ECSP13012703A - Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak - Google Patents

Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak

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Publication number
ECSP13012703A
ECSP13012703A ECSP13012703A ECSP13012703A EC SP13012703 A ECSP13012703 A EC SP13012703A EC SP13012703 A ECSP13012703 A EC SP13012703A EC SP13012703 A ECSP13012703 A EC SP13012703A
Authority
EC
Ecuador
Prior art keywords
cyclobutyl
pyrrolopyridine
derivatives substituted
jak inhibitors
pyrrolopyrimidine derivatives
Prior art date
Application number
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English (en)
Inventor
Joseph Glenn
James D Rodgers
Wenyu Zhu
Lixin Shao
Stacey Shepard
Original Assignee
Incyte Corp
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Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of ECSP13012703A publication Critical patent/ECSP13012703A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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Abstract

La presente invención provee pirrolopirimidinas y pirrolopiridinas sustituidas con ciclobutilo de la fórmula I:en donde X, Y, Z, L, A, R5, n y m se definen con anterioridad, así como sus composiciones y métodos de uso que modulan la actividad de Janus quinasas (JAKs) y son de utilidad en el tratamiento de enfermedades relacionadas con la actividad de JAKs que incluyen, por ejemplo, trastornos inflamatorios, trastornos autoinmunes, cáncer y otras enfermedades.
ECSP13012703 2010-11-19 2013-06-19 Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak ECSP13012703A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41570510P 2010-11-19 2010-11-19

Publications (1)

Publication Number Publication Date
ECSP13012703A true ECSP13012703A (es) 2013-08-30

Family

ID=45094278

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13012703 ECSP13012703A (es) 2010-11-19 2013-06-19 Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak

Country Status (23)

Country Link
US (3) US8933085B2 (es)
EP (1) EP2640723A1 (es)
JP (1) JP5917545B2 (es)
KR (1) KR20140019300A (es)
CN (1) CN103415515B (es)
AR (1) AR083933A1 (es)
AU (1) AU2011329734B2 (es)
BR (1) BR112013012502A2 (es)
CA (1) CA2818542A1 (es)
CL (1) CL2013001412A1 (es)
CO (1) CO6761386A2 (es)
CR (1) CR20130280A (es)
EA (1) EA026201B1 (es)
EC (1) ECSP13012703A (es)
IL (1) IL226407A (es)
MX (1) MX344478B (es)
NZ (1) NZ611151A (es)
PE (1) PE20140146A1 (es)
PH (1) PH12013501001A1 (es)
SG (1) SG190839A1 (es)
TW (1) TW201249845A (es)
UA (1) UA113156C2 (es)
WO (1) WO2012068450A1 (es)

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TW201406761A (zh) * 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
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TWI761825B (zh) 2012-11-15 2022-04-21 美商英塞特控股公司 盧梭利替尼之緩釋性劑型
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