ピロール−２−イル）フラン誘導体 |
| WO1997017070A1 (en) | 1995-11-06 | 1997-05-15 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
| CN1246847A (zh) | 1996-12-23 | 2000-03-08 | 杜邦药品公司 | 作为Xa因子抑制剂的含氮杂芳族化合物 |
| AU1918299A (en) | 1998-02-23 | 1999-09-06 | Warner-Lambert Company | Substituted quinoxaline derivatives as interleukin-8 receptor antagonists |
| AU2003254282A1 (en) | 2002-08-01 | 2004-02-23 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
| US7417152B2 (en) | 2003-05-02 | 2008-08-26 | Elan Pharmaceuticals, Inc. | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases |
| WO2004103968A1 (en) | 2003-05-26 | 2004-12-02 | Aponetics Ag | Sulfopyrroles |
| AU2004259012C1 (en) | 2003-07-23 | 2012-08-02 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
| EP2336107B1 (en) | 2004-09-30 | 2015-09-23 | Takeda Pharmaceutical Company Limited | Proton pump inhibitors |
| EP2327692B9 (en) | 2005-08-30 | 2014-06-04 | Takeda Pharmaceutical Company Limited | 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors |
| EP2005957B1 (en) | 2006-03-31 | 2012-05-30 | Takeda Pharmaceutical Company Limited | Acid secretion inhibitor |
| US8933105B2 (en) * | 2007-02-28 | 2015-01-13 | Takeda Pharmaceutical Company Limited | Pyrrole compounds |
| JP2009077078A (ja) | 2007-09-19 | 2009-04-09 | Brother Ind Ltd | 位置検出システム |
| EP2196459B1 (en) | 2007-09-28 | 2016-11-02 | Takeda Pharmaceutical Company Limited | 5-membered heterocyclic compound |
| PE20090709A1 (es) | 2007-09-28 | 2009-07-15 | Takeda Pharmaceutical | Compuestos heterociclico de 5 miembros |
| PE20091846A1 (es) | 2008-05-19 | 2009-12-16 | Plexxikon Inc | DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS |
| MX2011000460A (es) | 2008-07-18 | 2011-03-15 | Takeda Pharmaceutical | Derivados de benzazepina y su uso como antagonistas de histamina h3. |
-
2010
- 2010-03-25 US US13/260,507 patent/US8895588B2/en active Active
- 2010-03-25 AU AU2010228220A patent/AU2010228220B2/en not_active Ceased
- 2010-03-25 MA MA34275A patent/MA33214B1/fr unknown
- 2010-03-25 NZ NZ595890A patent/NZ595890A/xx not_active IP Right Cessation
- 2010-03-25 WO PCT/JP2010/055257 patent/WO2010110378A1/ja not_active Ceased
- 2010-03-25 PE PE2011001696A patent/PE20120618A1/es not_active Application Discontinuation
- 2010-03-25 CN CN201080023162.7A patent/CN102448953B/zh active Active
- 2010-03-25 SG SG2011067808A patent/SG174476A1/en unknown
- 2010-03-25 EP EP10756174.8A patent/EP2412713B1/en active Active
- 2010-03-25 MX MX2011009943A patent/MX2011009943A/es active IP Right Grant
- 2010-03-25 KR KR1020117024240A patent/KR101656906B1/ko active Active
- 2010-03-25 UA UAA201112488A patent/UA107457C2/uk unknown
- 2010-03-25 JP JP2011506117A patent/JP5552481B2/ja active Active
- 2010-03-25 GE GEAP201012426A patent/GEP20156222B/en unknown
- 2010-03-25 EA EA201171168A patent/EA019853B1/ru not_active IP Right Cessation
- 2010-03-25 CA CA2756086A patent/CA2756086A1/en not_active Abandoned
- 2010-03-25 BR BRPI1009090A patent/BRPI1009090A2/pt not_active IP Right Cessation
-
2011
- 2011-08-25 EC EC2011011419A patent/ECSP11011419A/es unknown
- 2011-09-19 IL IL215235A patent/IL215235A/en not_active IP Right Cessation
- 2011-09-21 TN TN2011000474A patent/TN2011000474A1/fr unknown
- 2011-09-23 CL CL2011002351A patent/CL2011002351A1/es unknown
- 2011-09-23 DO DO2011000296A patent/DOP2011000296A/es unknown
- 2011-10-11 ZA ZA2011/07435A patent/ZA201107435B/en unknown
- 2011-10-12 CR CR20110533A patent/CR20110533A/es unknown
- 2011-10-26 CO CO11144548A patent/CO6460700A2/es active IP Right Grant
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