EE02973B1 - Difenüülbutüül-piperasiinkarboksamiidi kasutamine narkomaaniavastase ravimi valmistamiseks ja farmatseutiline kompositsioon - Google Patents

Difenüülbutüül-piperasiinkarboksamiidi kasutamine narkomaaniavastase ravimi valmistamiseks ja farmatseutiline kompositsioon

Info

Publication number: EE02973B1
Authority: EE; Estonia
Prior art keywords: drug; diphenylbutyl; piperazinecarboxamide; manufacture; pharmaceutical composition
Prior art date: 1991-03-22

Application number

EE9400358A

Other languages

English (en)

Estonian (et)

Inventor

Bj�rk Anders

Christensson Erik

Original Assignee

Pharmacia & Upjohn Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-22

Filing date

1994-11-17

Publication date

1997-04-15

1994-11-17 Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab

1997-04-15 Publication of EE02973B1 publication Critical patent/EE02973B1/xx

Links

229940079593 drug Drugs 0.000 title abstract 4
239000003814 drug Substances 0.000 title abstract 4
PTPTUSSTCDZDGG-UHFFFAOYSA-N 2-(4,4-diphenylbutyl)piperazine-1-carboxamide Chemical compound NC(=O)N1CCNCC1CCCC(C=1C=CC=CC=1)C1=CC=CC=C1 PTPTUSSTCDZDGG-UHFFFAOYSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
NNAIYOXJNVGUOM-UHFFFAOYSA-N amperozide Chemical compound C1CN(C(=O)NCC)CCN1CCCC(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 NNAIYOXJNVGUOM-UHFFFAOYSA-N 0.000 abstract 2
230000000631 nonopiate Effects 0.000 abstract 2
206010012335 Dependence Diseases 0.000 abstract 1
208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
206010048010 Withdrawal syndrome Diseases 0.000 abstract 1
229950000388 amperozide Drugs 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
230000001629 suppression Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Addiction (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Toxicology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)

EE9400358A 1991-03-22 1994-11-17 Difenüülbutüül-piperasiinkarboksamiidi kasutamine narkomaaniavastase ravimi valmistamiseks ja farmatseutiline kompositsioon EE02973B1 (et)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9100860A SE9100860D0 (sv)	1991-03-22	1991-03-22	New use

Publications (1)

Publication Number	Publication Date
EE02973B1 true EE02973B1 (et)	1997-04-15

Family

ID=20382242

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9400358A EE02973B1 (et)	1991-03-22	1994-11-17	Difenüülbutüül-piperasiinkarboksamiidi kasutamine narkomaaniavastase ravimi valmistamiseks ja farmatseutiline kompositsioon

Country Status (24)

Country	Link
US (2)	US5434156A (de)
EP (1)	EP0538422B1 (de)
JP (1)	JP3221611B2 (de)
KR (1)	KR100196674B1 (de)
AT (1)	ATE199057T1 (de)
AU (1)	AU653797B2 (de)
BG (1)	BG61829B1 (de)
BR (1)	BR9204969A (de)
CA (1)	CA2083505C (de)
CZ (1)	CZ282222B6 (de)
DE (1)	DE69231680T2 (de)
DK (1)	DK0538422T3 (de)
EE (1)	EE02973B1 (de)
ES (1)	ES2154261T3 (de)
GR (1)	GR3035805T3 (de)
HU (2)	HU217833B (de)
IE (1)	IE920920A1 (de)
NO (1)	NO301311B1 (de)
PT (1)	PT100279B (de)
RO (1)	RO109702B1 (de)
RU (1)	RU2095062C1 (de)
SE (1)	SE9100860D0 (de)
SK (1)	SK279237B6 (de)
WO (1)	WO1992016211A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9100860D0 (sv) *	1991-03-22	1991-03-22	Kabi Pharmacia Ab	New use
SE9201239D0 (sv)	1992-04-21	1992-04-21	Kabi Pharmacia Ab	Agents for treating substance abuse disorders
JP3571114B2 (ja) *	1995-07-11	2004-09-29	ポーラ化成工業株式会社	麻薬拮抗剤
US6265393B1 (en)	1998-08-07	2001-07-24	Heinrichs William Leroy	Prevention of endometriosis signs or symptons
US6090780A (en) *	1999-04-07	2000-07-18	Chandon Prasad	Histidyl-proline diketopiperazine and method of use
GB9923748D0 (en)	1999-10-07	1999-12-08	Glaxo Group Ltd	Chemical compounds
USRE39921E1 (en)	1999-10-07	2007-11-13	Smithkline Beecham Corporation	Chemical compounds
GB0025354D0 (en)	2000-10-17	2000-11-29	Glaxo Group Ltd	Chemical compounds
US20050192271A1 (en) *	2003-07-15	2005-09-01	Hythiam, Inc.	Use of selective chloride channel modulators to treat alcohol and/or stimulant substance abuse
ATE338575T1 (de) *	2001-01-17	2006-09-15	Hythiam Inc	Verwendung von flumazenil bei der entwicklung eines arzneimittels zur behandlung von alkoholabhängigkeit
ES2287255T3 (es) *	2001-02-15	2007-12-16	Hythiam, Inc.	Uso de flumazenil para producir un medicamento parta el tratamiento de la dependencia a cocaina.
US7183410B2 (en) *	2001-08-02	2007-02-27	Bidachem S.P.A.	Stable polymorph of flibanserin
US20030060475A1 (en) *	2001-08-10	2003-03-27	Boehringer Ingelheim Pharma Kg	Method of using flibanserin for neuroprotection
UA78974C2 (en) *	2001-10-20	2007-05-10	Boehringer Ingelheim Pharma	Use of flibanserin for treating disorders of sexual desire
US10675280B2 (en)	2001-10-20	2020-06-09	Sprout Pharmaceuticals, Inc.	Treating sexual desire disorders with flibanserin
GB0203020D0 (en)	2002-02-08	2002-03-27	Glaxo Group Ltd	Chemical compounds
JP2005522436A (ja)	2002-02-08	2005-07-28	グラクソ　グループ　リミテッド	ピペリジルカルボキシアミド誘導体またはそのタキキニン介在疾患の治療における使用
GB0203022D0 (en)	2002-02-08	2002-03-27	Glaxo Group Ltd	Chemical compounds
US20050239798A1 (en) *	2004-04-22	2005-10-27	Boehringer Ingelheim Pharmaceuticals, Inc.	Method for the treatment of premenstrual and other female sexual disorders
CA2563743A1 (en) *	2004-04-22	2005-11-03	Boehringer Ingelheim International Gmbh	New pharmaceutical compositions for the treatment of sexual disorders ii
US20060025420A1 (en) *	2004-07-30	2006-02-02	Boehringer Ingelheimn International GmbH	Pharmaceutical compositions for the treatment of female sexual disorders
WO2006024471A1 (en) *	2004-09-03	2006-03-09	Boehringer Ingelheim International Gmbh	Method for the treatment of attention deficit hyperactivity disorder
JP2008531714A (ja) *	2005-03-04	2008-08-14	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	不安障害の治療用及び／又は予防用の医薬組成物
WO2006096439A2 (en) *	2005-03-04	2006-09-14	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases
WO2006096435A1 (en) *	2005-03-04	2006-09-14	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for the treatment and/or prevention of depression
WO2006119884A2 (en) *	2005-05-06	2006-11-16	Boehringer Ingelheim International Gmbh	Method for the treatment of drug abuse with flibanserin
US20060264512A1 (en) *	2005-05-19	2006-11-23	Boehringer Ingelheim International Gmbh	Method for the treatment of sexual dysfunction due to medical conditions
JP2008540673A (ja) *	2005-05-19	2008-11-20	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	薬剤誘発性性機能不全の治療方法
ES2646326T3 (es)	2005-08-03	2017-12-13	Sprout Pharmaceuticals, Inc.	Uso de flibanserina en el tratamiento de la obesidad
US20070123540A1 (en) *	2005-10-29	2007-05-31	Angelo Ceci	Sexual desire enhancing medicaments comprising benzimidazolone derivatives
WO2007048803A1 (en) *	2005-10-29	2007-05-03	Boehringer Ingelheim International Gmbh	Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
US20070105869A1 (en) *	2005-11-08	2007-05-10	Stephane Pollentier	Use of flibanserin for the treatment of pre-menopausal sexual desire disorders
BRPI0712039A2 (pt) *	2006-05-09	2011-12-20	Boehringer Ingelheim Int	uso de flibanserina para o tratamento de distúrbios de desejo sexual pós-menopausa
WO2008000760A1 (en)	2006-06-30	2008-01-03	Boehringer Ingelheim International Gmbh	Flibanserin for the treatment of urinary incontinence and related diseases
EP2043648A1 (de) *	2006-07-14	2009-04-08	Boehringer Ingelheim International GmbH	Verwendung von flibanserin zur behandlung von sexualstörungen bei frauen
CL2007002214A1 (es) *	2006-08-14	2008-03-07	Boehringer Ingelheim Int	Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp
BRPI0716439B8 (pt)	2006-08-14	2021-05-25	Boehringer Ingelheim Int	sistemas de liberação farmacêutico compreendendo flibanserina, processo para preparação e uso dos mesmos
BRPI0716436B8 (pt) *	2006-08-25	2021-05-25	Boehringer Ingelheim Int	sistema de liberação controlada e método para fabricação do mesmo
CL2008002693A1 (es)	2007-09-12	2009-10-16	Boehringer Ingelheim Int	Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO154582C (no) *	1978-10-20	1986-11-05	Ferrosan Ab	Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider.
SE9100860D0 (sv) *	1991-03-22	1991-03-22	Kabi Pharmacia Ab	New use

1991
- 1991-03-22 SE SE9100860A patent/SE9100860D0/xx unknown
1992
- 1992-03-23 ES ES92907159T patent/ES2154261T3/es not_active Expired - Lifetime
- 1992-03-23 KR KR1019920702939A patent/KR100196674B1/ko not_active Expired - Fee Related
- 1992-03-23 AT AT92907159T patent/ATE199057T1/de not_active IP Right Cessation
- 1992-03-23 SK SK3449-92A patent/SK279237B6/sk unknown
- 1992-03-23 HU HU9203632A patent/HU217833B/hu not_active IP Right Cessation
- 1992-03-23 CA CA002083505A patent/CA2083505C/en not_active Expired - Fee Related
- 1992-03-23 US US07/949,869 patent/US5434156A/en not_active Expired - Fee Related
- 1992-03-23 BR BR9204969A patent/BR9204969A/pt not_active Application Discontinuation
- 1992-03-23 PT PT100279A patent/PT100279B/pt not_active IP Right Cessation
- 1992-03-23 HU HU9203632A patent/HU9203632D0/hu unknown
- 1992-03-23 WO PCT/SE1992/000182 patent/WO1992016211A1/en not_active Ceased
- 1992-03-23 RO RO92-01457A patent/RO109702B1/ro unknown
- 1992-03-23 IE IE092092A patent/IE920920A1/en not_active IP Right Cessation
- 1992-03-23 AU AU14280/92A patent/AU653797B2/en not_active Ceased
- 1992-03-23 DK DK92907159T patent/DK0538422T3/da active
- 1992-03-23 CZ CS923449A patent/CZ282222B6/cs not_active IP Right Cessation
- 1992-03-23 JP JP50658392A patent/JP3221611B2/ja not_active Expired - Fee Related
- 1992-03-23 DE DE69231680T patent/DE69231680T2/de not_active Expired - Fee Related
- 1992-03-23 EP EP92907159A patent/EP0538422B1/de not_active Expired - Lifetime
- 1992-03-23 RU RU9292016400A patent/RU2095062C1/ru not_active IP Right Cessation
- 1992-11-20 BG BG97108A patent/BG61829B1/bg unknown
- 1992-11-23 NO NO924502A patent/NO301311B1/no unknown
1994
- 1994-11-17 EE EE9400358A patent/EE02973B1/xx not_active IP Right Cessation
1995
- 1995-04-25 US US08/428,899 patent/US5618817A/en not_active Expired - Fee Related
2001
- 2001-04-27 GR GR20010400653T patent/GR3035805T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU9203632D0 (en)	1993-03-29
JPH05507731A (ja)	1993-11-04
NO301311B1 (no)	1997-10-13
PT100279A (pt)	1993-07-30
SK279237B6 (sk)	1998-08-05
CA2083505C (en)	2003-06-10
JP3221611B2 (ja)	2001-10-22
NO924502L (no)	1992-11-23
SK344992A3 (en)	1995-11-08
SE9100860D0 (sv)	1991-03-22
KR100196674B1 (ko)	1999-06-15
BG97108A (bg)	1994-03-24
NO924502D0 (no)	1992-11-23
DK0538422T3 (da)	2001-05-07
BG61829B1 (bg)	1998-07-31
RU2095062C1 (ru)	1997-11-10
US5618817A (en)	1997-04-08
EP0538422B1 (de)	2001-02-07
WO1992016211A1 (en)	1992-10-01
RO109702B1 (ro)	1995-05-30
KR930700108A (ko)	1993-03-13
GR3035805T3 (en)	2001-07-31
PT100279B (pt)	1999-06-30
CZ282222B6 (cs)	1997-06-11
CA2083505A1 (en)	1992-09-23
ATE199057T1 (de)	2001-02-15
AU1428092A (en)	1992-10-21
IE920920A1 (en)	1992-09-23
CZ344992A3 (en)	1994-02-16
ES2154261T3 (es)	2001-04-01
AU653797B2 (en)	1994-10-13
DE69231680T2 (de)	2001-06-07
BR9204969A (pt)	1993-07-27
DE69231680D1 (de)	2001-03-15
HUT64696A (en)	1994-02-28
EP0538422A1 (de)	1993-04-28
HU217833B (hu)	2000-04-28
US5434156A (en)	1995-07-18

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2007-08-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20061117

Publication	Publication Date	Title
SE9100860D0 (sv)	1991-03-22	New use
KR930702022A (ko)	1993-09-08	인슐린의 경구 투여에 의한 타잎 1 당뇨병의 치료 또는 예방법
FI941770A0 (fi)	1994-04-15	Tehostettu ihonläpäisyjärjestelmä lääkeaineiden parannettua paikallista antoa varten
FI941771A0 (fi)	1994-04-15	Tehostettu ihonläpäisyjärjestelmä lääkeaineiden parannettua paikallista antoa varten
EP1685839B8 (de)	2013-06-26	Peroral zu verabreichende Arzneiform enthaltend eine Kombination von einem Opioid-Agonisten und einem Opioid- Antagonisten
DK0591492T3 (da)	1999-02-15	Farmaceutisk præparat indeholdende et defineret lipidsystem
KR910019618A (ko)	1991-12-19	발기부전증 치료용 제약 조성물
PT1102586E (pt)	2005-02-28	Utilizacao de extractos de ginkgo biloba para a preparacao de um medicamento para o tratamento da esclerose lateral amiotrofica
KR100321319B1 (ko)	2002-07-27	물질남용장애를치료하는방법및제약학적조성물
KR890004705A (ko)	1989-05-09	항바이러스성 제제
KR960703593A (ko)	1996-08-31	(R)-암로디핀에 의한 평활근 세포 이동의 억제 (Inhibition of Smooth Muscle Cell Migration by (R)-Amlodipine)
EP0272393A3 (de)	1989-09-06	Pharmazeutische Mischung
NZ332484A (en)	2001-01-26	use of pyridyl and pyrimidyl substituted piperazine derivatives for treating substance abuse disorders
KR940011006A (ko)	1994-06-20	황금추출물을 유효성분으로 하는 치주질환예방 및 치료제 조성물
KR920002150A (ko)	1992-02-28	항말라리아 약학적 배합제
CA2123853A1 (en)	1994-11-19	Smoking Suppressant and Method of Application Thereof
ATE224716T1 (de)	2002-10-15	Pharmazeutische zusammensetzungen von cinchonin dihydrochlorid
ATE14837T1 (de)	1985-08-15	Pharmazeutische zusammensetzungen.
UA20877A (uk)	1997-10-07	Препарат "кардіовіт" для лікування та профілактики серцево-судинних захворювань
BG95724A (en)	1995-01-31	Medicaments with analgetic, antiphlogestic and antibacterial effect for external use
KR880002520A (ko)	1988-05-09	망막증의 치료방법